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Pharmacokinetic Comparison and Bioequivalence Evaluation of Two 20-mg Vonoprazan Fumarate Tablets in Bangladeshi Healthy Male Subjects

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Journal of Biosciences and Medicines 2024年第8期12卷 230-243页

作者： md. Alimur Reza Uttom Kumar Bhowmik Sabrina Akter Tushi Nayan Ghosh Nithon Chandra Sahana md. ashraful islam Nafisa Ahamed Arifa Akram Novus Clinical Research Services Ltd. Dhaka Bangladesh Medical College for Women & Hospital Dhaka Bangladesh National Institute of Laboratory Medicine & Referral Centre (NILMRC) Dhaka Bangladesh

Background: Vonoprazan fumarate, a novel potassium-competitive acid blocker, outperforms traditional proton pump inhibitors in acid suppression and can be effectively combined with antibiotics to eradicate Helicobacter pylori. Objective: The study aimed to determine if two Vonoprazan formulations—Vonoprazan Fumarate 20 mg Tablet of Beximco Pharmaceuticals Limited, Bangladesh (test product) and Takecab 20 mg Tablet of Takeda Pharmaceutical Company Limited, Japan (reference product)—met FDA’s bioequivalence requirements by comparing their pharmacokinetic characteristics in healthy Bangladeshi adults. Methods: This was a single-center, randomized, open-label, two-period, two-sequence, laboratory-blind, double-crossover experiment. After 10 hours of fasting, 18 subjects were randomly assigned to receive a single oral dose of either formulation. During each treatment period, blood samples were collected at specific times (pre-dose and up to 48 hours post-dose) to measure plasma Vonoprazan levels using liquid chromatography-tandem mass spectrometry. A non-compartmental model was used to calculate pharmacokinetic parameters using the plasma drug concentration-time profile. A statistical comparison of the pharmacokinetic parameters of the two formulations of the test and reference product was conducted using SAS® statistical software to assess the bioequivalence. Primary pharmacokinetic parameters (Cmax, AUC0-t, and AUC0-∞) and secondary parameters (Tmax, T1/2, Kel, and AUC extrapolation) were calculated for both drug formulations. If the confidence intervals for the natural log-transformed Cmax, AUC0-t, and AUC0-∞ values fell between 80% and 125%, the drug products would be considered bioequivalent. Result: The geometric mean ratio of Vonoprazan between the test and reference groups was found to be 109.04% (99.47% - 119.53%), 101.37% (95.58% - 107.50%), and 101.24% (95.43% - 107.41%), with 90% confidence intervals (CIs) for the Cmax, AUC0–t, and AUC0–∞, and these outcomes

关键词： Bioequivalence Vonoprazan Pharmacokinetics

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TaARPC5 is required for wheat defense signaling in response to infection by the stripe rust fungus

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The Crop Journal 2022年第1期10卷 88-97页

作者： Jia Guo Huan Peng Tuo Qi Sanding Xu md ashraful islam Brad Day Qing Ma Zhensheng Kang Jun Guo State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityYangling 712100ShaanxiChina Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMI 48824USA

Numerous studies using a combination of confocal microscopic-and pharmacological-based approaches have demonstrated that the actin cytoskeleton dynamically responds to pathogen ***,we observed that phalloidin treatment induced actin nucleation,resulting in enhanced resistance of wheat against the stripe rust pathogen Puccinia striiformis ***(Pst).To define the mechanism underpinning this process,we characterized a family of conserved actin-binding proteins,the actin related protein(ARP)family,which controls actin ***,we identified and characterized a wheat ARPC gene(Ta ARPC5),which encodes a 136-amino acid protein containing a P16-Arc domain,the smallest subunit of the ARP2/3 *** ARPC5 m RNA accumulation was induced following the infection of plants with the avirulent Pst strain,and following the elicitation with flagellin(e.g.,flg22)as *** localization analysis revealed that Ta ARPC5 is primarily localized to the cortical actin cytoskeleton,and its precise cellular localizations suggest the proximity to processes correlated with the actin-organelle *** treatment with virulent Pst,Ta ARPC5-knockdown plants exhibited a significant reduction in the expression of PTI-specific m ***,we observed enhanced induction of reactive oxygen species(ROS)accumulation and a decrease in Ta CAT1 expression following infection with an incompatible Pst *** with yeast complementation assays,the current study demonstrates a role for Ta ARPC5 in resistance signaling in wheat against Pst infection by regulating the host actin cytoskeleton.

