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PCSK9与脑胆固醇稳态及阿尔茨海默病的潜在关联

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医药导报 2021年第6期40卷 773-775页

作者：李媛赵震宇 md sayed ali sheikh 胡涛夏珂中南大学湘雅医院心血管内科长沙421008 中南大学湘雅医院临床药理研究所长沙421008 阿尔苏夫医科大学心血管内科沙特阿拉伯2014

前蛋白转化酶枯草杆菌蛋白酶kexin9型(PCSK9)抑制剂在血脂管理中备受关注,而PCSK9与脑胆固醇稳态及阿尔茨海默病(AD)的潜在关联鲜为人知。研究显示脑胆固醇依赖原位合成且AD患者脑脊液中PCSK9水平升高,但PCSK9不能穿过血-脑屏障。该文... 详细信息

前蛋白转化酶枯草杆菌蛋白酶kexin9型(PCSK9)抑制剂在血脂管理中备受关注,而PCSK9与脑胆固醇稳态及阿尔茨海默病(AD)的潜在关联鲜为人知。研究显示脑胆固醇依赖原位合成且AD患者脑脊液中PCSK9水平升高,但PCSK9不能穿过血-脑屏障。该文将阐述PCSK9参与脑胆固醇稳态及AD的可能机制及作用靶点,并进一步探讨PCSK9抑制剂在心血管领域的应用是否对患者神经认知功能产生影响。

关键词：前蛋白转化酶枯草杆菌蛋白酶kexin9型抑制剂脑胆固醇稳态阿尔茨海默病神经认知功能

冠心病合并代谢综合征患者血浆LOX-1和脂联素的水平变化及相关性研究

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冠心病合并代谢综合征患者血浆LOX-1和脂联素的水平变化及相关性...

作者：孟加拉阿里（DR md sayed ali sheikh）中南大学

学位级别：硕士

目的：评估血浆凝集素样氧化型低密度脂蛋白受体-1和脂联素在冠心病合并代谢综合征患者中的水平。方法：收集2009年8月-2010年6月间我院心内科住院的冠心病患者为研究对象,其中平均年龄为66岁的冠心病者30例（CAD组,男13,女7）;平... 详细信息

目的：评估血浆凝集素样氧化型低密度脂蛋白受体-1和脂联素在冠心病合并代谢综合征患者中的水平。方法：收集2009年8月-2010年6月间我院心内科住院的冠心病患者为研究对象,其中平均年龄为66岁的冠心病者30例（CAD组,男13,女7）;平均年龄为6 1岁的冠心病合并代谢综合征者30例（CAD+MS组,13男,17女）;平均年龄为53岁的代谢综合征者30例（MS组,23男,7女）;平均年龄为51岁的来我院体检中心的正常健康对照组30例（22男,8女）。对所有的研究对象进行问卷获取一般资料,并收集外周肘静脉血检测生化指标,采用ELISA法检测LOX-1和脂联素的浓度。结果：血压和BMI在CAD+MS组（142±9mmHg/82±7 mmHg、27.2±1Kg/m2）、MS组（136±6 mmHg/74±7mmHg、25.6±1 Kg/m2）合CAD组（129±10mmHg/77±7mmHg、23.7±1.3 Kg/m2）均高于正常对照组（124±8 mmHg/72±5mmHg、21.1±1.5 Kg/m2）,且差异有统计学意义（均P＜0.05）;血浆甘油三酯、空腹血糖、谷草转氨酶、谷丙转氨酶、肌酐、尿酸和高敏C反应蛋白在CAD+MS组（2.1±1.4mmol/L、6.2±0. mmol/L、23.5±4.8 U/L、21.2±4 U/L、89.3±16 mg/L、314.7±55.1 mmol/L、12.0±8.5 mg/L）均高于正常对照组（0.84±0.3mmol/L、4.5±0.3 mmol/L、11.2±3.6U/L、14.5±4.5U/L、71.0±9.8 mg/L、251.9±42mmol/L、0.7±0.8mg/L）,且差异有统计学意义（均P＜0.05）。尿素氮在CAD组（5.5±0.9mmol/L）均高于CAD+MS组（5.3±1mmol/L）、MS组（4.8±1.4mmol/L）和正常对照组（3.9±0.6mmol/L）、且差异有统计学意义（均P＜0.05）。血浆LOX-1在CAD+MS组（435.9±105.9pg/ml）水平最高,其次是CAD组（196.2±40.4pg/ml）、MS组（140.9±15pg/ml）、正常对照组（87.1±8.5 pg/ml）,且各组间差异有统计学意义（均P＜0.05）。相反,脂联素在CAD+MS组（263.6±26.6μg/L）水平最低,其次是CAD组（369.9±20.7μg/L）、MS组（450.8±25μg/L）、正常对照组（510.9±29.3μtg/L）,且四组间差异有统计学意义（均P＜0.05）。进一步分析发现,血浆LOX-1和脂联素水平不受年龄和性别的影响,且二者的变化呈显著负相关。结论：冠心病患者血浆LOX-1的水平增高,以CAD+MS组增高最为显著;相反,冠心病患者血浆脂联素的水平降低,以CAD+MS组降低最为显著。

