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Distinguishing Single-Metal Nanoparticles with Subdiffraction Spatial Resolution Using Variable-Polarization Fourier Transform Nonlinear Optical Microscopy

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Chemical & Biomedical Imaging 2023年第1期1卷 91-98页

作者： megan A.Steves Kenneth L.Knappenberger,Jr Department of Chemistry The Pennsylvania State UniversityUniversity ParkPennsylvania 16802United States California Institute for Quantitative Biosciences University of CaliforniaBerkeleyBerkeleyCalifornia 94720United States

The development and use of interferometric variablepolarization Fourier transform nonlinear optical(vpFT-NLO)imaging to distinguish colloidal nanoparticles colocated within the optical diffraction limit is *** a collinear train of phase-stabilized pulse pairs with orthogonal electric ffeld vectors,the polarization of nonlinear excitation ffelds are controllably modulated between linear,circular,and various elliptical *** modulation is achieved by precise control over the time delay separating the orthogonal pulse pairs to within hundreds of *** resultant emission from gold nanorods is imaged to a 2D array detector and correlated to the excitation ffeld polarization and plasmon resonance frequency by Fourier *** nanorods with length-to-diameter aspect ratios of 2 support a longitudinal surface plasmon resonance at approximately 800 nm,which is resonant with the excitation fundamental carrier *** in the intrinsic linear and circular dichroism resulting from variation in their relative alignment with respect to the laboratory frame enable optical differentiation of nanorods separated within 50 nm,which is an approximate 5-fold improvement over the diffraction limit of the *** experimental results are supported by analytical *** addition to subdiffraction spatial resolution,the vpFT-NLO method intrinsically provides the polarization-and frequency-dependent resonance response of the nanoparticles�providing spectroscopic information content along with super-resolution imaging capabilities.

关键词： nonlinear optics polarization circular dichroism imaging Fourier transform spectroscopy plasmons super-resolution microscopy

Phase Specific Comparisons of High and Low Vertical Jump Performance in Collegiate Female Athletes

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Journal of Science in Sport and Exercise 2023年第4期5卷 322-327页

作者： Paul T Donahue megan Rush Ayden K McInnis Thomas Littlefield School of Kinesiology and Nutrition University of Southern MississippiHattiesburgMSUSA

Introduction Countermovement vertical jump testing has become a staple in athlete assessment *** the popularity of jump testing has grown,a need and interest has also grown in identifying the factors that underpin high-level *** jump height alone as a variable in evaluating vertical jump performance has been questioned in athletic populations,other variables such as the reactive strength index modified(RSIm)allow for not only evaluating the outcome,but the strategy used in obtaining that *** Thus,the purpose of this investigation was to examine the differences in high and low vertical jump performances,as determined by the RSIm in female collegiate *** Thirty NCAA Division I female volleyball and basketball athletes performed countermovement vertical jump trials on a force *** sample was then broken into two groups as determined by median RSIm *** sample t-test were then used to compare *** High RSIm group displayed greater jump heights(P<0.05).Additionally,the high performing group displayed lower eccentric duration times(P<0.05).No differences between groups were seen in kinetic *** The high performing group displayed faster eccentric times which translated to lower values in time to take-off though not statistical *** higher RSIm values appear to be a result of both greater jump heights and reduced time to take ***,focus being placed on the speed of the movement during training would be of benefit in improving RSIm values.

关键词： Reactive Strength Index modified Countermovement Jump Athlete Monitoring

Lactate reloaded–reevaluation of the importance of lactate monitoring in the management of adult sepsis in the emergency department

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BIOCELL 2021年第3期45卷 445-449页

作者： GABOR XANTUS BALINT KISS GYULA molnar CANDICE MATHESON V.A NNA GYARMATHY PETER L.KANIZSAI Cardiff University CardiffCF103ATUK Semmelweis University Budapest1085Hungary Dalhuis University Halifax HalifaxNS B3H 4R2Canada EpiConsult Biomedical Consulting and Medical Communications Agency DoverDE 19901USA Pecs University Clinical CentrePecs7626Hungary

