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Regularities in Sequences of Observations

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Open Journal of Statistics 2012年第4期2卷 408-414页

作者： Mahkame megan Khoshyaran ETC Economics Traffic Clinic 34 Avenue des champs Elysèes75008 ParisFrance

The objective of this paper is to propose an adjustment to the three methods of calculating the probability that regularities in a sample data represent a systemic influence in the population data. The method proposed is called data profiling. It consists of calculating vertical and horizontal correlation coefficients in a sample data. The two correlation coefficients indicate the internal dynamic or inter dependency among observation points, and thus add new information. This information is incorporated in the already established methods and the consequence of this integration is that one can conclude with certainty that the probability calculated is indeed a valid indication of systemic influence in the population data.

关键词： Systematic Influence Theory of Large Samples Analysis of the Variance Principle Multiple Regression Data Profiling Vertical Correlation Coefficient Horizontal Correlation Coefficient

The Impact of Vehicular Networks on Urban Networks

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Journal of Transportation Technologies 2014年第4期4卷 303-314页

作者： Mahkame megan Khoshyaran Economics Traffic Clinic (ETC) Paris France

The objective of this paper is to study the impact of a vehicular network on a physical (road) network consisting of several intersections controlled by traffic lights. The vehicular network is considered to be a random graph superimposed on a regular Hamiltonian graph. The two graphs are connected by hyperlinks. The evolution of traffic at intersections given the existence of vehicular networks is measured by the method of reflective triangles.

关键词： Road Network Hamiltonian Graph Vehicular Network Hyperlinks Queue Lengths Delays Reflexion Triangles

fRAP 2.0:a community engagement method applied to cervical cancer disparities among Hispanic women

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Family Medicine and Community Health 2024年第S2期12卷 44-57页

作者： Autumn M Kieber-emmons Susan E Hansen Michael Topmiller Jaskaran Grewal Carlos Roberto Jaen Benjamin F Crabtree William L Miller Department of Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA College of Medicine USFTampaFloridaUSA Lehigh Valley Health Network AllentownPennsylvaniaUSA American Academy of Family Physicians-Health Landscape CincinattiOHUSA Lafayette College EastonPennsylvaniaUSA UT Health San Antonio San AntonioTexasUSA Rutgers Robert Wood Johnson Medical School PiscatawayNew JerseyUSA Cancer Institute of New Jersey New BrunswickNew JerseyUSA

focused Rapid Assessment Process(fRAP)2.0 is a community engagement approach combining geospatial mapping with rapid qualitative assessment in cyclical fashion within communities to capture multifactorial and multilevel features impacting primary care *** 2.0 offers primary care researchers a methodology framework for exploring complex community features that impact primary healthcare delivery and *** fRAP 2.0 study design expands the fRAP from a sequential design to a cyclical process of geospatial mapping and rapid qualitative assessment in search of modifiable contextual *** participants are stakeholders from various socioecological levels whose perspectives inform study outcomes that they may use to then become the agents of change for the very problems they helped ***,we present a proof-of-concept study for fRAP 2.0 examining disparities in cervical cancer mortality rates among Hispanic women in *** primary outcomes of interest are features at the community level,medical health system level and regional government policy levels that offer opportunities for collaborative interventions to improve cervical cancer *** this study,geospatial mapping of county and ZIP code-level variables impacting postdiagnosis cervical cancer care at community,medical and policy levels were created using publicly available data and then overlaid with maps created with Texas Cancer Registry data for cervical cancer cases in three of the largest population *** disparate areas were then qualitatively explored using participant observation and ethnographic field work,alongside 39 key informant *** discussion groups and stakeholder engagement existed at every phase of the *** the fRAP 2.0 method,we created an action-oriented roadmap of next steps to improve cervical cancer care disparities in the three Texas counties with emphasis on the high disparity *** identified local change

关键词： cervical qualitative policy

Lyme Disease Presenting as Ankylosing Spondylitis: A Case Report

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Case Reports in Clinical Medicine 2020年第11期9卷 354-359页

作者： megan Strauchman Mark Morningstar Natural Wellness & Pain Relief Center Grand Blanc MI USA

Lyme disease is a rapidly growing tick-borne infection in many parts of the United States. Due to the complexity of the various symptom presentations associated with Lyme disease, Borrelia burgdorferi, the bacteria that causes Lyme disease, is thought of as a disease-mimicking infection. The present case report summarizes the case of an adult female patient who was initially diagnosed with ankylosing spondylitis. After becoming refractory to autoimmune-based treatment interventions, she presented to an integrative medicine clinic where she was diagnosed with Lyme disease. Symptoms resolved after following and completing an anti-microbial based protocol, symptoms resolved. Her symptoms remained resolved at follow-up.

