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The relationship between intermittent limit cycles and postural instability associated with Parkinson’s disease

Journal of Sport and Health Science 2016年第1期5卷 14-24页

作者： James R.Chagdes Jessica E.Huber Meredith Saletta meghan darling-white Arvind Raman Shirley Rietdyk Howard N.Zelaznik Jeffrey M.Haddad Department of Mechanical and Manufacturing Engineering Miami University Oxford OH 45056 USA Department of Speech Language and Hearing Sciences Purdue University west Lafayette IN 47907 USA Department of communication Sciences and Disorders University of Iowa Iowa City IA 52242 USA Department of Speech Language and Hearing Sciences University of Arizona Tucson AZ 85721 USA School of Mechanical Engineering Purdue University West Lafayette IN 47907 USA Department of Health and Kinesiology Purdue University West Lafayette IN 47907 USA

Background:Many disease-specific factors such as muscular weakness,increased muscle stiffness,varying postural strategies,and changes in postural reflexes have been shown to lead to postural instability and fall risk in people with Parkinson's disease(PD).Recently,analytical techniques,inspired by the dynamical systems perspective on movement control and coordination,have been used to examine the mechanisms underlying the dynamics of postural declines and the emergence of postural instabilities in people with ***:A wavelet-based technique was used to identify limit cycle oscillations(LCOs) in the anterior–posterior(AP) postural sway of people with mild PD(n = 10) compared to age-matched controls(n = 10).Participants stood on a foam and on a rigid surface while completing a dual task(speaking).Results:There was no significant difference in the root mean square of center of pressure between *** out of 10 participants with PD demonstrated LCOs on the foam surface,while none in the control group demonstrated *** inverted pendulum model of bipedal stance was used to demonstrate that LCOs occur due to disease-specific changes associated with PD:time-delay and neuromuscular feedback ***:Overall,the LCO analysis and mathematical model appear to capture the subtle postural instabilities associated with mild *** addition,these findings provide insights into the mechanisms that lead to the emergence of unstable posture in patients with PD.

关键词： Balance Limit cycle Parkinson's disease Posture Wavelets

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Crystallization and impact history of a meteoritic sample of early lunar crust(NWA 3163)refined by atom probe geochronology

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Geoscience Frontiers 2019年第5期10卷 1841-1848页

作者： L.F. white D.E. Moser K.T. Tait B. Langelier I. Barker J.R. darling Centre for Applied Planetary Mineralogy Department of Natural HistoryRoyal Ontario MuseumTorontoOntarioM5S 2C6Canada Department of Earth Sciences University of TorontoTorontoOntarioM5S 3B1Canada Department of Earth Sciences University of Western OntarioLondonN6A 5B7Canada Canadian Centre for Electron Microscopy McMaster UniversityHamiltonOntarioCanada School of Earth and Environmental Science University of PortsmouthPortsmouthUK

Granulitic lunar meteorites offer rare insights into the timing and nature of igneous,metamorphic and impact processes in the lunar *** dating the different events recorded by these materials is very challenging,however,due to low trace element abundances (***,Nd,Lu,Hf),rare micrometerscale U-Th-bearing accessory minerals,and disturbed Ar-Ar systematics following a multi-stage history of shock and thermal *** we report on micro-baddeleyite grains in granulitic mafic breccia NWA 3163 for the first time and show that targeted microstructural analysis (electron backscatter diffraction) and nanoscale geochronology (atom probe tomography) can overcome these barriers to lunar chronology.A twinned (-90°/) baddeleyite domain yields a 232Th/208Pb age of 4328 ± 309 Ma,which overlaps with a robust secondary ion mass spectrometry (SIMS) 207Pb/206Pb age of 4308± 18.6 Ma and is interpreted here as the crystallization age for the igneous protolith of NWA 3163.A second microstructural domain,< 2 mm in width,contains patchy overprinting baddeleyite and yields a Th-Pb age of 2175± 143 Ma,interpreted as dating the last substantial impact event to affect the *** finding demonstrates the potential of combining microstructural characterization with nanoscale geochronology when resolving complex P-T-t histories in planetary materials,here yielding the oldest measured crystallization age for components of lunar granulite NWA 3163 and placing further constraints on the formation and evolution of lunar crust.

