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Optimal Port Design Minimizing Standing Waves with A Posteriori Long Term Shoreline Sustainability Analysis

China Ocean Engineering 2021年第6期35卷 802-813页

作者： megan cook Frédéric BOUCHETTE Bijan MOHAMMADI Léa SPRUNCK Nicolas FRAYSSE BRL Ingénierie Nı̂mes 30000France GEOSCIENCES-M University of MontpellierCNRSMontpellier 34090France GLADYS University of MontpellierCNRSLe Grau du Roi 30240France IMAG University of MontpellierCNRSMontpellier 34090France

Optimization theory is applied to a coastal engineering problem that is the design of a *** approach was applied to the redesign of La Turballe Port in order to increase the exploitable surface area and simultaneously reduce the occurrence of long waves within the *** defined the cost function as a weighted function of wave amplitude and with the chosen parameterization of the port,results show that an extended jetty and a widened mole yield a unique optimal *** work demonstrates that numerical optimization may be quick and efficient in the identification of port solutions consistent with classic engineering even in the context of complex problems.

关键词： optimization coastal engineering harbour design hydrodynamics shoreline analysis

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Overview of extended release tacrolimus in solid organ transplantation

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World Journal of Transplantation 2016年第1期6卷 144-154页

作者： Neha Patel Abigail cook Elizabeth Greenhalgh megan A Rech Joshua Rusinak Lynley Heinrich Department of Pharmacy Loyola Medical Center

Tacrolimus(Prograf?, Astellas Pharma Europe Ltd, Staines, United Kingdom; referred to as tacrolimusBID) is an immunosuppressive agent to prevent and treat allograft rejection in kidney transplant recipients in combination with mycophenolate mofetil, corticosteroids,with or without basiliximab induction. The drug has also been studied in liver, heart and lung transplant; however, these are currently off-label indications. An extended release tacrolimus formulation(Advagraf?, Astagraf XL?) allows for once-daily dosing, with the potential to improve adherence. Extended release tacrolimus has similar absorption, distribution, metabolism and excretion to tacrolimus-BID. Phase Ⅰ pharmacokinetic trials comparing extended release tacrolimus and tacrolimus-BID have demonstrated a decreased maximum concentration(C max) and delayed time to maximum concentration(t max) with the extended release formulation; however, AUC0-24 was comparable between formulations. Overall extended release tacrolimus has a very similar safety and efficacy profile to tacrolimus-BID. It is not recommended in the use of liver transplant patient's due to the increased risk of mortality in female recipients. There has been minimal data regarding the use of extended release tacrolimus in heart and lung transplant recipients. With the current data available for all organ groups the extended release tacrolimus should be dosed in a 1:1 fashion, the exception may be the cystic fibrosis population where their initial dose may need to be higher.

关键词： Tacrolimus Extended release tacrolimus Pharmacokinetics Pharmacoeconomics Solid-organ transplant

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