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Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy

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Translational Neurodegeneration 2022年第1期11卷 426-442页

作者： Scott C.Vermilyea Anne Christensen Joyce Meints Balvindar Singh Héctor Martell-Martínez mdRazaul karim Michael K.Lee Department of Neuroscience University of Minnesota-Twin Cities321 Church Street S.E.MinneapolisMNUSA6-145 Jackson Hall Institute for Translational Neuroscience University of Minnesota-Twin CitiesMin-neapolisMNUSA Aligning Science Across Parkinson’s(ASAP)Collaborative Research Network Chevy ChaseMDUSA University of Minnesota Medical School 420 Delaware Street SEMinneapolisMN 55455USA.

Background: Neuronal dysfunction and degeneration linked to α-synuclein (αS) pathology is thought to be responsible for the progressive nature of Parkinson’s disease and related dementia with Lewy bodies. Studies have indicated bidirectional pathological relationships between αS pathology and tau abnormalities. We recently showed that A53T mutant human αS (HuαS) can cause post-synaptic and cognitive deficits that require microtubule-associated protein tau expression. However, the role of tau in the development of αS pathology and subsequent neuronal dysfunction has been controversial. Herein, we set out to determine the role of tau in the onset and progression of αS pathology (α-synucleinopathy) using a transgenic mouse model of α-synucleinopathy lacking mouse tau expression. Methods: Transgenic mice expressing A53T mutant HuαS (TgA53T) were crossed with mTau−/− mice to generate TgA53T/mTau−/−. To achieve more uniform induction of α-synucleinopathy in mice, we used intramuscular injections of αS preformed fibrils (PFF) in non-transgenic (nTg), TgA53T, TgA53T/mTau−/−, and mTau−/− mice. Motor behavior was analyzed at 70 days post inoculation (dpi) of PFF and tissues for biochemical and neuropathological analysis were collected at 40 dpi, 70 dpi, and end stage. Results: Loss of tau expression significantly delayed the onset of motor deficits in the TgA53T model and the progression of α-synucleinopathy disease, as evidenced by a significant reduction in histopathological and behavioral markers of neurodegeneration and disease, and a significant improvement in survival. In vitro application of PFF to primary mouse hippocampal neurons demonstrated no changes in PFF uptake and processing or pS129 αS aggregation as a function of tau expression. However, PFF-induced neurotoxicity, including morphological deficits in nTg neurons, was prevented with tau removal. Conclusions: Collectively, our data suggest that tau is likely acting downstream of αS pathology to affect neuronal

关键词： α-Synuclein Tau Parkinson’s disease Lewy body disease Neurodegeneration

Healthcare delivery cost and anesthesiologists: Time to have a greater role and responsibility

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World Journal of Anesthesiology 2019年第3期8卷 19-24页

作者： Habib md Reazaul karim Department of Anaesthesiology and Critical Care All India Institute of Medical Sciences

With the advancement of technology and health sciences,health care delivery costs are steadily *** affects both households and ***,the present truth is that health has become an essential but unaffordable *** is very ***,up-to-date,costeffective health care delivery is one of the prime objectives,and focuses on administration and health care *** the per capita spent on health from public/government funds is very poor in developing countries,the responsibility of cost-effective health care delivery falls primarily on the shoulder of the treating *** are becoming an indispensable part of health care delivery,having a diverse role in the emergency,critical care,pain,and perioperative care of *** the population ages,the need for surgical care is also ***,the anesthesiologist can also play a more significant role in delivering cost-effective health care,and minimize the cost without affecting the *** brief narrative review analyzes the current practice of anesthesiologists in two prime areas in the context of cost-savings:Preoperative investigation and low/minimal flow anesthesia.

