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Identification of Key Genes as Potential Drug Targets for Gastric Cancer

清华大学学报:自然科学版(英文版) 2023年第4期28卷 649-664页

作者： md.Tofazzal hossain md.Selim Reza Yin Peng Shengzhong Feng Yanjie Wei Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganj 8100Bangladesh Guangdong Provincial Key Laboratory for Genome Stability and Disease Prevention and Regional Immunity and Diseases Department of PathologyShenzhen UniversityShenzhen 518060China

Gastric cancer(GC)is one of the most common cancers and ranks the third in cancer mortality all over the *** goal of this study was to identify potential hub-genes,highlighting their functions,signaling pathways,and candidate drugs for the treatment of GC *** used publicly available next generation sequencing(NGS)data to identify differentially expressed(DE)*** top DE genes were mapped to STRING database to construct the protein-protein interaction(PPI)network and top hub genes were selected for further *** found a total of 1555 DE genes with 870 upregulated and 685 downregulated genes in *** selected the top 400(200 upregulated and 200 downregulated)genes to construct a PPI network and extracted the top 15 hub *** gene ontology(GO)term and kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses of the 15 hub genes exposed some important functions and signaling pathways that were significantly associated with GC *** survival analysis of the hub genes disclosed that the lower expressions of the three hub genes CDH2,COL4A1,and COL5A2 were associated with better survival of GC *** three genes might be the candidate biomarkers for the diagnosis and treatment of ***,we considered 3 key proteins(genomic biomarkers)(COL4A1,CDH2,and CO5A2)as the drug target proteins(receptors),performed their docking analysis with the 102 meta-drug agents,and found Everolimus,Docetaxel,Lanreotide,Venetoclax,Temsirolimus,and Nilotinib as the top ranked 6 candidate drugs with respect to our proposed target proteins for the treatment against GC ***,the proposed drugs might play vital role for the treatment against GC patients.

关键词： gastric cancer hub genes candidate genes molecular docking candidate drugs

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Investigation and optimization of sampling characteristics of light field camera for flame temperature measurement

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Chinese Physics B 2019年第3期28卷 202-217页

作者： Yudong Liu md.Moinul hossain Jun Sun Biao Zhang Chuanlong Xu Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China School of Engineering and Digital Arts University of KentCanterburyKentCT27NTUK Sunny Central Research Institute Hangzhou 310052China

It is essential to investigate the light field camera parameters for the accurate flame temperature measurement because the sampling characteristics of the flame radiation can be varied with them. In this study, novel indices of the light field camera were proposed to investigate the directional and spatial sampling characteristics of the flame radiation. Effects of light field camera parameters such as focal length and magnification of the main lens, focal length and magnification of the microlens were investigated. It was observed that the sampling characteristics of the flame are varied with the different parameters of the light field camera. The optimized parameters of the light field camera were then proposed for the flame radiation sampling. The larger sampling angle(23 times larger) is achieved by the optimized parameters compared to the commercial light field camera parameters. A non-negative least square(NNLS) algorithm was used to reconstruct the flame temperature. The reconstruction accuracy was also evaluated by the optimized parameters. The results suggested that the optimized parameters can provide higher reconstruction accuracy for axisymmetric and non-symmetric flame conditions in comparison to the commercial light field camera.

关键词： light field camera flame radiation sampling parameter optimization temperature reconstruction

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Reproductive health and rights in the COVID-19 era:Why and how are rights and choices still the answer?

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Asian pacific Journal of Reproduction 2022年第4期11卷 155-157页

作者： md Anwer hossain Department of Population Sciences Faculty of Social SciencesUniversity of DhakaDhaka-1000Bangladesh

Amidst the coronavirus disease 2019(COVID-19)pandemic,the concern over the potential‘baby boom’or‘baby bust’had drawn renewed attention across the globe[1-3].However,historically alarmism over fertility rates gave rise to restrictive and coercive policies with an aim of‘controlling the population’that violated people’s sexual and reproductive health and rights(SRHR).In this perspective,the author argued that whether countries of the world face a COVID-19-induced short-term baby boom or bust,the solution lies in prioritizing the rights and choices of all people,especially their SRHR;not in adopting target-oriented population policies or coercive family planning programs.

关键词： priori fertility choice

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Responses in gas exchange and water status between drought-tolerant and-susceptible soybean genotypes with ABA application

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The Crop Journal 2015年第6期3卷 500-506页

作者： md.Mokter hossain Hon-Ming Lam Jianhua Zhang School of Life Sciences and Center for Soybean Research of the State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong

The purpose of this study was to investigate the physiological responses of drought-tolerant and drought-susceptible soybean genotypes to exogenous abscisic acid(ABA) application during progressive soil drying at seedling stages. Five-day old soybean seedlings were transplanted into PVC tubes filled with soil mixture. Seedlings were watered daily with similar water volumes until second trifoliate leaves emerged, and thereafter soil drying with or without exogenous ABA application was imposed. Half of the seedlings of each genotype were left for regular watering as control plants. Soil water status declined significantly over seven days of withholding water supply for both genotypes. Leaf expansion rate, stomatal conductance(g_s), leaf water potential(ψ_w), and relative water content of leaves(%RWC) declined significantly under soil drying as well as soil drying with ABA application, compared to their values for well-watered soybean genotypes. However, a drought-tolerant genotype(C12) responded more rapidly than a drought-susceptible genotype(C08) after imposition of soil drying and soil drying with exogenous ABA. In addition, application of exogenous ABA to water-restricted soybeans resulted in higher %RWC and ψwin the drought-tolerant than in the drought-susceptible genotype. Compared to the drought-susceptible genotype, the drought-tolerant genotype was more responsive to exogenous ABA application, resulting in a higher root-to-shoot ratio.

