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In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging

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Journal of Materials Science & Technology 2015年第5期31卷 427-436页

作者： Cindy Elschner Carolin Noack Carolin PreilBler Andreas krause Ulrich Scheler Ute Hempel leibniz-Institut fr Polymerforschung Dresden e.V. Hohe Str.601069 DresdenGermany CRTD/DFG-Center for Regenerative Therapies Dresden Fetscherstr.10501307 DresdenGermany Institut fr Physiologische Chemie Technische Universitt DresdenFiedlerstr.4201307 DresdenGermany NaMlab gGmbH Nthnitzer Str.6401187 DresdenGermany

Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical ***,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells（hMSC） and magnetic resonance imaging（MRI） compatibility of the potential material combination polyetheretherketone/titanium（PEEK/Ti） for medical *** of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or ***,PEEK is a bioinert material having a limited ability for direct bone *** to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular *** result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of *** appearance of metal-related artifact was discussed in electrical resistivity and magnetic ***,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface *** determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMSC and their cell area distribution,proliferation,osteogenic differentiation and mineral *** cellular stress was evaluated by the prostaglandin *** bonded materials both produced no disturbing artifacts in magnetic resonance *** to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibilit

关键词： Polyetheretherketone Titanium coating Biocompatibi

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Analysing the power transformer temperature limitation for avoidance of bubble formation

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High Voltage 2019年第3期4卷 210-216页

作者： James Hill Zhongdong Wang Qiang liu Christoph krause Gordon Wilson The University of Manchester ManchesterM139PLUK Weidmann Electrical Technology AG Rapperswil-JonaCH 8640Switzerland National Grid WarwickCV346DAUK

Failure of a transformer is a costly incident which can impact power system operation and result in loss of supply to *** can fail through a number of mechanisms,one of which is from the formation of bubbles within the ***,the loading guidance is set to avoid certain overload temperatures as high temperature is the main cause of bubbles *** paper analyses the limit set within the loading guides,comparing the most commonly cited temperature limit of 140℃ with values taken from across the full spectra of available studies in *** is concluded that there is sufficient evidence for further investigation into formation of bubbles from transformer insulation as employing a single temperature limit may be *** of a single temperature value is unsuitable,given the wide range of potential scenarios that the transformer fleet can *** has become the go-to rationale that the moisture content of the solid insulation is the key driver for transformer bubbling *** is true,however,it is shown that other factors such as solid insulation aged condition(determined through degree of polymerisation value)and the insulation type are also important considerations.

关键词： insulation limit power

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Particle flow simulations with homogenised lattice Boltzmann methods

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Particuology 2017年第5期15卷 1-13页

作者： Mathias J. krause Fabian Klemens Thomas Henn Robin Trunk Hermann Nirschl Institute for Applied and Numerical Mathematics Karlsruhe Institute of Technology 76021 Karlsruhe Germany Institute for Mechanical Process Engineering and Mechanics Karlsruhe Institute of Technology 76021 Karlsruhe Germany

An alternative approach to simulating arbitrarily shaped particles submersed in viscous fluid in two dimensions is proposed, obtained by adapting the velocity parameter of the equilibrium distribution function of a standard lattice Boltzmann method （lBM）. Comparisons of exemplifying simulations to results in the literature validate the approach as well as the convergence analysis. Pressure fluctuations occurring in ladd＇s approach are greatly reduced. In comparison with the immersed boundary method, this approach does not require cost intensive interpolations. The parallel efficiency of lBM is retained. An intrinsic momentum transfer is observed during particle-particle collisions. To demonstrate the capa- bilities of the approach, sedimentation of particles of several shapes is simulated despite omitting an explicit particle collision model.

关键词： Particulate flow simulationsArbitrarily shaped particleslattice Boltzmann methodsValidationSedimentation processes

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Prediction of methane emissions during the extraction of close-to-roof layer of a seam of large thickness

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Journal of Coal Science & Engineering(China) 2012年第4期18卷 337-343页

作者： krause Eugeniusz QU Xian-chao Central Mining Institute Katowice 43-190Poland Mine Safety Technology Branch China Coal Research InstituteBeijing 100013China

Prediction of methane emissions at the stage of longwall planning constitutes the basis for the determination of the appropriate method and parameters of ventilation and selection of prevention means including the methane drainage technol- ogy. The growth of methane saturation of coal seams with the extraction depth, with simultaneously increasing output concen- tration, contributes to the increase of the quantity of methane emitted into longwall areas. The subject matter of the article has been directed at the predicted quantity of methane emissions into planned longwalls with roof caving in the layer of seams adjacent to the roof of large thickness. The performed prognostic calculations of methane emissions into the longwall working were referred to two sources, i.e. methane liberated during coal mining by means of a cutter-loader and methane originating from the degasification of the floor layer destressed by the longwall conducted in the close-to-roof layer. The calculations of predictions allow to refer to the planned longwall, on account of the emitting methane, with possible and safe output quantity. Planning of extraction in the close-to-roof layer of a seam of large thickness with roof caving is especially important in con- ditions of increasing methane saturation with the depth of deposition and should be preceded by a prognostic analysis for de- termining the extraction possibilities of the planned longwall.