关键词： Ankylosing Spondylitis Infection Lyme Disease

Treating refractory depression in Parkinson’s disease:a meta-analysis of transcranial magnetic stimulation

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Translational Neurodegeneration 2018年第1期7卷 75-80页

作者： Alexandra M.Lesenskyj megan P.Samples Jill M.Farmer Christina R.Maxwell Rowan University School of Osteopathic Medicine StratfordNJ 08048USA Drexel Neurosciences Institute 245 N 15th Street ms 423PhiladelphiaPA 19102USA

Background:Parkinson’s disease(PD)is often accompanied by clinically identified *** effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to *** this reason,alternatives to standard anti-depressant treatments,such as repetitive transcranial magnetic stimulation(rTMS),have been evaluated within the Parkinson’s ***:A literature search was conducted on the PubMed database for all studies that evaluated rTMS as a treatment in patients with both depression and PD.A meta-analysis was performed on all studies that reported mean pre-and post-rTMS depression inventory *** used depression inventories included both self-report and clinician-administered *** size for individual study groups and across all studies was ***:Six of 7 studies meeting inclusion criteria reported significantly improved depression scores,large effect sizes,and significant *** weighted average effect size was calculated at 1.32 across all study groups that applied ***:Across all but one study,rTMS appears to effectively reduce depression scores among self-reported and clinician administered *** total weight average effect size showed that,when considering study sample sizes and degree of findings,this form of neurostimulation can relieve PD patients of their depressive ***,rTMS is a promising alternative to traditional anti-depressant therapies when treating refractory depression in patients with PD.

关键词： Parkinson’s disease Depression Transcranial magnetic stimulation

Diaporthe species occurring on citrus in China

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Fungal Diversity 2013年第4期61卷 237-250页

作者： Feng Huang Xin Hou megan M Dewdney Yushi Fu Guoqing Chen Kevin D Hyde Hongye Li Institute of Biotechnology Zhejiang UniversityHangzhouChina 310058 Citrus Research and Educator Center University of FloridaLake AlfredFL 33850USA Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand 57100 School of Science Mae Fah Luang UniversityChiang RaiThailand 57100

Diaporthe species are important pathogens of a wide range of hosts including many economically important *** citri is generally accepted to cause melanose of Citrus fruits,leaves and shoots;stem-end rot of fruits and gummosis of perennial *** this study,147 strains of Diaporthe were isolated from diseased leaves,twigs,fruits and branches of Citrus from Shaanxi,Zhejiang,Guangxi,Fujian,Guangdong,Jiangxi,Hunan,Chongqing and Shanghai and identified by morphology and molecular analysis of nuclear ribosomal internal transcribed spacer(ITS),partial sequences of translation elongation factor 1-α(EF 1-α),tubulin(TUB)and calmodulin(CAL)*** strains from Citrus clustered in three *** citri was the predominant species and is compared with strains from Florida,USA,where this species was first collected and *** new taxa differing from *** are described as *** and *** in this *** tests indicate that all three species are able to cause stem-end rot of fruits,while only *** could cause melanose on leaves.

关键词： Diaporthe citri Melanose Morphology Phomopsis Phylogenetic analysis

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

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World Journal of Gastroenterology 2014年第5期20卷 1192-1210页

作者： Georgina L Hold megan Smith Charlie Grange Euan Robert Watt Emad M El-Omar Indrani Mukhopadhya Gastro-intestinal Research Group Division of Applied Medicine University of Aberdeen Foresterhill

Our understanding of the microbial involvement in inflammatory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn’s disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or “dysbiosis” is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity (including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Gut microbiota, Innate immune response, Probiotics, Prebiotics, Faecal transplant

What gets in the way of social engagement in schizophrenia?

