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NecAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel methner Institute for Molecular medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NecAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized c-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NecAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NecAB2 interacts with predominantly striatal G-protein-coupled receptors, while NecAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NecAB proteins exhibit distinct subcellular localizations: NecAB1 is found in the nucleus and cytosol, NecAB2 resides in endosomes and the plasma membrane, and NecAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NecAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NecAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Impact of distance on postoperative follow-up in patients of pediatric surgery:a retrospective review

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World Journal of Pediatric Surgery 2020年第4期3卷 23-29页

作者： me.gan e.wie.e.anna c shawye. Section of General Surgery Department of SurgeryUniversity of ManitobaWinnipegManitobaCanada Section of Pediatric General Surgery Department of SurgeryChildren’s Hospital Research Institute of ManitobaUniversity of ManitobaWinnipegManitobaCanada

Objective centralization of medical services in canada has resulted in patients travelling long distances for healthcare,which may compromise their *** hypothesized that children living farther from a children’s hospital were offered and attended fewer follow-up *** We reviewed children less than 17 years of age referred to the general surgery clinic at a tertiary children’s hospital during a 2-year period who underwent *** statistics were *** We identified 723 *** majority were male(61%)with a median age of 7 years(range 18 days to16 years)and were from the major urban center(MUc)(56.3%).The median distance travelled to hospital for MUc patients was 8.9 km(range 0.9-22 km)vs 119.5 km(range 20.3-1950 km)for non-MUc *** children were offered more follow-up appointments(72.7%vs 60.8%,pcant differences existed in follow-up attendance rates(MUc 88.5%vs non-MUc 89.1%,p=0.84)or postoperative complications(9.8%vs 9.2%,p=0.78).There were no *** Patients living farther from a hospital were offered fewer follow-up appointments,but attended an equivalent rate of follow-ups when offered *** and remote follow-up are underused approaches that can permit follow-up appointments while reducing associated travel time and expenses.

关键词： patients surgery canada

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Solar wind transport into magnetosphere caused by magnetic reconnection at high latitude magnetopause during northward IMF: cluster-DSP conjunction observations

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Science china(Technological Sciences) 2008年第10期51卷 1677-1684页

作者： M. DUNLOP e. LUceK H. Rme c. M. cARR Rutherford Appleton Laboratory Didcot United Kingdom Imperial college of Science Technology and Medicine London United Kingdom ceSR BP4346 31028 Toulouse Cedex 4 France

An event of cluster-Double Star conjunction observations of magnetic reconnec-tion at high latitude magnetopause nightside of both cusps and solar wind trans-port into magnetosphere caused by such reconnection process has been investi-gated. During northward IMF, cluster/Sc1 observed accelerated flows and ion heating associated with magnetic reconnection at high latitude magnetopause nightside of southern cusp. And Double Star observed cold dense solar wind plasma transported into dayside magnetosphere. The analysis on such conjunction observations shows that: (1) during northward IMF, magnetic reconnection occurs at high latitude nightside of southern cusp, accompanied by accelerated flows that are observed by cluster/Sc1; (2) the direction of the accelerated flows, with its sunward component Vx, dawnward component Vy, northward component Vz, is quite consistent with the theoretical anticipation under the condition of northward IMF with dawnward component By; (3) reconnection can heat plasma more in par-allel direction than in perpendicular direction, to a level of about 4 keV; (4) with reconnection taking place at high latitude magnetopause nightside of the southern cusp, Tc-1 observed cold and dense plasma transported into magnetosphere; (5) by reconnection at high latitude magnetopause nightside of both cusps, solar wind flux tube can be captured by magnetosphere and pulled into dayside magneto-sphere. This event presents further observational evidence for magnetic reconnec-tion at high latitude magnetopause nightside of both cusps as an important mech-anism of sol-ar w-ind transport into magnetosphere.