关键词： ARPC5 Cytoskeleton Wheat Puccinia striiformis f.sp.tritici Virus-induced gene silencing(VIGS)

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Stripe Rust Effector PstGSRE1 Disrupts Nuclear Localization of ROS-Promoting Transcription Factor TaLOL2 to Defeat ROS-Induced Defense in Wheat

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Molecular Plant 2019年第12期12卷 1624-1638页

作者： Tuo Qi Jia Guo Peng Liu Fuxin He Cuiping Wan md ashraful islam Brett M.Tyler Zhensheng Kang Jun Guo State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiP.R.China Center for Genome Research and Biocomputing Oregon State UniversityCorvallisORUSA

Puccinia striiformis ***(Pst),a biotrophic plant pathogen,secretes numerous effectors to modulate host defense *** the molecular mechanisms by which Pst effectors regulate wheat immunity is of great importance for the development of novel strategies for durable control of stripe *** this study,we identified a glycine-serine-rich effector gene,PstGSRE1,which is highly induced dur-ing early *** expression of PstGSRE1 RNAi constructs in wheat significantly reduced virulence of Pst and increased H2O2 accumulation in ***1 was shown to target the reactive ox-ygen species(ROS)-associated transcription factor TaLOL2,a positive regulator of wheat ***1 disrupted nuclear localization of TaLOL2 and suppressed ROS-mediated cell death induced by TaLOL2,thus compromising host *** work reveals a previously unrecognized strategy whereby rust fungi exploit the PstGSRE1 effector to defeat ROS-associated plant defense by modulating the subcellular compartment of a host immune regulator and facilitate pathogen infection.

关键词： host-induced gene silencing effector glycine-serine-rich transcription factor Puccinia striiformis f.sp.tritici reactive oxygen species

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Characterization, prevalence and antibiogram study of Staphylococcus aureus in poultry

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 253-256页

作者： Yeasmeen Ali md.ashraful islam Nazmul Hasan Muzahid Mohd.Omar Faruk Sikder md.Amzad Hossain Lolo Wal Marzan Department of Genetic Engineering & Biotechnology University of Chittagong Graduate School of Biomedical Sciences Texas Tech University Health Sciences Center

Objective: To reveal the presence of methicillin resistant Staphylococcus aureus(S. aureus)(MRSA) in poultry samples and to determine the antibiogram pattern against five ***: Samples from different poultry farm of Chittagong city, Bangladesh were examined for S. aureus by different biochemical tests and confirmed as MRSA by identifying the presence of mec A gene using PCR. Antibiotic resistance pattern in S. aureus was determined by antibiotic disk diffusion ***: In this study, a total of 60 samples(30 from nasal swabs and 30 from cloacal swabs) were used, of which 54 were confirmed as S. aureus by different biochemical tests. Among these, 12 were confirmed as MRSA by detecting mec A gene using *** antibiogram study, both nasal and cloacal samples showed the highest resistance against penicillin-G and the lowest resistance was observed against ***: Based on the present study, it can be said that different antibiotics are used extensively in poultry that leads to MRSA and is alarming for human health.

