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Novel Point Mutations in 3'-Untranslated Region of GATA4 Gene Are Associated with Sporadic Non-syndromic Atrial and Ventricular Septal Defects

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Current Medical Science 2022年第1期42卷 129-143页

作者： Mehri KHATAMI Sajedeh GHORBANI Mojgan Rezaii ADRIANI Sahar BAHALOO Mehri Azami NAEINI Mohammad mehdi HEIDARI mehdi hadadzadeh Department of Biology Faculty of ScienceYazd UniversityYazd ***Iran Department of Cardiac Surgery Afshar HospitalShahid Sadoughi University of Medical SciencesYazd ***Iran

Objective:Transcription factor GATA4 has significant roles in embryonic heart *** of GATA4 appear to be responsible for a wide variety of congenital heart defects(CHD).Despite the high prevalence of GATA4 mutations in CHD phenotypes,extensive studies have not been *** 3'-untranslated region(3'-UTR)of tho GATA4 gene comprises regulatory motifs and microRNA binding sites that are critical for the appropriate gene expression,nuclear transportation,and regulation of translation,and stability of *** study aimed to evaluate the association between mutations in the 3'-UTR of the GATA4 gene and CHD risk among Iranian patients.

关键词： congenital heart disease GATA4 S'-untranslated region mutation in-silico analysis

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Analysis of the hot deformation of ZK60 magnesium alloy

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Journal of Magnesium and Alloys 2017年第4期5卷 369-387页

作者： Amir hadadzadeh Mary A.Wells Mechanical and Mechatronics Engineering Department University of WaterlooWaterlooON N2L 3G1Canada

Hot deformation of cast-homogenized and extruded(in both the extrusion and transverse directions)ZK60 magnesium alloy was conducted using the Gleeble®3500 thermal-mechanical simulation testing system.A new approach to model the high temperature constitutive behavior of the alloy was done using two well-known equations(*** sine and Ludwig equations).For this approach,the deformation conditions were divided into regimes of low and high temperature and strain rate(four regimes).Constitutive model development was conducted in each regime and the material parameters(P)were evaluated as strain,strain rate and temperature-dependent variables;P(ε,ε,T).Using this approach,the flow curves were predicted with high accuracy relative to the experimental ***,detailed information on the evolution of hot deformation activation energy was obtained using the modified hyperbolic sine *** the modified Ludwig equation,details of strain hardening and strain rate sensitivity of the ZK60 material during hot deformation were obtained.

关键词： ZK60 magnesium alloy Hot deformation Constitutive modeling Zener-Hollomon Hyperbolic sine Ludwig equation

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Mathematical modeling of thermo-mechanical behavior of strip during twin roll casting of an AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2013年第2期1卷 101-114页

作者： Amir hadadzadeh Mary A.Wells Department of Mechanical and Mechatronics Engineering University of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada

The effect of set-back distance on the thermo-mechanical behavior of the strip during twin roll casting(TRC)of an AZ31 magnesium alloy was modeled using finite element method(FEM).Model validation was done by comparing the predicted and measured exit strip surface temperature as well as the secondary dendrite arm spacing(SDAS)through the thickness of the sheet to those measured during *** results showed as the set-back distance increases,the strip exit temperature decreases and the solidification front moves toward the entry of the roll *** cast strip also experiences more plastic deformation and consequently,the normal stress on the strip surface and effective strain at the strip center-line ***,higher separating forces were predicted for longer set-back *** predictions showed that changing the set-back distance by varying the final thickness has a more significant effect on the temperature and stress-strain fields than altering the nozzle opening height.

关键词： Twin roll casting process AZ31 magnesium alloy Thermal-fluid-stress model Set-back distance Roll separating force

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Influence of I-phase and W-phase on microstructure and mechanical properties of Mg-8Li-3Zn alloy

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Transactions of Nonferrous Metals Society of China 2015年第3期25卷 713-720页

作者：魏国兵彭晓东张宝 Amir hadadzadeh 许天才谢卫东材料科学与工程学院重庆400044 重庆大学国家镁合金材料工程技术研究中心重庆400044 Department of Mechanical and Mechatronics Engineering University of Waterloo

Microstructures and mechanical properties of LZ83?xY alloys containingI-phase andW-phase were investigated by XRD, OM, SEM and EDS. The experimental results show that the content ofI-phase andW-phase changes by varying Zn/Y mass ratio in the LZ83?xY alloys. The cohesion ofI-phase/α-Mg eutectic pockets can enhance the strength in the as-cast LZ83?0.5Y and LZ83?1.0Y alloys, while theW-phase has no obvious strengthening effect on the LZ83?1.5Y alloy. In the extruded alloys, the I-phase andW-phase were extruded into the particles with nanoscale size in theβ-Li matrix phase. The dispersion strengthening of W-phase was more obvious because of the higher volume fraction. The ultimate tensile strength of extruded LZ83?1.5Y alloy is up to 238 MPa while the elongation is up to 20%.

关键词： Mg-8Li-3Zn alloy I-phase W-phase mechanical properties as-cast microstructure

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Deformation behavior and constitutive model for dual-phase Mg-Li alloy at elevated temperatures

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Transactions of Nonferrous Metals Society of China 2016年第2期26卷 508-518页

作者：魏国兵彭晓东胡发平 Amir hadadzadeh 杨艳谢卫东 Mary A.WELLS 重庆大学材料科学与工程学院重庆400044 Mechanical and Mechatronics Engineering Department University of Waterloo

In order to study the deformation behavior and evaluate the workability of the dual-phase Mg-9Li-3Al-2Sr alloy, isothermal hot compression tests were conducted using the Gleeble-3500 thermal-mechanical simulator, in ranges of elevated temperatures （423-573 K） and strain rates （0.001-1 s^-1）. Plastic instability is evident during the deformation which is in the form of serrated flow; serrated yielding is attributed to the locking of mobile dislocations by the Mg and Li atoms which diffuse during the deformation. The relationships between flow stress, strain rate and deformation temperature were analyzed and the deformation activation energy and some basic material factors at different strains were calculated using the Arrhenius equation. The effects of temperature and strain rate on deformation behavior were represented using the Zener–Hollomon parameter in an exponent-type equation. To verify the validity of the constitutive model, the predicted values and experimental flow curves under different deformation conditions were compared, the correlation coefficient （0.9970） and average absolute relative error （AARE=4.41%） were calculated. The results indicate that the constitutive model can be used to accurately predict the flow behavior of dual-phase Mg-9Li-3Al-2Sr alloy during high temperature deformation.

关键词： constitutive model Mg-Li alloy plastic instability Zener-Hollomon parameter

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