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Chemical identification,antioxidant,cholinesterase inhibitory,and cytotoxic properties of fucoidan extracted from Persian Gulf Sargassumangustifolium

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Acta Oceanologica Sinica 2022年第12期41卷 133-141页

作者： Arghavan Hosseinpouri mehdi mohammadi Elham Ehsandoost Paria Sharafi-Badr Narges Obeidi Department of Cellular and Molecular Sciences Faculty of SciencesPersian Gulf UniversityBushehr 75168Iran Department of Marine Biotechnology Persian Gulf InstitutePersian Gulf UniversityBushehr 75168Iran Department of Biotechnology Persian Gulf Algae Development TechnologyDelvar Industrial Zone No.55Bushehr 75168Iran Department of Food Science and Technology Shiraz UniversityShiraz 71441-65186Iran Department of Pharmacognosy and Pharmaceutical Biotechnology School of PharmacyIran University of Medical SciencesTehran 14496-14535Iran Department of Hematology Faculty of ParamedicineBushehr University of Medical SciencesBushehr 75146-33341Iran

Marine macroalgal sulfated fucose-containing polysaccharides,like fucoidan,have drawn significant attention due to their biotechnological potentials,such as anti-cancer,antioxidant,and anti-cholinesterase *** fucoidan derived from brown macroalgae Sargassum angustifolium species(FSA)was investigated for its cytotoxic effects and alterations in cell proliferation,and cell cycle-related gene expression in the present study occurred on NB4 cell *** results showed that FSA would induce p53,p21,pro-apoptotic genes and increase expression of the p15 gene as a cell arrest ***,FSA inhibited the anti-apoptotic effect of the Bcl-2 gene and decreased dnmt-1 gene *** significantly exhibited potent 2,2-diphenyl-1-picrylhydrazyl(DPPH)radical scavenging activity(p<0.05)with an IC_(50) value of 0.157 mg/mL and showed moderate anti-acetylcholinesterase activity with an IC_(50) value of 1.20μg/*** results indicated the potential of FSA for the development of therapeutic or preventive agents of cancer and Alzheimer’s disease mainly through cytotoxic effect and AChE(acetylcholinesterase)inhibition as well as additional antioxidant capacities.

关键词： fucoidan Sargassum angustifolium cytotoxicity antioxidant anti-cholinesterase

Improving the Surface Roughness of Dental Implant Fixture by Considering the Size,Angle and Spraying Pressure of Sandblast Particles

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Journal of Bionic Engineering 2024年第1期21卷 303-324页

作者： Ehsan Anbarzadeh Bijan mohammadi School of Mechanical Engineering Iran University of Science and TechnologyTehranIran

In this study,different conditions of sandblasting on dental implant fixtures were investigated to achieve the best sandblasting conditions.18 different sandblasting conditions(Using 152 implant fixture samples)were examined,including parameters such as particle size,particle blasting pressure,and particle blasting *** surface treatment of the samples was performed using the SLA+Anodizing *** testing was performed for each of the 18 different states,and the average surface roughness of each of these was compared with each ***,a bone layer was placed on the sample with the closest average surface roughness to the standard and the least amount of aluminum oxide on its surface among the 18 different states,to confirm the accuracy and quality of the desired surface roughness by examining the bone formation process and *** results showed that state No.4(sandblast particle size:75µm,spraying pressure of sandblast particles:4 bar,sandblast particle spraying angle:30 degrees),which was prepared using the SLA+Anodizing method and had a surface roughness of 1.989µm(The percentage of Al_(2)O_(3)on the surface=6%),had the best sandblasting conditions and showed 95%cell viability and accelerated the treatment and bone formation process for about a *** simulation results,using Abaqus software,indicated that the stress distribution on the surface of the implant fixture in contact with the bone surface has increased by approximately 4.3%for state *** will help prevent loosening of the dental implant fixture over time.

