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human leukocyte antigen B polymorphism and association between hLA-B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

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Rheumatology & Autoimmunity 2022年第1期2卷 15-21页

作者： md kamrul h.sajib Shamim Ahmed Syed A.haq Minhaj R.Choudhury Mohammed Uddin Furkan Uddin Muhammad S.A.Khan Mohammad M.Zaman Department of Rheumatology Dhaka Medical College HospitalDhakaBangladesh Department of Rheumatology Bangabandhu Sheikh Mujib Medical UnivesityDhakaBangladesh Department of human Genetics Mohammed Bin Rashid University of Medicine and Health SciencesCollege of MedicineDubaiUAE Genetics and Genomic Department NeuroGen HealthcareDhakaBangladesh Department of Medicine Sheikh Hasina Institute of Burn and Plastic SurgeryDhakaBangladesh Advisor(Research and Publication) World Health OrganizationDhakaBangladesh

Objectives:To determine the association of human leukocyte antigen B(hLA‑B)alleles with ankylosing spondylitis and the allelic association of hLAB27 with endoplasmic reticulum aminopeptidase 1(ERAP1)single-nucleotide polymorphism(SNP)rs30187 in patients with ankylosing spondylitis(AS).Methods:We studied 48 consecutively enrolled well-defined AS patients and 48 healthy controls recruited from the outpatient clinic of the rheumatology department of Bangabandhu Sheikh Mujib Medical University(BSMMU),Dhaka,*** genotype hLA-B alleles from peripheral blood DNA,we designed sequence-specific primers for polymerase chain ***'s sequencing method was used to detect the ERAP1 rs30187 *** hLA-B allele distributions were compared between cases and *** infer an allelic association between hLA-B27 and ERAP1,allele distributions from both loci were compared using ***-squared test or Fisher's exact test was used to quantify the association,and their strength of association was tested by odds ratio(OR)with 95%confidence interval(CI).Results:The frequency of hLA-B27 was found to be higher in AS patients(60.4%)than in healthy controls(8.3%).hLA-B27 allele had an OR of 16.8(95%CI=5.2–54.4)for the development of ***,4%of AS patients had both hLA-B27 and *** significant association was found between ERAP1 rs30187 SNP and hLA-B27 in patients with AS(OR=1.7,95%CI=0.5–5.6).Conclusions:hLA-B27 was significantly associated with AS in patients in ***,no association between ERAP1 rs30187 SNP and hLA-B27 was observed.

关键词： AS Bangladesh ERAP1 rs30187 SNP hLA-B hLA-B27

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hLA-DQ and-DR alleles in patients with SLE:A tertiary hospital-based case–control study in Bangladesh

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Rheumatology & Autoimmunity 2023年第1期3卷 43-49页

作者： Muhammad S.A.Khan Shamim Ahmed Iftekhar h.Bandhan Farhana Zaman mdkamrul h.sajib Shirin Tarafder Minhaj R.Choudhury Syed A.haq Mohammad M.Zaman Sheikh hasina National Institute of Burn and Plastic Surgery DhakaBangladesh Department of Rheumatology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh Upazilla health Complex BancharampurB-BariaBangladesh Department of Community Medicine Universal Medical CollegeDhakaBangladesh Department of Rheumatology Dhaka Medical College HospitalDhakaBangladesh Green Life Center for Rheumatic Care and Research DhakaBangladesh World health Organization DhakaBangladesh

Background:Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by the involvement of multiple organs and autoantibody *** study aimed to determine the association of human leukocyte antigen(hLA)-DQ and-DR alleles with SLE at a tertiary hospital in ***:This case-control study was conducted in the Department of Rheumatology,Bangabandhu Sheikh Mujib Medical University(BSMMU),Dhaka,*** patients who fulfilled the 1997 revised American College of Rheumatology classification criteria for SLE were considered cases(n=41).The controls(n=32)were selected from the hospital staff of BSMMU,including doctors and nurses who did not suffer from any known rheumatic diseases,and there was no such disease in their first-degree *** chain reaction using a sequence-specific primer(PCRSSP)in a low-resolution typing method was carried out on blood samples collected for hLA-DQ and-DR allele ***:The cases and controls had comparable mean ages(31 vs.32 years),and most cases were female(95.1%vs.34.4%).The most frequent clinical manifestations were mucocutaneous(85.4%),followed by musculoskeletal(70.7%)and constitutional symptoms(58.5%).The cases had a significantly higher frequency of hLA-DR2 allele compared with healthy controls(70.7%vs.43.8%;odds ratio:3.1;95%confidence interval:1.2-8.2).In addition,hLADQ6 allele was found to have a significant association with mucocutaneous manifestations of the cases(88.9%,P=0.03).Conclusions:Bangladeshi adults having hLA-DR2 may be more susceptible to ***-DQ6 allele might be associated with mucocutaneous manifestations of SLE.

