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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

Remote condition monitoring of rail tracks using distributed acoustic sensing(DAS):A deep CNN-LSTM-SW based model

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Green Energy and Intelligent Transportation 2024年第5期3卷 70-85页

作者： md Arifur rahman Suhaima Jamal Hossein Taheri The Laboratory for Advanced Non-Destructive Testing In-situ Monitoringand Evaluation(LANDTIE)Department of Manufacturing EngineeringGeorgia Southern UniversityStatesboro 30458GAUSA Information Technology Department Georgia Southern UniversityStatesboro 30458GAUSA

Railroad condition monitoring is paramount due to frequent passage through densely populated *** significance arises from the potential consequences of accidents such as train derailments,hazardous materials leaks,or collisions which may have far-reaching impacts on communities and the surrounding *** a solution to this issue,the use of distributed acoustic sensing(DAS)-fiber optic cables along railroads provides a feasible tool for monitoring the health of these extended ***,analyzing DAS data to assess railroad health or detect potential damage is a challenging *** to the large amount of data generated by DAS,as well as the unstructured patterns and substantial noise present,traditional analysis methods are ineffective in interpreting this *** paper introduces a novel approach that harnesses the power of deep learning through a combination of CNNs and LSTMs,augmented by sliding window techniques(CNN-LSTM-SW),to advance the state-of-the-art in the railroad condition monitoring *** well as it presents the potential for DAS and fiber optic sensing technologies to revolutionize the proposed CNN-LSTM-SW model to detect conditions along the rail track *** insights from the data of High tonnage load(HTL)-a 4.16 km fiber optic and DAS setup,we were able to distinguish train position,normal condition,and abnormal conditions along the ***,our investigation demonstrated that the proposed approaches could serve as efficient techniques for processing DAS signals and detecting the condition of railroad infrastructures at any remote distance with DAS-Fiber optic cable ***,in terms of pinpointing the train's position,the CNN-LSTM architecture showcased an impressive 97%detection *** a sliding window,the CNN-LSTM labeled data,the remaining 3%of misclassified labels have been improved dramatically by predicting the exact locations of each type of ***,these prop

关键词： Distributed acoustic sensing(DAS)-Fiber optic cable Railroad condition monitoring and anomaly detection High tonnage load(HTL) Convolutional neural network-long short-term memory-sliding window(CNN-LSTM-SW)

Tracking of microplastics distribution patterns and their characterisation in deposited road dust from Dhaka city,Bangladesh

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Emerging Contaminants 2024年第3期10卷 386-399页

作者： Mohammad Toha R-Rafiul rahman Sadia Sikder md Ahedul Akbor md Mostafizur rahman Department of Environmental Science Bangladesh University of ProfessionalsMirpurCantonmentDhaka1216Bangladesh Department of Environmental Sciences Jahangirnagar UniversitySavarDhaka1342Bangladesh Laboratory of Environmental Health and Ecotoxicology Department of Environmental SciencesJahangirnagar UniversitySavarDhaka1342Bangladesh Institute of National Analytical Research and Service(INARS) Bangladesh Council of Scientific and Industrial Research(BCSIR)DhanmondiDhaka1205Bangladesh

The widespread presence of microplastics(MPs)in road dust has considerable concern regarding their potential risks to ecosystems and human *** the massive production of plastic,the erudition of MPs distribution patterns in various sizes of deposited road dust is still limited around the ***,the aim of this research is to provide an unambiguous picture of MPs distributional pattern,identification,classification,quantification,and features from road dust in various zones and types of roadways in Dhaka,*** study examined MPs in road dust samples with particle sizes ranging from 300 to 150 mm(Group-A),149-75 mm(Group-B),andunpaved road(325 items/5 g)>soil samples(294 items/5 g),roadside dust samples(284 items/5 g),and mid-road(283 items/5 g).By taking into account all sizes of road dust samples,the MPs were classified as fiber(70.26%),fragment(26.12%),beads(0.66%),films(1.32%),and foams(1.58%).It was found that adults inhaled MPs an average of 1612 items/day,while they ingested an average of 880 items/*** had an inhalation rate of 1232 items/day and an ingestion rate of 10267 items/day,which was 4e17 times greater than in other *** study identified 22 MPs polymer types,and SEM results show that MPs surfaces are being weathered into nanoplastics,creating a more hazardous environment.

