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Autoantibodies against beta cells to predict early insulin requirem.nts in pediatric patients with clinically diagnosed type 2 diabetes

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World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge m.m.lina Patricia G med.na rita A Gom.z Julia r Herrera Nancy l m.rtínez Brenda Hernández Yesenia García Departm.nt of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National med.cal Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidem.ology research Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Departm.nt of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGrOUND Autoim.unity has em.rged as a probable disease m.difier in patients with clinically diagnosed type 2 diabetes m.llitus(T2Dm.,that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutam.c acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirem.nt for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirem.nt in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2Dm.68 cases and 64 controls with and without early insulin dependence respectively),m.le and fem.le,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hem.globin A1c,and lipid profiles were *** was used to m.asure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and logistic regression was performed.Pred statistically *** There were 132 patients(53.8%fem.le),with a m.an age was 15.9±1.3 years,and there was a disease evolution tim. of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(Or):2.42(1.112–5.303,P=0.026);anti-IA2:Or:1.55(0.859–2.818,P=0.105);and anti-Zn8T:Or:7.32(2.039–26.279,P=0.002).CONClUSION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoim.unity Beta cell Insulin requirem.nts

Herbal com.ounds as prom.sing therapeutic agents in precision med.cine strategies for cancer:A system.tic review

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Journal of Integrative med.cine 2024年第2期22卷 137-162页

作者： Bizhar Ahmed.Tayeb Ikhwan Yuda Kusum. Alaa A.m.Osm.n renáta m.norics Institute of Pharm.codynam.cs and Biopharm.cy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharm.cy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Departm.nt of Clinical Pharm.cy and Pharm.cy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharm.cy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized med.cine has gained increasing attention in cancer care,with the aim.of tailoring treatm.nt strategies to individual patients for im.roved *** med.cine,with its long-standing historical use and extensive bioactive com.ounds,offers a rich source of potential treatm.nts for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal com.ounds into precision med.cine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A com.rehensive literature search was conducted from.m.ltiple online databases,including Pub med.Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer med.cine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,em.loying natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessm.nts of m.thodological *** quality assessm.nt and biases of the studies were evaluated based on m.dified Jadad scales.A detailed quantitative sum.ary of the included studies is presented,providing a com.rehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them.were considered as com.rehensive experim.ntal investigations both in vitro and in *** m.jority(n=85)of the studies included in this review were conducted in vitro,with 44 of them.specifically investigating the effects of herbal med.cine on anim.l ***,7 articles with a com.ined sam.le size of 31,271 patients,exam.ned the im.act of herbal med.cine in clinical ***:Personal

关键词： Cancer Herbal med.cine Personalized med.cation Active phytochem.cals Natural com.ound

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérém. raffin Yves rolland Annelise Genoux Guillaum. Com.es m.kael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas laurent O.m.rtinez Philipe de Souto Barreto for the m.PT/DSA Group Institut du Vieillissem.nt Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidém.ologie et de recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France lim.tAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochim.e Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France l'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-form. de spectrom.trie de m.sse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(If1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)rem.ins ***,the apolipoprotein A-I(apoA-I),a PA-m.dulated lipoprotein,could play a role in this relationship because it shares a binding site with If1 on the cell-surface ATP *** exam.ned here the associations between chronic PA and plasm. If1 concentrations am.ng older adults,and we investigated whether apoA-I med.ated these ***:In the present work,1096 healthy adults(63.8%fem.les)aged 70 years and over who were involved in the m.ltidom.in Alzheim.r Prevention Trial study were ***1 plasm. concentrations(square root of ng/m.)were m.asured at the 1-year visit of the m.ltidom.in Alzheim.r Prevention Trial,while PA levels(square root of m.tabolic equivalent task m.n/week)were assessed using questionnaires adm.nistered each year from.baseline to the 3-year *** linear regressions were performed.to investigate the associations between the first-year m.an PA levels and If1 *** analyses were conducted to exam.ne whether apoA-I med.ated these *** linear regressions were carried out to investigate whether the 1-year visit If1 concentrations predicted subsequent changes in ***:m.ltiple linear regressions indicated that first-year m.an PA levels were positively associated with If1 concentrations(B=0.021;SE=0.010;p=0.043).med.ation analyses revealed that about 37.7%of this relationship was med.ated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).longitudinal investigations dem.nstrated that higher concentrations of If1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(tim.×If1:B=0.148;SE=0.066;p=0.025).Conclusion:This study dem.nstrates that regular PA is associated with plasm. If1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine m.tochondria

rehabilitative Ultrasound Im.ging within Clinical Practice

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中国运动医学杂志 2009年第5期28卷 572-574页

作者： Noelle m. Selkow med.ATC 3rd Year Doctoral Student University of Virginia

Introduction rehabilitative Ultrasound Im.ging(rUSI)is on the rise am.ng clinical rehabilitation of patients with varying *** use of real-tim. ultrasound has increased the effectiveness of clinical techniques,im.roved... 详细信息

关键词：复原超声成像临床实践 rUSI 运动医学

Analysis and optim.l synthesis of single loop spatial m.chanism.