关键词： alleles Bangladesh hLA-DQ hLA-DR systemic lupus erythematosus

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Impact of Action Observation Therapy along with Usual Physiotherapy Intervention of Individual with Alzheimer’s Disease

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Advances in Alzheimer's Disease 2024年第1期13卷 1-10页

作者： Zahid Bin Sultan Nahid Faruq Ahmed Tuhin Ahammed md Kutub Uddin md Sirazul Islam S M Maruf hossain sajib md Rafiqul Islam Department of Physiotherapy Saic College of Medical Science and Technology Mirpur Bangladesh Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Savar Bangladesh Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Mymensingh Bangladesh Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Mirpur Bangladesh Department of Physiotherapy State College of Health Sciences Dhaka Bangladesh

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairments in the initial stage, which lead to severe cognitive dysfunction in the later stage. Action observation therapy (AOT) is a multisensory cognitive rehabilitation technique where the patient initially observes the actions and then tries to perform. The study aimed to examine the impact of AOT along with usual physiotherapy interventions to reduce depression, improve cognition and balance of a patient with AD. A 67 years old patient with AD was selected for this study because the patient has been suffering from depression, dementia, and physical dysfunction along with some other health conditions like diabetes and hypertension. Before starting intervention, a baseline assessment was done through the Beck Depression Inventory (BDI) tool, the Mini-Cog Scale, and the Berg Balance Scale (BBS). The patient received 12 sessions of AOT along with usual physiotherapy interventions thrice a week for four weeks, which included 45 minutes of each session. After four weeks of intervention, the patient demonstrated significant improvement in depression, cognition, and balance, whereas the BDI score declined from moderate 21/63 to mild 15/63 level of depression. The Mini-Cog score improved from 2/5 to 4/5, and the BBS score increased from 18/56 to 37/56. It is concluded that AOT along with usual physiotherapy intervention helps to reduce depression, improve cognition and balance of people with AD.

关键词： Alzheimer’s Disease Action Observation Therapy Physiotherapy Intervention

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Nutritional Composition and Bioactive Compounds of Bael (Aegle marmelos) and Development of Functional Food Products

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Food and Nutrition Sciences 2023年第4期14卷 328-340页

作者： Sajon Kumar Biswas md. Zainul Abedin Biddut Chandra Dey md. sajib Al Reza Luthfunnesa Bari md. Abu Zubair Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Tangail Bangladesh Postharvest Technology Division Bangladesh Agricultural Research Institute (BARI) Gazipur Bangladesh

Aegle marmelos, widely known as bael, belongs to the Rutaceae family. It is one of the most inexpensive and appealing fruits, considered to be an essential source of natural antioxidants and bioactive components. The major purpose of the research study was to investigate the nutritional composition and bioactive constituents of bael pulp, as well as to develop new value-added products that maintain the maximum quantity of nutrients. The developed food products were subjected to evaluate sensory attributes according to a nine-point hedonic scale. It was found that the moisture, protein, fat, crude fiber, and total ash content of bael fruit pulp were 61.20%, 2.48%, 0.47%, 3.04%, and 1.29%, respectively. When compared to the catechin standard, the antioxidant activity of such extract indicated good antioxidant capacity, with an IC50 value of 75.68 μg/ml for methanol extract. Vitamin C content was about 10.21 mg/100g. Besides, total flavonoid and phenolic contents were found as 140 mg of Quercetin Equivalent (QE)/g and 106.65 mg of Gallic Acid Equivalent (GAE)/g, respectively. Results of sensory attributes revealed that there was a significant difference (P ba and bael bar. The overall acceptability of bael murabba (6.7) and bael bar (7.1) is acceptable in quality, but their specific characteristics were found slightly different by the test panelists. These products might be applicable for the treatment of several diseases like atherosclerosis, diabetes, constipation, irritable bowel syndrome, peptic ulcer, tumor, and osteoporosis.