关键词： Dental implants Surface treatment Sandblast Surface roughness Osseointegration

Approximate solution of Volterra-Fredholm integral equations using generalized barycentric rational interpolant

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 220-238页

作者： Hadis Azin Fakhrodin mohammadi Department of Mathematics University of HormozganBandar AbbasP.O.Box 3995Iran

It is well-known that interpolation by rational functions results in a more accurate approximation than the polynomials ***,classical rational interpolation has some deficiencies such as uncontrollable poles and low convergence *** contrast with the classical rational interpolants,the generalized barycentric rational interpolants which depend linearly on the interpolated values,yield infinite smooth approximation with no poles in real *** this paper,a numerical collocation approach,based on the generalized barycentric rational interpolation and Gaussian quadrature formula,was introduced to approximate the solution of Volterra-Fredholm integral *** types of points in the solution domain are used as interpolation *** obtained numerical results confirm that the barycentric rational interpolants are efficient tools for solving Volterra-Fredholm integral ***,integral equations with Runge’s function as an exact solution,no oscillation occurrs in the obtained approximate solutions so that the Runge’s phenomenon is avoided.

关键词： Barycentric rational interpolation Volterra-Fredholm integral equations Gaussian quadrature Runge's phenomenon

Annual growth of Fagus orientalis is limited by spring drought conditions in Iran’s Golestan Province

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Journal of Forestry Research 2024年第1期35卷 128-142页

作者： Khalil Ghorbani Jahangir mohammadi Laleh Rezaei Ghaleh Department of Water Engineering Faculty of Water and Soil EngineeringGorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Forestry Gorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Water Engineering Faculty of AgricultureUrmia UniversityUrmiaIran

Due to the lack of a uniform and accurate defi-nition of‘drought’,several indicators have been introduced based on different variables and methods,and the efficiency of each of these is determined according to their relationship with *** relationship between two drought indices,SPI(standardized precipitation index)and SPEI(standard-ized precipitation-evapotranspiration index)in different sea-sons was investigated using annual rings of 15 tree samples to determine the effect of drought on the growth of oriental beech(Fagus orientalis Lipsky)in the Hyrcanian forests of northern *** different evapotranspiration calcula-tion methods were evaluated on SPEI efficiency based on Hargreaves-Samani,Thornthwaite,and Penman-Monteith methods using the step-by-step M5 decision tree regression *** results show that SPEI based on the Penman-Monteith in a three-month time scale(spring)had similar temporal changes and a better relationship with annual tree rings(R^(2)=0.81)at a 0.05 significant *** change and a decreasing trend in the time series of annual tree rings are similar to the variation in the SPEI based on the Penman-Monteith *** affecting evapotranspiration,temperature,wind speed,and sunshine hours(used in the Penman-Monteith method),increased but precipitation *** non-linear modeling methods,SPEI based on Penman-Monteith best illustrated climate changes affecting tree growth.

关键词： Climate change Drought index Hyrcanian forests SPEI'Annual growth rings Fagus orientalis

Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2021年第3期27卷 177-182页

作者： Khalil Moradi Hossein Ashtarian Nicholas Yakubu Danzima Hamid Saeedi Behrouz Bijan Farzaneh Akbari Mohammad mehdi mohammadi Intensive Care Unit Imam Reza HospitalKermanshah University of Medical SciencesKermanshahIran Health Education Department Health SchooKermanshah University of Medical SciencesKerm anshahIran School of Nursing and Micwilery Tehran University of Medical SciencesTehranIran Student Research Comite School of NursingTabriz University of Medical SciencesTabrizIran