关键词：冠心病凝集素样氧化型低密度脂蛋白受体-1 脂联素代谢综合征动脉粥样硬化

The role of circulating miRNAs in diagnosis of acute myocardial infarction and the pathological significance

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The role of circulating miRNAs in diagnosis of acute myocard...

Boron Nitride-Integrated Lithium Batteries:Exploring Innovations in Longevity and Performance

第十一届全国免疫学学术大会

作者： Zhu Ping md sayed ali sheikh Li Chuanchang Xia Ke Li Fei Deng Xu Salma Umme Yang Tianlun Peng Jun Department of Cardiovascular Surgery Guangdong Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Sciences Department of Cardiology Xiangya HospitalCentral South University Center for Vascular Biology and Inflammation Cardiovascular DivisionDepartment of MedicineBrigham and Women's HospitalHarvard Medical School Department of Gynecology and obstetrics Xiangya 3rd HospitalCentral South University Department of Pharmacology School of Pharmaceutical SciencesCentral South University

Objectives: We aimed to explore the diagnostic value of circulating miRNAs(miR-149, miR-208 b, miR-378, miR-424, miR-499 and miR-765) in AMI patients, and protective role of miR-208 b or miR-378 or metoprolol during H/R injury in H9c2 cell with their underlying mechanisms. Methods: 205 AMI patients and 85 healthy subjects, twelve week-old C57BL/6 mice AMI and H9c2 cells were included in this study. Total RNA was isolated from plasma and cardiac cell with TRIzol reagent. Circulating miRNAs levels were measured by quantitative real-time polymerase chain reaction. Results: We found that miR-208 b, miR-499 and miR-765 levels were significantly up-regulated by 9.6 fold, 5.2 fold, and 5.1 fold in AMI patients compared with healthy subjects(p<0.001). Plasma miR-149, miR-378 and miR-424 levels were markedly downregulated by 5.5 fold, 4.9 fold and 5 fold in AMI patients compared with controls(p<0.001). Plasma levels of these miRNAs were returned towards normal at 96 h after PCI(p<0.001). We also found that plasma miR-208 b, miR-499 and miR-765 levels were significantly elevated by 11.5 fold, 3.9 fold, and 4.7 fold, while miR-149, miR-378 and miR-424 levels were noticeably decreased by 3.7 fold, 4.1 fold and 3.8 fold in Mice AMI compared with controls(p<0.001). The ROC curves of plasma miR-208 b, miR-499, miR-765, miR-149, miR-378 and miR-424 represented a strong discrimination between AMI patients and healthy subjects, with an area under curve(AUC) of 0.974, 0.971, 0.965, 0.963 0.969 and 0.973, respectively. Conclusions: Our findings suggested that miR-208 b, miR-499, miR-765, miR-149, miR-378, miR-424 may be used as a novel and sensitive diagnostic biomarker for AMI patients. Inhibition of miR-208 b and overexpression of miR-378 were effectively protected cardiomyocyte damage during H/R injury through their potential targets NLK and TRAF6, represents a new therapeutic approach for ischemic heart disease. Furthermore, metoprolol protected cardiomyocytes damage against H/R in

关键词： cardiomyocytes damage circulating miRNAs AMI pathological new therapeutic approach

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Energy & Environmental Materials 2024年第6期7卷 13-40页

作者： Shayan Angizi sayed ali Ahmad Alem Mahdi Torabian Maryam Khalaj Dmitri Golberg Amir Pakdel Department of Chemical Engineering McMaster University1280 Main St WHamiltonONL8S 4L7 Canada Institute of Chemistry of Polymeric Materials Montanuniversität LeobenOtto-Glöckel-Strasse 2A-8700 LeobenAustria Department of Chemistry Materials and Chemical EngineeringPolitecnico di MilanoPiazza Leonardo da Vinci 3220133 MilanItaly Department of Materials Science and Engineering Northwestern UniversityEvanstonIL60208 USA Centre for Materials Science and School of Chemistry and Physics Queensland University of Technology(QUT)2 GeorgeBrisbaneQLD4000 Australia Research Centre for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Namiki 1Ibaraki3050044 Japan Department of Mechanical Manufacturing and Biomedical EngineeringTrinity College DublinThe University of DublinDublinD02PN40 Ireland