关键词： Bael Aegle marmelos Bioactive Compounds Antioxidant Activity Bael Murabba and Bar

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Analysis of Proteotranscriptomics Landscape Reveals Differentially Regulated Pathways in Toxoplasma gondii Infected Mouse Liver

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Computational Molecular Bioscience 2022年第1期12卷 20-57页

作者： Tanzina Tarannum md. Saruar Alam Atiqur Rahman sajib Chakraborty hossain Uddin Shekhar Taibur Rahman Laboratory of Infection Biology Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh Laboratory Clinical Biochemistry and Translational Medicine Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh

Toxoplasma gondii (T. gondii) an intracellular protozoan parasite, infects mammals including human population world-wide. Upon primary infection, the parasite contributes to mild flu like symptoms in immune competent host, but life threatening complication is seen in immune compromised patients and in pregnant women. Understanding the host-parasite interaction is critical for understanding the pathogenesis and biology parasite reactivation in the host. In this study, we used proteotrasncriptomics analyses by integrating the transcriptomics and proteomics data of T. gondii infected mouse liver to uncover the effector molecules responsible for disease pathogenesis that can be used as candidate markers for diagnosis and drug target. With this aim, we systematically integrated transcriptomicand proteomic data, representing the parasite infected mouse liver. Out of 2758 differentially expressed genes (DEGs) and 301 differentially expressed proteins (DEPs), 159 overlapping genes were identified. Among them, 86 genes were upregulated and 72 were downregulated in their respective mRNA and protein levels in the infected condition. Gene Ontology (GO) analysis revealed that the upregulated genes were mostly associated with immune system processes whereas the downregulated genes were involved in oxidation-reduction process and metabolism of lipid, and fatty acids. Protein-protein interaction (PPI) network analysis uncovered an interaction-hub including, Psmb8, Psmb9 and Tap1 for upregulated proteins and Cyp1A2, Cyp4A10 and Cyp3A11 for down-regulated proteins. Further studies are needed to validating these effector molecules. These molecules are likely to play a vital role in disease pathogenesis, as well as can be used as potential diagnostic marker and drug target candidates.

关键词： Toxoplasma gondii Transcriptome Proteome Mouse Liver Differentially Expressed Genes and Proteins Gene Ontology Analysis Protein-Protein Interaction hub-Proteins homology Modeling Effector Molecules

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Nutritional, Textural, Sensory Properties and Storage Stability Evaluation of Newly Formulated Strawberry Bar

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Food and Nutrition Sciences 2023年第4期14卷 287-299页

作者： Nargis Akter md. sajib Al Reza md. Esrafil md. Al Amin Sonyia Akter Neaz Morshed Reza md. Nazmul huda Nasim Pratima Roy Dina Department of Food Technology and Nutritional Science Faculty of Life Science Mawlana Bhashani Science and Technology University Santosh Bangladesh Department of Biological Sciences Graduate School of Science Tokyo Metropolitan University Hachioji Japan Department of Chemistry and Biochemistry The University of Texas at Arlington Arlington USA