关键词： Microplastics Road dust SEM FTIR Health impact Distribution pattern

Thornthwaite moisture index and depth of suction change under current and future climate‒An Australian study

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1761-1775页

作者： md Rajibul Karim Bikash Devkota md Mizanur rahman Hoang Bao Khoi Nguyen UniSA STEM University of South AustraliaMawson Lakes CampusMawson LakesSouth Australia5095Australia

Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical *** changes in moisture content in soil lead to effective stress changes and can be accompanied by significant volume changes in reactive/expansive *** volume change leads to ground movement and can exert additional stresses on structures founded on or within a shallow depth of such *** change is likely to amplify the ground movement potential and the associated problems are likely to *** effect of atmospheric boundary interaction on soil behaviour has often been correlated to Thornthwaite moisture index(TMI).In this study,the long-term weather data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for *** changes in TMI were then correlated to the depth of suction change(H s),an important input in ground movement *** all climate scenarios considered,reductions in TMI and increases in H s values were observed.A hypothetical design scenario of a footing on expansive soil under current and future climate is *** is observed that a design that might be considered adequate under the current climate scenario,may fail under future scenarios and accommodations should be made in the design for such events.

关键词： Climate change Future prediction Thornthwaite moisture index(TMI) Characteristic surface movement Infrastructure resilience

Surface Morphology and Thermo-Electrical Energy Analysis of Polyaniline (PANI) Incorporated Cotton Fabric

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Energy Engineering 2024年第1期121卷 1-12页

作者： md.Shohan Parvez md.Mustafizur rahman Mahendran Samykano Mohammad Yeakub Ali Automotive Engineering Research Group Faculty of Mechanical and Automotive Engineering TechnologyUniversiti Malaysia Pahang Al-Sultan AbdullahPekanMalaysia Department of Textile Engineering Khulna University of Engineering&Technology(KUET)KhulnaBangladesh Centre for Research in Advanced Fluid and Processes(CARIFF) Universiti Malaysia Pahang Al-Sultan AbdullahLebuhraya Tun RazakGambangMalaysia Mechanical Engineering Programme Area Faculty of EngineeringUniversiti Teknologi BruneiBruneiDarussalam

With the exponential development in wearable electronics,a significant paradigm shift is observed from rigid electronics to flexible wearable ***(PANI)is considered as a dominant material in this sector,as it is endowed with the optical properties of both metal and ***,its widespread application got delineated because of its irregular rigid form,level of conductivity,and precise choice of *** PANI in textile materials can generate promising functionality for wearable *** research work employed a straightforward in-situ chemical oxidative polymerization to synthesize PANI on Cotton fabric surfaces with varying dopant(HCl)***-treatment using NaOH is implemented to improve the conductivity of the fabric surface by increasing the monomer *** research explores the morphological and structural analysis employing SEM,FTIR and *** surface resistivity was measured using a digital multimeter,and thermal stability is measured using *** successful polymerization,a homogenous coating layer is *** is revealed that the simple pre-treatment technique significantly reduces the surface resistivity of Cotton fabric to 1.27 kΩ/cm with increasing acid concentration and thermal *** electro-thermal energy can also reach up to 38.2°C within 50 s with a deployed voltage of 15 *** modified fabric is anticipated to be used in thermal regulation,supercapacitor,sensor,UV shielding,antimicrobial and other prospective functional applications.

关键词： Polyaniline cotton in-situ polymerization SEM TGA heating fabric

Turning Trash into Treasure: Developing an Intelligent Bin for Plastic Bottle Recycling

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Journal of Social Computing 2024年第1期5卷 1-14页

作者： Sirajam Munira Niloy Paul md Ashraful Alam md.Mahmudur rahman M.Shamim Kaiser Institute of Information Technology Jahangirnagar UniversityDhaka 1342Bangladesh

Plastic pollution has emerged as a major global concern due to its enduring nature and limited recycling *** response to this critical challenge,this paper presents a novel approach utilizing a Detection-Based Reward System(DBRS)alongside an innovative business model to promote effective plastic waste management,reduce plastic waste accumulation in the nature,and uphold environmental *** the YOLOv5 algorithm for its exceptional accuracy,speed,and open-source availability,plastic bottle detection becomes a pivotal aspect of this *** seamlessly enroll in the system,triggering an automated detection process that computes reward points corresponding to their deposited plastic *** reward points are meticulously stored within a centralized *** its operational facets,this comprehensive system encompasses a robust business model,strategically poised to capture widespread engagement with waste disposal practices,thereby contributing to the realization of Sustainable Development Goals(SDGs)geared towards fostering a healthier ***,the DBRS attains cutting-edge performance in plastic bottle detection,boasting an impressive mean Average Precision(mAP)of 0.973,underscoring its efficacy in tackling plastic pollution.