关键词： methane emission extraction close-to-roof layer coal seam large thickness longwall prediction

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A discrete contact model for complex arbitrary-shaped convex geometries

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Particuology 2023年第9期80卷 180-191页

作者： Jan E.Marquardt Ulrich J.Römer Hermann Nirschl Mathias J.krause lattice Boltzmann Research Group Karlsruhe Institute of TechnologyStraße am Forum 8Karlsruhe76131Germany Institute for Mechanical Process Engineering and Mechanics Karlsruhe Institute of TechnologyStraße am Forum 8Karlsruhe76131Germany Institute of Engineering Mechanics Karlsruhe Institute of TechnologyKaiserstraße 10Karlsruhe76131Germany Institute for Applied and Numerical Mathematics Karlsruhe Institute of TechnologyEnglerstraße 2Karlsruhe76131Germany

The shape of particles has a significant influence on the behavior of suspensions,as the particle-fluid,particle-particle,and particle-wall interactions depend on ***,the simultaneous consideration of complex particle shapes and four-way coupling remains a major *** is mainly due to a lack of suitable contact *** models for complex shapes have been proposed in literature,and most limit the accuracy of the particle-fluid *** this reason,this paper presents a novel contact model for complex convex particle shapes for use with partially saturated methods,in which we propose to obtain necessary contact properties,such as the indentation depth,by a discretization of the contact *** goal of the proposed model is to enable comprehensive and accurate studies of particulate flows,especially with high volume fractions,that lead to new insights and contribute to the improvement of existing industrial *** ensure correctness and sustainability,we validate the model extensively by studying cases with and without *** the latter case,we use the homogenized lattice Boltzmann *** provided investigations show a great agreement of the proposed discrete contact model with analytical solutions and the literature.

关键词： Partially saturated cells method Homogenized lattice Boltzmann method Arbitrarily shaped particle Discrete contact model Particle-resolved simulation OpenlB

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Rhythmical massage improves autonomic nervous system function:a single-blind randomised controlled trial

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Journal of Integrative Medicine 2018年第3期16卷 172-177页

作者： Georg Seifert Jenny-lena Kanitz Carolina Rihs Ingrid krause Katharina Witt Andreas Voss Department of Pediatric Oncology and Hematology Charité-Universit?tsmedizin Berlin Institute of Innovative Health Technologies Ernst-Abbe-Hochschule University of Applied Sciences

Background： Rhythmical massage therapy（RMT） is a massage technique used in anthroposophic ***： The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability（HRV）.Design, setting, participants and intervention： This study was a randomised, controlled and single-blinded trial, involving 44 healthy women（mean age：（26.20 ± 4.71） years）. The subjects were randomised to one of three arms： RMT with aromatic oil（RA）, RMT without aromatic oil（RM） or standardised sham massage（SM）. In the study the subjects were exposed to a standardised stress situation followed by one of the study techniques and Holter electrocardiograms（ECGs） were recorded for 24 *** outcome measures： HRV parameters were calculated from linear（time and frequency domain） and nonlinear dynamics（symbolic dynamics, Poincare plot analysis） of the 24-h Holter ECG ***： Short-and long-term effects of massage on autonomic regulation differed significantly among the three groups. Immediately after an RMT session, stimulation of HRV was found in the groups RA and RM. The use of an aromatic oil produced greater short-term measurable changes in HRV compared with rhythmic massage alone, but after 24 h the effect was no longer distinguishable from the RM *** lowest stimulation of HRV parameters was measured in the SM ***： RMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a temporary effect on HRV, indicating that the RM causes the most relevant long-term effect. The effect is relatively specific, as the physiological effects seen in the group of subjects who received only SM were considerably less pronounced.

关键词： Sham massage Well-being Mood Alertness Relaxation Stress Heart rate variability Randomised controlled trial

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Current Trend in Synthesis,Post-Synthetic Modifications and Biological Applications of Nanometal-Organic Frameworks(NMOFs)

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Chinese Journal of Chemistry 2019年第4期37卷 378-404页

作者： Ebenezer Baa Gary M.Watkins Rui.W.krause Derek.N.Tantohb Department of Chemistry Rhodes UniversityPO Box 94Grahamstown6140South Africa Department of Applied Chemistry University of JohannesburgPO Box 524Auckland Park2006South Africa

Since the early reports of MOFs and their interesting properties,research involving these materials has grown wide in scope and *** synthetic approaches have ensued in view of obtaining materials with optimised properties,the extensive scope of application spanning from energy,gas sorption,catalysis biological applications has meant exponentially evolved over the *** far-reaching synthetic and PSM approaches and porosity control possibilities have continued to serve as a motivation for research on these *** respect to the biological applications,MOFs have shown promise as good candidates in applicati ons involving drug delivery,BioMOFs,sensing,imaging amongst *** being a while away from successful entry into the market,observed results in sensing,drug delivery,and imaging put these materials on the spot light as candidates poised to usher in a revolution in *** this regard,this review article focuses current approaches in synthesis,post functionalization and biological applications of these materials with particular attention on drug delivery,imaging,sensing and BioMOFs.