关键词： Drought stress Exogenous ABA Leaf relative water content Stomatal conductance Soybean genotypes

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Stature estimation from footprint measurements in Bangladeshi adults

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Forensic Sciences Research 2022年第2期7卷 124-131页

作者： md Asadujjaman md Harun Or Rashid md Sohel Rana md Mosharraf hossain Department of Industrial&Production Engineering Rajshahi University of Engineering&TechnologyRajshahiBangladesh

The estimation of stature is very important in forensic investigation,as it provides useful data that can narrow the pool of potentially matching *** purpose of this study was to develop formulae for the estimation of stature from footprint measurements in Bangladeshi *** study included 118 randomly selected men and 130 randomly selected women,all aged 18–50 *** each participant,stature and six footprint measurements were taken by means of standard measurement *** measurements were found to be positively correlated with *** was estimated by using linear regression *** right T1 length in men(R:þ0.587,R^(2):0.345)and the right T2 length in women(R:þ0.506,R^(2):0.256)were the most reliable individual estimators of ***,when data were combined for both sexes,the right T2 length was identified as the most reliable estimator of stature,with higher values of R(þ0.792)and R^(2)(0.627).In conclusion,human stature can be successfully estimated by using footprint measurements;this finding can be applied in forensic research and investigation.

关键词： Forensic sciences forensic anthropology anthropometry footprint stature estimation forensic identification

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Design and analysis of high birefringence and nonlinearity with small confinement loss photonic crystal fiber

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Frontiers of Optoelectronics 2019年第2期12卷 165-173页

作者： Rekha SAHA md.Mahbub hossain md. Ekhlasur RAHAMAN Himadri Shekhar MONDAL Electronics and Communication Engineering Discipline Khulna UniversityKhulna 9208Bangladesh

High birefringence with low confinement loss photonic crystal fiber (PCF) has significant advantages in the field of sensing, dispersion compensation devices, nonlinear applications, and polarization filter. In this report, two different models of PCFs are presented and compared. Both the models contain five air holes rings with combination of circular and elliptical air holes arrangement. Moreover, the elliptical shaped air holes polarization and the third ring air holes rotational angle are varied. To examine different guiding characteristics, finite element method (FEM) with perfectly matched layer (PML) absorbing boundary condition is applied from 1.2 to 1.8 |im wavelength range. High birefringence, low confinement loss, high nonlinearity, and moderate disper-sion values are successfully achieved in both the PCFs models. Numeric analysis shows that model-1 gives higher birefringence (2.75 ×10^-2) and negative dispersion (-540.67 ps/(nm ·km)) at 1.55 |im wavelength. However, model-2 gives more small confinement loss than model-1 at the same wavelength. In addition, the proposed design demonstrates the variation of rotation angle has great impact to enhance guiding properties especially the birefringence.

关键词： birefringence dispersion polarization main-taining photonic crystal fiber (PCF) polarization-selective devices polarization

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Brain Tumor Auto-Segmentation on Multimodal Imaging Modalities Using Deep Neural Network

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Computers, Materials & Continua 2022年第9期72卷 4509-4523页

作者： Elias hossain md.Shazzad hossain md.Selim hossain Sabila Al Jannat Moontahina Huda Sameer Alsharif Osama S.Faragallah Mahmoud M.A.Eid Ahmed Nabih Zaki Rashed Department of Software Engineering Daffodil International UniversityDhaka 1207Bangladesh Department of Computing and Information System Daffodil International UniversityDhaka 1207Bangladesh Department of Computer Science&Engineering BRAC UniversityDhaka 1212Bangladesh Department of Information and Communication Engineering Bangladesh University of Professionals(BUP)Dhaka 1216Bangladesh Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Electrical Engineering College of EngineeringTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Electronics and Electrical Communications Engineering Department Faculty of Electronic EngineeringMenouf 32951Egypt