关键词： Health expenditures Cost control Anesthesiologists Anesthesia

Floating Solar Plants and Relevant Environmental,Health,and Safety Challenges

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Journal of Environmental Science and Engineering(A) 2023年第6期12卷 229-241页

作者： md M karim Rakika Rimsa Arub Masud Environment Health and Safety DepartmentGEEC Ltd.108 Earlsbridge Blvd.BramptonOntarioL7A 3W7Canada Department of Health Science University of WaterlooWaterlooOntarioN2L 3G1Canada

An Environmental Impact Assessment(EIA)was conducted for 2×150 MW Floating Photovoltaic(FPV)plants,based on the World Bank’s new Environmental and Social Framework(ESF).The project was the first of its kind financed by the World Bank in Pakistan and was geared towards renewable energy development in the *** components of the project included the installation of high-density polyethylene floats,Photovoltaic(PV)panels,underwater transmission cables to floating or shoreline inverters and transformers,and overhead transmission lines to existing or new *** EIA was commissioned to identify all environmental,health,and safety challenges associated with the construction and operation of the FPV plants.A risk screening criterion based on the World Bank ESF was employed to identify these challenges,while a mitigation hierarchy and hierarchy of control were used in providing measures to address these *** environmental challenges identified were pollution of surface water and degradation of aquatic habitat from bird droppings on the floating panels;changes to the thermal structure and evaporation rate of the water body as a result of decreased sunlight access;direct impacts of shading on fish and aquatic algae;impacts on migratory birds and their habitats;and impacts on fish movements due to the anchoring and cabling of the ***,the project-specific occupational health and safety challenges identified were the risk of falling and drowning in the water during the installation and maintenance of the panels over the *** measures were provided for the identified *** conclusion,the construction and operation of FPV plants have environmental,health,and safety *** is therefore recommended that the mitigation measures provided should be incorporated into the earlier stages of the design and operation of future similar FPV plants around the world.

关键词： Photovoltaic floating solar impacts occupational health and safety mitigation hierarchy hierarchy of control

Zoonotic Enterocytozoon bieneusi genotypes in Pere David's deer(Elaphurus davidianus) in Henan,China

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Zoonotic Enterocytozoon bieneusi genotypes in Pere David's d...

中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者：张振杰 HUANG Jian-ying md Robiul karim ZHAO Jin-feng DONG Hai-ju AI Wei-chang LI Fu-huang ZHANG Long-xian 王荣军 College of Animal Science and Veterinary Medicine Henan Agricultural University The Wild Animals Rescue Center of Henan Province College of Veterinary Medicine China Agricultural University

Enterocytozoon bieneusi is a zoonotic pathogen of the phylum Microspore that infects humans as well as a variety of animal species *** molecular epidemiologic studies have characterized this parasite in various hosts,isolates from many susceptible hosts have not yet been *** experiment was conducted to study Enterocytozoon bieneusi genotypes in Pere David’s deer(Elaphurus davidianus) in Henan,*** this study,*** was isolated from 47 Pere David’s deer(Elaphurus davidianus) in Henan,China and characterized via PCR analysis of the internal transcribed spacer(ITS) *** was detected in 16 out of 47(34.0%) fecal specimens *** analysis of the ITS revealed six known genoty pes:Type Ⅳ(4),EbpC(4),EbpA(4),BEB6(2),COS-Ⅰ(1),and COS-Ⅱ(1).Of these,TypeⅣ,EbpC,and EbpA are known to cause human microsporidiosis worldwide,whereas the remaining genotypes are generally specific to *** present study indicated that Pere David’s deer are naturally infected with ***,predominantly with zoonotic genotypes,and may pose a risk for human transmission.

关键词： Enterocytozoon bieneusi genotyping ITS Pere David’s deer.

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犬和猫毕氏肠微孢子虫基因型分布研究

犬和猫毕氏肠微孢子虫基因型分布研究

中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： md Robiul karim 董海聚李俊强齐萌宁长申张龙现河南农业大学牧医工程学院河南省人兽共患病国际联合实验室

为了解我国不同地区犬和猫毕氏肠微孢子虫的感染情况及基因型分布规律,2012年3月至2012年12月间对郑州、新乡、许昌、西安和重庆等地收集的276份犬和猫粪便样品基于ITS基因进行***的PCR扩增和测序,结果共扩增出44个目的条带,总感染率为1... 详细信息

