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Identification of Key Genes as Potential Drug Targets for Gastric Cancer

Tsinghua Science and Technology 2023年第4期28卷 649-664页

作者： md.tofazzal Hossain md.Selim Reza Yin Peng Shengzhong Feng Yanjie Wei Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganj 8100Bangladesh Guangdong Provincial Key Laboratory for Genome Stability and Disease Prevention and Regional Immunity and Diseases Department of PathologyShenzhen UniversityShenzhen 518060China

Gastric cancer(GC)is one of the most common cancers and ranks the third in cancer mortality all over the *** goal of this study was to identify potential hub-genes,highlighting their functions,signaling pathways,and candidate drugs for the treatment of GC *** used publicly available next generation sequencing(NGS)data to identify differentially expressed(DE)*** top DE genes were mapped to STRING database to construct the protein-protein interaction(PPI)network and top hub genes were selected for further *** found a total of 1555 DE genes with 870 upregulated and 685 downregulated genes in *** selected the top 400(200 upregulated and 200 downregulated)genes to construct a PPI network and extracted the top 15 hub *** gene ontology(GO)term and kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses of the 15 hub genes exposed some important functions and signaling pathways that were significantly associated with GC *** survival analysis of the hub genes disclosed that the lower expressions of the three hub genes CDH2,COL4A1,and COL5A2 were associated with better survival of GC *** three genes might be the candidate biomarkers for the diagnosis and treatment of ***,we considered 3 key proteins(genomic biomarkers)(COL4A1,CDH2,and CO5A2)as the drug target proteins(receptors),performed their docking analysis with the 102 meta-drug agents,and found Everolimus,Docetaxel,Lanreotide,Venetoclax,Temsirolimus,and Nilotinib as the top ranked 6 candidate drugs with respect to our proposed target proteins for the treatment against GC ***,the proposed drugs might play vital role for the treatment against GC patients.

关键词： gastric cancer hub genes candidate genes molecular docking candidate drugs

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期100卷 125-143页

作者： md Al Raihan C.Adam Dyker Department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Variability in total antioxidant capacity, antioxidant leaf pigments and foliage yield of vegetable amaranth

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Journal of Integrative Agriculture 2018年第5期17卷 1145-1153页

作者： Umakanta Sarker md.tofazzal islam md Golam Rabbani Shinya Oba Department of Genetics and Plant Breeding Faculty of AgricultureBangabandhu Sheikh Mujibur Rahman Agricultural University Laboratory of Field Science Faculty of Applied Biological ScienceGifu University Department of Biotechnology Faculty of AgricultureBangabandhu Sheikh Mujibur Rahman Agricultural University Department of Horticulture Faculty of AgricultureBangladesh Agricultural University

Twenty vegetable amaranth genotypes were evaluated for total antioxidant capacity, antioxidant leaf pigments, vitamins, and selection of suitable genotypes for extraction of juice in a randomized complete block design（RCBD） with three replications. Vegetable amaranth was rich in chlorophyll, β-cyanins, β-xanthins, betalains, carotene, ascorbic acid and total antioxidant. The genotypes VA14, VA16, VA18, VA15, and VA20 could be selected as amaranth vegtable varieties with high yields and abundance antioxidant leaf pigments and vitamins to produce juice. The genotypes VA13 and VA19 had above-average foliage yield and high antioxidant profiles while the genotypes VA2, VA3, VA9, VA11, VA12, and VA17 had a high antioxidant profiles and below-average foliage yield. These genotypes could be used as a donor parent for integration of potential high antioxidant profiles genes into other genotypes. The correlation study revealed a strong positive association among all the antioxidant leaf pigments, total antioxidant capacity and foliage yield. Selection based on total antioxidant capacity, antioxidant leaf pigments could economically viable to improve the yield potential of vegetable amaranth genotypes. Total carotene and ascorbic acid exhibited insignificant genotypic correlation with all the traits except total antioxidant capacity. This indicates that selection for antioxidant vitamins might be possible without compromising yield loss.