关键词： transport process magnetic reconnection solar wind-magnetosphere interactions

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Role of hyperfine mixing in b→c semileptonic decays of doubly-heavy baryons

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chinese Physics c 2010年第9期34卷 1488-1490页

作者： c.Albertus e.Hernández J.Nieves Departamento de Física Fundamental e IUFFyM Universidad de Salamanca Instituto de Física corpuscular (IFIc) Centro Mixto CSIC-Universidad de ValenciaInstitutos de Investigación de Paterna

We analyze the effects of hyperfine mixing in b → c semileptonic decays of doubly heavy *** qualitatively confirm the results by *** and *** in ***.A,2009,24： 2401– 2413,finding that mixing has a great impact on those ***,predictions without mixing differ by a factor of 2 and this discrepancy translates to the mixed case where large differences in decay widths are observed between the two calculations.

关键词： doubly-heavy baryons semileptonic decay hyperfine mixing

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On Proof of the c^1 Stability conjecture

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Acta Mathematica Sinica,english Series 2005年第3期21卷 533-540页

作者： Yong ZHANG Shao Bo gan School of Mathematical Sciences Soochow University Suzhou 215006 P. R. China School of Mathematical Sciences Peking University Beijing 100084 P. R. China

It seems that in Mane＇s proof of the c^1 Ω-stability conjecture containing in the famous paper which published in I. H. e. S. （1988）, there exists a deficiency in the main lemma which says that for f ∈F^1 （M） there exists a dominated splitting TMPi（f） =ei^s the direlf sum of e and F Fi^u（O 〈 i 〈 dim M） such that if ei^s is contracting, then Fi^u is expanding. In the first part of the paper, we give a proof to fill up this deficiency. In the last part of the paper, we, under a weak assumption, prove a result that seems to be useful in the study of dynamics in some other stability context.

关键词： The c^1 stability conjecture Dominated splitting Shadowing property Axiom A No-cycle condition

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Status and prospects for symmetric organic redox flow batteries

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Journal of energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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chronic hepatitis c virus infection and atherosclerosis: clinical impact and mechanisms

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World Journal of Gastroenterology 2014年第13期20卷 3410-3417页

作者： Luigi e Adinolfi Rosa Zampino Luciano Restivo Amedeo Lonardo Barbara Guerrera Aldo Marrone Fabio Nascimbeni anna Florio Paola Loria Department of medical SurgicalNeurologicalMetabolicand Geriatric SciencesSecond University of Naples80100 NaplesItaly Department of Internal medicine EndocrinologyMetabolism and GeriatricsUniversity of Modena and Reggio Emilia41126 Modena Italy Vascular Surgery Second University of Naples80100 NaplesItaly

Hepatitis c virus(HcV)infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases,which are associated with excess *** of published studies supports the view that HcV infection should be considered a risk factor for the development of carotid atherosclerosis,heart failure and *** contrast,findings from studies addressing coronary artery disease and HcV have yielded conflicting ***,meta-analytic reviews and prospective studies are *** pathogenic mechanisms connecting HcV infection,chronic liver disease,and atherogenesis are not completely ***,it has been hypothesized that HcV may promote atherogenesis and its complications through several direct and indirect biological mechanisms involving HcV colonization and replication within arterial walls,liver steatosis and fibrosis,enhanced and imbalanced secretion of inflammatory cytokines,oxidative stress,endotoxemia,mixed cryoglobulinemia,perturbed cellular and humoral immunity,hyperhomocysteinemia,hypo-adiponectinaemia,insulin resistance,type 2 diabetes and other components of the metabolic *** these complex mechanisms is of fundamental importance for the development of novel therapeutic approaches to prevent and to treat vascular complications in patients with chronic HcV ***,it seems that HcV clearance by interferon and ribavirin treatment significantly reduces non-liver-related mortality;moreover,interferon-based treatment appears to decrease the risk of ischemic stroke.

关键词： Hepatitis c virus Atherosclerosis coronary artery disease Stroke Inflammation

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Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis

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cellular & Molecular Immunology 2015年第4期12卷 493-503页

作者： anna-Karin e Palm Heike c Friedrich Anja mezger Maya Salomonsson Linda K Myers Sandra Kleinau Department of cell and Molecular Biology Uppsala University Uppsala Sweden Department of Pediatrics University of Tennessee Health ScienceCenter Memphis TN USA