关键词： Antibiogram Zoonotic transmission Swab mecA gene Opportunistic fungus

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A candidate effector protein PstCFEM1 contributes to virulence of stripe rust fungus and impairs wheat immunity

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Stress Biology 2022年第1期2卷 428-439页

作者： Xingxuan Bai Huan Peng Farhan Goher md ashraful islam Sanding Xu Jia Guo Zhensheng Kang Jun Guo State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina

Common in Fungal Extracellular Membrane(CFEM)domain proteins are considered to be unique to fungi and closely related to ***,the Puccinia striiformis ***(Pst)effector containing the CFEM domain has not been ***,we obtained an effector,PstCFEM1,containing a functional N-terminal signal peptide sequence and the CFEM domain from Pst race ***-PCR assay indicated that the transcript levels of PstCFEM1 were highly induced during the early stages of *** of PstCFEM1 suppressed Pst322(an elicitor-like protein of Pst)-trigged cell death,reactive oxygen species(ROS)accumulation and callose ***-induced gene silencing(HIGS)experiments showed that knockdown of PstCFEM1 decreased the virulence of Pst,while ROS accumulation in silenced plants increased near the infection *** addition,wheat containing the PstCFEM1-silenced construct increased resistance to multiple races of *** data suggest that PstCFEM1 suppresses wheat defense by inhibiting ROS accumulation and contributes to increased virulence of Pst.

关键词： Pst CFEM domain Effector Virulence Wheat

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A Modified and Secured RSA Public Key Cryptosystem Based on “n” Prime Numbers

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Journal of Computer and Communications 2018年第3期6卷 78-90页

作者： Muhammad Ariful islam md. ashraful islam Nazrul islam Boishakhi Shabnam Department of Information and Communication Technology (ICT) Mawlana Bhashani Science and Technology University Tangail Bangladesh Uttara University Dhaka Bangladesh

Cryptography is the study that provides security service. It concerns with confidentiality, integrity, and authentication. Public key cryptography provides an enormous revolution in the field of the cryptosystem. It uses two different keys where keys are related in such a way that, the public key can use to encrypt the message and private key can be used to decrypt the message. This paper proposed an enhanced and modified approach of RSA cryptosystem based on “n” distinct prime number. This existence of “n” prime number increases the difficulty of the factoring of the variable “N” which increases the complexity of the algorithm. In this approach, two different public key and private key generated from the large factor of the variable “N” and perform a double encryption-decryption operation which affords more security. Experiment on a set of a random number provided that the key generation time, analysis of variable “N”, encryption and decryption will take a long time compared to traditional RSA. Thus, this approach is more efficient, highly secured and not easily breakable.

关键词： RSA Algorithm Encryption Decryption Cryptosystem Security Public Key Private Key

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Thickness, Distribution and Quality Assessment of Gopalganj-Madaripur Peat Deposits: A Case Study of Potential Economic Opportunities in Mid-Eastern Low-Lying Bangladesh

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International Journal of Geosciences 2014年第9期5卷 943-955页

作者： Mrinmoy Kumar Maitra md. ashraful islam md. Al Mamun Department of Geological Sciences University of Canterbury Christchurch New Zealand Department of Geology University of Dhaka Dhaka Bangladesh Padma Mining & Energy Corporation Limited Dhaka Bangladesh

The present research work illustrates the extent, distribution and a generalized quality assessment of southern low-lying peat deposits in Madaripur and part of Gopalganj district that covers approximately 17,000 hectare areas. Based on the survey of 800 boreholes, drilled in this region at different times by several government and non-government organizations for the purposes of peat exploration and hydrogeological investigation, reveals that the study area is composed of a considerable amount of peat deposits in various localities among which the deposits at Baghia-Chanda beel in Madaripur and Gopalganj districts are the most remarkable. The average peat thickness (in-situ condition), studied during field investigation, is 6.5 feet for the upper peat deposits, overlying with an average of 3.5 feet of alluvium cover, followed by the lower peat layer of about 3 feet thick that begins at an average depth of 8 feet and separated by a thin bluish grey silty clay sediments from the upper one. The lower part of the study area, locally known as beels, is the most prospective region for peat, whereas the western part is less potential either having no peat intersection or minimal peat thickness. The overburden covers, on the other hand are inversely correlated with the peat thicknesses, i.e., thick overburden tend to correlate with thin peat deposits and the thickest peat intersections have no or minimal overburden. Due to the variation in bulk density and peat depth, this Holocene peat has an average of 59.10% carbon stock. Nitrogen levels, more than 3%, indicate that the peat developed from the decomposition of reeds, sedges, bushes and trunks of trees (higher in nitrogen) rather than either moss or grass (lower in nitrogen). Higher sulphur content (about 2.7%) reflected the influence of brackish environments where the formation of FeS2 took place in the roots of existing vegetation. The calorific values, about 1308.8 k-cal/kg (after 20% moisture reduction), suggest that

