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Pancreatic acinar cell carcinoma:A comprehensive review

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World Journal of Gastroenterology 2022年第40期28卷 5827-5844页

作者： Luis Fernando Calimano-Ramirez Taher Daoud Dheeraj Reddy Gopireddy Ajaykumar C Morani Rebecca Waters kazim Gumus Albert Russell klekers Priya R Bhosale mayur k virarkar Department of Radiology University of Florida College of Medicine JacksonvilleJacksonvilleFL 32209United States Department of Diagnostic Radiology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Diagnostic Radiology University of Florida College of Medicine JacksonvilleJacksonvilleFL 32209United States Department of Pathology and Lab Medicine The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Research and Diagnostic Radiology University of Florida College of Medicine JacksonvilleJacksonvilleFL 32209United States

Acinar cell carcinoma(ACC)is a rare pancreatic malignancy with distinctive clinical,molecular,and morphological *** long-term survival of ACC patients is substantially superior to that of pancreatic adenocarcinoma *** there are no significant patient series about ACCs,our understanding of this illness is mainly based on case reports and limited patient *** resection is the treatment of choice for patients with the disease restricted to one organ;however,with recent breakthroughs in precision medicine,medicines targeting the one-of-a-kind molecular profile of ACC are on the *** are no standard treatment protocols available for people in which a total surgical resection to cure the condition is not *** a result of shared genetic alterations,ACCs are chemosensitive to agents with activity against pancreatic adenocarcinomas and colorectal *** role of neoadjuvant or adjuvant chemoradiotherapy has not been *** article aims to do a comprehensive literature study and present the most recent information on acinar cell cancer.

关键词： Acinar cell carcinoma Pancreas Imaging Immunohistochemical stains Molecular features Surgery Chemotherapy

Comments on"Review of the role of diagnostic modalities and imaging findings in the COVID-19 pandemic"

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World Journal of Radiology 2022年第2期14卷 50-54页

作者： Sai Swarupa R Vulasala Dheeraj R Gopireddy Priya Bhosale mayur k virarkar Department of Radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Diagnostic Radiology UT MD Anderson Cancer CenterHoustonTX 77030United States

The present letter to the editor corresponds to the article entitled“Comprehensive literature review on the radiographic findings,imaging modalities,and the role of radiology in the coronavirus disease 2019(COVID-19)pandemic”by Pal et al,published in World J Radiol.2021;13(9):*** zero to unknown prevalence,COVID-19 has created a heterogeneous and unforeseen situation across the *** providers encountered new challenges in image interpretation,characterization,and prognostication of the *** et al delineated the radiological findings,which would guide the radiologists to identify the early signs of severe infection.

关键词： COVID-19 Computed tomography Lung ultrasound COVID-19 scoring systems

Multilocular thymic cysts-a diagnostic challenge on computed tomography

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World Journal of Clinical Cases 2025年第3期13卷 61-65页

作者： Nirmal kumar Reddy Onteddu Naga Sai Rasagna Mareddy Sai Swarupa R Vulasala Jayabharath Onteddu mayur virarkar Department of Internal Medicine University of Florida College of MedicineJacksonvilleFL 32209United States Department of Diagnostic Radiology University of AlabamaBirminghamAL 35294United States Department of Diagnostic Radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Public Health Sciences University of FloridaGainesvilleFL 32611United States

A recent case report provided a patient scenario,wherein,a 39-year-old male patient presented with occasional palpitations,headache,and *** of tumor markers did not show any abnormal ***,a computed tomography(CT)scan was undertaken,and its findings were affirmative of thymic ***,the postoperative histopathological assessment of the mass,after its resection,confirmed it as an anterior mediastinal multilocular thymic cyst(MTC),with concurrent acute upper respiratory tract infection and acute ***,this case report advocates the need for a preoperative histopathological examination with CT imaging to minimize the risk of confusing an MTC with a malignant thymic tumor.

