检索结果-南通市图书馆

On the QoS for ATM Networks Using a New Buffer Utilization Technique

光学学报 2003年第S1期23卷 705-706页

作者： md. julius hossain md. Nurul Huda Department of Computer Science University of Dhaka Dhaka BangladeshDepartment of Computer Science University of Dhaka Dhaka Bangladesh

A buffer sharing scheme need to meet many competing objectives like robustness to changes in traffic conditions, fairness, efficiency, implementation simplicity, etc. Of the existing techniques, Push Out (PO) is optimum in terms of overall cell loss performance, but its delay performance is worse than that of all other methods for the multiple space priority. Another scheme named Dynamic Threshold (DT) is robust and adaptive which has good delay performance. A hybrid technique named Dynamic Threshold wi...

关键词： ATM in on for On the QoS for ATM Networks Using a New Buffer Utilization Technique

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in the development of molecular genetic tools for Mycobacterium tuberculosis

引用

Journal of Genetics and Genomics 2018年第6期45卷 281-297页

作者： Chiranjibi Chhotaray Yaoju Tan julius Mugweru md.Mahmudul Islam H.M.Adnan Hameed Shuai Wang Zhili Lu Changwei Wang Xinjie Li Shouyong Tan Jianxiong Liu Tianyu Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Respiratary Disease Department of Clinical LaboratoryCuangzhou Chest HospitalGuangzhou 510095China Department of Biological Sciences University of EmbuP.O Box 6-60100EmbuKenya

Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference（CRISPRi）, a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed.

关键词： Mycobacterium tuberculosis Molecular genetic tools Gram-positive Recombineering Drug resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Drug resistance mechanisms and novel drug targets for tuberculosis therapy

引用

Journal of Genetics and Genomics 2017年第1期44卷 21-37页

作者： md.Mahmudul Islam H.M. Adnan Hameed julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Shouyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Respiratory Disease Department of Clinical Laboratory The Guangzhou Chest Hospital Guangzhou 510095 China Institute of Chemical Biology and Drug Discovery Stony Brook University-State University of New York Stony Brook NY 11794-3400 USA Stanley Ho Centre for Emerging Infectious Diseases The Chinese University of Hong Kong Hong Kong Special Administrative Region China Center for Tuberculosis Research Department of Medicine Johns Hopkins University Baltimore MD 21231-1002 USA

Drug-resistant tuberculosis （TB） poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug- resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuber- culosis. This review summarizes the anti-TB drug resistance mechanisms, furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs. Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M. tuberculosis. However, further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance.

关键词： Tuberculosis Mycobacterium tuberculosis Resistance Drug target Mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predicting Infiltrative Hepatocellular Carcinoma Patient Outcome Post-TACE:MR Bias Field Correction Effect on 3D-quantitative Image Analysis

引用

Journal of Clinical and Translational Hepatology 2020年第3期8卷 292-298页

作者： Cuihong Liu Susanne Smolka Xenophon Papademetris Duc Do Minh Geliang Gan Yanhong Deng MingDe Lin julius Chapiro Ximing Wang Christos Georgiades Kelvin Hong Department of Ultrasound Diagnosis and Treatment Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinanShandongChina Department of Radiology and Biomedical Imaging Yale University School of MedicineNew HavenCTUSA Department of Diagnostic and Interventional Radiology CharitéUniversity HospitalBerlinGermany Department of Biomedical Engineering Yale UniversityNew HavenCTUSA School of Public Health Yale UniversityNew HavenCTUSA Department of Radiology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinanShandongChina Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Russell H.Morgan Department of Radiology and Radiological Science Division of Vascular and Interventional RadiologyThe Johns Hopkins HospitalBaltimoreMDUSA

Background and Aims:To investigate the impact of MR bias field correction on response determination and survival prediction using volumetric tumor enhancement analysis in patients with infiltrative hepatocellular carcinoma,after transcatheter arterial chemoembolization(TACE).Methods:This study included 101 patients treated with conventional or drug-eluting beads TACE between the years of 2001 and ***-automated 3D quantification software was used to segment and calculate the enhancing tumor volume(ETV)of the liver with and without bias-field correction on multi-phasic contrast-enhanced MRI before and 1-month after initial ***(expressed as cm3)at baseline imaging and the relative change in ETV(as%change,ETV%)before and after TACE were used to predict response and survival,*** survival analyses included Kaplan-Meier curve generation and Cox proportional hazards modeling.Q statistics were calculated and used to identify the best cut-off value for ETV to separate responders and non-responders(ETV cm3).The difference in survival was evaluated between responders and non-responders using Kaplan-Meier and Cox ***:MR bias field correction correlated with improved response calculation from baseline MR as well as survival after TACE;using a 415 cm3 cut-off for ETV at baseline(hazard ratio:2.00,95%confidence interval:1.23-3.26,p=0.01)resulted in significantly improved response prediction(median survival in patients with baseline ETV<415 cm3:19.66 months vs.≥415 cm3:9.21 months,p<0.001,log-rank test).A≥41%relative decrease in ETV(hazard ratio:0.58,95%confidence interval:0.37-0.93,p=0.02)was significant in predicting survival(ETV≥41%:19.20 months ***<41%:8.71 months,p=0.008,log-rank test).Without MR bias field correction,response from baseline ETV could be predicted but survival after TACE could ***:MR bias field correction improves both response assessment and accuracy of survival prediction using whole liver tumor enhance