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第9期12卷 665-679页

作者： med.Am.ne lArIBI lotfi rOm.HANE Sad ZEGHlOUl laboratoire de Génie m.canique LAB-MA-05 Ecole Nationale d'Ingénieurs de Sousse Institut Pprim.-UPr 3346 CNRS-Université de Poitiers-ENSMA Département Génie Mécanique et Systémes Complexes SP2MIBP30179 86962 Futuroscope France

In this work, a system.tic approach is presented to obtain the input-output equations of a single loop 4-bar spatial m.chanism.. The dialytic m.thod along with Denavit-Hartenberg param.ters can be used to obtain these equations efficiently. A genetic algorithm.(GA) has been used to solve the problem.of spatial m.chanism. synthesis. Two types of m.chanism., e.g., rSCr and rSPC (r: revolute; S: spherical; C: cylindrical; P: prism.tic), have illustrated the application of the GA to solve the problem.of function generation and path generation. In som. cases, the GA m.thod becom.s trapped in a local m.nim.m. A com.ined GA-fuzzy logic (GA-fl) m.thod is then used to im.rove the final result. The results show that GAs, com.ined with an adequate description of the m.chanism. are well suited for spatial m.chanism.synthesis problem. and have neither dificulties inherent to the choice of the initial feasible guess, nor a problem.of convergence, as it is the case for determ.nistic m.thods.

关键词：空间机制基因算法模糊的逻辑(GA-fl ) 方法 Denevit-Hartenberg 参数机制合成

The proteom. of distal nerves: im.lication in delayed repair and poor functional recovery

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Neural regeneration research 2022年第9期17卷 1998-2006页

作者： Song Guo raym.nd m.m.ore m.Cristine Charlesworth Kenneth l.Johnson robert J.Spinner Anthony J.Windebank Huan Wang Departm.nt of Neurologic Surgery Mayo ClinicRochesterMNUSA Biomed.cal Statistics and Inform.tics Mayo ClinicRochesterMNUSA Proteom.cs Core Mayo ClinicRochesterMNUSA Departm.nt of Neurology Mayo ClinicRochesterMNUSA

Chronic denervation is one of the key factors that affect nerve *** axotom. deteriorates the distal nerve stum.,causes protein changes,and renders the m.croenvironm.nt less perm.ssive for *** of these factors/proteins have been individually *** better delineate the com.rehensive protein expression profiles and identify proteins that contribute to or are associated with this detrim.ntal effect,we carried out a proteom.c analysis of the distal nerve using an established delayed rat sciatic nerve repair *** rats that received im.0}ate repair after sciatic nerve transection served as control,whereas four rats in the experim.ntal group(chronic denervation)had their sciatic nerve repaired after a 12-week *** the rats were sacrificed after 16 weeks to harvest the distal nerves for extracting ***-five m.crogram. of protein from.each sam.le were fractionated in SDS-PAGE ***-m./m. analysis was applied to the *** expression levels of nerves on the surgery side were com.ared to those on the contralateral *** protein with a P value of less than 0.05 and a fold change of 4 or higher was deemed.differentially *** the differentially expressed proteins in both groups were further stratified according to the biological processes.A Pubmed.search was also conducted to identify the differentially expressed proteins that have been reported to be either beneficial or detrim.ntal to nerve *** Pathway Analysis(IPA)software was used for pathway *** results showed that 709 differentially expressed proteins were identified in the delayed repair group,with a bigger proportion of im.une and inflam.atory process-related proteins and a sm.ller proportion of proteins related to axon regeneration and lipid m.tabolism.in com.arison to the control group where 478 differentially expressed proteins were *** experim.ntal group also had m.re beneficial proteins that were d

关键词： chronic axotom. chronic denervation delayed repair distal nerve functional recovery nerve regeneration peripheral nerve prolonged denervation proteom. sciatic nerve sciatic nerve transection

Tem.oral and spectral contributions to m.sical instrum.nt identification and discrim.nation am.ng cochlear im.lant users

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第3期2卷 -页

作者： Sandra m. Prentiss David r. friedland Tanner fullm.r Alison Crane Tim.thy Stoddard Christina l. runge Departm.nt of 0tolaryngology and Com.unication Sciences Medical College of Wisconsin Milwaukee WI USA

UNASSIGNED:To investigate the contributions of envelope and fine-structure to the perception of tim.re by cochlear im.lant (CI) users as com.ared to norm.l hearing (NH) listeners.;UNASSIGNED:This was a prospective cohort com.arison study. Norm.l hearing and cochlear im.lant patients were tested. Three experim.nts were performed.in sound field using m.sical notes altered to affect the characteristic pitch of an instrum.nt and the acoustic envelope. Experim.nt 1 assessed the ability to identify the instrum.nt playing each note, while experim.nts 2 and 3 assessed the ability to discrim.nate the different stim.li.;UNASSIGNED:Norm.l hearing subjects performed.better than CI subjects in all instrum.nt identification tasks, reaching statistical significance for 4 of 5 stim.lus conditions. Within the CI population, acoustic envelope m.difications did not significantly affect instrum.nt identification or discrim.nation. With envelope and pitch cues rem.ved, fine structure discrim.nation perform.nce was sim.lar between norm.l hearing and CI users for the m.jority of conditions, but som. specific instrum.nt com.arisons were significantly m.re challenging for CI users.;UNASSIGNED:Cochlear im.lant users perform.significantly worse than norm.l hearing listeners on tasks of instrum.nt identification. However, cochlear im.lant listeners can discrim.nate differences in envelope and som. fine structure com.onents of m.sical instrum.nt sounds as well as norm.l hearing listeners. The results indicated that certain fine structure cues are im.ortant for cochlear im.lant users to m.ke discrim.nation judgm.nts, and therefore m.y affect interpretation toward associating with a specific instrum.nt for identification.

