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Performance evaluation of NeuMoDx 96 system for hepatitis B and C viral load

World Journal of Virology 2023年第4期12卷 233-241页

作者： Gagan Chooramani Jasmine Samal Nitiksha Rani Gaurav Singh Reshu Agarwal meenu bajpai Manoj Kumar Manya Prasad Ekta Gupta Department of Clinical Virology Institute of Liver&Biliary SciencesNew Delhi 110070India Department Transfusion Medicine Institute of Liver&Biliary SciencesNew Delhi 110070India Department of Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Epidemiology and Clinical Research Institute of Liver and Biliary SciencesNew Delhi 110070India

BACKGROUND Hepatitis B virus(HBV)and hepatitis C virus(HCV)viral load(VL)estimation is essential for the management of both HBV and HCV *** to a longer turnaround time for VL estimation,many patients drop out from the cascade of *** achieve the global goals of reducing morbidity and mortality due to HBV/HCV and moving towards their elimination by 2030,molecular diagnostic platforms with faster and random(*** sample)access are *** To evaluate the performance of the recently launched NeuMoDx 96 random access system with the conventional COBAS^(■)AmpliPrep/COBAS TaqMan system for HBV and HCV VL *** Archived once-thawed plasma samples were retrieved and tested on both *** between the assays was determined by linear regression and Bland-Altman *** study included samples from 186 patients,99 for HBV of which 49 were true infected HBV cases(hepatitis B surface antigen,antihepatitis B core antibody,and HBV DNA-positive)and 87 for HCV assay in which 39 were true positives for HCV infection(anti-HCV and HCV RNA-positive).RESULTS The median VL detected by NeuMoDx for HBV was 2.9(interquartile range[IQR]:2.0-4.3)log_(10)IU/mL and by COBAS it was 3.70(IQR:2.28-4.56)log_(10)IU/mL,with excellent correlation(R2=0.98).In HCV,the median VL detected by NeuMoDx was 4.9(IQR:4.2-5.4)log_(10)IU/mL and by COBAS it was 5.10(IQR:4.07-5.80)log_(10)IU/mL with good correlation(R2=0.96).CONCLUSION The overall concordance between both the systems was 100%for both HBV and HCV VL ***,no genotype-specific bias for HBV/HCV VL quantification was seen in both the *** findings reveal that NeuMoDx HBV and HCV quantitative assays have shown overall good clinical performance and provide faster results with 100%sensitivity and specificity compared to the COBAS AmpliPrep/COBAS TaqMan system.

关键词： Hepatitis B Hepatitis C NeuMoDx Random access Viral load COBAS AmpliPrep

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Characterization and Propagation of Historical and Projected Droughts in the Umatilla River Basin, Oregon, USA

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Advances in Atmospheric Sciences 2024年第2期41卷 247-262,I0020-I0028页

作者： Sudip GAUTAM Alok SAMANTARAY Meghna BABBAR-SEBENS meenu RAMADAS School of Civil and Construction Engineering Oregon State UniversityCorvallisOR 97331USA School of Infrastructure Indian Institute of TechnologyBhubaneswarOdisha 752050India

Climate change is expected to have long-term impacts on drought and wildfire risks in Oregon as summers continue to become warmer and drier. This paper investigates the projected changes in drought characteristics and drought propagation in the Umatilla River Basin in northeastern Oregon for mid-century(2030–2059) and late-century(2070–2099) climate scenarios. Drought characteristics for projected climates were determined using downscaled CMIP5 climate datasets from ten climate models and Soil and Water Assessment Tool to simulate effects on hydrologic processes. Short-term(three months) drought characteristics(frequency, duration, and severity) were analyzed using four drought indices, including the Standardized Precipitation Index(SPI-3), Standardized Precipitation-Evapotranspiration Index(SPEI-3), Standardized Streamflow Index(SSI-3), and the Standardized Soil Moisture Index(SSMI-3). Results indicate that short-term meteorological droughts are projected to become more prevalent, with up to a 20% increase in the frequency of SPI-3drought events. Short-term hydrological droughts are projected to become more frequent(average increase of 11% in frequency of SSI-3 drought events), more severe, and longer in duration(average increase of 8% for short-term droughts).Similarly, short-term agricultural droughts are projected to become more frequent(average increase of 28% in frequency of SSMI-3 drought events) but slightly shorter in duration(average decrease of 4%) in the future. Historically, drought propagation time from meteorological to hydrological drought is shorter than from meteorological to agricultural drought in most sub-basins. For the projected climate scenarios, the decrease in drought propagation time will likely stress the timing and capacity of water supply in the basin for irrigation and other uses.

