检索结果-南通市图书馆

Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

Translational Neurodegeneration 2023年第1期12卷 604-637页

作者： Sina Shadfar Sonam Parakh md shafi jamali Julie D.Atkin Centre for Motor Neuron Disease Research Macquarie Medical SchoolMacquarie UniversitySydneyNSW 2109Australia La Trobe Institute for Molecular Science La Trobe UniversityBundooraMelbourneVIC 3086Australia

Redox homeostasis refers to the balance between the production of reactive oxygen species(ROS)as well as reactive nitrogen species(RNS),and their elimination by *** is linked to all important cellular activities and oxidative stress is a result of imbalance between pro-oxidants and antioxidant *** stress perturbs many cellular activities,including processes that maintain the integrity of *** acids are highly reactive and therefore particularly susceptible to *** DNA damage response detects and repairs these DNA *** DNA repair processes are therefore essential for maintaining cellular viability,but they decline considerably during *** damage and deficiencies in DNA repair are increasingly described in age-related neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***,oxidative stress has long been associated with these ***,both redox dysregulation and DNA damage increase significantly during aging,which is the biggest risk factor for neurodegenerative ***,the links between redox dysfunction and DNA damage,and their joint contributions to pathophysiology in these conditions,are only just *** review will discuss these associations and address the increasing evidence for redox dysregulation as an important and major source of DNA damage in neurodegenerative *** these connections may facilitate a better understanding of disease mechanisms,and ultimately lead to the design of better therapeutic strategies based on preventing both redox dysregulation and DNA damage.

关键词： Redox dysregulation DNA damage Neurodegeneration Reactive oxygen species Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of dielectric barrier discharge treatment on mechanical and dyeing properties of wool

引用

Plasma Science and Technology 2018年第6期20卷 89-98页

作者： Rahul NAVIK Sameera shafi md Miskatul ALAM md Amjad FAROOQ Lina LIN Yingjie CAI Hubei Provincial Engineering Laboratory for Clean Production and High Value Utilization of Bio-Based Textile Materials Wuhan Textile UniversityWuhan 430073People＇s Republic of China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People＇s Republic of China

Physical and chemical properties of wool surface significantly affect the absorbency,rate of dye bath exhaustion and fixation of the industrial ***,surface modification is a necessary operation prior to coloration process in wool wet processing *** treatment is an effective alternative for physiochemical modification of wool ***,optimum processing parameters to get the expected modification are still under investigation,hence this technology is still under development in the wool wet processing ***,in this paper,treatment parameters with the help of simple dielectric barrier discharge plasma reactor and air as a plasma gas,which could be a promising combination for treatment of wool substrate at industrial scale were schematically studied,and their influence on the water absorbency,mechanical,and dyeing properties of twill woven wool fabric samples are *** is expected that the results will assist to the wool coloration industries to improve the dyeing processes.

关键词： air plasma reactive dye surface energy wool

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Encoder-Decoder Based LSTM Model to Advance User QoE in 360-Degree Video

引用

Computers, Materials & Continua 2022年第5期71卷 2617-2631页

作者： Muhammad Usman Younus Rabia shafi Ammar Rafiq Muhammad Rizwan Anjum Sharjeel Afridi Abdul Aleem jamali Zulfiqar Ali Arain Ecole Doctorale Mathematiques InformatiqueTelecommunicationde ToulouseUniversity Paul SabatierToulouse31330France School of Electronics and Information Northwestern Polytechnical UniversityXi’an710129China Department of Computer Science NFC Institute of Engineering and Fertilizer ResearchFaisalabad38000Pakistan Department of Electronic Engineering The Islamia University of BahawalpurBahawalpur63100Pakistan Department of Electrical Engineering Sukkur IBA UniversitySukkur65200Pakistan Department of Electronic Engineering Quaid-e-Awam University of EngineeringScience and Technology(QUEST)Nawabshah67450Pakistan Department of Telecommunication Engineering MUETJamshoro76060Pakistan

The development of multimedia content has resulted in a massiveincrease in network traffic for video streaming. It demands such types ofsolutions that can be addressed to obtain the user’s Quality-of-Experience(QoE). 360-degree videos have already taken up the user’s behavior by ***, the users only focus on the part of 360-degree videos, known as aviewport. Despite the immense hype, 360-degree videos convey a loathsomeside effect about viewport prediction, making viewers feel uncomfortablebecause user viewport needs to be pre-fetched in advance. Ideally, we canminimize the bandwidth consumption if we know what the user motionin advance. Looking into the problem definition, we propose an EncoderDecoder based Long-Short Term Memory (LSTM) model to more accuratelycapture the non-linear relationship between past and future viewport positions. This model takes the transforming data instead of taking the direct inputto predict the future user movement. Then, this prediction model is combinedwith a rate adaptation approach that assigns the bitrates to various tiles for360-degree video frames under a given network capacity. Hence, our proposedwork aims to facilitate improved system performance when QoE parametersare jointly optimized. Some experiments were carried out and compared withexisting work to prove the performance of the proposed model. Last but notleast, the experiments implementation of our proposed work provides highuser’s QoE than its competitors.

关键词： Encoder-decoder based lSTM 360-degree video streaming LSTM QoE viewport prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice

引用

Cellular & Molecular Immunology 2009年第2期6卷 111-116页

作者： shafi Mojadadi Abbas jamali Behzad Khansarine jad Hoorieh Soleimanjahi Taravat Bamdad Neuroscience research center Kerman University of Medical Sciences Department of Virology Faculty of medical science Tarbiat Modares University Dept of virology School of medicalsciences Tarbiat Modares University Dept of Microbiology Arak University of Medical Sciences

Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte （CTL） activity in the inhibition of herpes simplex virus type 1 （HSV-1） reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-γ. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation.

关键词： acute morphine herpes simplex virus-1 reactivation cell-mediated immunity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MAR Technique to Reverse the Declining Trend of Groundwater Level in Barind Area, NW, Bangladesh

引用

Journal of Water Resource and Protection 2019年第6期11卷 748-757页

作者： md. Iquebal Hossain Niamul Bari shafi Uddin Miah Chowdhury Sarwar Jahan md. Ferozur Rahaman Department of Civil Engineering Rajshahi University of Engineering & Technology Rajshahi Bangladesh Barind Multipurpose Development Authority Rajshahi Bangladesh Department of Geology and Mining University Rajshahi Rajshahi Bangladesh Institute of Environmental Science University of Rajshahi Rajshahi Bangladesh

The study was carried out in the drought prone water stressed Barind area to know the state of rainfall, trend of groundwater level and groundwater management options including Managed Aquifer Recharge (MAR) techniques. Rainfall and groundwater level data have been used and shown a decreasing trend in Godagari and Mohonpur Upazila. But in Niamatpur Upazila rainfall is in reverse condition of rising trend. Decreasing trend of groundwater level (GWL) has been found in the entire study area. The decreasing trend of GWL demands judicious management of groundwater for the area. For recovery of GWL as well as groundwater management, a recharge well as MAR structure has been installed and observed that the situation is better than the before and increasing GWL. More research and study are necessary to know about the trend of groundwater level for the whole Barind area and to introduce proper designed and modified MAR techniques to reverse the declining situation of GWL.

关键词： Groundwater Groundwater Level MAR Rainfall Water Management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：