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Promising applications of D-amino acids in periprosthetic joint infection

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Bone Research 2023年第2期11卷 248-272页

作者： Matthew Caldwell megan Hughes Fei Wei Christopher Ngo Raven Pascua Abinaya Sindu Pugazhendhi Melanie J.Coathup Biionix Cluster&College of Medicine University of Central FloridaBlvdOrlandoFL32827USA School of Biosciences Cardiff UniversityCF103AT WalesUK Burnett School of Biomedical Sciences College of MedicineUniversity of Central Florida6900 Lake NonaBlvdOrlandoFL32827USA

Due to the rise in our aging population,a disproportionate demand for total joint arthroplasty(TJA)in the elderly is *** joint infection(PJI)represents one of the most challenging complications that can occur following TJA,and as the number of primary and revision TJAs continues to rise,an increasing PJI burden is *** advances in operating room sterility,antiseptic protocols,and surgical techniques,approaches to prevent and treat PJI remain difficult,primarily due to the formation of microbial *** difficulty motivates researchers to continue searching for an effective antimicrobial *** dextrorotatory-isoforms of amino acids(D-AAs)are essential components of peptidoglycan within the bacterial cell wall,providing strength and structural integrity in a diverse range of *** many tasks,D-AAs regulate cell morphology,spore germination,and bacterial survival,evasion,subversion,and adhesion in the host immune *** administered exogenously,accumulating data have demonstrated that D-AAs play a pivotal role against bacterial adhesion to abiotic surfaces and subsequent biofilm formation;furthermore,D-AAs have substantial efficacy in promoting biofilm *** presents D-AAs as promising and novel targets for future therapeutic *** their emerging antibacterial efficacy,their role in disrupting PJI biofilm formation,the disassembly of established TJA biofilm,and the host bone tissue response remains largely *** review aims to examine the role of D-AAs in the context of *** to date suggest that D-AA bioengineering may serve as a promising future strategy in the prevention and treatment of PJI.

关键词： prevention spite furthermore

Potentially traumatic events,coping strategies and associations with mental health and well-being measures among conflict-affected youth in Eastern Democratic Republic of Congo

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Global Health Research and Policy 2016年第1期1卷 54-71页

作者： megan Cherewick Shannon Doocy Wietse Tol Gilbert Burnham Nancy Glass Department of International Health Johns Hopkins Bloomberg School of Public Health615 N.Wolfe St.BaltimoreMD 21205USA Department of Mental Health Johns Hopkins Bloomberg School of Public Health624 N.BroadwayHH 863BaltimoreMD 21205USA Department of International Health Johns Hopkins School of NursingJohns Hopkins Center for Global Health615 N.Wolfe St.BaltimoreMD 21205USA

Background:Youth in conflict and post-conflict settings are exposed to a variety of potentially-traumatic events that impact their mental health and *** purposes of this study were to examine coping strategies among conflict-affected youth exposed to potentially-traumatic events and the relationship to psychological symptoms and well-being in the Democratic Republic of Congo(DRC).Methods:A total of 434 male and female youth(ages 10–15 years)completed data collection with a trained Congolese *** survey instrument included measures of exposure to potentially traumatic events,an adapted coping strategies checklist,and measures of psychosocial distress and *** factor analyses was used to identify coping strategies and Hierarchical regression was used to assess how coping strategies were associated with psychological symptoms including internalizing and externalizing problems and well-being outcomes including prosocial behavior and ***:Exploratory Factor analysis suggested four coping strategies;problem-focused,emotion-focused,avoidance and faith-based ***-focused coping strategies were associated with greater internalizing and externalizing problems and lower prosocial behavior in both boys and ***,when problem-focused strategies were used with emotion-focused coping strategies,the result was fewer internalizing problems in girls and fewer externalizing problems in boys and ***-focused,avoidance and faith based strategies were associated with better ***:These results suggest a complex relationship between coping strategies,psychological symptoms and well-being and contradict evidence that problem-focused strategies benefit mental health while emotion-focused strategies harm mental health,particularly in conflict and post-conflict *** results suggest coping flexibility,or use of multiple coping strategies may be particularly useful to improving mental

关键词： Conflict Trauma Coping Mental health Resilience Well-being

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跨文化判断与决策(英文)

心理科学进展 2013年第3期21卷 381-388页

作者：纪丽君 megan Kaulius 女皇大学心理学系

本文对判断和决策研究领域所发现的跨文化差异进行了回顾。鉴于大多数判断和决策的跨文化研究都集中于对亚洲和西方文化的比较,本文也主要关注这方面的研究发现。具体来说,本文回顾了在概率判断及信心、风险知觉、冒险行为、消费者行为... 详细信息