关键词： Umatilla drought SPI SPEI SSI SSMI

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Organic-inorganic hybrid materials and architectures in optoelectronic devices: Recent advancements

ChemPhysMater

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ChemPhysMater 2024年第3期3卷 252-272页

作者： M.Arya S.Heera P.meenu K.G.Deepa Department of Physics University of KeralaThiruvananthapuram 695581India Department of Nanoscience and Nanotechnology University of KeralaThiruvananthapuram 695581India

Organic-inorganic hybrids are next-generation materials for use in high-performance optoelectronic devices owing to their adaptabilities in terms of design and *** article reviews the application of hybrid materials and layers in several widely used optoelectronic devices,i.e.,light amplification by stimulated emission of radiation(LASER),solar cells,and light-emitting diodes(LEDs).The effects of the incorporation of inorganic particles on photostability and optical gain are analyzed in the first section with reference to dye and perovskite ***,the strategies used in blending inorganic nanostructures into organic solar cells and bulk heterojunctions are *** use of various organic layers as electron-and hole-transport materials in Si heterojunction solar cells is reviewed in ***,the benefits of the presence of organic components in quantum-dot-and perovskite-based LEDs are derived from the *** integration of organic and inorganic components with optimal interfaces and morphologies is a challenge in developing hybrid materials with improved efficiencies.

关键词： Optoelectronics Hybrid material Device performance Photostability Advantages

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Th17 cells, pathogenic or not？ TGF-β3 imposes the embargo

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Cellular & Molecular Immunology 2013年第2期10卷 101-102页

作者： meenu Sharma Unite 872 Institut National de la Sante et de la Recherche Medicale Paris France Universite de Technotogie de Compiegne Compiegne France Centre de Recherche des Cordeliers Equipe 16- Immunopathology and therapeutic immunointerven- tion Universite Pierre et Marie Curie Paris France Universite Paris Descartes Pads France nternational Associated Laboratory IMPACT (Institut National de la Sante et de la Recherche Medicale France--Indian Council of Medical Research India) National Institute of Immunohaematology Mumbai India

Th17 cells that express lineage-spe- cific transcription factor RORC inhuman （and RORTt in mice） and pro- duce cytokines IL-17A, IL-17F, IL-21, GM-CSF and IL-22, constitute distinct subset of CD4＋ T cells.

关键词： pathogenic TGF-β3 embargo

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Experimental study and optimization of cutting parameters in machining of super alloy with hybrid ultrasonic method

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Advances in Manufacturing 2017年第3期5卷 199-216页

作者： Dipesh Popli meenu Gupta Department of Mechanical Engineering National Institute of Technology Kurukshetra 136119 India

Super alloys are intensively used in various industries, especially in the aerospace industry, because of their special characteristics. A number of holes are sometimes required to be drilled into super alloys for aircraft at their final stage assembly. In the present study, a hybrid ultrasonic machining method, called rotary ultrasonic machining （RUM）, was successfully used in super alloy drilling. The empirical modeling of the process parameters of RUM was performed for the super alloy （Inconel 718） using an experimental design approach, called response surface methodology （RSM）. Parameters, namely tool rotation, feed rate, ultrasonic power, and abrasive grit size, were selected as input variables. The others were kept constant. The performance was measured in terms of the machining rate and the surface roughness. The developed models were found to be reliable representatives of the experimental results with prediction errors less than 4-5%. Moreover, the feed rate for the quality and productivity aspect was found to be the most critical factor. The optimized values of the machining rate and the surface roughness achieved through a multi-response optimization were 0.9 825 mm3/s and 0.951 ***, respectively.

关键词： Super alloy Rotary ultrasonic machining(RUM) Ultrasonic ·Roughness Machining

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Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke Zhang meenu Bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran Wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai Chong He Liming Wang Yu Jiang Jian-Lin Han Yulin Chen Ping Zhou Hubert Pausch Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland Institute of Animal Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life Sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic Sciences Kashi UniversityKashi 844000China Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

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Assessment of groundwater quality with special emphasis on nitrate contamination in parts of Gautam Budh Nagar district,Uttar Pradesh, India

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Acta Geochimica 2019年第5期38卷 703-717页

作者： meenu Agarwal Meenakshi Singh Jakir Hussain Galgotias University Plot No.2Sector 17-A Yamuna ExpresswayGreater NoidaGautam Budh NagarUttar PradeshIndia National River Water Quality Laboratory Central Water CommissionNew Delhi 110016India