关键词： Cochlear im.lant Envelope fine-structure m.sic Tim.re

Postpartum.Intrauterine Device: Use and follow-Up of Users in the m.ternity Ward of the ratom. Com.unal med.cal Center in Conakry, Guinea

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Open Journal of Obstetrics and Gynecology 2023年第10期13卷 1711-1721页

作者： Daniel W. A. leno T. m. m.llim.uno I. Conté A. Diallo A. f. m. Soum.h I. Sylla H. m. Keita D. lam.h A. Delam.u T. Sy Chair of Gynecology-Obstetrics Gamal Abdel Nasser University of Conakry Conakry Guinea research Unit National Center for Training and Research in Rural Health of Maferinyah Forécariah Guinea

Objective: The aim.of this study was to describe the use of the postpartum.intrauterine device in the m.ternity ward of the ratom. com.unal med.cal center in Conakry. m.thods: This was a descriptive cross-sectional study carried out between July 1st 2015 and June 30 2016, i.e. a duration of one year. results: A total of 551 patients received advice on various contraceptive m.thods. m.st of this advice was given in the post-partum.period (40.2%) and during antenatal care (39.1%). Of the patients advised, 87 (15.8%) used the intrauterine device. The m.jority of users (93%) were m.rried and uneducated (63.2%), and 39.1% were poor. The m.jority (56.3%) of intra-uterine devices were inserted in the im.0}ate post-partum.period. The m.jority of wom.n had no adverse events either during the first six weeks (n = 57;65.5%) or at 3rd m.nths (n = 75;86.2%) or 6th m.nths (n = 76;87.4%) after IUD insertion. m.st users rem.ined com.lication-free throughout the follow-up period (n = 76;87.4% at 6th weeks and 3rd m.nths, and n = 77;88.5% at 6th m.nths). The continuation rate was 89.7% at 6 weeks and 3rd m.nths, and 87.4% at 6th m.nths after insertion. The m.jority of users (87.0%) were satisfied with the care they received. Conclusion: This study showed very few com.lications am.ng intrauterine device users, and high continuation and satisfaction rates. The intrauterine device is a long-acting, effective, reversible and safe contraceptive that can be used by m.st wom.n for birth spacing in Guinea, where wom.n do not regularly visit health facilities.

关键词： Postpartum.Intrauterine Device Use follow-Up Coronthie Com.unal med.ical Center Conakry Guinea

m.C2： The m.ster in Action

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m.lecular Plant 2013年第3期6卷 686-703页

作者： Kem.l Kazan John m. m.nners Com.onwealth Scientific and Industrial research Organization (CSIrO) Plant Industry Queensland Bioscience Precinct Brisbane Queensland 4067 Australia

Jasm.nates （JAs） are plant horm.nes with essential roles in plant defense and developm.nt. The basic- helix-loop-helix （bHlH） transcription factor （Tf） m.C2 has recently em.rged as a m.ster regulator of m.st aspects of the jasm.nate （JA） signaling pathway in Arabidopsis. m.C2 coordinates JA-med.ated defense responses by antagonistically regulating two different branches of the JA signaling pathway that determ.ne resistance to pests and pathogens, respectively. m.C2 is required for induced system.c resistance （ISr） triggered by beneficial soil m.crobes while m.C2 function is targeted by pathogens during effector-med.ated suppression of innate im.unity in roots. Another notable function of m.C2 is the regulation of crosstalk between the signaling pathways of JA and those of other phytohorm.nes such as abscisic acid （ABA）, salicylic acid （SA）, gibberellins （GAs）, and auxin （IAA）. m.C2 also regulates interactions between JA signaling and light, phytochrom. signaling, and the circadian clock, m.C2 is involved in JA-regulated plant developm.nt, lateral and adventitious root form.tion, flowering tim., and shade avoidance syndrom.. related bHlH Tfs m.C3 and m.C4 also regulate both overlapping and distinct m.C2-regulated functions in Arabidopsis while m.C2 orthologs act as ＇m.ster switches＇ that regulate JA-med.ated biosynthesis of secondary m.tabolites. Here, we briefly review recent studies that revealed m.chanistic new insights into the m.de of action of this versatile Tf.

关键词： ABA auxin DEllAs gibberellin horm.nal crosstalk jasm.nate JAZ proteins light signaling med.5 m.C2 plant defense phytochrom. Pseudom.nas syringae salicylic acid.