An analytical study was conducted to develop a strawberry bar and analysis of the nutritional quality and storage stability of a newly formulated strawberry bar. In proximate analysis moisture, ash, ph, acidity, vitamin C, total phenolic content, and antioxidant of strawberry pulp were found 82%, 0.5%, 2.57, 1.38%, 49 mg/100g, 0.33%, 75.17% whereas, in the strawberry bar, it was found 18%, 0.71%, 2.10, 1.10%, 22 mg/100g, 0.14%, 56.13% respectively. For textural properties analysis, the textural profile of the strawberry bar such as hardness, factorability, viscosity, cohesiveness, adhesiveness, springiness, gumminess, chewiness, probe diameter, threshold, filtering range of strawberry bar was found 5.538 × 104 N/m, 0.000 N/m2, 1.687 × 104 N/m2, 0.6636, 2.908 × 103 J/m3, 0.8664, 3.675 × 104 N/m2, 3.184 × 104 N/m2, 20.000 mm, 5 N, 0.4 N respectively whereas the maximum level was 17.4 N at 29.628 seconds and the minimum level was -5.3 N at 30.166 seconds. The sensory evaluation of the strawberry bar was conducted based on nine-point hedonic scales. The sensory evaluation results indicated that the appearance of the strawberry bar was liked very much and the taste, texture, color, aroma, and overall acceptability of the strawberry bar were liked moderately by panelists. In microbiological analysis, the Total Viable Count (TVC) and Total Coliform Count (TCC) of the strawberry bar were found safe levels for up to third days. But on the sixth day, the TCC of the strawberry bar was not found and the TVC of the strawberry bar was found 17 × 104 cfu/g respectively which is higher than the permitted value (Gulf Standard: 105 cfu/g). From the microbial point of view, the newly formulated strawberry bar was safe to consume for up to 3 days but not for 6 days.

关键词： Strawberry Pulp Strawberry Bar Antioxidant Sensory Evaluation Texture Gallic Acid

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十字形钢管混凝土柱抗震性能有限元分析

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四川建材 2022年第4期48卷 89-91页

作者： md.sajib hossain 刘孝禹肖家浩翟荃杨浩长江大学城市建设学院湖北荆州434023 深圳市恒泰基建筑工程有限公司广东深圳518055

使用ABAQUS软件建立了9个十字形钢管混凝土柱模型,并对其进行了低周反复荷载下的抗震试验。分析了钢管壁厚、长宽比和轴压比对十字形钢管混凝土柱抗震性能的影响。通过与实际试验对比得出结论:本文提出的有限元模型可以较为准确地预测... 详细信息

使用ABAQUS软件建立了9个十字形钢管混凝土柱模型,并对其进行了低周反复荷载下的抗震试验。分析了钢管壁厚、长宽比和轴压比对十字形钢管混凝土柱抗震性能的影响。通过与实际试验对比得出结论:本文提出的有限元模型可以较为准确地预测试件的破坏模式和极限承载力,证明本文模型有较好的可行性;十字形钢管混凝土柱的极限承载力与钢管壁厚和长宽比成正相关,与轴压比成负相关。

关键词：异形钢管混凝土组合柱抗震性能有限元分析

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Effect of Mg Addition on the Structure and Properties of Al-4.5 Cu-3.4 Fe <i>In-Situ</i>Cast Composite

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Journal of Materials Science and Chemical Engineering 2020年第3期8卷 66-73页

作者： Nurul Afsar Chowdhury md. Arifur Rahman Khan sajib Aninda Dhar Department of Materials and Metallurgical Engineering Bangladesh University of Engineering and Technology Dhaka Bangladesh Pilot Plant and Process Development Centre (PP & PDC) Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh

Ternary Al-4.5 (wt%) Cu-3.4 (wt%) Fe in-situ composite was prepared at 1100°C by conventional casting method. however, this particular alloy contains larger needle-shaped intermetallics of Al3Fe phase. These exert adverse effect on the mechanical properties of the alloys. The larger shape and uneven orientation of the intermetallic were found to be responsible for the degradation of properties. The main purpose of this study was to modify the geometry of those needles by adding magnesium (Mg) as a fourth material. A series of alloys were prepared by adding 4, 6, 8, 10, wt% Mg in Al-4.5 (wt%) Cu-3.4 (wt%) Fe alloy. Microstructures were observed by optical microscopy. Mechanical properties like ultimate tensile strength, % elongation, % area reduction, hardness and wear test were determined. The study revealed that Mg transformed the needles of Al3Fe into globular shape which gave the alloys better mechanical properties.

