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Prospective evaluation of laparoscopic Roux en Y gastric bypass in patients with clinically severe obesity

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World Journal of Gastroenterology 2008年第39期14卷 6024-6029页

作者： Kostantinos Vagenas Spyros Panagiotopoulos Ioannis Kehagias Stavros Nikolaos Karamanakos Nancy mead Fotis Kalfarentzos Department of Surgery University of Patras School of MedicineUniversity HospitalRion 26504Greece Nutrition Support and Morbid Obesity Clinic University of Patras School of MedicineUniversity HospitalRion 26504Greece

AIM: To evaluate and present our experience with laparoscopic Roux en Y gastric bypass (RYGB) in a selected patient population. METHODS: A cohort of 130 patients with a body mass index (BMI) between 35 and 50 kg/m2 were evaluated in relation to postoperative morbidity,weight loss and resolution of co-morbidities for a period of 4 years following laparoscopic RYGB. RESULTS: Early morbidity was 10.0%,including 1 patient with peritonitis who was admitted to Intensive Care Unit (ICU) and 1 conversion to open RYGB early in the series. There was no early or late mortality. Maximum weight loss was achieved at 12 mo postoperatively,with mean BMI 30 kg/m2,mean percentage of excess weight loss (EWL%) 66.4% and mean percentage of initial weight loss (IWL%) 34.3% throughout the follow-up period. The majority of preexisting comorbidities were resolved after weight loss and no major metabolic disturbances or nutritional deficiencies were observed. CONCLUSION: Laparoscopic RYGB appears to be a safe and effective procedure for patients with BMI 35-50 kg/m2 with results that are comparable to previously published data mostly from the USA but from Europe as well.

关键词： Laparoscopic gastric bypass Evaluation Obesity

Dental pulp stem cells, a paracrine-mediated therapy for the retina

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Neural Regeneration Research 2014年第6期9卷 577-578页

作者： Ben mead Ann Logan Martin Berry Wendy Leadbeater Ben A. Scheven Neurotrauma and Neurodegeneration Section School of Clinical and Exper-imental Medicine University of Birmingham School of Dentistry University of Birmingham

Author contributions： mead B was responsible for study conception and design, collection and^or assembly of data, data analysis and interpretation and manuscript writing. Logan A participated in study conception and design, data analysis and interpretation and manuscript writing. Berry M was responsible for manuscript writing. Scheven BA was in charge of study conception and design, data analysis and interpretation and manuscript writing. Leadbeater W participated in study conception and design, data analysis and interpretation and manuscript writing. All authors approved the final version of this paper.

关键词： stem cell DPSCs RGCs a paracrine-mediated therapy for the retina Dental pulp stem cells BMSCs

加速分数型布朗运动粒子追踪模型在水面污染扩散中的应用

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水利学报 2009年第12期39卷 1517-1523页

作者：瞿波 Paul S.Addison Christopher T.mead 南通大学理学院江苏南通226001 Cardio Digital Ltd Elvingston Science Centre HR Wallingford Ltd

对沿海水域的non-Fickian扩散现象的观测表明,沿海表层水域的Hurst指数H并不局限于0～1的范围。因此本研究在分数型布朗运动的基础上,引进加速分数型布朗运动来模拟non-Fickian扩散,使表面Hurst指数可以大于1,从而建立了一种新型的粒子... 详细信息

对沿海水域的non-Fickian扩散现象的观测表明,沿海表层水域的Hurst指数H并不局限于0～1的范围。因此本研究在分数型布朗运动的基础上,引进加速分数型布朗运动来模拟non-Fickian扩散,使表面Hurst指数可以大于1,从而建立了一种新型的粒子追踪技术,由此来模拟沿海水域中的non-Fickian传播。随后对使用粒子云模拟沿海水域中污染物的non-Fickian扩散的方法进行了研究。并通过比较实际观测数据,以及英国HR Wallingford传统的Fickian扩散模型的计算结果表明,本文模拟的结果较好。

关键词：分数型布朗运动加速分数型布朗运动粒子追踪模型 Fickian扩散 non-Fickian扩散

Peptide Variant Detection by a Living Yeast Biosensor via an Epitope-Selective Protease

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BioDesign Research 2023年第1期5卷 1-11页

作者： Tea Crnković Benjamin J.Bokor mead E.Lockwood Virginia W.Cornish Department of Chemistry Columbia UniversityNew YorkNY 10027USA. Department of Biological Sciences Columbia UniversityNew YorkNY 10027USA. School of General Studies Columbia UniversityNew YorkNY 10027USA. Department of Systems Biology Columbia UniversityNew YorkNY 10027USA. Department of Biological Engineering Massachusetts Institute of TechnologyCambridge02139 MAUSA.