关键词： Current Trend Post-Synthetic Modifications Nanometal-Organic Frameworks(NMOFs)

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liver sinusoidal endothelial and biliary cell repopulation following irradiation and partial hepatectomy

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World Journal of Gastroenterology 2010年第31期16卷 3928-3935页

作者： Petra krause Margret Rave-Frank Hendrik Andreas Wolff Heinz Becker Hans Christiansen Sarah Koenig Department of General Surgery University Medical Centre Goettingen Department of Radiotherapy University Medical Cen-tre Goettingen

AIM: To investigate whether irradiation (IR) and partial hepatectomy (PH) may prepare the host liver for nonparenchymal cell (NPC) ***: livers of dipeptidyl peptidase(DPP)-deficient rats were pre-conditioned with external beam IR (25 Gy) delivered to two-thirds of the right liver lobules followed by a one-third PH of the untreated lob-ule. DPP-positive liver cells (NPC preparations enriched for liver sinusoidal endothelial cells (lSECs) and hepatocytes) were transplanted via the spleen into the recipient livers. The extent and quality of donor cell engraftment and growth was studied over a long-term interval of 16 wk after ***: Host liver staining demonstrated 3 different repopulation types. Well def ined clusters of donor-derived hepatocytes with canalicular expression of DPP were detectable either adjacent to or in between large areas of donor cells (covering up to 90% of the section plane) co-expressing the endothelial marker platelet endothelial cell adhesion molecule. The third type consisted of formations of DPP-positive duct-like structures which co-localized with biliary epithelial ***: liver IR and PH as a preconditioning stimulus enables multiple cell liver repopulation by donor hepatocytes, lSECs, and bile duct cells.

关键词： Cell transplants Dipeptidyl peptidase protein Endothelial cells liver cell transplantation liver irradiation liver repopulation

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A SQUID Bootstrap Circuit with a large Parameter Tolerance

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Chinese Physics letters 2013年第1期30卷 219-222页

作者： ZHANG Guo-Feng ZHANG Yi Hans-Joachim krause KONG Xiang-Yan Andreas Offenhäusser XIE Xiao-Ming State Key laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences(CAS)Shanghai 200050 Peter Grünberg Institute(PGI-8) Forschungszentrum Jülich(FZJ)D-52425JülichGermany Joint Research laboratory on Superconductivity and Bioelectronics Collaboration between CAS-Shanghai&FZJShanghai 200050

The voltage biased(SQUID)bootstrap circuit(SBC)was recently introduced as an effective means to reduce the preamplifier noise *** analyze the tolerances of the SBC noise suppression performance to spreads in SQUID and SBC circuit *** is found that the tolerance to spread mainly caused by the integrated circuit fabrication process could be extended by a one-time adjustable current feedback.A helium-cooled niobium SQUID with a loop inductance of 350 pH is employed to experimentally verify the *** this work,design criteria for fully integrated SBC devices with a high yield can be derived.

关键词： SQUID Bootstrap spread

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Multiverse Model: External Universe(s) as Source of Dark Energy

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Journal of High Energy Physics, Gravitation and Cosmology 2021年第4期7卷 1306-1314页

作者： Werner krause Berlin Germany

The lambda Cold Dark Matter (ΛCDM) model is currently the best model to describe the development of the Universe from the Big Bang to the present time. It is composed of six parameters, two of them, Dark Energy (DE) and CDM, with unknown physical explanations. DE, leading to accelerated expansion of the Universe, is considered a scalar field characterized by exerting its force by repulsive gravity. We examined whether DE can be explained as the warping of spacetime in our Universe by external universes as components of a Multiverse or, in other words, as the gravitational pull exerted by other universes. The acceleration, the resultant kinetic energy, Ekin, and the cosmological constant, Λ, were calculated for one to four external universes. The acceleration is approx. 10-11 m/s2, which is in agreement with observations. Its value is dependent upon the numbers and relative positions of external universes. DE density is approx. 10-29 kg/m3 and Λ is in the range of 10-38 s-2 and 10-55 m-2, respectively. Warping of spacetime by external universes as a physical explanation for DE seems feasible and warrants further considerations.

关键词： Accelerated Expansion of the Universe Dark Energy Gravitational Pull Warping of Spacetime Multiverse

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