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Diabetic cardiomyopathy:Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis

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World Journal of Diabetes 2024年第8期15卷 1659-1662页

作者： Lu Cai Yi Tan md shahidul islam Michael Horowitz Kupper A Wintergerst Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Department of Medicine University of AdelaideAdelaide 5005Australia Pediatric Research Institute Division of EndocrinologyDepartment of PediatricsWendy Novak Diabetes InstituteNorton Children’s HospitalUniversity of LouisvilleLouisvilleKY 40202United States

Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively ***,most studies have focused mainly on whether diabetes increases the NLRP3 inflammasome and associated pyroptosis in the heart of type 1 or type 2 diabetic rodent models,and whether various medications and natural products prevent the development of DCM,associated with decreased levels of cardiac NLRP3 inflammasome and *** direct link of NLRP3 inflammasome and associated pyroptosis to the pathogenesis of DCM remains unclear based on the limited evidence derived from the available studies,with the approaches of NLRP3 gene silencing or pharmaceutical application of NLRP3 specific *** thus emphasize the requirement for more systematic studies that are designed to provide direct evidence to support the link,given that several studies have provided both direct and indirect evidence under specific *** editorial emphasizes that the current investigation should be circumspect in its conclusion,i.e.,not overemphasizing its role in the pathogenesis of DCM with the fact of only significantly increased expression or activation of NLRP3 inflammasome and pyroptosis in the heart of diabetic rodent *** clear-cut evidence-based causative roles of NLRP3 inflammasome and pyroptosis in the pathogenesis of DCM can help to develop effective and safe medications for the clinical management of DCM,targeting these biomarkers.

关键词： Diabetic cardiomyopathy Nucleotide oligomerization domain NOD-like receptor protein 3 inflammasome Cardiac cell death Pyroptosis

Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza md.shahidul islam md.Mamunur Rashid md.Khalid Juhani Rafi Tanvir Ahmed Siddiqui md.Muzahid Ahmed Ezaj Srabonti Saha md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

Surgical or medical treatment of obesity-associated type 2 diabetesan increasing clinical conundrum

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World Journal of Diabetes 2024年第10期15卷 2036-2040页

作者： Ryan J Jalleh Karen L Jones md shahidul islam Lu Cai Michael Horowitz Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Endocrine and Metabolic Unit Royal Adelaide HospitalAdelaide 5000South AustraliaAustralia Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States

In this editorial,we comment on the article by He et al,specifically in relation to the efficacy of bariatric surgery vs glucagon-like peptide-1 receptor agonist(GLP-1RA)therapy in the management of type 2 diabetes(T2D)associated with *** surgery has now also been shown to be safe and effective in pre-teens and teenagers with obesity and T2D,but information on newer GLP-1RAs in these groups is predictably *** older individuals(age>65 years),both bariatric surgery and GLP-1RA therapy improve cardiovascular ***-tric surgery is not infrequently associated with post-operative postprandial hypoglycemia,which is not the case with GLP-1RAs and,paradoxically,there is evidence that GLP-1RAs may reduce both the frequency and severity of postprandial *** trials of the long-term efficacy of bariatric surgery and GLP-1RAs are indicated.

关键词： Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist Obesity Diabetes Weight loss Bariatric surgery Metabolic surgery Hypoglycemia

Sorbitol-based osmotic diarrhea:Possible causes and mechanism of prevention investigated in rats

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World Journal of Gastroenterology 2006年第47期12卷 7635-7641页

作者： md shahidul islam Ei Sakaguchi Laboratory of Animal Nutri-tion Faculty of Agriculture Okayama University 1-1-1 Tsushima-naka Okayama City 700-8530 Japan