关键词： ascorbic acid betalain carotene chlorophyll β-cyanins β-xanthins total antioxidant capacity foliage yield correlation

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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： Masashi Fujitani Abu md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

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Steel Surface Defect Detection Using Learnable Memory Vision Transformer

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Computers, Materials & Continua 2025年第1期82卷 499-520页

作者： Syed Tasnimul Karim Ayon Farhan md.Siraj Jia Uddin Department of Computer Science and Engineering BRAC UniversityDhaka1212Bangladesh Department of AI and Big Data Endicott CollegeWoosong UniversityDaejeon34606Republic of Korea

This study investigates the application of Learnable Memory Vision Transformers(LMViT)for detecting metal surface flaws,comparing their performance with traditional CNNs,specifically ResNet18 and ResNet50,as well as other transformer-based models including Token to Token ViT,ViT withoutmemory,and Parallel *** awidely-used steel surface defect dataset,the research applies data augmentation and t-distributed stochastic neighbor embedding(t-SNE)to enhance feature extraction and *** techniques mitigated overfitting,stabilized training,and improved generalization *** LMViT model achieved a test accuracy of 97.22%,significantly outperforming ResNet18(88.89%)and ResNet50(88.90%),aswell as the Token to TokenViT(88.46%),ViT without memory(87.18),and Parallel ViT(91.03%).Furthermore,LMViT exhibited superior training and validation performance,attaining a validation accuracy of 98.2%compared to 91.0%for ResNet 18,96.0%for ResNet50,and 89.12%,87.51%,and 91.21%for Token to Token ViT,ViT without memory,and Parallel ViT,*** findings highlight the LMViT’s ability to capture long-range dependencies in images,an areawhere CNNs struggle due to their reliance on local receptive fields and hierarchical feature *** additional transformer-based models also demonstrate improved performance in capturing complex features over CNNs,with LMViT excelling particularly at detecting subtle and complex defects,which is critical for maintaining product quality and operational efficiency in industrial *** instance,the LMViT model successfully identified fine scratches and minor surface irregularities that CNNs often *** study not only demonstrates LMViT’s potential for real-world defect detection but also underscores the promise of other transformer-based architectures like Token to Token ViT,ViT without memory,and Parallel ViT in industrial scenarios where complex spatial relationships are *** research m

关键词： Learnable Memory Vision Transformer(LMViT) Convolutional Neural Networks(CNN) metal surface defect detection deep learning,computer vision image classification learnable memory gradient clipping label smoothing t-SNE visualization

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Enhancement of Growth and Grain Yield of Rice in Nutrient Deficient Soils by Rice Probiotic Bacteria

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Rice science 2017年第5期24卷 264-273页

作者： md Mohibul Alam KHAN Effi HAQUE Narayan Chandra PAUL md Abdul KHALEQUE Saleh M. S. AL-GARNI Mahfuzur RAHMAN md.tofazzal islam Department of Biotechnology Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur 1706 Bangladesh Department of Biochemistry & Microbiology North South University Dhaka 1229 Bangladesh Department of Rural Development Administration Bioenergy Crop Research Institute Muan 534833 Republic of Korea Department of Biological Sciences King Abdulaziz University Jeddah 2589 Kingdom of Saudi Arabia West Virginia University Morgantown West Virginia 26505 USA

Plant associated bacteria are promising alternatives to chemical fertilizers for plant growth and yield improvement in an eco-friendly *** this study,rice associated bacteria were isolated and assessed for mineral phosphate solubilization and indole-3-acetic acid(IAA) production activity in *** promising strains,which were tentatively identified as phylotaxon Pseudochrobactrum sp.(BRRh-1),Burkholderia sp.(BRRh-2),Burkholderia sp.(BRRh-3),Burkholderia sp.(BRRh-4),Pseudomonas aeruginosa(BRRh-5 and BRRh-6) based on their 16 S rRNA gene phylogeny,exhibited significant phosphate solubilizing activity in National Botanical Research Institute phosphate growth medium,and BRRh-4 displayed the highest phosphate solubilizing activity,followed by *** p H of the culture broth declined,resulting in increase of growth rate of bacteria at p H 7,which might be due to organic acid secretion by the *** presence of L-tryptophan,five isolates synthesized IAA and the maximum IAA was produced by BRRh-2,followed by *** of two most efficient phosphate solubilizing isolates BRRh-4 and BRRh-5 by root dipping(colonization) of seedling and spraying at the flowering stage significantly enhanced the growth and grain yield of rice variety BRRI ***,application of both strains with 50% of recommended nitrogen,phosphorus and potassium fertilizers produced equivalent or higher grain yield of rice compared to the control grown with full recommended fertilizer doses,which suggests that these strains may have the potential to be used as bioinoculants for sustainable rice production.