本文对判断和决策研究领域所发现的跨文化差异进行了回顾。鉴于大多数判断和决策的跨文化研究都集中于对亚洲和西方文化的比较,本文也主要关注这方面的研究发现。具体来说,本文回顾了在概率判断及信心、风险知觉、冒险行为、消费者行为以及经济判断和决策中所存在的跨文化差异。综述结果表明尽管亚洲人和西方人的判断和决策行为存在很大的跨文化差异,研究也发现了显著的文化内差异。目前关于判断和决策的跨文化差异的研究还相对匮乏,未来还需要更多的研究来进一步了解判断和决策行为的跨文化差别及机制。

关键词：文化判断决策风险决策

Genome-wide analysis reveals signatures of complex introgressive gene flow in macaques(genus Macaca)

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Zoological Research 2021年第4期42卷 433-449页

作者： Yang Song Cong Jiang Kun-Hua Li Jing Li Hong Qiu megan Price Zhen-Xin Fan Jing Li Key Laboratory of Bio-resources and Eco-environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuan 610064China Institute of Animal Genetics and Breeding College of Animal Science and TechnologySichuan Agricultural UniversityChengduSichuan 611130China Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife College of Life SciencesSichuan UniversityChengduSichuan 610064China

The genus Macaca serves as an ideal research model for speciation and introgressive gene flow due to its short period of diversification(about five million years ago)and rapid radiation of constituent *** understand evolutionary gene flow in macaques,we sequenced four whole genomes(two *** and two ***)and combined them with publicly available macaque genome data for genome-wide *** analyzed 14 individuals from nine Macaca species covering all Asian macaque species groups and detected extensive gene flow signals,with the strongest signals between the fascicularis and silenus species ***,we detected bidirectional gene flow between *** and *** estimated proportion of the genome inherited via gene flow between the two species was 6.19%.However,the introgression signals found among studied island species,such as Sulawesi macaques and ***,and other species were largely attributed to the genomic similarity of closely related species or ancestral ***,gene flow signals varied in individuals of the same species(***,***,***,*** and ***),suggesting very recent gene flow after the populations *** sequentially Markovian coalescence(PSMC)analysis showed all macaques experienced a bottleneck five million years ago,after which different species exhibited different fluctuations in demographic history trajectories,implying they have experienced complicated environmental variation and climate *** results should help improve our understanding of the complicated evolutionary history of macaques,particularly introgressive gene flow.

关键词： Macaca Whole genome Introgression Gene flow Demographic history

Challenges in managing ST elevation myocardial infarction during the COVID-19 pandemic

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World Journal of Cardiology 2021年第4期13卷 76-81页

作者： megan Smith Aniruddha Singh Douglas McElroy Shilpi Mittal Richard Pham Department ofCardiology University of Kentucky College of MedicineBowling GreenKY 42101United States Department of Cardiology Western Kentucky Heart and Lung Research FoundationBowling GreenKY 42101United States Department of Cardiology The Medical CenterBowling GreenKY 42101United States Department of Biology Western Kentucky UniversityBowling GreenKY 42101United States Department of Neurology Vanderbilt University Medical CenterNashvilleTN 37232United States

BACKGROUND Coronavirus disease 2019(COVID-19)may contribute to delayed presentations of acute myocardial *** presentation with late reperfusion is often associated with an increased risk of mechanical complications and adverse *** delays are possible as every patient who is acutely sick is being considered a potential case or a career of ***,standardized personal protective equipment precautions are established for all members of the team,regardless of pending COVID-19 testing which might further add to *** To compare performance measures and clinical outcomes of all patients who presented to our facility with ST elevation myocardial infarction(STEMI)during the COVID-19 pandemic to same time cohort from *** All patients who presented to our facility with STEMI during the pandemic were compared to a matched cohort during the same time period in *** with unknown time of symptom onset and inpatient STEMI patients were *** outcome was major adverse cardiac events(MACE)in-hospital and up to 14 d after STEMI,including death,myocardial infarction,cardiac arrest,or *** differences among groups for continuous variables were tested through ANOVA,using SYSTAT,version ***-square tests of association were used to compare patient characteristics among groups using *** risk scores and associated tests for significance were calculated for discrete variables using MedCalc(MedCalc Software,Ostend,Belgium).RESULTS There was a significantly longer time interval from symptom onset to first medical contact(FMC)in the COVID-19 group(P50%)lesion(s)remote from the culprit ***-hospital and 14 d MACE were more prevalent in the COVID-19 group

关键词： COVID-19 ST elevation myocardial infarction First medical contact to balloon Major adverse cardiac events Cardiac arrest Death

Effects of Dedication in the Workplace

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疯狂英语（初中天地） 2020年第10期 13-15页

作者： megan Kudisch 不详

宋代理学大家朱熹说:"敬业者,专心致志以事其业也。"即用一种恭敬严肃的态度对待自己的工作,认真负责,一心一意,精益求精。拥有敬业精神也会给我们的工作和生活带来积极的影响。Dedication is (1)crucial to *** people have talent,ski... 详细信息

宋代理学大家朱熹说:"敬业者,专心致志以事其业也。"即用一种恭敬严肃的态度对待自己的工作,认真负责,一心一意,精益求精。拥有敬业精神也会给我们的工作和生活带来积极的影响。Dedication is (1)crucial to *** people have talent,skills,access to opportunities,good fortune,and connections,which are means to ***,even if you (2)possess two or three of these factors,if you are not dedicated to being the best version of yourself,you probably will not achieve continued success (3)throughout your life.

