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IMPLEMENTATION OF 3-VALUED PARACONSISTENT LOGIC PROGRAMMING TOWARDS DECISION MAKING SYSTEM OF AGENTS

Journal of Systems Science and Systems Engineering 2018年第3期27卷 322-339页

作者： Yuki Goto megumi fujita Naoyuki Nide Graduate School of System Informatics Kobe University (Until Mar. 2018) Faculty of Science and Engineering Kindai University Faculty Division of Human Life and Environmental Sciences Nara Women's University

Due to the rapid development of applications of artificial intelligence and robotics in recent years, the necessity of reasoning and decision making with uncertain and inaccurate information is increasing. Since robots in the real world are always exposed to behavioral inaccuracies and uncertainty arising from recognition methods, they may occasionally encounter contradictory facts during reasoning on action decision. Paraconsistent logic programming is promising to make appropriate action decisions even when an agent is exposed to such uncertain information or contradictory facts, but there has been no implementation of this programming to the best of our knowledge. We propose a resolution algorithm for the 3-valued paraconsistent logic programming system QMPT0 and its implementation on SWI-Prolog. We also describe an application of the 3-valued paraconsistent logic programming regarding agent decision making.

关键词： Agent-based modelling for complex systems paraconsistent logic programming solver implementation declarative programming application for agents

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Low-Molecular-Weight Heparin and Protamine-Based Polyelectrolyte Nano Complexes for Protein Delivery (A Review Articles)

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Journal of Biomaterials and Nanobiotechnology 2011年第5期2卷 500-509页

作者： Masayuki Ishihara Satoko Kishimoto megumi Takikawa Yasutaka Mori Shingo Nakamura Masanori fujita 不详

We produced low-molecular-weight heparin/protamine micro (nano) particles (LMW-H/P MPs·NPs) as a carrier for heparin-binding growth factors (GFs), such as fibroblast growth factor (FGF)-2 and various GFs in platelet-rich plasma (PRP). A mixture of LMW-H (MW: approximately 5000 Da, 6.4 mg/ml) and protamine (MW: approximately 3000 Da, 10 mg/ml) at a ratio of 7:3 (vol:vol) yields a dispersion of micro (nano) particles (200 nm - 3 μm in diameter). The diluted LMW-H solution in saline (0.32 mg/ml) mixed with diluted protamine (0.5 mg/ml) at a ratio at 7:3 (vol:vol) resulted in soluble nanoparticles (approximately 100 nm in diameter). The generated NPs could be then stabilized by adding 2 mg/ml dextran (MW: 178-217 kDa) and remained soluble after lyophilization of dialyzed LMW-H /P NPs solution. The LMW-H/P MPs·NPs adsorb GFs, control their release, protect GFs and activate their biological activities. Furthermore, administration of GFs-containing F/P MPs·NPs exhibited significantly higher inductions of vascularization and fibrous tissue formation in vivo than GFs alone. LMW-H/P MPs·NPs can also efficiently bind to tissue culture plates and retain the binding of GFs. The LMW-H/P MPs·NP-coated matrix with various GFs or cytokines provided novel biomaterials that could control cellular activity such as proliferation and differentiation. Thus, LMW-H/P MPs·NPs are an excellent carrier for GFs and are a functional coating matrix for various kinds of cell cultures.

关键词： Polyelectrolyte Complexes Nanoparticles Heparin-Binding Growth Factors Platelet-Rich Plasma Drug Delivery

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