Objective To determine the effectiveness and safety of essential oil from Citrus aurantium on anxiety in patients undergoing coronary *** A single-blind,randomized controlled trial was conducted in 80 patients experiencing coronary angiography in Imam Ali Hospital in Kermanshah,Iran from April to November in *** patients were randomly divided into intervention and control groups by a random number table,40 cases in each *** patients in the intervention group inhaled Citrus aurantium essential oil for 15–20 min about 60 min before *** the same procedure,distilled water was used instead of Citrus aurantium in the control *** State-Trait Anxiety Inventory(STAI)was filled in and vital signs including systolic blood pressure(SBP),diastolic blood pressure(DBP),respiratory and pulse rate were recorded before and 20 min after the *** reactions after intervention were *** In the intervention group,the mean scores of STAI,SBP,DBP,respiratory and pulse rate were 53.30±10.13,134.82±11.75 mm Hg,84.49±6.99 mm Hg,17.87±1.73 times/min,and 76.48±12.55 beats/min at baseline and significantly decreased to 42.37±10.15,124.49±10.48 mm Hg,79.23±6.62 mm Hg,14.54±1.43 times/min,and 70.03±13.66 beats/min respectively 20 min after intervention(all P0.05).All subjects reported no adverse *** Inhalation of the essential oil from Citrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography.

关键词： single-blind randomized controlled trial essential oil Citrus aurantium anxiety coronary angiography non-drug treatment aromatherapy

Brucellosis: Pathophysiology and new promising treatments with medicinal plants and natural antioxidants

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Asian Pacific Journal of Tropical Medicine 2018年第11期11卷 597-608页

作者： Mohsen Alizadeh Ali Safarzadeh Mahmoud Bahmani Fatemeh BeyranvAND mehdi mohammadi Kimia Azarbaijani Mahmoud Rafieian-Kopaei Saber Abbaszadeh Razi Herbal Medicines Research Center Lorestan University of Medical Sciences Student Research Committee Lorestan University of Medical Sciences Biotechnology and Medicinal Plants Research Center Ilam University of Medical Sciences Medical Plants Research Center Basic Health Sciences Institute Shahrekord University of Medical Sciences

Brucellosis is an old, infectious and common zoonosis whose causative agents are Gramnegative bacteria from the Brucella genus. Brucellosis is transmitted through direct contactwith infected animals or using unpasteurized dairy products of goats, pigs, camels, sheep,buffalo and cows. Brucellosis is still the most common zoonosis in the world, with mostof cases occurring in developing countries. Today, an approach to traditional medicine andmedicinal plants, especially with regards to the repeated recommendations of the World HealthOrganization, is a necessity. One-third of chemical drugs are produced by using plants andthere is a high potential to produce more drugs from plants. Medicinal plants are helpful inthe management of various conditions, especially bacterial diseases. Although there is notenough scientific evidence regarding the clinical effectiveness of herbal drugs for the treatmentof brucellosis, there is strong evidence on the antimicrobial effects of herbal drugs to preventinfection. Therefore, this article seeks to describe the antibacterial effects of some plantderived essential oils or extracts, so that they can serve as promising choices to develop newanti-Brucella medications, as suitable alternatives to conventional antibiotics for brucellosis, asmuch as possible, taking into account the benefits of these herbal drugs.

关键词： Brucellosis Undulant fever Malta fever Herbal drugs Phytotherapy Antioxidant

A typology of clustered housing for older adults towards opportunities for social interaction:A case study of Dutch social housing

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Frontiers of Architectural Research 2024年第3期13卷 561-574页

作者： Kim Hamers Nienke Moor Masi mohammadi Research Group Architecture in Health HAN University of Applied SciencesArnhemthe Netherlands Chair Smart Architectural Technologies Eindhoven University of TechnologyEindhoventhe Netherlands

Dutch housing associations are dealing with a growing number of tenants who are ageing in ***,there is a lack of suitable housing that meets the(social)needs of this target *** housing,which offers a socio-spatial context that facilitates encounters between residents,is considered a promising housing concept to(partly)fill this ***,clustered housing is a broad concept consisting of a variety of housing types that differ from each other in the extent to which people“live together”.Still little is known about which types of clustered housing can be distinguished in relation to the potential for social ***,in this article we distinguish between types of clustered housing based on social,organizational,and spatial building *** have mapped these characteristics by combining real estate data of housing association Woonzorg Nederland with survey data collected among their building *** on this dataset,an explorative cluster analysis was performed,resulting in four types of clustered ***,further exploration of the data shows that,from the perspective of building managers,residents of certain types of clustered housing interact more often and feel more connected with each other than residents of non-clustered housing types.

