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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed md.Atiar rahman Farjana Sharmen A.S.M.Ali Reza md.Shahidul Islam md.Mamunur Rashid md.Khalid Juhani Rafi Tanvir Ahmed Siddiqui md.Muzahid Ahmed Ezaj Srabonti Saha md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

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基于深度学习的HVAC系统负荷预测

基于深度学习的HVAC系统负荷预测

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作者： md.TUHINUR rahman 西南科技大学

学位级别：硕士

供热通风与空气调节（Heating,Ventilation and Air Conditioning,HVAC）系统是大型建筑的重要组成部分之一,在商业超市、高层写字楼、室内体育场馆等建筑中广泛使用。HVAC系统的能耗优化控制是建筑设计中的重要问题,也是使用HVAC系统... 详细信息

供热通风与空气调节（Heating,Ventilation and Air Conditioning,HVAC）系统是大型建筑的重要组成部分之一,在商业超市、高层写字楼、室内体育场馆等建筑中广泛使用。HVAC系统的能耗优化控制是建筑设计中的重要问题,也是使用HVAC系统的业主特别关心的问题。实现对HVAC系统能耗的预测是对其进行优化控制的前提,本论文基于受限玻尔兹曼机（Restricted Boltzmann Machine,RBM）和人工神经网络（Artificial Neural Network,ANN）提出了一种预测HVAC系统能耗的新模型。新模型利用了RBM强大的特征提取能力和无监督学习能力,同时利用了ANN的非线性拟合能力。首先,输入训练数据对RBM进行预训练,使得RBM能够自主提取数据的隐含特征信息以供ANN进行学习;然后,将学到的隐含特征信息与原始输入进行有机组合,形成一个协调一致的集合;最后,将整个集合作为输入数据对ANN进行训练,得到预测模型。为了测试新预测模型的准确性,本文利用重庆市某大型商业超市的真实HVAC能耗数据进行数值实验。实验结果表明,新模型的特征提取能力和预测能力都明显高于单独使用RBM或ANN时的结果,与其它HVAC系统能耗预测模型的对比试验结果也表明该预测模型具有较高的准确性。具体指标表现为该模型的平均绝对误差（Mean Absolute Error,MAE）为0.1541%,均方误差（Mean Square Error,MSE）为0.3405%,均方根误差（Root Mean Square Error,RMSE）为0.5835%,均处在一个极低的水平,拟合度值（R）为1,也处于一个较好的水平。数值实验的结果表明本文提出的新模型是准确可靠的,能够用于HVAC系统能耗预测。本文提出的HVAC系统能耗预测模型有望应用于实际的HVAC能耗预测中,为HVAC系统能耗优化控制提供准确的预测保障,同时为HVAC系统能耗预测问题的研究提供新的视角。

关键词：供热通风与空气调节系统负荷预测受限玻尔兹曼机人工神经网络

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An Overview of Soil Improvement through Ground Grouting

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Journal of Geoscience and Environment Protection 2024年第1期12卷 51-63页

作者： md.Ratan Bhuiyan Salequr rahman Masum md.Tushar Parvej S M Sanuwar School of Civil Engineering Hydraulic Engineering Tianjin University Tianjin China College of Civil Engineering and Architecture China Three Gorges University Yichang China

Soil is an essential component of what surrounds us in nature, providing as the basis for our infrastructure and construction. However, soil is not always suitable for construction due to a variety of geotechnical issues such as inadequate bearing capacity, excessive settlement, and liquefaction susceptibility. Through improving the engineering qualities of soil, such as strength, permeability, and stability, ground grouting is a specific geotechnical method used. Using a fluid grout mixture injected into the subsurface, holes are filled and weak or loose strata are solidified as the material seeps into the soil matrix. The approach’s adaptability in addressing soil-related issues has made it more well-known in the fields of civil engineering and construction. In the end, this has improved groundwater management, foundation support, and overall geotechnical performance.

关键词： Grouting Soil Improvement Permeation Grouting Compaction Grouting and Jet Grouting

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Trehalose:A sugar molecule involved in temperature stress management in plants

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The Crop Journal 2024年第1期12卷 1-16页

作者： Ali Raza Savita Bhardwaj md.Atikur rahman Pedro García-Caparrós Madiha Habib Faisal Saeed Sidra Charagh Christine H.Foyer Kadambot H.M.Siddique Rajeev K.Varshney College of Agriculture Fujian Agriculture and Forestry University(FAFU)Fuzhou 350002FujianChina Department of Botany School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara 144411India Department of Botany MCM DAV CollegeKangraHimachal Pradesh 176001India Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Agronomy Department of Superior School Engineering University of AlmeríaAlmeríaSpain National Institute for Genomics and Advanced Biotechnology National Agricultural Research CentrePark Rd.Islamabad 45500Pakistan Agriculture Health and Environment DepartmentNatural Resources InstituteFaculty of Engineering&ScienceUniversity of GreenwichKent ME44TBUK State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhouZhejiangChina School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK The UWA Institute of Agriculture The University of Western AustraliaCrawleyPerth 6009Australia WA State Agricultural Biotechnology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochWA 6150Australia