The current global warming,coupled with the growing demand for energy in our daily lives,necessitates the development of more efficient and reliable energy storage *** batteries(LBs)are at the forefront of emerging power sources addressing these *** studies have shown that integrating hexagonal boron nitride(h-BN)nanomaterials into LBs enhances the safety,longevity,and electrochemical performance of all LB components,including electrodes,electrolytes,and separators,thereby suggesting their potential value in advancing eco-friendly energy *** review provides an overview of the most recent applications of h-BN nanomaterials in *** begins with an informative introduction to h-BN nanomaterials and their relevant properties in the context of LB ***,it addresses the challenges posed by h-BN and discusses existing strategies to overcome these limitations,offering valuable insights into the potential of BN *** review then proceeds to outline the functions of h-BN in LB components,emphasizing the molecular-level mechanisms responsible for performance ***,the review concludes by presenting the current challenges and prospects of integrating h-BN nanomaterials into battery research.

关键词： electrode electrolyte hexagonal boron nitride lithium battery separator

Correction‐enabled reversible data hiding with pixel repetition for high embedding rate and quality preservation

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IET Cyber-Systems and Robotics 2024年第3期6卷 49-61页

作者： Mohammad ali Kawser Hussain Nyeem md Abdul Wahed School of Transportation Science and Engineering Beihang UniversityBeijingChina Department of Electrical Electronic and Communication Engineering(EECE)Military Institute of Science and Technology(MIST)DhakaBangladesh

A novel correction‐enabled Pixel Repetition(PR)‐based Reversible Data Hiding(RDH)framework,featuring a new embedding scheme is *** proposed RDH scheme uses contextually redundant block pixels,generated via PR,in a two‐phase adaptive embedding process,enhancing both image quality and data embedding ***,each 2×2 block encodes 4 bits of data using new mapping conditions that facilitate seed pixel reconstruction from remaining block pixels and provide additional embedding ***,an innovative post‐embedding error correction technique,based on 2^(k)‐bit error‐correction,minimises post‐embedding distortion,further improving image *** error correction approach augments data embedding robustness,vital for applications like medical imaging,telemedicine,and digital watermarking that requires high embedding capacity with minimum possible *** proposed scheme surpasses existing state‐of‐the‐art methods in embedding ratedistortion performance,validated through subjective and objective ***,statistical analysis,including histogram and fragility testing,confirms the scheme's potential for image authentication across diverse multimedia *** correctionenabled RDH with PR offers enhanced embedding capacity and image quality preservation,making it particularly advantageous for applications requiring robust data hiding while maintaining visual fidelity.

关键词： data assimilation vision

Surface Morphology and Thermo-Electrical Energy Analysis of Polyaniline (PANI) Incorporated Cotton Fabric

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Energy Engineering 2024年第1期121卷 1-12页

作者： md.Shohan Parvez md.Mustafizur Rahman Mahendran Samykano Mohammad Yeakub ali Automotive Engineering Research Group Faculty of Mechanical and Automotive Engineering TechnologyUniversiti Malaysia Pahang Al-Sultan AbdullahPekanMalaysia Department of Textile Engineering Khulna University of Engineering&Technology(KUET)KhulnaBangladesh Centre for Research in Advanced Fluid and Processes(CARIFF) Universiti Malaysia Pahang Al-Sultan AbdullahLebuhraya Tun RazakGambangMalaysia Mechanical Engineering Programme Area Faculty of EngineeringUniversiti Teknologi BruneiBruneiDarussalam

With the exponential development in wearable electronics,a significant paradigm shift is observed from rigid electronics to flexible wearable ***(PANI)is considered as a dominant material in this sector,as it is endowed with the optical properties of both metal and ***,its widespread application got delineated because of its irregular rigid form,level of conductivity,and precise choice of *** PANI in textile materials can generate promising functionality for wearable *** research work employed a straightforward in-situ chemical oxidative polymerization to synthesize PANI on Cotton fabric surfaces with varying dopant(HCl)***-treatment using NaOH is implemented to improve the conductivity of the fabric surface by increasing the monomer *** research explores the morphological and structural analysis employing SEM,FTIR and *** surface resistivity was measured using a digital multimeter,and thermal stability is measured using *** successful polymerization,a homogenous coating layer is *** is revealed that the simple pre-treatment technique significantly reduces the surface resistivity of Cotton fabric to 1.27 kΩ/cm with increasing acid concentration and thermal *** electro-thermal energy can also reach up to 38.2°C within 50 s with a deployed voltage of 15 *** modified fabric is anticipated to be used in thermal regulation,supercapacitor,sensor,UV shielding,antimicrobial and other prospective functional applications.