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World Journal of Psychiatry 2021年第1期11卷 13-26页

作者： Lauren P Weittenhiller megan E Mikhail Jasmine Mote Timothy R Campellone Ann M Kring Department of Psychology University of CaliforniaBerkeleyCA 94720United States Department of Psychology Michigan State UniversityEast LansingMI 48824United States Department of Occupational Health Tufts UniversityMedfordMA 02155United States

BACKGROUND Social engagement-important for health and well-being-can be difficult for people with *** research indicates that despite expressing interest in social interactions,people with schizophrenia report spending less time with others and feeling *** motivations and barriers may play an important role for understanding social engagement in *** To investigate how people with schizophrenia describe factors that impede and promote social *** We interviewed a community sample of people with(n=35)and without(n=27)schizophrenia or schizoaffective disorder about their social interactions with friends and family over the past week and planned social activities for the coming *** reviewed the interview transcripts and developed a novel coding system to capture whether interactions occurred,who had initiated the contact,and frequency of reported social barriers(i.e.,internal,conflict-based,logistical)and social motivations(i.e.,instrumental,affiliative,obligation-based).We also assessed symptoms and *** People with schizophrenia were less likely than people without schizophrenia to have spent time with friends[t(51.04)=2.09,P=0.042,d=0.51)],but not *** with schizophrenia reported more social barriers than people without schizophrenia[F(1,60)=10.55,P=0.002,ηp2=0.15)]but did not differ in reported social ***,people with schizophrenia reported more internal[t(45.75)=3.40,P=0.001,d=0.83)]and conflict-based[t(40.11)=3.03,P=0.004,d=0.73)]barriers than people without *** barriers and motivations were related to real-world social functioning for people with schizophrenia,such that more barriers were associated with more difficulty in close relationships(r=-0.37,P=0.027)and more motivations were associated with better community functioning(r=0.38,P=0.024).CONCLUSION These findings highlight the importance of assessing first person accounts of social barriers

关键词： Social engagement Schizophrenia Social motivation Social barriers

Shifts in the Holstein dairy cow milk fat globule membrane proteome that occur during the first week of lactation are affected by parity

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Journal of Animal Science and Biotechnology 2021年第2期12卷 534-548页

作者： Mallory C.Honan megan J.Fahey Amanda J.Fischer-Tlustos Michael A.Steele Sabrina L.Greenwood Department of Animal and Veterinary Sciences The University of VermontBurlingtonVT 05405USA Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada Department of Agriculture Food&Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2P5Canada

Background:The milk fat globule membrane(MFGM)proteomes of colostrum and transition milk are rich sources of proteins that are likely important for neonatal calf *** addition,characterization of these proteomes could also yield valuable information regarding mammary gland physiology of the early postpartum lactating *** objectives of this research were to characterize the MFGM proteomes of colostrum and transition milk through sample collections at four timepoints postpartum,including the first milking(M1,colostrum),second milking(M2,transition milk),fourth milking(M4,transition milk),and fourteenth milking(M14,mature milk),and compare these proteomes between multiparous(MP;n=10)and primiparous(PP;n=10)Holstein dairy *** MFGM proteins were labeled using Tandem Mass tagging and analyzed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).Protein identification was completed using MASCOT and Sequest in Proteome Discoverer *** scaled abundance values were analyzed using PROC MIXED in SAS to determine the effects of milking(MIL),parity(PAR),and MIL×*** adaptive false-discovery rate(FDR)-adjusted P values were determined using PROC *** characterization and bioinformatic analysis were completed using a combination of PANTHER,Blast,and ***:A total of 104 common proteins were identified in each of the MFGM *** analysis revealed that 70.2%of identified proteins were affected by *** these,78.1%were lower in M14 compared with M1,including immune-related proteins lactotransferrin,lactadherin and *** affected 44.2%of *** the proteins affected by PAR,84.8%were higher in MP cows compared with PP cows,including apolipoprotein E and histones 2A,2B,3,and 4 *** subfamily 1 member 1A and annexin 5 were higher in samples from PP ***×parity affected 32.7%of identified proteins,including lactotransferrin,gelsolin,vitamin D binding protein,and S100 ***

关键词： Colostrum LC-MS/MS Parity