Trehalose(Tre)is a non-reducing disaccharide found in many species,including bacteria,fungi,invertebrates,yeast,and even plants,where it acts as an osmoprotectant,energy source,or protein/membrane *** relatively small amounts in plants,Tre concentrations increase following exposure to abiotic ***-6-phosphate,a precursor of Tre,has regulatory functions in sugar metabolism,crop production,and stress *** the various abiotic stresses,temperature extremes(heat or cold stress)are anticipated to impact crop production worldwide due to ongoing climate *** small amounts of Tre can mitigate negative physiological,metabolic,and molecular responses triggered by temperature *** also interacts with other sugars,osmoprotectants,amino acids,and phytohormones to regulate metabolic reprogramming that underpins temperature stress *** plants expressing Tre-synthesis genes accumulate Tre and show improved stress ***-wide studies of Tre-encoding genes suggest roles in plant growth,development,and stress *** review discusses the functions of Tre in mitigating temperature stress—highlighting genetic engineering approaches to modify Tre metabolism,crosstalk,and interactions with other molecules—and in-silico approaches for identifying novel Tre-encoding genes in diverse plant *** consider how this knowledge can be used to develop temperature-resilient crops essential for sustainable agriculture.

关键词： Abiotic stress Gene expression Genetic engineering Osmolyte Trehalose-6-phosphate

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Recent progress in two-dimensional metallenes and their potential application as electrocatalyst

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Journal of Energy Chemistry 2024年第7期94卷 577-598页

作者： Umer Shahzad Mohsin Saeed Muhammad Fazle Rabbee Hadi M.Marwani Jehan Y.Al-Humaidi Muhammad Altaf Raed H.Althomali Kwang-Hyun Baek md.Rabiul Awual Mohammed M.rahman Department of Chemistry Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Biotechnology Yeungnam UniversityGyeongsanSouth Korea Center of Excellence for Advanced Materials Research(CEAMR) King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.BOX 84428Riyadh 11671Saudi Arabia Department of Chemistry Center of Excellence for Innovation in Chemistry(PERCH-CIC)Center of Excellence in Materials Science and TechnologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry College of Art and SciencePrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir 11991Saudi Arabia Western Australian School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityGPO Box U 1987PerthWA 6845Australia

In this article,we looked at metallenes,a novel class of two-dimensional(2D)metals that are attracting interest in the energy and catalysis *** is one area where their exceptional physicochemical and electrical characteristics might be *** are unique because they include several metal atoms that are not in a coordinated *** makes them more active and improves their atomic uti-lization,which in turn increases their catalytic *** article delves into the potential of two-dimensional metals as electrocatalysts for carbon dioxide reduction,fuel oxidation,oxygen evolution,and oxygen reduction reactions in the context of sustainable energy *** to the exception-ally high surface-to-volume ratio,large surface area as well as their optimized atomic use efficiency,2D materials defined by atomic layers are crucial for surface-related sustainable energy *** to its exceptional properties,such as high conductivity and the ability to enhance the exposure of active metal sites,2D metallenes have recently attracted a lot of interest for use in catalysis,electronics,and energy-related *** their highly mobility,adjustable surface states,and electrical struc-tures that can be fine-tuned,2D metallenes are promising nanostructure materials for use in energy con-version with the sustainable applications.

关键词： Metallenes Electrocatalysts Electrochemical processes Atomically thin structure

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Preparation of Durable Antibacterial Polyester Fabrics by Grafting with the Natural Quaternary Ammonium Compound Betaine

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Materials Sciences and Applications 2024年第9期15卷 378-398页

作者： md.Shariful Islam md.Kamrul Hasan Arifur rahman Shakhauat Hossen md.Anwarul Islam Sachi Xinbo Ding School of Textile Science and Engineering International Silk Institute Zhejiang Sci-Tech University Hangzhou China King Graduate School Monroe College Bronx NY USA

Recently, the textile industry has increasingly advocated for natural resource-based healthcare textiles. This research presents a facile and eco-friendly approach to developing durable antibacterial polyester fabrics. Polyester fabric was first subjected to an alkaline hydrolysis to impart hydroxyl groups on the fiber surface. A natural antibacterial agent, betaine, was then covalently bonded to the hydrolyzed polyester fiber surface through esterification. XPS, Raman, SEM, and Wicking measurements were carried out to verify the esterification reaction. Antibacterial tests confirmed that betaine treatment grafted polyester fabrics revealed a remarkable antibacterial effect with inhibition rates > 99.9% against both E. coli and S. aureus and still remained inhibition rates of up to 91.5% against both bacteria after home washing for 20 cycles. Moreover, the modification significantly increased the capillary effect of polyester fabric but did not cause apparent adverse effects on the fabric’s hand or tensile strength. Overall, this grafting strategy for durable, antibacterial polyester fabric represents a significant practicality in the textile industry.