关键词： Polyaniline cotton in-situ polymerization SEM TGA heating fabric

Photon orbits and phase transition for Letelier AdS black holes immersed in perfect fluid dark matter

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Chinese Physics C 2024年第6期48卷 247-259页

作者： Ashima Sood md Sabir ali J.K.Singh Sushant G.Ghosh Department of Mathematics Netaji Subhas University of TechnologyNew Delhi-110078India Centre for Theoretical Physics Jamia Millia IslamiaNew Delhi 110025India Department of Physics Mahishadal Raj CollegePurba MedinipurWest Bengal721628India Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China Key Laboratory of Quantum Theory and Applications of MoE Lanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics&Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China Astrophysics and Cosmology Research Unit School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa

We obtain an exact solution for spherically symmetric Letelier AdS black holes immersed in perfect fluid dark matter(PFDM).Considering the cosmological constant as the positive pressure of the system and volume as its conjugate variable,we analyze the thermodynamics of our black holes in the extended phase *** to the background clouds of strings parameter(a)and the parameter endowed with PFDM(β),we analyze the Hawking temperature,entropy,and specific ***,we investigate the relationship between the photon sphere radius and phase transition for the Letelier AdS black holes immersed in *** the analysis,with a particular condition,non-monotonic behaviors are found between the photon sphere radius,impact parameter,PFDM parameter,temperature,and *** can regard the changes in both the photon sphere radius and impact parameter before and after phase transition as the order parameter;their critical exponents near the critical point are equal to the same value,1/2,similar to that in ordinary thermal *** indicates that a universal relation of gravity may exist near the critical point for a black hole thermodynamic system.

关键词： AdS black holes perfect fluid dark matter Letelier spacetime photon orbit extended phase space thermodynamics correlation of photon orbit and thermodynamics

Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-sayed Mohamed Z.sayed-Ahmed Shaimaa Ahmed Awad ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

Rao Algorithms-Based Structure Optimization for Heterogeneous Wireless Sensor Networks

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Computers, Materials & Continua 2024年第1期78卷 873-897页

作者： Shereen K.Refaay Samia A.ali Moumen T.El-Melegy Louai A.Maghrabi Hamdy H.El-sayed Faculty of Computers and Artificial Intelligence Sohag UniversitySohag82524Egypt Faculty of Engineering Assiut UniversityAssiut711745Egypt College of Engineering University of Business and TechnologyJeddah23411Saudi Arabia

The structural optimization of wireless sensor networks is a critical issue because it impacts energy consumption and hence the network’s *** studies have been conducted for homogeneous networks,but few have been performed for heterogeneouswireless sensor *** paper utilizes Rao algorithms to optimize the structure of heterogeneous wireless sensor networks according to node locations and their initial *** proposed algorithms lack algorithm-specific parameters and metaphorical *** proposed algorithms examine the search space based on the relations of the population with the best,worst,and randomly assigned *** proposed algorithms can be evaluated using any routing protocol,however,we have chosen the well-known routing protocols in the literature:Low Energy Adaptive Clustering Hierarchy(LEACH),Power-Efficient Gathering in Sensor Information Systems(PEAGSIS),Partitioned-based Energy-efficient LEACH(PE-LEACH),and the Power-Efficient Gathering in Sensor Information Systems Neural Network(PEAGSIS-NN)recent routing *** compare our optimized method with the Jaya,the Particle Swarm Optimization-based Energy Efficient Clustering(PSO-EEC)protocol,and the hybrid Harmony Search Algorithm and PSO(HSA-PSO)*** efficiencies of our proposed algorithms are evaluated by conducting experiments in terms of the network lifetime(first dead node,half dead nodes,and last dead node),energy consumption,packets to cluster head,and packets to the base *** experimental results were compared with those obtained using the Jaya optimization *** proposed algorithms exhibited the best *** proposed approach successfully prolongs the network lifetime by 71% for the PEAGSIS protocol,51% for the LEACH protocol,10% for the PE-LEACH protocol,and 73% for the PEGSIS-NN protocol;Moreover,it enhances other criteria such as energy conservation,fitness convergence,packets to cluster head,and packets to the base sta

关键词： Wireless sensor networks Rao algorithms optimization LEACH PEAGSIS