Progressive developments in industrial and agricultural activities are causing a critical stress on groundwater quality in developing *** objective of this paper is to assess and evaluate the contamination level of groundwater caused by leachate in 11 villages of the Gautam Budh Nagar district in Uttar Pradesh,*** systematically sampled 22 groundwater samples and 13 leachate samples to ascertain the source of pollution on groundwater *** standard analytical methods given by the American Public Health Association(APHA)(Standard methods for examination of water and wastewater,23rd ***,AWWA,WPCF,Washington,2017)were used for quantitative estimation of hydrochemical parameters of collected *** results of the analysis of groundwater samples indicate that pH values range from 7.31 to *** mean magnesium concentration in groundwater samples is 58.93±21.44 mg/*** of the groundwater samples taken,approximately 41%and 73%of samples analysis results have been found beyond the acceptable limit with respect to the parameters of turbidity and total dissolved solids,respectively,according to the Bureau of Indian Standards(Indian standard specification for drinking water(IS:10500).BIS,Manak Bhawan,New Delhi,2012)for drinking *** 95.4%of groundwater samples and 92.3%of leachate samples have high nitrate concentrations above the standard limit of BIS(45 mg/L),*** Piper plot shows that 50%of the samples belong to the Ca^2+-Mg^2+-HCO3^-*** and Durov's diagrams indicate that the mean concentrations of ions are in the order of Na^+>Mg^2+>Ca^2+>K^+(for cations)and HCO3^->NO3^->C1^->SO42^->CO32^->F-(for anions)in groundwater of the study *** spatial variation of the hydrochemical parameters shows that groundwater is heavily contaminated with respect to *** results indicate that the groundwater of villages Achheja,Bisrakh road,Dujana,Badalpur and Sadopur is not suitable for drinking.

关键词： Leachate Hydrochemical parameters Piper plot Ternary and Durov's diagram Spatial variation

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Coupled heat and moisture transfer of a single mung bean grain based on IR heating

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International Journal of Modeling, Simulation, and Scientific Computing 2017年第2期8卷 25-38页

作者： Maninder meenu Paramita Guha Sunita Mishra Academy of Scientific&Innovative Research CSIR-Central Scientific Instruments Organisation Chandigarh 160030India CSIR-Central Scientific Instruments Organisation Sector 30C Chandigarh160030India

Infrared(IR)heating is often used for the treatment of liquid and solid *** treatment is known to enhance their shelf life by reducing moisture content and inactivating the *** bean(a type of pulse from India)is a short season crop;suffers maximum storage loss when compared to other legume *** losses are due to moisture and temperature *** of grains is an important postharvest *** drying is advantageous over the conventional drying *** this paper,the drying of mung bean is *** experimental setup is developed to obtain the required moisture and temperature *** equivalent model is simulated using COMSOL multiphysics software and the percentage error between the experimental and simulated models is *** of numerical implementation are presented and possible further extensions are identified.

关键词： Mung bean infrared heating finite element modeling simulation COMSOL multiphysics.

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Real-Time Analysis of COVID-19 Pandemic on Most Populated Countries Worldwide

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Computer Modeling in Engineering & Sciences 2020年第12期125卷 943-965页

作者： meenu Gupta Rachna Jain Akash Gupta Kunal Jain Department of Computer Science and Engineering Chandigarh UniversityPunjab140301India Department of Computer Science and Engineering Bharati Vidyapeeth’s College of EngineeringNew Delhi110063India

The spread of the Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)has already taken on pandemic extents,influencing even more than 200 nations in a couple of ***,regulation measures in China have decreased new cases by over 98%,this decrease is not the situation everywhere,and most of the countries still have been affected by *** objective of this research work is to make a comparative analysis of the top 5 most populated countries namely United States,India,China,Pakistan and Indonesia,from 1st January 2020 to 31st July *** research work also targets to predict an increase in the number of deaths and total infected cases in these five *** our research,the performance of the proposed framework is determined by using three Machine Learning(ML)regression algorithms namely Linear Regression(LR),Support Vector Regression(SVR),andRandom Forest(RF)*** proposed model is also validated upon the infected and death cases of further *** performance of these three algorithms is compared using the RootMean Square Error(RMSE)*** Forest algorithm shows best performance as compared to other proposed algorithms,with the lowest RMSE value in the prediction of total infected and total deaths cases for all the top five most populated countries.

关键词： COVID-19 SARS COV-2 country-wise analysis most populated countries pandemic mortality rate

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Shear Strength Evaluation of Concrete Beams Reinforced with BFRP Bars and Steel Fibers without Stirrups

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Computers, Materials & Continua 2016年第2期51卷 81-103页

作者： Smitha Gopinath S.meenu A.Ramachandra Murthy Scientist.CSIR-Structural Engineering Research Centre Chennai 600113India Project Student CSIR-Structural Engineering Research CentreChennai 600113India

This paper presents experimental and analytical investigations on concrete beams reinforced with basalt fiber reinforced polymer(BFRP)and steel fibers without *** behaviour of BFRP reinforced beams and steel fiber reinforced beams were evaluated and the effect of combining BFRP bars and steel fiber was investigated in *** is found that combining s teel fibers with BFRP could change the shear failure of BFRP reinforced beam to flexural ***,the existing analytical models were reviewed and compared to predict the shear strength of both FRP reinforced and steel fiber reinforced *** on the review,the appropriate model was chosen and modified to predict the shear strength of BFRP reinforced beam along with steel fibers.

关键词： Basalt fiber reinforced polymer(BFRP) Steel fibers Flexure,Shear strength

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