关键词： indole-3-acetic acid mineral phosphate solubilization rice plant growth promotion plant associated bacterium grain yield fertilizer

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Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-Hun Jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Potassium hydroxide

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Sensing and Uptake of Nitrogen in Rice Plant: A Molecular View

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Rice science 2019年第6期26卷 343-355页

作者： md Saiful islam Department of Soil Science Patuakhali Science and Technology University Graduate School of Agricultural and Life Sciences The University of Tokyo

As a main feature of plant autotrophy, assimilation of inorganic nitrogen (N) is not only of fundamental interest to the crop, but also a crucial factor in crop productivity. N is the main plant mineral nutrient needed for chlorophyll production and other plant cell components (proteins, nucleic acids and amino acids). I highlighted the novel aspects of N responsive sensors, transporters and signaling molecules recently identified in the monocot rice plant, and discussed their potential roles in N sensing and transporting. Furthermore, over the last couple of years, N sensing has been shown to be affected by different external factors, which act as local signals to trigger systemic signaling coordinated by long-distance transport or mobile signals in plant body. Understanding of this complex regulatory network provides a foundation mechanism for the development of novel strategies to increase the acquisition and transportation efficiency of nitrogen under varying N conditions for rice production.

关键词： rice nitrate signaling gene function

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MOVPE Growth of In_xGa_(1-x)N(x～0.4) and Fabrication of Homo-junction Solar Cells

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Journal of Materials Science & Technology 2013年第2期29卷 128-136页

作者： md. Rafiqul islam md. Rejvi Kaysir md. Jahirul islam A. Hashimoto A. Yamamoto Department of Electrical and Electronic Engineering KUETKhulna 9203 Bangladesh Graduate School of Engineering University of Fukui 3-9-1 BunkyoFukui 910-8507 Japan

The metal organic vapor phase epitaxy （MOVPE） growth of indium gallium nitride （InGaN） has been discussed in detail towards the fabrication of solar cell. The InGaN film with In contents up to 0.4 are successfully grown by controlling the fundamental growth parameters such as the precursor gas flow rates, temperature etc. The formation of metallic In originates from the higher value （0.74） of trimethylindium/ （trimethylindium ＋ triethylgallium）（TMI/（TMI ＋ TEG）） molar ratio with low （4100） V/lll weight molar ratio while the lower value （0.2） of TMI/（TMI ＋ TEG） causes the phase separation. It is also necessary to control the growth rate and epitaxial film thickness to suppress the phase separation in the material. The crystalline quality of grown films is studied and it is found to be markedly deteriorated with increasing In content. The lattice parameters as well as the thermal expansion coefficient mismatch between GaN template and InGaN epi-layer are primarily considered as the reasons to deteriorate the film quality for higher In content. By using Ino.16Ga0.84N films, an n＋-p homo-junction structure is fabricated on 0.65 μm GaN template. For such a device, the response to the light illumination （AM 1.5） is observed with an open circuit voltage of 1.4 V and the short circuit current density of 0.25 mA/cm2. To improve the performance as well as increase solar photon capturing, the device is further fabricated on thick GaN template with higher In content. The In0.25Ga0.75N n＋-p junction solar cell is found better performance with an open circuit voltage of 1.5 V and the short circuit current density of 0.5 mA/cm2. This is the InGaN p-n homo-junction solar cell with the highest In content ever reported by MOVPE.

关键词： InGaN Metal organic vapor phase epitaxy (MOVPE) Growth Film quality Doping p-n junction

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Mechanical and thermodynamical stability of BiVO4 polymorphs using first-principles study

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Chinese Physics B 2017年第3期26卷 395-403页

作者： A K M Farid UI islam md Nurul Huda Liton H M Tariqul islam md Al Helal md Kamruzzaman Department of Computer Science and Engineering Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Physics Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Chemistry Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Physics and Materials Science and Center of Super-Diamond and Advanced Films (COSDAF) City University of Hong Kong Hong Kong SAR China

First principles calculations of structural, electronic, mechanical, and thermodynamic properties of different poly- morphs of BiVO4 are performed using Bender-type plane/wave ultrasoft pseudopotentials within the generalized gradient approximation （GGA） in the flame of density functional theory （DFT）. The calculated structural and electronic properties are consistent with the previous theoretical and experimental results. The electronic structures reveal that m-BiVO4, op- BiVO4, and st-BiVO4 have indirect band gaps, on the other hand, zt-BiVO4 has a direct band gap. From the DOS and Mulliken＇s charge analysis, it is observed that only m-BiVO4 has 6s2 Bi lone pair. Bond population analysis indicates that st-BiVO4 shows a more ionic nature and a similar result is obtained from the elastic properties. From the elastic prop- erties, it is observed that st-BiVO4 is more mechanically stable than the others, st-BiVO4 is more ductile and useful for high electro-optical and electro-mechanical coupling devices. Our calculated thermodynamic properties confirm the similar characteristics found from electronic and elastic properties, m-BiVO4 is useful as photocatalysts, solid state electrolyte, and electrode and other polymorphs are applicable in electronic device fabrications.

关键词： BiVO4 crystal structure lone pair mechanical stability

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