Polyreactive innate-type B cells account for many B cells expressing self-reactivity in the periphery. Improper regulation of these B cells may be an important factor that underlies autoimmune disease. Here we have explored the influence of self-reactive innate B cells in the development of collagen-induced arthritis （cIA）, a mouse model of rheumatoid arthritis. We show that splenic marginal zone （MZ）, but not B- 1 B cells exhibit spontaneous IgM reactivity to autologous collagen II in na＇=＇ve mice. Upon immunization with heterologous collagen II in complete Freund＇s adjuvant the collagen-reactive MZ B cells expanded rapidly, while the B-1 B cells showed a modest anti-collagen response. The MZ B cells were easily activated by toll-like receptor （TLR） 4 and 9-1igands in vitro, inducing proliferation and cytokine secretion, implying that dual engagement of the B-cell receptor and TLRs may promote the immune response to self-antigen. Furthermore, collagen-primed MZ B cells showed significant antigen-presenting capacity as reflected by cognate T-cell proliferation in vitroand induction of IgG anti-collagen antibodies in vivo. MZ B cells that were deficient in complement receptors I and 2 demonstrated increased proliferation and cytokine production, while Fcy receptor lib deficiency of the cells lead to increased cytokine production and antigen presentation. In conclusion, our data highlight self-reactive MZ B cells as initiators of the autoimmune response in cIA, where complement and Fc receptors are relevant in controlling the self-reactivity in the cells.

关键词： arthritis complement receptors Fc receptors marginal zone B cells, mice

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Dynamics of air transport networks：A review from a complex systems perspective

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chinese Journal of Aeronautics 2017年第2期30卷 469-478页

作者： Luis e.c.Rocha Department of Public Health Sciences Karolinska Institutet Stockholm 17177 Sweden Department of Mathematics University of Namur 5000 Belgium

Air transport systems are highly dynamic at temporal scales from minutes to *** dynamic behavior not only characterizes the evolution of the system but also affect the system＇s *** the evolutionary mechanisms is thus fundamental in order to better design optimal air transport networks that benefits companies,passengers and the *** this review,we briefly present and discuss the state-of-the-art on time-evolving air transport *** distinguish the structural analysis of sequences of network snapshots,ideal for long-term network evolution（*** evolution）,and temporal paths,preferred for short-term dynamics（*** evolution）.We emphasize that most previous research focused on the first modeling approach（***-term） whereas only a few studies look at high-resolution temporal *** conclude the review highlighting that much research remains to be done,both to apply already available methods and to develop new measures for temporal paths on air transport *** particular,we identify that the study of delays,network resilience and optimization of resources（aircraft and crew） are critical topics.

关键词： Air transport Airport network complex network Dynamic network Temporal network

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Diagnosis of sewer pipe defects on image recognition of multi-features and support vector machine in a southern chinese city

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Frontiers of environmental Science & engineering 2019年第2期13卷 29-41页

作者： Xiangyang Ye Jian’e Zuo Ruohan Li Yajiao Wang Lili gan Zhonghan Yu Xiaoqing Hu State Key Joint Laboratory of environment Simulation and Pollution control School of EnvironmentTsinghua UniversityBeijing 100084China Thunip corp. Ltd.27F/Section CS&T BuildingTsinghua S&T ParkBeijing 100084China china Water environment Group.10F Campbell Building89th Jinbao StreetBeijing 101101China

closed circuit television(ccTV)systems are widely used to inspect sewer pipe *** the diagnosis process,the manual diagnosis of defects is time consuming,labor intensive and error *** assist inspectors in diagnosing sewer pipe defects on ccTV inspection images,this paper presents an image recognition algorithm that applies features extraction and machine learning *** algorithm of image recognition techniques,including Hu invariant moment,texture features,lateral Fourier transform and Daubechies(DBn)wavelet transform,was used to describe the features of defects,and support vector machines were used to classify sewer pipe *** to the inspection results,seven defects were defined;the diagnostic system was applied to a sewer pipe system in a southern city of china,and 28,760 m of sewer pipes were *** results revealed that the classification accuracies of the different defects ranged from 51.6% to 99.3%.The overall accuracy reached 84.1%.The diagnosing accuracy depended on the number of the training samples,and four fitting curves were applied to fit the *** to this paper,the logarithmic fitting curve presents the highest coefficient of determination of 0.882,and more than 200 images need to be used for training samples to guarantee the accuracy higher than 85%.

关键词： Sewer pipe defects Defect diagnosing Image recognition Multi-features extraction Support vector machine

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