关键词： Baddeleyite U-Th-Pb isotopes EBSD Atom probe tomography Geochronology Northwest Africa 3163

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Marine invasions enter the genomic era： three lessons from the past, and the way forward

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Current Zoology 2016年第6期62卷 629-642页

作者： Frederique VIARD Patrice DAVID John A. darling Sorbonne Universites UPMC Univ Paris 06 CNRS UMR 7144 Lab. Adaptation Et Diversite En Milieu Marin Team Div&Co Station Biologique De Roscoff Roscoff 29682 France CEFE UMR 5175 CNRS-Universite De Montpellier- UM III-EPFIE 1919 Route De Mende Montpellier Cedex 34293 France National Exposure Research Laboratory United States Environmental Protection Agency Research Triangle Park NC 27711 USA

The expanding scale and increasing rate of marine biological invasions have been documented since the early 20th century. Besides their global ecological and economic impacts, non-indigenous species （NIS） also have attracted much attention as opportunities to explore important eco-evolutionary processes such as rapid adaptation, long-distance dispersal and range expansion, and secondary contacts between divergent evolutionary lineages. In this context, genetic tools have been extensively used in the past 20 years. Three important issues appear to have emerged from such studies. First, the study of NIS has revealed unexpected cryptic diversity in what had previously been assumed homogeneous entities. Second, there has been surprisingly little evidence of strong founder events accompanying marine introductions, a pattern possibly driven by large propagule loads. Third, the evolutionary processes leading to successful invasion have been difficult to ascertain due to faint genetic signals. Here we explore the potential of novel tools associated with high-throughput sequencing （HTS） to address these still pressing issues. Dramatic increase in the number of loci accessible via HTS has the potential to radically increase the power of analyses aimed at species delineation, exploring the population genomic consequences of range expansions, and examining evolutionary processes such as admixture, introgression, and adaptation. Nevertheless, the value of this new wealth of genomic data will ultimately depend on the ability to couple it with expanded ＂traditional＂ efforts, including exhaustive sampling of marine populations over large geographic scales, integrated taxonomic analyses, and population level exploration of quantitative trait differentiation through common-garden and other laboratory experiments.

关键词： biological invasions cryptic species cryptogenic species eco-evolutionary processes genornics metabarcoding

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Secondary aorto-esophageal fistula after thoracic aortic aneurysm endovascular repair treated by covered esophageal stenting

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World Journal of Clinical Cases 2016年第8期4卷 233-237页

作者： Mary Tao Eran Shlomovitz Gail darling Graham Roche-Nagle Division of Vascular Surgery Toronto General Hospital Department of Interventional Radiology Peter Munk Cardiac Centre Toronto General Hospital Department of Thoracic Surgery Toronto General Hospital

Thoracic endovascular aortic repair for thoracic aortic aneurysms is an accepted alternative to open surgery, especially in patients with significant comorbidities. The procedure itself has a low risk of complications and fistulas to surrounding organs are rarely reported. An 86-year-old patient was admitted to our hospital with gastro intestinal(GI) bleeding and a suspected aortoesophageal fistula. Eight months prior, the patient had undergone a stent graft repair of a mycotic thoracic aneurysm. Computerized tomography angiography and upper GI endoscopy confirmed an aortoesophageal fistula, which was treated by esophageal stenting. With early recognition, esophageal stenting may have a role in the initial emergency control of bleeding from and palliation of aortoesophageal fistula.

关键词： Endovascular therapy Bleeding Aortic aneurysm

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Antibacterial activity of selected ethnomedicinal plants from South India

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 375-378页

作者： Rajendran darling Anpin Raja Solomon Jeeva Juststella Wilfred Prakash Johnson Marimuthu Antonisamy Varaprasadham Irudayaraj Department of Botany Scott Christian College(Autonomous)Nagercoil-629 003Tamil NaduIndia Centre for Biodiversity and Biotechnology Department of BotanyNesamony Memorial Christian CollegeMarthandam-629 165Tamil NaduIndia Denartment of Botanr Scott Christian College(Autonomous)Naeercoil-629 003Tamil NaduIndia Department of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)TirunelveliTamil NaduIndia