关键词： Polyester Fabric Betaine Antibacterial Durability Capillary

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Are Socially Responsible Banks More Risk Averse and Dividends Providers?Empirical Evidence from a Developing Economy

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Journal of Sustainable Business and Economics 2024年第2期7卷 1-20页

作者： md.Al Amin Rana Sikder Tanvir rahman Sohan Department of Accounting Mawlana Bhashani Science and Technology University Department of Management Mawlana Bhashani Science and Technology University

Purpose:This study examines whether socially responsible firms are uninterested in risk-taking and whether socially responsible banks are more dividend providers than socially irresponsible *** conducted the analysis using the least-squares method for 290-panel data observations of 32 commercial banks operating in Bangladesh from 2008 to ***:We employed Ordinary Least Squares Regression for 290-panel data observations of 32 commercial banks operating in Bangladesh from 2008 to 2018 using EViews software ***,we conducted descriptive analysis and correlations using SPSS *** considered CSRI and CSRPI as the indicators of corporate social responsibility,dividend per share and stock dividend as a proxy of dividend policy,LEV(leverage),and non-performing loan to total loan as the indicators of financial risk,and lastly,Z score as the indicator of financial ***:Studies have shown that banks prioritizing social responsibility tend to pay dividends to their shareholders more frequently and consistently than banks that do *** particular,banks that invest heavily in corporate social responsibility(CSR)tend to maintain a stable dividend payout,which can help address agency problems that arise from overinvestment in the CSR ***,we found that banks that make huge expenditures on CSR also seem to have a low eagerness for ***,we found that the financial stability of a socially responsible bank is high and stable enough,which will help efficiently handle the bank’s financial risks,reduce price fluctuations,and increase financial assets that generally influence a bank’s monetary ***:Banks implementing fruitful CSR strategies can produce substantial shareholder advantages through high dividend payout *** expansion in CSR-related expenditure does not prompt a cut-down or reduce the portion of income paid out as dividends to ***,the Output of our study will

关键词： Corporate Social Responsibility Business stability Risk Stakeholders Dividend policy Bangladesh

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Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health 2024年第7期16卷 703-716页

作者： md. Habibur rahman Yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian Seong Hoon Goh Yundeok Kim Cheol-Su Kim Doo-Sup Kim Kyu-Jae Lee Department of Convergence Medicine Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Neurosurgery Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Internal Medicine Division of Hematology-Oncology Wonju Severance Christian Hospital Wonju Republic of Korea Department of Orthopaedic Surgery Wonju College of Medicine Yonsei University Wonju Republic of Korea

1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.

关键词： Knee Osteoarthritis Low-Intensity Continuous Ultrasound Stimulator Clinical Trial Visual Analogue Scale Western Ontario and McMaster Universities Osteoarthritis Index

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3DGE-UNet磁共振成像的脑胶质瘤全自动分割算法:对不充分全局特征提取的改进

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四川大学学报（医学版） 2024年第2期55卷 447-454页

作者：田恒屹王瑜计亚荣 rahman md.ostafizur 北京工商大学人工智能学院北京100048

目的脑胶质瘤及其子区域的全自动分割是计算机辅助肿瘤临床诊断的基础,卷积神经网络在脑部磁共振成像(magnetic resonance imaging, MRI)分割过程中,小卷积核只能提取局部特征而无法有效融合全局特征,缩小了对影像信息的感知范围,从而... 详细信息