关键词： Metal Matrix Composites (MMCs) Intermetallic Compounds Al-Cu-Fe Alloy In-Situ Composite Mg Addition

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Development of Web Based Online Medicine Delivery System for COVID-19 Pandemic

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Journal of Software Engineering and Applications 2021年第1期14卷 26-43页

作者： Mohammad Monirujjaman Khan md. Rabbi Amin Abdullah Al Mamun Ahsan Ahmed sajib Department of Electrical and Computer Engineering North South University Dhaka Bangladesh

Average Bangladeshis spend a significant amount of income on medicine. A reliable and fast online medicine delivery system is not ubiquitous. Most people buy medicine from the local Pharmacies. They need to go to medicine stores to buy the specific medicine prescribed by the specialized doctors. Sometimes all prescribed medicines are not available in local Pharmacies therefore people need to go to other areas to buy the medicines. It is very time consuming and people need to spend money as well for this. In our country, traffic jams are a very big problem. People waste longer time on the road due to traffic jams. here most of the pharmacies are closed at night time but sometimes in an emergency situation medicine is very essential. In this case an online web based e-commerce medicine delivery system is needed very much. In addition, currently the whole world is suffering due to COVID-19 pandemic. Coronavirus is very contagious which we all know. In this pandemic time it is not risk free to go out to buy medicine from the pharmacies. Due to COVID-19, medicine scarcity is also an important issue. In this situation, an online medicine delivery system can play an important role. By considering the above mentioned facts, a reliable and fast online solution is proposed. This paper presents the development of a web based online medicine delivery system. A reliable, fast, safe and user-friendly online based e-commerce web application has been developed in this paper. Medicine delivery system has also been included with this proposed system. This platform is a dynamic web application built in hypertext Preprocessor (PhP) based Laravel framework with a powerful back end. It is hosted on a dedicated Virtual Private Server (VPS). This system is lightning fast and optimized very well for searching engines. With the help of the developed platform, drugs will be available at one’s doorstep very fast, safely and r

关键词： Medicine Delivery Online Laravel Framework PhP MySQL CSS AJAX Android Web Application Virtual Private Server COVID-19 Pandemic E-Commerce

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Investigation of the Potential Association between Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and Antibiotic Resistance Pattern of Bacterial Strains Isolated from Medical Waste and Environmental Water

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Open Journal of Medical Microbiology 2018年第2期8卷 13-25页

作者： md.Shahariar Alam sajib Chakraborty Taibur Rahman md.Ismail hosen Anik Paul A.K.M.Mahbub hasan M.Anwar hossain Department of Biochemistry and Molecular Biology University of DhakaDhakaBangladesh

Enterobacteriaceae are important human pathogens that cause many food and waterborne illness. Rapid emergence of multi-drug resistant bacteria in Bangladesh has become a serious problem. Phage-host interaction is now considered as the major driving force for the conversion of non-pathogenic bacteria to pathogenic ones. Evolution of highly pathogenic and antibiotic resistant bacteria largely depends upon the horizontal gene transfer by means of plasmid, megaplasmid and bacteriophages. Conversely, bacteria may acquire a novel defence mechanism called CRISPR (Clustered regularly interspersed short palindromic repeats) that can restrict horizontal transfer of plasmids and bacteriophages to limit the spread of antibiotic resistance genes among bacterial species. In this study, twenty bacterial strains were isolated from water of different medical waste and Buriganga river. Therefore, CRISPR locus was investigated following various biochemical and molecular analysis of those bacterial isolates. Identification of the bacterial isolates was conducted by Polymerase Chain Reaction (PCR) based assay of 16S rDNA extracted from those isolated strains. Results indicated that most strains were identified as Proteus mirabilis and Citrobacter freundii which mainly cause septicemia, and pneumonia in human. Thereafter, antibiogram of these strains was performed by using 11 different antibiotic discs where bacterial isolates from medical drainage system showed more resistant to antibiotics than the river water. In this study, CRISPR locus was also investigated within the genome of the isolated bacterial stains but unexpectedly, we did not find any CRISPR locus in their genome. In conclusion, we confirm that multi-drug resistant bacterial strains are devoid of CRISPR locus suggesting a possible negative association between CRISPR locus and antibiotic resistance. Further studies to pinpoint are required to elucidate the underlying mechanism of the association between CRISPR and antibioti

关键词： Enterobacteriaceae Antibiotic Resistance Proteus Mirabilis Citrobacter freundii CRISPR-Cas

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