为了解我国不同地区犬和猫毕氏肠微孢子虫的感染情况及基因型分布规律,2012年3月至2012年12月间对郑州、新乡、许昌、西安和重庆等地收集的276份犬和猫粪便样品基于ITS基因进行***的PCR扩增和测序,结果共扩增出44个目的条带,总感染率为15.94%(44/276)。犬和猫样品的感染率分别为21.29%(34/158)和8.47%(10/94),流浪犬的感染率(13.89%)明显低于宠物犬(27.91%)。重庆犬***的感染率为46.67%,高于郑州犬(17.02%)和西安犬(11.77%)的感染率。根据测序结果分析,本研究共发现18个***基因型,其中犬感染了5个已报道的基因型(PtEbIX、CM1、Peru8、EbpC、Type IV)和6个新基因型(CD1-6),猫感染了4个已报道的基因型(PtEbIX、BEB6、D和I)和3个新基因型(CC1-3)。种系发育分析显示,5个新基因型CD1、CD2、CD4、CC2和CC3,与EbpC、D、TypeⅣ、Peru8和CM1均位于***基因型的Group1群中,该群为人兽共患的致病性群,提示5个新基因型具有人兽共患特性,有重要的公共卫生意义。

关键词：犬猫毕氏肠微孢子虫基因型

孟加拉国肉鸡和土鸡胃肠道中分泌免疫球蛋白的浆细胞

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孟加拉国肉鸡和土鸡胃肠道中分泌免疫球蛋白的浆细胞

第15届世界禽病大会、中国畜牧兽医学会2007年学术年会

作者： Mir Rubayet Jahan Lucky md.Zahirul Islam Khan md.Nabiul Islam Robin Mohammad Rabiul karim 王宏俊 Department of Anatomy and Histology BAU Mymensingh.Bangladesh Department of Anatomy and Histology BAU Mymensingh.Bangladesh Department of Anatomy and Histology BAU Mymensingh.Bangladesh Department of Anatomy and Histology BAU Mymensingh.Bangladesh

消化系统直接与食物中微生物接触,在肉鸡和孟加拉土鸡(deshi)消化道黏膜内发现有上皮淋巴结、黏膜固有层淋巴结和浆细胞能够分泌多种免疫球蛋白,它们可能与机体的防御功能有关。新鲜采集食

关键词：消化道分泌免疫球蛋白的浆细胞肉鸡土鸡孟加拉国

Exploring the practice of common oral diseases among the patients visiting in the selected dental college and hospital in Bangladesh

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Life Research 2022年第4期5卷 1-5页

作者： Khalid Hasan Pasha md.Fazlul karim md.Mahmudur Rahman Ashek Elahi Noor md.Mamunur Rashid Nahid Al Nomann Kazi Golam Mohiuddin Department of Oral&Maxillofacial Surgery Sapporo Dental College and HospitalDhaka-1230Bangladesh Department of Microbiology Kumudini Women’s Medical CollegeMirzapurTangail-1900Bangladesh Department of Gastroenterology Dhaka Medical College and HospitalDhaka-1312Bangladesh Department of Dental Public Health Sapporo Dental College and HospitalDhaka-1230Bangladesh New Labaid Diagnostic Center&Hospital Brahmanbaria-3400Bangladesh Department of Science of Dental Materials Sapporo Dental College and HospitalDhaka-1230Bangladesh

Background:Having the ability to identify potential health risk factors such as lifestyle,ethnicity,health status,and social determinants associated with oral health status risk,health care providers can take an active role in health screening to discover any need for clinical preventive services,including dental preventive services,and can detect health ***:A descriptive type of cross-sectional study was conducted to explore the practice of common oral diseases among the patients visiting in the selected dental college and hospital in Bangladesh from October 2019 to December *** 100 patients were interviewed through a semi-structured questionnaire,followed by an oral examination through a checklist and a face-to-face interview.A systematically random sampling technique was employed to select the study ***:Among them,the(21-30)year age group shows a maximum 20%,whereas the(71-80)year age group represents the minority with only 2%.Among them,56%were male and 44%were *** represent the majority of 26%,whereas others(day laborers)represent only 4%.Decayed teeth remained in 72%of cases,teeth were missing in 31%of cases,and filled teeth were present in 24%of cases.A majority of 71%clean teeth once daily,whereas only 29%clean teeth twice ***,only 30%brush teeth at night and a maximum of 95%brush teeth in the ***,a maximum of 68%use toothpaste and brushes,while only 4%use meswak for cleaning their *** 4%of cases with no debris,51%of cases with less than 1/3rd of the tooth with debris,32%of cases with 1/3rd-2/3rd of the tooth with debris,and 13%of cases with more than 2/3rd of the tooth with debris were ***,about 30%had no calculus,52%less than 1/3rd of tooth,16%in between 1/3rd and 2/3rd of tooth,and 2%more than 2/3rd of the calculus was *** 47%of mild,22%of moderate,6%of severe and 25%had no ***,for treatment purposes,20.69%was advised for scaling,19.66%for