AIM: To study the possible causes of sorbitol (S)-based diarrhea and its mechanism of reduction by rice gruel (RG) in cecectomized rats. METHODS: S was dissolved either in distilled water or in RG (50 g/L) and ingested as a single oral dose (1.2 g/kg body mass, containing 0.5 g/L phenol red as a re-covery marker) by S (control) and S + RG groups (n = 7), respectively. This dose is over the laxative dose for hu-mans. Animals were sacrificed exactly 1 h after dose in-gestion, without any access to drinking water. The whole gastro-intestinal tract was divided into seven segments and sampled to analyze the S and marker remaining in its ***: Gastric-emptying and intestinal transit were comparatively slower in the S + RG group. Also, the S absorption index in the 3rd and last quarter of the small intestine (24.85 ± 18.88% vs 0.0 ± 0.0% and 39.09 ± 32.75% vs 0.0 ± 0.0%, respectively, P < 0.05) was sig-nificantly higher in the S + RG group than in the control group. The S absorption index and the intestinal fluid volume are inversely related to each other. CONCLUSION: The intestinal mal-absorption of S is the main reason for S-based osmotic diarrhea. Where RG en-hanced the absorption of S through passive diffusion, the degree of diarrhea was reduced in cecectomized rats.

关键词： Cecectomized rat Sorbitol Diarrhea Rice gruel Phenol red

Red honeybush(Cyclopia genistoides)tea mitigates oxidative imbalance and hyperlipidemia,while improving glucose homeostasis in type 2 diabetic rats

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Food Science and Human Wellness 2023年第6期12卷 2029-2039页

作者： Xin Xiao Ochuko L.Erukainure md.shahidul islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Red honeybush tea(RHT)is a tea product developed from Cyclopia *** is endemic to South *** refreshment,RHT has over the years been used traditionally in the treatment of various diseases including type 2 *** study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes(T2D)model of rats.T2D was induced starting with feeding 10%fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin(40 mg/kg body weight(BW)).Five weeks of treatment of RHT led to significant(PmdA levels and enhanced level of GSH,activity of SOD,catalase,GR in most of organs(pancreas,liver,kidneys,and heart).Signifi cantly(P<0.05)improved morphological changes in the islets andβ-cells were observed in rats treated with *** data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.

关键词： Red honeybush tea(Cyclopia genistoides) Antioxidants Anti-diabetes Type 2 diabetes

Recent therapeutic targets for the prevention and management of diabetic complications

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世界糖尿病杂志:英文版(电子版) 2023年第9期14卷 1330-1333页

作者： md shahidul islam Lu Cai Michael Horowitz Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute University of LouisvilleLouisvilleKY 40202United States Department of Medicine University of AdelaideAdelaide 5005Australia

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature *** some diabetic complications have decreased in the developed world,the majority are still prevalent,with an increasing trend in the developing *** used therapies are mainly‘glucocentric’,focusing on the optimization of glycemic control to prevent,delay or manage diabetes-associated complications-other common comorbidities,such as dyslipidemia and hypertension are often *** a number of novel therapeutic approaches have been reported recently,some of them have not received comparable attention in relation to either further studies or potential clinical *** editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications,as well as potential directions for future research and development in this area.

关键词： Diabetic complications Oxidative stress Phytochemicals Zinc Silent information regulator 1 FOXO Micro RNA

Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 533-538页

作者： Abu Nasim Nizami md Atiar Rahman Nazim Uddin Ahmed md shahidul islam Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh Department of Biochemistry School of BiochemistryGenetics and MicrobiologyUniversity of KwaZulu-NatalDurban 4000South Africa Bangladesh Council of Scientific and Industrial Research(BCSIR) Chittagong-4220Bangladesh

Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of ***: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely:preventive(n=18) and therapeutic(n=24).Preventive group was further subdivided into 3 groups of 6 rats namely:preventive control(PC),preventive lithiatic control(PLC) and preventive lithiatic ***(PLLM).Similarly,therapeutic group was also subdivided into 4 groups of 6 rats namely:therapeutic control(TC),therapeutic lithiatic control(TLC).therapeutic lithitatic L macrophylla(TLLM) and therapeutic lithiatic cystone(TLCYS).The lithiasis was induced by 0.75%(v/v) ethylene glycol in the drinking water of all groups except the PC and TC *** urinary ionic parameters such as calcium,inorganic phosphate,oxalate,magnesium & creatinine and renal morphology were altered by ediylene glycol,which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L macrophylla extract(500 mg/kg BW daily).Results:Significant difference on recovery was observed between preventive and dierapeutic interventional ***-urolithiatic effect of cystone was significantly(P<0.001) higher than extracts.L macrophylla extract was found nontoxic in the acute toxicity ***:The results of this study demonstrated very promising antiurolithiatic effect of *** extract with preventive and therapeutic treatments in this experimental condition.