For about a quarter of a century,monitoring lactate levels and/or lactate clearance has been an unquestionable cornerstone in sepsis *** elevated lactate level appeared to be an independent predictor of mortality,and the consequent metabolic acidosis was thought to explain a number of pathophysiological changes seen in septic *** physiological and clinical findings seem to challenge the adverse role of lactic acidosis in *** suggests that lactate levels are not necessarily directly proportional to either tissue or cellular hypoxia,and conversely,despite high lactate levels,increased peripheral tissue oxygen pressure can be measured in adult patients with septic *** to the most recent understanding of in vitro and in vivo evidence,the elevated lactate level in sepsis might be a normal reaction due to adrenergic stress with potential beneficial/protective physiological effects,as *** the one hand,burning lactic may help fuel the body during critical illness,but on the other hand,with a slight drop in pH,the body may counteract certain deleterious changes during the dysregulated host response;reduce the chances of reperfusion myocardial injury,and improve tissue oxygenation by shifting the haemoglobin dissociation curve to the *** the pathophysiological process in sepsis resulting in elevated lactate levels may aid management in an emergency,medicine,and intensive care *** more in-depth physiological knowledge,physicians may inevitably surpass normalisation heuristics and deliver personalized rather than protocolised sepsis resuscitation.

关键词： Reevaluation Lactate Sepsis Resuscitation

NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: Is Hungary different?

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World Journal of Gastroenterology 2005年第3期11卷 407-411页

作者： Carsten Büning Tomas molnar Ferenc Nagy Janos Lonovics Renita Weltrich Bettina Bochow Janine Genschel Hartmut Schmidt Herbert Lochs Department of Gastroenterology Department of Medicine

AIM: To analyse the impact of NOD2/CARD15 mutations on the clinical course of Crohn 's disease patients from an eastern European country (Hungary). METHODS: We investigated the prevalence of the three common NOD2/CARD15 mutations (Arg702Trp, Gly908Arg, 1007finsC) in 148 patients with Crohn's disease, 128 patients with ulcerative colitis and 208 controls recruited from the University of Szeged, Hungary. In patients with Crohn 's disease, the prevalence of NOD2/CARD15 mutations was correlated to the demographical and clinical parameters. RESULTS: In total, 32.4% of Crohn's disease patients carried at least one mutant allele within NOD2/CARD15 compared to 13.2% of patients with ulcerative colitis (P = 0.0002) and to 11.5% of controls (P

关键词： Crohn's disease NOD2/CARD15 gene Mutation

Applications and advancements in animal models for antiviral research on mosquito-borne arboviruses

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Animal Models and Experimental Medicine 2024年第5期7卷 673-684页

作者： megan Caifeng Tang Ka Heng Wong Adzzie Shazleen Azman Rafidah Lani School of Science Monash University MalaysiaSunwaySelangorMalaysia Department of Medical Microbiology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Vector-borne diseases caused by arthropod-borne viruses(arboviruses) are a considerable challenge to public health globally. Mosquito-borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito-borne arboviruses, playing a role in understanding disease mechanisms,vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal-to-human translational success. Genetically engineered mouse models, hamster models and non-human primate(NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long-tailed macaques as potential NHP models for arbovirus research is possible;however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld.

关键词： animal models arbovirus biomedical research ethics i nfectious diseases

The diagnosis of central vestibular disorders based on the complementary examination of the vestibulospinal reflex

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Journal of Otology 2022年第1期17卷 1-4页

作者： Stefani Maihoub Andras molnar Laszl Tamas Agnes Szirmai Department of Otorhinolaryngology and Head and Neck Surgery Faculty of MedicineSemmelweis UniversityBudapestHungary

Objectives:Stance and gait unsteadiness along with vertigo contribute to a central vestibular *** objective analysis ultrasound-computer-craniocorpography(US-COMP-CCG)can be *** of the study was to characterize the unsteadiness in central vestibular disorders and discuss the possible diagnostic usage of *** and results:Hundred-and-ninety patients(70 male and 120 female,mean age±SD,58.94±15.27)suffering from central vestibular disorder and 230 healthy control patients(78 male and 152 female,mean age±SD,50.94±15.27)were *** and gait analysis was according to vestibulospinal tests of *** SPSS V24 software was used for statistical ***-Whitney U test and Chi-square test were used,along with sensitivity and specificity *** significance level was p<*** to schematic and statistical analysis instability and postural sway were increased in the vertigo population and statistically significant difference was *** categorical analysis significant correlation was detected[standing test:longitudinal sway(p<0.00001),lateral sway(p<0.00001),forehead covering area parameters(p=0.0001);stepping test:longitudinal deviation(p=0.05),lateral sway(p=0.011)parameters].Conclusions:Clinicians should consider that postural instability is prominently present in this population and might be of a diagnostic importance.