关键词： smart environment reward system YOLOv5 deep learning business model

GliomaCNN: An Effective Lightweight CNN Model in Assessment of Classifying Brain Tumor from Magnetic Resonance Images Using Explainable AI

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2425-2448页

作者： md.Atiqur rahman Mustavi Ibne Masum Khan md Hasib M.F.Mridha Sultan Alfarhood Mejdl Safran Dunren Che Department of Computer Science and Engineering Ahsanullah University of Science and TechnologyDhaka1208Bangladesh Department of Computer Science and Software Engineering The University of Western AustraliaPerthWA 6009Australia Department of Computer Science American International University-BangladeshDhaka1229Bangladesh Department of Computer Science College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia School of Computing Southern Illinois UniversityCarbondale62901USA

Brain tumors pose a significant threat to human lives and have gained increasing attention as the tenth leading cause of global *** study addresses the pressing issue of brain tumor classification using Magnetic resonance imaging(MRI).It focuses on distinguishing between Low-Grade Gliomas(LGG)and High-Grade Gliomas(HGG).LGGs are benign and typically manageable with surgical resection,while HGGs are malignant and more *** research introduces an innovative custom convolutional neural network(CNN)model,*** stands out as a lightweight CNN model compared to its *** research utilized the BraTS 2020 dataset for its *** with the gradient-boosting algorithm,GliomaCNN has achieved an impressive accuracy of 99.1569%.The model’s interpretability is ensured through SHapley Additive exPlanations(SHAP)and Gradient-weighted Class Activation Mapping(Grad-CAM++).They provide insights into critical decision-making regions for classification *** challenges in identifying tumors in images without visible signs,the model demonstrates remarkable performance in this critical medical application,offering a promising tool for accurate brain tumor diagnosis which paves the way for enhanced early detection and treatment of brain tumors.

关键词： Deep learning magnetic resonance imaging convolutional neural networks explainable AI boosting algorithm ablation

Advances in DNA methylation and its role in cytoplasmic male sterility in higher plants

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Journal of Integrative Agriculture 2024年第1期23卷 1-19页

作者： Atiqur rahman Hasan Sofiur rahman Shakil Uddin Naima Sultana Shirin Akhter Ujjal Kumar Nath Shamsun Nahar Begum Mazadul Islam Afroz Naznin Nurul Amin Sharif Ahmed Akbar Hossain Department of Genetics and Plant Breeding Bangladesh Agricultural UniversityMymensingh 2202Bangladesh Plant Breeding Division Bangladesh Institute of Nuclear AgricultureMymensingh 2202Bangladesh Tuber Crop Research Centre Bangladesh Agricultural Research Institute(BARI)Joydebpur 1701Bangladesh Horticulture Research Centre Bangladesh Agricultural Research Institute(BARI)Joydebpur 1701Bangladesh Biotechnology Division Bangladesh Agricultural Research Institute(BARI)Joydebpur 1701Bangladesh International Rice Research Institute Bangladesh OfficeDhaka 1213Bangladesh Division of Soil Science Bangladesh Wheat and Maize Research InstituteDinajpur 5200Bangladesh

The impact of epigenetic modifications like DNA methylation on plant phenotypes has expanded the possibilities for crop *** methylation plays a part in the regulation of both the chromatin structure and gene expression,and the enzyme involved,DNA methyltransferase,executes the methylation process within the plant *** regulating crucial biological pathways,epigenetic changes actively contribute to the creation of the ***,epigenome editing may assist in overcoming some of the drawbacks of genome editing,which can have minor off-target consequences and merely facilitate the loss of a gene’s *** drawbacks include gene knockout,which can have such off-target *** review provides examples of several molecular characteristics of DNA methylation,as well as some plant physiological processes that are impacted by these epigenetic changes in the *** also discuss how DNA alterations might be used to improve crops and meet the demands of sustainable and environmentally-friendly farming.

关键词： DNA methylation epigenetics CMS male sterility chromatin architecture gene expression higher plants

Complete separation of the urinary tract from proximal rectum during PSARP surgery: our experience with the novel technique

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World Journal of Pediatric Surgery 2024年第1期7卷 66-69页

作者： md Samiul Hasan md Nazmul Islam Refoyez Mahmud Umama Huq Ashrarur rahman Pediatric Surgery Bangladesh Shishu Hospital and InstituteDhakaBangladesh

Anorectal malformation(ARM)is a frequently occurring surgical condition in neonates,with a prevalence of 1 in 4000 live births.'In boys with this anomaly,the rectum and urinary tract share a common wall for some distance,often ending up in fistulous *** goals of definite reconstruction are to separate the rectum from the urinary tract without injuring the urethra and mobilizing the rectum to the perineum within the muscle *** the rectum and the urinary tract is the most critical part of this operation and is associated with a significant risk of urinary tract injury.2-5 The original procedure described by Pena and Devries involves multiple stay sutures on the rectal mucosa just above the fistula,lifting the mucosa and continuing a submucosal dissection up to the prostate,where the entire thickness of the intestine can be separated from the urinary tract.

关键词： urinary rectum intestine