We previously demonstrated that we could hijack the fungal pheromone signaling pathway to provide a living yeast biosensor where peptide biomarkers were recognized by G-protein-coupled receptors and engineered to transcribe a ***,we demonstrated that the protease could be reintroduced to the biosensor to provide a simple mechanism for distinguishing single-amino-acid changes in peptide ligands that,otherwise,would likely be difficult to detect using binding-based *** characterized the dose–response curves for five fungal pheromone G-protein-coupled receptors,peptides,and proteases—Saccharomyces cerevisiae,Candida albicans,Schizosaccharomyces pombe,Schizosaccharomyces octosporus,and Schizosaccharomyces *** scanning was carried out for the most selective of these—*** and ***—with and without the *** peptide variants were discovered,which showed diminished cleavage by the protease(CaPep2A and CaPep2A13A).Those peptides were then distinguished by utilizing the biosensor strains with and without the protease,which selectively cleaved and altered the apparent concentration of peptide required for half-maximal activation for 2 peptides—CaPep and CaPep13A,respectively—by more than one order of *** results support the hypothesis that the living yeast biosensor with a sequence-specific protease can translate single-amino-acid changes into more than one order of magnitude apparent shift in the concentration of peptide required for half-maximal *** further engineering by computational modeling and directed evolution,the biosensor could likely distinguish a wide variety of peptide sequences beyond the alanine scanning carried out *** the future,we envision incorporating proteases into our living yeast biosensor for use as a point of care diagnostic,a scalable communication language,and other applications.

关键词： apparent otherwise utilizing

HIV/AIDS Treatment and Prevention in India : Modeling the Costs and Consequences

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丛书名： Health, Nutrition, and Population Series

2004年

作者： Over A. mead.

ISBN: (纸本)0821356577

How should governments respond to the increasing domestic and international pressures to finance antiretroviral therapy for AIDS patients? Once prohibitively expensive outside rich countries, antiretroviral therapy is now increasingly affordable, especially in India where patent laws and a dynamic pharmaceutical industry have facilitated the production and marketing of some of the best available drug combinations at prices below a dollar a day. This title projects the future implications of three alternative AIDS treatment financing policies for the health burden of AIDS in India and for its overall health expenditures. The Indian government's 2004 treatment initiative contains elements of all three of these options. Written by an interdisciplinary team of AIDS experts, the book presents new data on the supply and demand for antiretroviral treatment in India and new models of the epidemiological effects and the financial costs of alternative policies. The book shows that the lower prices of antiretroviral therapy, plus the fact that therapy can reduce transmission by the treated patient, imply that such therapy could save healthy years of life at a cost of between $146 and $280 per year. However, these conclusions depend on the assumption that treatment has no effect on risk behavior in key populations which account for most of the epidemic's spread. Sensitivity analysis reveals that multiplier effects due to behavioral responses would overwhelm the direct biological effects of treatment, leading the authors to recommend that India proceed cautiously. Careful monitoring of the population's response to treatment availability should suggest how to maximize the beneficial effects of treatment on risk behavior and to avoid the perverse effects

关键词： AIDS (Disease)

来源：畅想之星图书光盘版（南... 评论

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解决一维材料黏附行为的实验方法综述

Engineering 2023年第5期24卷 39-72,I0001,I0002页

作者： James L.mead Shiliang Wang Sören Zimmermann Sergej Fatikow Han Huang Department of Computing Science University of OldenburgOldenburg D-26129Germany School of Physics and Electronics Central South UniversityChangsha 410083China School of Mechanical and Mining Engineering The University of QueenslandBrisbaneQLD 4072Australia

一维(1D)材料(如纳米管和纳米线)的黏附行为在集成一维组件的新型器件以及基于一维阵列的仿生黏合剂的有效制造、功能和可靠性中起着决定性作用。本文汇编并批判性地评估了最近的实验技术,旨在表征由一维材料形成的界面的粘附行为(包括... 详细信息

一维(1D)材料(如纳米管和纳米线)的黏附行为在集成一维组件的新型器件以及基于一维阵列的仿生黏合剂的有效制造、功能和可靠性中起着决定性作用。本文汇编并批判性地评估了最近的实验技术,旨在表征由一维材料形成的界面的粘附行为(包括当这些材料与衬底或邻近的一维材料接触时)。讨论了一维材料与表面的构象以及与之相关的多粗糙度接触的发生,并探讨了界面附着和剥离过程中黏附和摩擦的耦合。考虑了一维材料作为增强剂在纳米复合材料中的应用以及相关的界面表征技术。研究了样品制备和黏附测试过程中存在的环境条件对一维界面相互作用的潜在影响,并最终改变了一维材料的粘附行为。最后,简要介绍了当前的挑战和未来的方向,包括测试环境的系统调查和通过表面改性改变附着力。