关键词： Effects yourself continued

Landsat 8 and Alos DEM geological mapping reveals the architecture of the giant Mesoproterozoic Kunene Complex anorthosite suite(Angola/Namibia)

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Geoscience Frontiers 2023年第5期14卷 308-328页

作者： Jeremie Lehmann Alan M.Brower Trishya M.owen-Smith Grant M.Bybee Ben Hayes Department of Geology University of JohannesburgSouth Africa Jurumani Solutions Midrand 1685South Africa School of Geosciences University of the Witwatersrand2050 JohannesburgSouth Africa

The quasi-monomineralic composition and huge spatial extent of massif-type anorthosites make detecting lithological regions and boundaries *** use processed Landsat 8 OLI multispectral images and ALOS digital elevation models integrated with field and petrographic observations to characterize the architecture of the≥17,000 km2 Mesoproterozoic Kunene Complex(KC)anorthosite suite in Angola and *** of false colour composite bands 6,4 and 1 and band ratios 4/2(ferric minerals),6/5(ferrous minerals)and 6/7(OH-bearing minerals),as well as assessment of the PCA and MNF matrices of eigenvectors and eigenvalues from Landsat 8 data using available spectral libraries,have substantially improved the interpretation of the Kunene Complex rock types and *** dataset shows that the reflectance signature of KC anorthositic rocks is primarily a function of the degree of metasomatism,which is most significant in olivine-poor rock *** weathering intensity of the olivine-bearing anorthosite substrate is another control on the remote sensing *** remote sensing and field-based approach has enabled us to divide the KC anorthosite suite into six distinct spectral and architecture domains and at least four distinct magmatic plutons when considering available high-precision geochronological *** northernmost pluton(ca.1380 Ma)of massive,olivine-bearing anorthosite shows distinct remote sensing signatures in the band ratio and MNF images marked by the dominance of OH-bearing and subordinate ferric *** central pluton(1412–1400 Ma)is composed of NNE-to N-striking steeply dipping interlayered olivine-bearing and olivinepoor anorthosite,which correspond to ridges of dark-coloured,low albedo rocks with subordinate slightly oxidised ferrous mineral spectral signatures,and valleys of low albedo and OH-bearing mineral spectral signatures.A NNE-striking tectonic zone along a linear belt of KC granite gneiss separates the northern and central plu

关键词： Remote sensing Structural geology LANDSAT 8 Alos DEM Lineaments Proterozoic massif-type anorthosite

Arabidopsis EED1 encoding a plant-specific nuclear protein is essential for early embryogenesis

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Journal of Genetics and Genomics 2020年第1期47卷 61-64页

作者： Mai Yang Chun Yan megan Griffith Jinping Zhao Yongbiao Zhang Daoxin Xie Jianbin Yan MOE Key Laboratory of Bioinformatics Tsinghua-Peking Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing100084China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing100191China Institute of Molecular and Cell Biology Singapore117609Singapore

Embryogenesis is central to the life cycle of higher plants,which starts from division of the single-cell zygote and culminates in formation of the mature embryo with major cell *** a process generally involves tightl... 详细信息

关键词： formation. Arabidopsis pattern

Endovascular treatment of vasculogenic erectile dysfunction

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Asian Journal of Andrology 2015年第1期17卷 40-43,I0007页

作者： Edward D Kim Ryan C owen Gregory S White Osama O Elkelany Cyrus D Rahnema University of Tennessee Graduate School of Medicine Knoxville TN USA.

The treatment of erectile dysfunction （ED） has been a fascination involving multiple medical specialities over the past century with urologic, cardiac and surgical experts all contributing knowledge toward this multifactorial disease. With the well-described association between ED and cardiovascular disease, angiography has been utilized to identify vasculogenic impotence. Given the success of endovascular drug-eluting stent （DES） placement for the treatment of coronary artery disease, there has been interest in using this same technology for the treatment of vasculogenic ED. For men with inflow stenosis, DES placement to bypass arterial lesions has recently been reported with a high technical success rate. Comparatively, endovascular embolization as an approach to correct veno-occlusive dysfunction has produced astonishing procedural success rates as well. However, after a thorough literature review, arterial intervention is only recommended for younger patients with isolated vascular injuries, typically from previous traumatic experiences. Short-term functional outcomes are less than optimal with long-term results yet to be determined. In conclusion, the hope for a minimally invasive approach to ED persists but additional investigation is required prior to universal endorsement.

关键词： erectile dysfunction impotence penile erection vasculogenic