Objective:To screen the antimicrobial potential of three ethnomedicinal plants Chassalia curviflora Thw.(***),Cyclea peltata Hook.F.& Thomson(***) and Euphorbia hirta L(***) used in folk medicines in Aarukani hills Kani tribe,Tamil Nadu,India against human bacterial ***:Antibacterial efficacy was performed by disc diffusion method against the pathogens viz.,Escherichia coli(***)(ATCC 35218),Staphylococcus aureus (***)(ATCC 6538),Salmonella typhi(***)(MTCC 733),Proteus vulgaris(***), Proteus mirabilis(***) and Streptococcus pyogenes(***) and incubated for 24 h at 37°***:The maximum degree of antibacterial activity was observed in *** followed by *** *** showed comparatively low degree of antibacterial *** methanolic extract of *** showed the antibacterial activity against three pathogens viz.,***,*** and *** with the inhibition zones 12 mm,10 mm and 9 mm,respectively,hexane extracts of *** also showed the antibacterial activity against two selected pathogens viz.,*** and *** with 15 mm and 12 mm of inhibition *** the three different concentrations(025,0.50 & 0.75 mg/mL) of methanolic extract of C. peltata show the inhibitory effect on the three susceptible bacteria ***,*** and E. coli with the maximum inhibition in the highest concentration(0.75 mg/mL).The methanolic and hexane extracts of *** exhibited the antibacterial activity against only one bacterium each *** and *** with the maximum zone of inhibition 13 and 11 mm respectively. The methanolic and hexane extracts of *** exhibited the antibacterial activity against only one bacterium *** with the maximum zone of inhibition 13 and 11 mm respectively. Conclusions:The present investigation revealed that the ***,*** and *** are potentially good source of antibacterial agents and demonstrates

关键词： Antibacterial Folk medicine Kani tribe

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Reinventing Systems for Equity

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ECNU Review of Education 2024年第2期7卷 214-229页

作者： Linda darling-Hammond Learning Policy Institute I530 Page Mill Road SuitePalo AltoCAUSA

Highlights Around the world,nations are grappling with the longstanding inequalities in education and society that were made more visible during the pandemic-along with the increasing educational demands of our fast-changing,knowledge-based *** article outlines the anatomy of educational inequality and the demands for students to develop“learning ability.”

关键词： Educational equity education reform teacher development

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Protein-activated atomic layer deposition for robust crude-oil-repellent hierarchical nano-armored membranes

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Science Bulletin 2024年第2期69卷 218-226页

作者： Xiaobin Yang Pan Sun Yajie Wen Anil U.Mane Jeffrey W.Elam Jun Ma Shaomin Liu Seth B.darling Lu Shao MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chemical Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA Applied Materials Division Argonne National LaboratoryLemont IL 60439USA Advanced Materials for Energy-Water Systems Energy Frontier Research Center Argonne National LaboratoryLemont IL 60439USA Pritzker School of Molecular Engineering University of ChicagoChicago IL 60637USA Department of Physics University of Ilinois at ChicagoChicago IL 60607USA School of Environment Harbin Institute of TechnologyHarbin 150090China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerth WA 6845Australia

Atomic layer deposition(ALD)offers unique capabilities to fabricate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced membrane separations towards sustainable energy-water ***,current ALD technique is inhibited on most non-polar polymeric membranes due to lack of accessible nucleation ***,we report a facile method to efficiently promote ALD coating on hydrophobic surface of polymeric membranes via novel protein activation/*** a proof of concept,TiO2 ALD-coated membranes activated by bovine serum albumin exhibit remarkable superhydrophilicity,ultralow underwater crude oil adhesion,and robust tolerance to rigorous environments including acid,alkali,saline,and *** importantly,excellent cyclable crude oil-in-water emulsion separation performance can be *** mechanism for activation/sensitization is rooted in reactivity for a particular set of amino ***,the universality of protein-sensitized ALD is demonstrated using common egg white,promising numerous potential usages in biomedical engineering,environmental remediation,lowcarbon manufacturing,catalysis,and beyond.

关键词： Membrane separation Atomic layer deposition Water treatment Antifouling

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Freshers' Week

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英语世界 2020年第9期39卷 127-128页

作者： Ellen darling Jon Porter

Each September in the UK,thousands of new students move to new cities to start their university life with'freshers'week'.I found out more about it.1 New students starting their time at university are known as freshers...

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Freshers' Week

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英语世界 2019年第9期 127-128页

作者： Ellen darling Jon Porter

Each September in the UK, thousands of new students move to new cities to start their university life with ‘freshers’ week’. I found out more about it.1 New students starting their time at university are known as freshers and freshers’ week is a UK university tradition. It’s an introductory week for the new students to find their way around

关键词： Activity Freshers

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The Rise and Fall of the Welsh Language

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英语世界 2020年第8期 127-128页

作者： Ellen darling Jon Porter

Croeso i Gymru! If you don’t know what this means, read on to find out more.1 When you cross over the border from England into Wales you don’t have to show your passport but you do notice a difference immediately.

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