关键词： Clustered housing Typology Seniors Social housing

Design of a Novel Electrochemical Aptasensor Based on Molybdenum Disulfide Nanosheets for Lysozyme Detection

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Journal of Analysis and Testing 2024年第1期8卷 16-27页

作者： Tavoos Beiki Ghasem Najafpour-Darzi Maedeh mohammadi Mohsen Shakeri Biotechnology Research Laboratory Department of Chemical EngineeringBabol Noshirvani University of TechnologyBabol 47148-71167Iran Department of Mechanical Engineering Babol Noshirvani University of TechnologyBabol 47148-71167Iran

The precise detection of lysozyme plays a crucial role in early diagnosis of kidney failure in leukemia ***,we designed an electrochemical aptasensor to detect lysozyme using a glassy carbon electrode(GCE)modified with molybdenum disulfide(MoS_(2))nanosheets decorated with chitosan(Ch)and gold nanoparticles(Au).In the next steps of aptasensor preparation,aptamer(Apt)strands were immobilized on MoS_(2)-Au-Ch/GCE surface via electrostatic interactions,and bovine serum albumin(BSA)solution was applied to cover unbonded areas on Apt/MoS_(2)-Au-Ch/*** MoS_(2)-Au-Ch nanocomposite can warrant enhanced immobilization of aptamers and strong signals because of wrinkle-like structure and base planes in MoS nanosheets,presence of abundant amino and carboxyl functional groups in chitosan and Au *** pulse voltammetry(DPV)was used to evaluate the electrochemical behavior of the aptasensor at each preparation step and its detection *** developed electrochemical aptasensor based on MoS nanosheets showed remarkable performance for lysozyme detection in the range from 1 pmol/L to 10 nmol/L with a limit of detection of 2.2 fmol/*** proposed aptasensor provided excellent selectivity against BSA,uric acid,cytochrome C,lysozyme and their *** addition,it displayed great stability of about 99.58%of the initial signal upon 21-day *** on human serum and urine samples yielded promising recoveries ranging from 98 to 105%.Hence,MoS_(2)-Au-Ch nanocomposite-based aptasensor could be an outstanding candidate for medical device applications and protein quantification.

关键词： Electrochemical aptasensor Lysozyme MoS_(2)nanosheets Apt/MoS_(2)-Au-Ch/GCE

A Review of Image Steganography Based on Multiple Hashing Algorithm

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Computers, Materials & Continua 2024年第8期80卷 2463-2494页

作者： Abdullah Alenizi Mohammad Sajid mohammadi Ahmad A.Al-Hajji Arshiya Sajid Ansari Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Computer Science College of Engineering and Information TechnologyOnaizah CollegesQassim56312Saudi Arabia

Steganography is a technique for hiding secret messages while sending and receiving communications through a cover *** ancient times to the present,the security of secret or vital information has always been a significant *** development of secure communication methods that keep recipient-only data transmissions secret has always been an area of ***,several approaches,including steganography,have been developed by researchers over time to enable safe data *** this review,we have discussed image steganography based on Discrete Cosine Transform(DCT)algorithm,*** have also discussed image steganography based on multiple hashing algorithms like the Rivest–Shamir–Adleman(RSA)method,the Blowfish technique,and the hash-least significant bit(LSB)*** this review,a novel method of hiding information in images has been developed with minimal variance in image bits,making our method secure and effective.A cryptography mechanism was also used in this *** encoding the data and embedding it into a carry image,this review verifies that it has been ***,embedded text in photos conveys crucial signals about the *** review employs hash table encryption on the message before hiding it within the picture to provide a more secure method of data *** the message is ever intercepted by a third party,there are several ways to stop this operation.A second level of security process implementation involves encrypting and decrypting steganography images using different hashing algorithms.

关键词： Image steganography multiple hashing algorithms Hash-LSB approach RSA algorithm discrete cosine transform(DCT)algorithm blowfish algorithm