目的脑胶质瘤及其子区域的全自动分割是计算机辅助肿瘤临床诊断的基础,卷积神经网络在脑部磁共振成像(magnetic resonance imaging, MRI)分割过程中,小卷积核只能提取局部特征而无法有效融合全局特征,缩小了对影像信息的感知范围,从而导致分割精度不足的问题。本研究旨在利用膨胀卷积,针对三维(three-dimensional, 3D)-UNet不能充分提取全局特征的问题进行改进。方法 (1)算法构建:本文提出一种带有三条全局上下文特征提取通路的3D-UNet模型,即3DGE-UNet模型。使用脑部肿瘤分割挑战赛(Brain Tumor Segmentation Challenge, BraTS)2019提供的公开数据集(335例患者),设计一种全局上下文特征提取(more global contextual feature extraction, GE)模块,并将该模块引入到3DUNet网络的第一、二、三条跳跃连接处,利用该模块充分提取图像的不同尺度全局特征,并与上采样得到的特征图叠加,扩大模型感受野,实现不同尺度特征的深层融合,从而完成端到端的脑肿瘤全自动分割。(2)算法验证:图像数据来源于BraTs2019数据集(335例患者术前MRI图像,包括T1、T1ce、T2和FLAIR四种模态图像和一张医生标注的肿瘤标签图像),将数据集分别按照8∶1∶1划分为训练集、验证集和测试集。以医生标注的肿瘤标签图像为金标准,使用Dice系数(综合评价有效性)、敏感度(病灶区域的查全率)和95%Hausdorff距离(肿瘤边界的分割精度)在测试集中评估算法对完整肿瘤区域(whole tumor, WT)、核心肿瘤区域(tumor core, TC)和增强肿瘤区域(enhancing tumor, ET)三种区域的分割性能,分别使用无GE模块的3D-UNet模型和有GE模块的3DGE-UNet模型进行检测,内部验证GE模块设置的有效性。使用3DGEUNet模型、ResUNet、UNet++、nnUNet、UNETR检测上述性能指标,并比较5种算法模型的收敛性,外部验证3DGEUNet模型的有效性。结果 (1)在内部验证中,改进的3DGE-UNet模型在测试集中分割WT、TC和ET区域的Dice均值分别为91.47%、87.14%和83.35%,与传统的3D-UNet模型相比(89.79%、85.13%和80.90%),综合评价达到了最优值,对于三个区域的分割精度都有提升(P<0.05)。3DGE-UNet模型与3D-UNet模型相比,ET区(86.46%vs. 80.77%)具有更高的敏感度(P<0.05),在查全率方面表现更为优越,在面对病灶区域时,3DGE-UNet模型更倾向于正确识别并捕获更全面的阳性区域,更为有效地避免漏诊发生。3DGE-UNet模型在肿瘤WT区域边缘分割的出色性能,其95%Hausdorff距离均值优于3DUNet模型(8.17 mm vs. 13.61 mm,P<0.05),但在TC区(8.73 mm vs. 7.47 mm)和ET区(6.21 mm vs. 5.45 mm)的性能表现与3DUNet模型相似。(2)在外部验证中,其余4种算法仅TC的Dice均值(87.25%)、WT的敏感度均值(94.59%)、TC的敏感度均值(86.98%)和ET的平均95%Hausdorff距离(5.37 mm)优于3DGE-UNet模型,但差异无统计学意义。3DGE-UNet模型可以在训练阶段快速收敛,速度优于其他外部模型。结论 3DGE-UNet模型可以有效地提取和融合不同尺度的特征信息,提高脑肿瘤分割的准确性。

关键词：脑胶质瘤核磁共振成像图像处理计算机辅助人工智能

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Development of Framework for ACI-Powered Human Resource Recruitment Assistant

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Management Studies 2024年第3期12卷 182-187页

作者： md.Jawadur rahman Gabriele M.Murry Stephanie Schmitt-Rüth OTH Amberg-Weiden AmbergGermany

The landscape of human resource management within large enterprises necessitates efficient and unbiased recruitment practices to ensure organisational effectiveness and foster diversity(Ayoko&Fujimoto,2023).Traditional hiring processes often create biases,which cause additional challenges in achieving proper objectives(Bogen,2021).According to Workable(***),the average time to fill a job requisition is 41 days(Howden,2023).This paper proposes a framework for the development and implementation of an Artificially Capable Intelligent(ACI)-powered Human Resource(HR)Assistant for large enterprises(possibly more than 300 employees)to eliminate these unnecessary challenges caused by biases in hiring practices,therefore directly addressing fair and just participation in society and the world of *** framework integrates ACI technologies,particularly candidate identification,to revolutionise HR *** leveraging ACI algorithms,the proposed hyper-realistic assistant aims to revolutionise the recruitment *** will significantly reduce the average time to fill job ***,the ACI-powered system is designed to mitigate biases inherent in traditional hiring practices,thus fostering a fair and inclusive environment for all candidates in the shortest possible time *** paper includes the key components and working processes of the ACI-powered HR Assistant *** a comprehensive theoretical analysis,the paper investigates the system’s working process and how the framework aligns with the goal of promoting a fair and participatory environment in the world of ***,the proposed framework represents a main step towards enhancing organisational effectiveness,fostering diversity,and advancing equitable recruitment practices in the futuristic workplace.

关键词： artificial capable intelligence human resource

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