关键词： Imaging findings Multilocular thymic cyst Histopathology Thymic cancer Mediastinal mass

Hepatic Hemangioendothelioma: An update

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 248-266页

作者： mayur virarkar Mohammed Saleh Radwan Diab Melissa Taggart Peeyush Bhargava Priya Bhosale Department of Diagnostic Radiology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Radiology The University of Medical BranchGalvestonTX 77555United States

Primary epithelioid hemangioendotheliomas of the liver(EHL)are rare tumors with a low *** molecular background of EHL is still under investigation,with WWTR1-CAMPTA1 mutation may function as a tumor ***,this tumor is misdiagnosed with angiosarcoma,cholangiocarcinomas,metastatic carcinoma,and hepatocellular carcinoma(sclerosing variant).Characteristic features on imaging modalities such as ultrasound,computed tomography,magnetic resonance imaging and positron emission tomography/computed tomography guide in diagnosis and ***“halo sign”and the“lollipop sign”on computed tomography and magnetic resonance imaging are described in the ***,there are no standardized guidelines for treating EHL with treatment options are broad including:chemotherapy,ablation,surgery and liver transplantation with inconsistent results.

关键词： Epithelioid hemangioendotheliomas Halo sign Lollipop sign Angiosarcoma Cholangiocarcinomas Hepatocellular carcinoma

Revolutionizing palliative care:Electrocautery-enhanced lumenapposing metal stents in endoscopic-ultrasound-guided biliary drainage for malignant obstructions

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2358-2361页

Patients with malignant biliary obstruction,following endoscopic retrograde cholangiopancreatography(ERCP)failure could be referred for endoscopicultrasound-guided biliary drainage through electrocautery-enhanced(ECE)lumen-apposing metal stent(LAMS)***,the efficacy and safety of ECE-LAMS in this scenario have remained debatable due to minimal scientific *** current confirmed 91.0%clinical success,96.7%technical success,7.3%reintervention rate,and 17.5%adverse events,following the treatment of malignant biliary obstruction with ECE-LAMS ***,ECE-LAMS proved to be a generalizable strategy for managing biliary obstruction for patients who were excluded from ERCP.

关键词： Endoscopic retrograde cholangiopancreatography Electrocautery-enhancedlumen-apposing metal stent Biliary drainage Biliary stent Endoscopic ultrasound

Radiomics analysis with three-dimensional and two-dimensional segmentation to predict survival outcomes in pancreatic cancer

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World Journal of Radiology 2023年第11期15卷 304-314页

作者： Mohammed Saleh mayur virarkar Hagar S Mahmoud Vincenzo k Wong Carlos Ignacio Gonzalez Baerga Miti Parikh Sherif B Elsherif Priya R Bhosale Department of Diagnostic Radiology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Diagnostic Radiology The University of Florida College of MedicineJacksonvilleFL 32209United States keck School of Medicine University of South CaliforniaLos AngelesCA 90033United States

BACkGROUND Radiomics can assess prognostic factors in several types of tumors,but considering its prognostic ability in pancreatic cancer has been *** To evaluate the performance of two different radiomics software in assessing survival outcomes in pancreatic cancer *** We retrospectively reviewed pretreatment contrast-enhanced dual-energy computed tomography images from 48 patients with biopsy-confirmed pancreatic ductal adenocarcinoma who later underwent neoadjuvant chemoradiation and *** were segmented using TexRad software for 2-dimensional(2D)analysis and MIM software for 3D analysis,followed by radiomic feature *** proportional hazard modeling correlated texture features with overall survival(OS)and progression-free survival(PFS).Cox regression was used to detect differences in OS related to pretreatment tumor size and residual tumor following *** Wilcoxon test was used to show the relationship between tumor volume and the percent of residual ***-Meier analysis was used to compare survival in patients with different tumor densities in Hounsfield units for both 2D and 3D *** 3D analysis showed that higher mean tumor density[hazard ratio(HR)=0.971,P=0.041)]and higher median tumor density(HR=0.970,P=0.037)correlated with better OS.2D analysis showed that higher mean tumor density(HR=0.963,P=0.014)and higher mean positive pixels(HR=0.962,P=0.014)correlated with better OS;higher skewness(HR=3.067,P=0.008)and higher kurtosis(HR=1.176,P=0.029)correlated with worse *** entropy correlated with better PFS(HR=0.056,P=0.036).Models determined that patients with increased tumor size greater than 1.35 cm were likely to have a higher percentage of residual tumors of over 10%.CONCLUSION Several radiomics features can be used as prognostic tools for pancreatic ***,results vary between 2D and 3D *** tumor density was the only variable that could reliably predict OS,irrespective

关键词： Radiomics Pancreas Cancer Segmentation