关键词： Bengal Basin Depression Incipient Peat Proximate Analysis

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Assessment of Physicochemical and Bacteriological Quality of Different Surface Water Samples of Tangail District, Bangladesh

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Advances in Microbiology 2017年第11期7卷 769-789页

作者： Nasreen Jahan Safaiatul islam Fatematuz Zuhura Evamoni md. Jakir Hossain Sabiha Akter md. Ronzu Ahmmed md. ashraful islam Shahin Mahmud Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Santosh Tangail Department of Biotechnology and Genetic Engineering Noakhali Science and Technology University Sonapur Noakhali Bangladesh Department of Environmental Science and Resource Management Mawlana Bhashani Science and Technology University Santosh Tangail Department of Statistics Mawlana Bhashani Science and Technology University Santosh Tangail

Surface water, a vital element of ecosystem must be hygienic, but unfortunately the pollution of this water is now an alarming problem. The present work deals with the assessment of physicochemical and bacteriological profile of several untreated surface water sources to ensure its suitability for using domestic purposes and drinking along with the impact of bacterial contaminated water on public health and antibiotic resistance pattern of these bacteria. The samples were collected from twenty sampling point (13 ponds, 4 lakes, 2 rivers and one canal) of Tangail District from January 2017 to July 2017. To understand the seasonal variation, water samples were measured in two month;February (dry season) and June (wet season). Most of the water sampling points were polluted by dumping of waste, cattle wash and were not suitable for the drinking or other domestic purposes. Obtained results showed that water of the study area is slightly alkaline, no remarkable variation in the temperature of the water in both seasons and DO of all the sampling station were lower than standard limit during February. The mean concentration (M.C.) of total Coliform were 4 × 1022 cfu/100ml and 4.5 × 1018 cfu/100ml at February and June respectively and all the sampling point were contaminated with fecal coliform. Other pathogenic bacteria, E. coli (M.C: 1.1 × 1011 cfu/100ml at February and M.C: 2.2 × 107 cfu/100ml at June), Salmonella spp. (M.C: 1.1 × 105 cfu/100ml at February and M.C: 3.4 × 105 cfu/100ml at June), Shigella spp. (M.C: 8 × 104 cfu/100ml at February and M.C: 3.4 × 107 cfu/100ml at June), Vibrio spp. (M.C: 8.6 × 105 cfu/100ml at February and M.C: 1.1 × 108 cfu/100ml at June) were isolated from several of the investigated water sources. The total counts of these pathogenic bacteria exceeded the acceptable limit during both season and also showed resistance against a broad range of commercially available antibiotics. People who were using these water frequently suffering from var

关键词： pH Dissolved Oxygen Coliform E. coli Shigella spp. Salmonella spp. Vibrio spp. Antibiotic Tangail

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Geochemistry of Neogene Mudrocks from Sitakund Anticline, Bengal Basin: Implications for Provenance, Weathering, Tectonic Setting and Depositional Environment

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Journal of Geoscience and Environment Protection 2017年第6期5卷 147-171页

作者： md. Yousuf Gazi S. M. Mainul Kabir md. Badrul Imam Aminur Rahman md. ashraful islam Department of Geology University of Dhaka Dhaka Bangladesh Institute of Mining Mineralogy and Metallurgy Joypurhat Bangladesh

