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<i>ε</i>-Optimality in Multivalued Optimization

American Journal of Operations Research 2013年第4期3卷 413-420页

作者： S. K. Suneja megha sharma Department of Mathematics University of Delhi Delhi India

In this paper we apply the directional derivative technique to characterize D-multifunction, quasi D-multifunction and use them to obtain ε-optimality for set valued vector optimization problem with multivalued maps. We introduce the notions of local and partial-ε-minimum (weak) point and study ε-optimality, ε-Lagrangian multiplier theorem and ε-duality results.

关键词： D-Multifunction Partial-ε-Minimum Point ε-Optimality ε-Duality

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Antifertility potential of leaves and seeds of Delonix regia in female rats

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Asian pacific Journal of Reproduction 2023年第3期12卷 117-123,I0001,I0002页

作者： Garg megha sharma Aditi Choudhary Manjusha Kaur Prabhjeet Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetraIndia

Objective:To evaluate the antifertility activity of hydroalcoholic extract of Delonix regia(*** Hook.)*** and seeds which are traditionally being used by Yanadi tribe to treat ***:Three experimental animal models,including anti-implantation,early abortifacient,and estrogenic activity in female rats,were used for evaluation of the antifertility activity of both extracts at two dose levels(250 and 500 mg/kg,orally).There were five groups in the anti-implantation and early abortifacient activity while six groups in estrogenic activity including the *** number of implants,resorptions,vaginal cornification,body weight,uterus weight,and biochemical parameters were ***:At doses 250 and 500 mg/kg,the leaf extract was found to have strong anti-implantation *** extract administered at the same doses also caused a significant rise in the number of resorptions,showing early abortifacient activity,increased uterine weight,and altered numerous biochemical ***,the seed extract only displayed slight anti-implantation activity at both ***:Based on these preliminary findings,we can conclude that the leaf extract outperformed the seed extract in terms of antifertility activity,exhibiting potent estrogenic,anti-implantation and early abortifacient activities in a dose-dependent *** findings are consistent with the literature study and corroborate to the antifertility activity of the plant.

关键词： Delonix regia Anti-implantation Early abortifacient Estrogenic Gulmohar Ovariectomy

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Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats

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The Journal of Biomedical Research 2012年第3期26卷 200-210页

作者： Ashish Kumar sharma Akash sharma Rita Kumari Kunal Kishore Divya sharma Bharthu Parthsarthi Srinivasan Ashok sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant sharma Varnika Srivastava Sneha Joshi megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam Department of Pharmacology Gyan Vihar School of PharmacySuresh Gyan Vihar UniversityJagatpuraJaipur(Rajasthan)302025India Department of Pharmacology Delhi Institute of Pharmaceutical Sciences&ResearchPushpviharNew Delhi 110017India Department of Pharmacology Kota Collage of PharmacyRIICO Industrial AreaRanpurKota(Rajasthan)Pincode 302025India

Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu- ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide- streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly im- proved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 （P 〈 0.001）. Signif- icant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 （P 〈 0.001）. Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regen- eration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.

关键词： diabetic neuropathy nicotinamide-streptozotocin metformin pioglitazone glimipiride sitagliptin amitriptyline

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