关键词： dental caries abscess broken down root broken down crown decayed missing filled tooth root canal treatment orthopentomogram intra oral periapical cone beam computed tomography body mass index

Virtual Reality in Surgery: Double Blind, Randomized Clinical Trial of Pain Control and Augmented Satisfaction

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Surgical Science 2023年第6期14卷 456-467页

作者： karim W. Sadik Matthew P. Miller Nicholas Evertsen Crystal D. Sadik Hugo J. R. Bonatti Department of Surgery Guthrie Robert Packer Hospital Sayre PA USA Meritus Surgical Specialists Hagerstown MD USA

Introduction: Virtual reality (VR) utilizing a head-mounted display allows viewers to immerse themselves in a virtual environment. This technology may be useful in attenuating pain and anxiety and reducing patient subjective stress as well as objective physiological increase in heart rate and blood pressure. Aside from the improved experience, physiological stress is reduced which results in improved patient outcomes. Patients and methods: Eligible participants were all adults aged 18 or over who had non craniofacial lesions requiring minor surgery. A total of 99 adult patients who were capable of independent consent were randomized to receive a virtual reality experience (VR) or standard music distraction (no VR). Patients were recruited for the study during their office visit when scheduling minor procedure surgery. This was a single center, double-blind, controlled study conducted at Guthrie Clinic Robert Packer Hospital in Sayre, Pennsylvania between March 2019 to January 2020 (pre-pandemic). Ethics approval for this study was obtained from the Institutional Review Board of the Guthrie Clinic. Results: The change in systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) significantly decreased from pre-procedure to mid-procedure in the VR group compared with standard. Herein our results are presented. Conclusions: Reductions in intraprocedural SBP, DBP and HR can be achieved when using VR. Although subjective reporting of pain and anxiety were not different between groups, VR significantly improves patient satisfaction compared with non VR standards.

关键词： Virtual Reality Plastic Surgery Pain Control

我国绵羊和山羊毕氏肠微孢子虫的分子流行性调查

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我国绵羊和山羊毕氏肠微孢子虫的分子流行性调查

第八届全国畜牧兽医青年科技工作者学术研讨会

作者：史柯李梦婕王晓星李俊强 md Robiul karim 王荣军张龙现菅复春宁长申河南农业大学牧医工程学院

引言到目前为止,已经在超过30个国家的人和动物体内鉴定出超过200个毕氏肠微孢子虫ITS基因型。然而,对中国地区的绵羊和山羊微孢子虫感染的报道较少。本研究采集大量样品进行分子鉴定,以期获得中国绵羊和山羊毕氏肠微孢子虫的流行及基...

引言到目前为止,已经在超过30个国家的人和动物体内鉴定出超过200个毕氏肠微孢子虫ITS基因型。然而,对中国地区的绵羊和山羊微孢子虫感染的报道较少。本研究采集大量样品进行分子鉴定,以期获得中国绵羊和山羊毕氏肠微孢子虫的流行及基因型分布情况。材料与方法从中国7省市共采集1025份绵羊和山羊新鲜粪便样品,分别进行基因组DNA的提取,及基于ITS基因的巢式PCR的扩增。将阳性样品进行测序鉴定,获得序列应用DNAStar、ClustalX、Mega 5等生物学软件进行序列拼接、比对与分析,构建分子种系发育进化树。

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