Geochemical analysis of Neogene mudrocks from Sitakund anticline, Chittagong Tripura Fold Belt (CTFB), Bengal Basin, Bangladesh, was deployed to delineate the provenance, tectonics and depositional environments. Representative samples went through mineralogical and geochemical analysis concerning major, trace and rare earth element analysis. Rigaku ZSX Primus and NITON XL3t 800 XRF instruments were utilized for the determination of major and trace elements. The experiment results reveal that the Neogene mudrocks are rich in silica having concentration of 58.10% to 62.60% with an average of 59.90%. Therefore, the geochemical response from the experiments apparently proved the existence of the active continental margin setting for the Neogene mudrocks. Different concentrations and ratios of major oxides satisfy that the mudrocks were derived from felsic source rocks. In addition, chemical index of alteration (CIA) values for the Neogene mudrocks vary from 67.81 to 77.57 with an average 74.41 indicating significant weathering at the source areas. Moreover, U/Th, Cu/Zn, Ni/Co and V/Cr ratios designate that the mudrocks were deposited in oxidizing depositional environment.

关键词： Geochemistry Neogene mudrocks Tectonic setting Provenance Weathering Depositional Environment Sitakund Anticline and Bengal Basin

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小麦衰老相关基因TaSAG39的生物信息学及表达模式分析

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华北农学报 2022年第2期37卷 18-27页

作者：孙丽丽晋秀娟赵锴 md ashraful islam 卢娟王曙光孙黛珍山西农业大学农学院山西太谷030801 省部共建有机旱作农业国家重点实验室(筹) 山西太原030031

半胱氨酸蛋白酶是蛋白质降解过程中的一类水解酶,参与植物的衰老与成熟,在植物生长发育过程中发挥重要作用。基于前期得到的小麦衰老阶段转录组数据中筛选到一个衰老特异的半胱氨酸蛋白酶(SAG39),为了研究TaSAG39基因在小麦衰老过程中... 详细信息

半胱氨酸蛋白酶是蛋白质降解过程中的一类水解酶,参与植物的衰老与成熟,在植物生长发育过程中发挥重要作用。基于前期得到的小麦衰老阶段转录组数据中筛选到一个衰老特异的半胱氨酸蛋白酶(SAG39),为了研究TaSAG39基因在小麦衰老过程中发挥的作用,采用生物信息学分析方法和实时荧光定量(qRT-PCR)技术对TaSAG39的基因结构和表达模式进行分析。结果表明,其氨基酸序列与小麦祖先种节节麦、野生二粒小麦以及硬粒小麦亲缘关系最近,含有木瓜蛋白酶亚家族特有的活性位点Cys-His-Asn以及EFNIN结构。TaSAG39-5A、TaSAG39-5B、TaSAG39-5D基因组全长分别为1455,1435,1439 bp,编码序列长分别为1041,1050,1038 bp,均含2个外显子和1个内含子;其编码的蛋白分别由346,349,345个氨基酸组成,分子质量约37 ku,等电点5.53~5.67,为稳定的带负电的亲水性蛋白;主要构成元件为无规则卷曲和α-螺旋,在蛋白质N段含有信号肽,具有保守的Inhibitor_I29和Peptidase_C1结构域,含有35~37个磷酸化位点,其中以丝氨酸磷酸化位点和苏氨酸磷酸化位点为主。TaSAG39蛋白可能与半胱氨酸蛋白酶抑制剂以及14-3-3蛋白互作,该基因启动子中含有脱落酸、茉莉酸甲酯、生长素、光、干旱、低温以及胁迫响应等有关的顺式作用元件。qRT-PCR结果证实,TaSAG39基因受自然衰老、黑暗、干旱、茉莉酸甲酯、高温、生长素诱导表达,在自然衰老过程中基因的诱导表达最为显著。

关键词：小麦 TaSAG39 半胱氨酸蛋白酶生物信息学分析表达模式

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