关键词： 3D volume measurement Infiltrative HCC TACE Segmentation Bias field correction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

左心室肥厚下一个可治疗的沉默杀手？

引用

美国医学会杂志（中文版） 2005年第6期24卷 368-370页

作者： julius M. Gardin, md.Michael S. Lauer, md.倪钧（译）沈卫峰（校） Division of Cardiology St John Hospital ＆ Medical Center Detroit Mich Dr Lauer is also Contributing Editor JAMA. Department of Cardiovascular Medicine Cleveland Clinic Foundation Cleveland Ohio Dr Lauer is also Contributing Editor JAMA. 不详

左心室心肌重量增加与大多数慢性心脏疾病密切相关。传统的看法认为，左心室肥厚（左心室重量极度增加）为心肌对压力和容量负荷过大的反应。在短期内，心肌重量增加使心脏对室壁压力和潜在血液动力学异常进行代偿，从而可能具有益作用... 详细信息

左心室心肌重量增加与大多数慢性心脏疾病密切相关。传统的看法认为，左心室肥厚（左心室重量极度增加）为心肌对压力和容量负荷过大的反应。在短期内，心肌重量增加使心脏对室壁压力和潜在血液动力学异常进行代偿，从而可能具有益作用。但是长期而言，左心室肥厚是有害的。

关键词：左心室肥厚左心室心肌重量心脏疾病左心室重量动力学异常容量负荷有益作用

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

抗高血压治疗期间心电图左心室肥厚消退及其对主要心血管事件的预测作用

引用

美国医学会杂志（中文版） 2005年第6期24卷 323-329页

作者： Peter M. Okin, md.Richard B. Devereux, md.Sverker Jern, md.Sverre E. Kjedsen, md.PhD Stevo julius, md. ScD Markkus S. Nieminen, md. PhD Steven Snapinn, PhD Katherine E. Harris, DrPH Peter Aurup, md.Jonathan M. Edelman, md.Hans Wedel, PhD Lars H. Lindholm, md. PhD Bjorn Dahlof md. PhD 倪靖炜（译）沈卫峰（校） Department of Medicine Division of Cardiology Cornell University Medical Center New York NY Sahlgrenska University Hospital/OEstra Goeteborg Sweden Ulleval University Hospital Oslo Norway University of Michigan Medical Center Ann Arbor Division of Cardiology Department of Medicine Helsinki University Central Hospital Helsinki Finland Amgen Inc Thousand Oaks Calif Merck Research Laboratories West Point Pa Merck ＆ Co Inc Whitehouse Station NJ Nordic School of Public Health Gbteborg Sweden Umea. University Umea Sweden 不详

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡... 详细信息

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡率越低，并与血压水平及其降低和治疗方式无关的假说。设计、设置及参试者：1995～2001年于9193例55至80岁（均值，67岁）男性和女性高血压患者进行的双盲、随机、平行组研究。心电图LVH用康奈尔电压一时间乘积或Sokolow—Lyon电压表示，患者均入选氯沙坦降低高血压终点事件干预研究（Losartan Intervention For Endpoint，LIFE）。干预：以氯沙坦或阿替洛尔为基础的治疗方案，随访评估至少4年（均值，4．8年[SD，0．9]）。主要结果测定：心血管死亡、心肌梗死或卒中复合终点与基线及随后1年或每年心电图LVH严重程度的关系。结果：1096例（11．9％）发生心血管死亡、非致死性心肌梗死或卒中。在控制治疗方式、基线Framingham危险记分、基线和治疗期间血压以及基线心电图LVH严重程度（康奈尔乘积或Sokolow—Lyon电压）的Cox回归模型中，康奈尔乘积和Sokolow—Lyon电压所示治疗中LVH严重程度较低者，复合心血管终点事件的发生率分别降低14％和17％（康奈尔乘积每降低1050mm×ms,[1-SD]：校正风险比[hazard ratio，HR]，0．86；95％可信区间[confidence interval，CI]，0．82～0．92；P〈0．001；Sokolow—Lyon电压每降低10．5mm[1-SD]：HR，0．83；95％CI，0．78～0．88；P〈0．01）。在平行分析中，较低的康奈尔乘积和Sokolow—Lyon电压均与较低的心血管死亡（分别为HR，0．78；95％CI，0．73～0．83；P〈0．001和HR，0．80；95％CI，0．73～0．87；P〈0．001）、心肌梗死（HR，0．90；95％CI，0．82～0．98；P=0．01和HR，0．90；95％CI，0．81～1．00；P=0．04））和卒中（HR，0．90；95％CI，0．84～0．96；P=0．002；HR，0．81；95％CI，0．75～0．89；P〈0．001）独立相关。结论：抗高血压治疗期间，根据康奈尔乘积和Sokolow—Lyon电压判定的心电图LVH程度较轻与心血管并发症和死亡可能性较低相关，而且独立于原发性高血压患者的血压降低及治疗方式。旨在改善或预防心电图LVH的抗高血压治疗可以改善患者的预后。

关键词：抗高血压治疗心血管事件治疗期间左心室肥厚心电图原发性高血压患者预测作用致死性心肌梗死心血管并发症 interval

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：