关键词：一维材料纳米复合材料一维阵列界面相互作用样品制备表面改性新型器件增强剂

Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

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Translational Neurodegeneration 2023年第1期12卷 225-241页

作者： Peter J.Richardson Daniel P.Smith Alex de Giorgio Xenia Snetkov Joshua Almond-Thynne Sara Cronin Richard J.mead Christopher J.McDermott Pamela J.Shaw BenevolentAI 4-8 Maple StreetLondon W1T 5HDUK BenevolentAI 15 MetroTech Centre8th FLBrooklynNY 11201USA Sheffield Institute for Translational Neuroscience Faculty of MedicineDentistry and HealthUniversity of SheffieldSheffieldUK NIHR Sheffield Biomedical Research Centre University of Sheffield and Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK

Amyotrophic lateral sclerosis(ALS)is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular *** with other multifactorial diseases,it is likely that drugs will need to target multiple disease processes and cell types to be *** review here the role of Janus kinase(JAK)/Signal transducer and activator of transcription(STAT)signalling in ALS,confirm the association of this signalling with fundamental ALS disease processes using the BenevolentAI Knowledge Graph,and demonstrate that inhibitors of this pathway could reduce the ALS pathophysiology in neurons,glia,muscle fibres,and blood ***,we suggest that inhibition of the JAK enzymes by approved inhibitors known as Jakinibs could reduce STAT3 activation and modify the progress of this *** of the Jakinibs highlights baricitinib as a suitable candidate due to its ability to penetrate the central nervous system and exert beneficial effects on the immune ***,we recommend that this drug be tested in appropriately designed clinical trials for ALS.

关键词： Janus kinase STAT3 Amyotrophic lateral sclerosis

Identification, Cloning and Characterization of Dictyoglomus Turgidum CelA, an Endoglucanase with Cellulase and Mannanase Activity

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Journal of Life Sciences 2011年第7期5卷 488-496页

作者： Phillip J. Brumm Spencer Hermanson Joshua Luedtke David A. mead C5-6 Technologies 2120 W. Greenview Drive Middleton W153562 USA

The discovery of new, highly active, biomass-degrading enzymes is important to the development of a sustainable biofuels industry. Dictyoglomus turgidum, a thermophilic, anaerobic eubacterium that ferments cellulose and produces ethanol and hydrogen, was chosen as a candidate to screen for novel enzymes. A novel thermostable endoglucanase, CelA, was identified and purified during screening of a shotgun library of Dic（yoglomus turgidum and subsequently subcloned and expressed in E. coli. The celA gene coding for a 312 amino acid protein showed low homology to proteins outside the genus Dictoglomi and lacked an apparent signal peptide. CelA had a broad substrate range, possessing both endo and exo activity on soluble and insoluble β-（1,4）-Iinked glucose-containing substrates as well as endo activity on soluble and insoluble β-（1,4）-linked mannose containing substrates. The specific activity of CelA was 226 U/rag using β-glucan, 66 U/mg using glucomannan, and 63 U/mg using CMC as substrates. The high temperature optimum of 70 ℃ to 80 ℃ and wide substrate range of the enzyme might make it an excellent tool for biomass degradation at high temperature.

关键词： Cellulase mannanase thermophilic biomass degradation Dictyoglomus turgidum.

感染预防与控制对改善导管相关血流感染的作用

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上海护理 2010年第1期10卷 87-88页

作者： Pad mead 新西兰奥克兰市曼奴考地区医管局

2009上海国际护理大会已于2009年11月20日顺利落下了帷幕,此次会议显现了巨大的社会效应,来自海内外众多资深专家和学者为大会奉献了精彩的演讲和阐述。为让广大临床护理人员更多地了解参加会议的专家和学者,本刊将不定期摘编参会专家... 详细信息

2009上海国际护理大会已于2009年11月20日顺利落下了帷幕,此次会议显现了巨大的社会效应,来自海内外众多资深专家和学者为大会奉献了精彩的演讲和阐述。为让广大临床护理人员更多地了解参加会议的专家和学者,本刊将不定期摘编参会专家、学者的报告,以飨读者。

关键词：导管血流感染预防与控制