关键词： Unsteadiness Central vestibular disorder Vestibulospinal reflex Ultrasound-computer-craniocorpography

A possible objective test to detect benign paroxysmal positional vertigo. The role of the caloric and video-head impulse tests in the diagnosis

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Journal of Otology 2022年第1期17卷 46-49页

作者： Andras molnar Stefani Maihoub Laszlo Tamas Agnes Szirmai Semmelweis University Department of Otolaryngology and Head and Neck SurgerySzigony u.36.H-1083BudapestHungary

Background:Benign paroxysmal positional vertigo(BPPV)is characterized by vertigo lasting from seconds to minutes,induced by head ***:Our study aimed to investigate the clinical significance of the caloric vestibular and video head-impulse tests(vHIT)diagnosing the ***:68 patients suffering from posterior canal BPPV(25 male,43 females,mean age±SD,54.5±13.2 years)and 56 patients with a normal functioning vestibular system as control were *** caloric test and vHIT was performed during the same medical *** paresis(CP%),gain(GA)and asymmetry(GA%)parameters were ***:The Dix-Hallpike manoeuvre was only positive in 4%of this *** CP%parameter was only pathologic in two patients,and there was no significant difference between control and BPPV patients(p=0.76).The GA value was never under 0.8 in this population,but GA%was abnormal in 63.2%.A significant difference comparing the GA%values to the control group was seen(p=0.034).There was no correlation detected between the CP%and GA%values in *** the GA%value,61%sensitivity and 76%specificity was ***:The Dix-Hallpike manoeuvre was not often positive in the non-acute phase of BPPV;therefore,objective testing is *** caloric test does not have clinical significance in BPPV,but vHIT can be helpful based on the GA%parameter。

关键词： Caloric test Video-head-impulse test Benign paroxysmal positional vertigo Objective diagnosis

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板块构造衍生的大陆构造

地质科技情报 1990年第1期9卷 45-51页

作者： Peter molnar 樊光明

在大陆漂移被接受的基础上,通过时地球上大多数大阶段地质历史的重新解释,成功地建立了板块构造学说。但是,岩石圈大板块刚体运动这一板块构造的基本原则并不适应于大陆内部,因为漂浮的大陆壳能够与下伏地幔拆离开来,形成山脉和宽阔而... 详细信息

在大陆漂移被接受的基础上,通过时地球上大多数大阶段地质历史的重新解释,成功地建立了板块构造学说。但是,岩石圈大板块刚体运动这一板块构造的基本原则并不适应于大陆内部,因为漂浮的大陆壳能够与下伏地幔拆离开来,形成山脉和宽阔而分散的构造活动带。

关键词：大陆构造板块构造

L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction

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Bone Research 2020年第1期8卷 53-62页

作者： Meenakshi AChellaiah megan CMoorer Sunipa Majumdar Hanan Aljohani Sharon CMorley Vanessa Yingling Joseph PStains Department of Oncology and Diagnostic Sciences School of DentistryUniversity of MarylandBaltimoreMDUSA Department of Orthopedics University of Maryland School of MedicineBaltimoreMDUSA Department of Pediatrics Division of Infectious Diseasesand Department of Pathology and ImmunologyWashington University School of MedicineSt.LouisMOUSA Department of Kinesiology California State UniversityEast BayHaywardCAUSA

Bone resorption requires the formation of complex, actin-rich cytoskeletal structures. During the early phase of sealing ring formation by osteoclasts, L-plastin regulates actin-bundling to form the nascent sealing zones(NSZ). Here, we show that L-plastin knockout mice produce osteoclasts that are deficient in the formation of NSZs, are hyporesorptive, and make superficial resorption pits in vitro. Transduction of TAT-fused full-length L-plastin peptide into osteoclasts from L-plastin knockout mice rescued the formation of nascent sealing zones and sealing rings in a time-dependent manner. This response was not observed with mutated full-length L-plastin(Ser-5 and-7 to Ala-5 and-7) peptide. In contrast to the observed defect in the NSZ, L-plastin deficiency did not affect podosome formation or adhesion of osteoclasts in vitro or in vivo. Histomorphometry analyses in 8-and 12-week-old female L-plastin knockout mice demonstrated a decrease in eroded perimeters and an increase in trabecular bone density, without a change in bone formation by osteoblasts. This decrease in eroded perimeters supports that osteoclast function is attenuated in L-plastin knockouts. Micro-CT analyses confirmed a marked increase in trabecular bone mass. In conclusion, female L-plastin knockout mice had increased trabecular bone density due to impaired bone resorption by osteoclasts. L-plastin could be a potential target for therapeutic interventions to treat trabecular bone loss.

关键词： sealing impaired fused