关键词： Urolithiasis Ethylene glycol Leea macrophylla Urinary parameter Rats

Potential therapeutic targets for the prevention of diabetic nephropathy:Glycyrrhetinic acid

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World Journal of Diabetes 2023年第12期14卷 1717-1720页

作者： Lu Cai Michael Horowitz md shahidul islam Pediatric Research Institute Department of PediatricsUniversity of LouisvilleLouisvilleKY 40202United States Department of Medicine University of AdelaideAdelaide 5005Australia Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa

Uncontrolled hyperglycemia or poorly managed disease increases the propensityfor a number of diabetes-related complications targeting major organs includingthe heart, eyes, and kidney. Although the mechanisms by which diabetes inducescardiovascular diseases include oxidative stress and inflammation, when insulinresistance remains the key to the pathogenesis, as implicated in the two reviews inthis issue. This editorial mainly comments on the potential preventive applicationof glycyrrhetinic acid (or 18β-GA) in relation to diabetic nephropathy. The therapeuticor preventive effects of 18β-GA, as a hydrolytic product of glycy-rrhizicacid that is a component of licorice, have been appreciated in other disorders, buthave received much less attention in relation to diabetic complications. A study inthis issue has identified 18β-GA as a therapeutic for preventing diabeticnephropathy and provides evidence to support efficacy in cultured human renaltubule cells in vitro. Although it represents a pilot study, the observations supporta new therapeutic approach that warrants further ex-ploration.

关键词： Insulin resistance Diabetic cardiomyopathy Diabetic nephropathy Glycyrrhetinic acid Licorice Chinese herbal remedy

Contribution of non-timber forest products to the livelihoods of the forest-dependent communities around the Khadimnagar National Park in northeastern Bangladesh

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Regional Sustainability 2021年第3期2卷 280-295页

作者： md.Habibur RAHMAN Bishwajit ROY md.shahidul islam Laboratory of Tropical Forest Resources and Environments Division of Forest and Biomaterials ScienceGraduate School of AgricultureKyoto UniversityKyoto606-8502Japan Bangladesh Institute of Social Research Trust LalmatiaDhaka1207Bangladesh Climate Change andSustainable Development Policies Faculty of ScienceUniversity of LisbonLisbon1749-016Portugal Research and Development Cell Bangladesh Knitwear Manufacturers and Exporters AssociationDhaka1000Bangladesh

Non-timber forest products(NTFPs)play a significant role in the improvement of the forest-dependent people’s livelihoodsaround the world,strengthening protection for the sustainable use of *** purpose of this research was to evaluate the influence of occupational category-wise(fuelwood collectors,farmers,small-scale businessmen,day labourers,and tea estate labourers)dependencyon NTFPsand the role of NTFPs on household income around the Khadimnagar National Park(KNP)in northeastern *** 2014,178purposively selected respondents from four villages(out of 22 villagesaround the KNP)were interviewed face-to-face using a semi-structured *** study observed that these forest-dependent communities utilized resources of the KNP mainly for domestic energy supply,household income,and house *** showed that income from NTFPs made a significant contribution to family *** data analysis indicated that small-scale businessmen earned relatively more income from NTFPs,followed by tea estate labourersand day *** study revealed significant negative relationships of the distance of households from the forest with the amount of NTFPs collected(P<0.01)and monthly income from NTFPs(P<0.01).Positive significant relationships were found between the amount of NTFPs collected and the time spent in NTFP collection(P<0.001),as well as betweenmonthly income from NTFPs and family size(P<0.001).The fuelwood collectors and farmers collected significantly greater amounts of NTFPs per trip(P<0.001)than other occupational *** households that were moderately to highly dependent on NTFPs collected significantly higher amounts of NTFPs pertrip(P<0.01)than the households that were moderately dependent and less dependent on *** dependence on KNP’sresources,community’sappreciation of the KNP’s ecosystem services for villagers’livelihoods,and community’s high levels of concern for forest conservation provided a foundation

关键词： Forest dependency Household income Non-timber forest products Forest sustainability Occupational categories Khadimnagar National Park