Due to the difficulties of brain tumor segmentation, this paper proposes a strategy for extracting brain tumors from three-dimensional MagneticResonance Image (MRI) and Computed Tomography (CT) scans utilizing3D U-Net Design and ResNet50, taken after by conventional classificationstrategies. In this inquire, the ResNet50 picked up accuracy with 98.96%, andthe 3D U-Net scored 97.99% among the different methods of deep *** is to be mentioned that traditional Convolutional Neural Network (CNN)gives 97.90% accuracy on top of the 3D MRI. In expansion, the imagefusion approach combines the multimodal images and makes a fused image toextricate more highlights from the medical images. Other than that, we haveidentified the loss function by utilizing several dice measurements approachand received Dice Result on top of a specific test case. The average mean scoreof dice coefficient and soft dice loss for three test cases was 0.0980. At thesame time, for two test cases, the sensitivity and specification were recordedto be 0.0211 and 0.5867 using patch level predictions. On the other hand,a software integration pipeline was integrated to deploy the concentratedmodel into the webserver for accessing it from the software system using theRepresentational state transfer (REST) API. Eventually, the suggested modelswere validated through the Area Under the Curve–Receiver CharacteristicOperator (AUC–ROC) curve and Confusion Matrix and compared with theexisting research articles to understand the underlying problem. ThroughComparative Analysis, we have extracted meaningful insights regarding braintumour segmentation and figured out potential gaps. Nevertheless, the proposed model can be adjustable in daily life and the healthcare domain to identify the infected regions and cancer of the brain through various imagingmodalities.

关键词： Brain cancer segmentation 3D U-Net ResNet50 Dice measurement ROC-AUC

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Industrial IoT Based Condition Monitoring for Wind Energy Conversion System

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CSEE Journal of Power and Energy Systems 2021年第3期7卷 654-664页

作者： md Liton hossain Ahmed Abu-Siada S.M.Muyeen md Mubashwar Hasan Momtazur Rahman Department of Electrical and Computer Engineering Curtin UniversityPerthAustralia School of Science Engineering and ITFederation UniversityAustralia Edith Cowan University Australia

Wind energy has been identified as the second dominating source in the world renewable energy generation after *** and distribution of wind energy has brought technology revolution by developing the advanced wind energy conversion system(WECS)including multilevel inverters(MLIs).The conventional rectifier produces ripples in their output waveforms while the MLI suffers from voltage balancing issues across the DC-link *** paper proposes a simplified proportional integral(PI)-based space vector pulse width modulation(SVPWM)to minimize the output waveform ripples,resolve the voltage balancing issue and produce better-quality output *** experiences various types of faults particularly in the DC-link capacitor and switching devices of the power *** faults,if not detected and rectified at an early stage,may lead to catastrophic failures to the WECS and continuity of the power *** paper proposes a new algorithm embedded in the proposed PI-based SVPWM controller to identify the fault location in the power converter in real *** most wind power plants are located in remote areas or offshore,WECS condition monitoring needs to be developed over the internet of things(IoT)to ensure system *** this paper,an industrial IoT algorithm with an associated hardware prototype is proposed to monitor the condition of WECS in the real-time environment.

关键词： Asset management condition monitoring fault diagnosis industrial internet of things(IoT) wind energy conversion system

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Nutrient dynamics associated with leaf litter decomposition of three agroforestry tree species (Azadirachta indica, Dalbergia sissoo, and Melia azedarach) of Bangladesh

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Journal of Forestry Research 2011年第4期22卷 577-582页

作者： Mahmood hossain Mohammad Raqibul Hasan Siddique md. Saidur Rahman md. Zaber hossain md. Mahedi Hasan Forestry and Wood Technology Discipline Khulna University Khulna - 9208 Bangladesh Soil Science Discipline Khulna University Khulna-9208 Forestry and Wood Technology Discipline Khulna University Khulna- 9208

Azadirachta indica A. Juss, Dalbergia, sissoo Roxb., and Melia azedarach L. are little studied species in nutrient return capabilities from leaf litter decomposition to maintenance of the soil fertility despite their importance in agroforestry practices of Bangladesh. A leaf litter decomposition experiment was conducted using a litterbag teeh7 nique to assess the nutrient reaun efficiency of these species. The de- composition rate of leaf litter was highest for M. azedarach and lowest for D. sissoo. Rainfall and temperature of study sites showed a significant （p〈0.05） positive relationship with the rate of leaf litter decomposition. The highest decay constant was observed for M. azedarach （6.67）. Nitrogen and Phosphorus concentration in leaf litter showed a decreased trend sharply at the end of the first month, whereas rapid decrease of Potassium concentration was reported within 10 days. Conversely, higher concentration of nutrient was observed at the later stages of decomposition. All three species showed a similar pattern of nutrient release （K 〉 N 〉 P） during the decomposition process of leaf litter. Among the studied species, D. sissoo was best in terms of N and P return and A. indica was best in terms of K return.

关键词： agroforestry decay constant decomposition leaf litter andnutrient dynamics

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Assessment of Physico-Chemical and Microbial Quality of Sugarcane Juice Sold by Street Vendors in Three Regions of Bangladesh

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Food and Nutrition Sciences（食品与营养科学） 2024年第4期 263页

作者： Nargis Akter Khan md. Murtaja Reza Linkon Munni Akter md. Alamgir hossain md. Mahbubur Rahman Tayeba Khan md. Abdul Alim md. Esrafil

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