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日本计量研究所的硅探测器辐射温度计的新进展

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国外计量 1988年第1期 30-32页

作者： F.sakuma 张雅芬

一、前言在420℃～1100℃温度范围内工作的辐射温度计,通常是以 IPTS 为依据,用一个比较黑体对照标准热电偶进行检定的。为改善检定精度,NRLM 使用固定点黑体及标准窄光带辐射温度计建立了一套新的辐射温度计传递体系。

关键词：辐射温度计光谱响应度温度范围输出电压黑体不接触式温度仪表分度值铜点

Curcumin Inhibits Adipogenesis Elicited by Clozapine in 3T3-L1 Cells

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Food and Nutrition Sciences 2018年第5期9卷 584-594页

作者： Satoru sakuma Maki Sumida Asami Sakabe Ayaka Nakamura Chisato Noda Kaho Tsujimoto Maimi Kobayashi Tomohiko Sano Yohko Fujimoto Tetsuya Kohda Department of Physiological Chemistry Osaka University of Pharmaceutical Sciences Osaka Japan

Although clozapine (CZP), which is used for schizophrenia treatment, causes weight gain, the mechanism remains unclear. We recently reported that the naturally occurring compound curcumin (CUR) suppresses adipogenesis in 3T3-L1 cells. The aims of the present study were to determine the mechanism by which CZP induces adipocyte differentiation of 3T3-L1 cells, and whether CUR reduces CZP-induced adipogenesis. We found that cells grown in the presence of CZP had significantly higher triacylglycerol levels, numbers of lipid-filled adipocytes, and mRNA expression levels of CCAAT-enhancer binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) than those grown without CZP. Treatment with CZP plus CUR resulted in major reductions in these four parameters. These results suggest that CZP enhances adipogenesis in 3T3-L1 cells via the C/EBPα-PPARγ pathway and that by interrupting CZP’s effects, CUR might be a potent agent for preventing CZP-induced weight gain.

关键词： Clozapine Curcumin Adipocyte Differentiation 3T3-L1 Cell Atypical Antipsychotic Drug

Disparity in clinical care for patients with inflammatory bowel disease between specialists and non-specialists

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Open Journal of Gastroenterology 2013年第1期3卷 64-71页

作者： Tomoko Hirakawa Jun Kato sakuma Takahashi Hideyuki Suzuki Mitsuhiro Akita Izumi Inoue Hisanobu Deguchi Sakiko Hiraoka Hiroyuki Okada Kazuhide Yamamoto Department of Endoscopy Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Second Department of Internal Medicine Wakayama Medical University Wakayama Japan

Background: Although inflammatory bowel disease (IBD) patients have been increasing and new thera-peutic options for IBD have been developed, there are relatively few clinicians who specialize in IBD. Patients treated by a non-specialist of IBD may not receive appropriate treatment. This study aimed to compare disease and medication status between IBD patients treated by a specialist and those treated by a non-specialist. Methods: Medical charts of ambulating IBD patients in two hospitals were examined. All patients in one hospital were treated by one of the IBD specialists, while in the other hospital, patients were treated by one of the gastroenterologists who was a non-specialist of IBD. Results: The numbers of IBD patients were 255 (hospital with specialists) and 74 (hospital without specialists), respectively. Disease activity of the patients was not well-controlled in the hospital without specialists compared to in the hospi- tal with specialists (ulcerative colitis (UC): p = 0.0006 and Crohn’s disease: p = 0.012, respectively). The proportion of UC patients who received an insufficient dose of mesalazine (Pentasa < 3 g/day or Asacol < 3.6 g/day) was higher in the hospital without specialists (47% vs. 15%, p < 0.0001). In the hospital without specialists, more patients received long-term corticosteroids (UC: 23% vs. 5%, p < 0.0001), while fewer patients received immunomodulators (UC: 8% vs. 46%, p < 0.0001). Conclusions: IBD patients of the hospital without specialists were not well-controlled and were not prescribed appropriately with thera-peutic drugs. Fostering and placement of the specialist of IBD is an urgent problem.

关键词： Inflammatory Bowel Disease Clinical Care Specialist

雌激素敏感指状蛋白(Efp)的表达与人晚期上皮性卵巢癌有关

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 37-38页

作者： sakuma M Akahira J.-I Suzuki T 朱亮 Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine 1- 1 Seiryo-machi Aoba-ku Sendai 980- 8574Japan

The estrogen-responsive ring finger protein (Efp)- gene, one of estrogen receptor (ER) target genes, is considered to be essential for estrogen-dependent cell proliferation. To understand the estrogenic action on ovarian cancer, we studied the relationships between Efp and ERs expressions and the correlations of Efp expression with clinicopathological parameters in epithelial ovarian cancer. Methods. The protein expressions for Efp, ERα and ERβ were examined by immunoblotting in 12 ovarian cancer cell lines. Efp mRNA expressions were evaluated by quantitative RT-PCR in 12 ovarian cancer cell lines. A total of 100 surgical specimens diagnosed as epithelial ovarian cancer were examined immunohistochemically using antibodies for Efp, ERα and ERβ . Results. Efp protein was detected in 8 out of 12 cell lines. In Efp protein-positive cell lines, Efp mRNA was expressed higher than that in negative (P = 0.021). All of the Efp protein-positive cell lines simultaneously expressed either ERα or ERβ protein. By immunohistochemical staining, Efp immunoreactivity was detected in 63 out of 100 ovarian cancer specimens and positive signals were in the cytoplasm of carcinoma cells. There were significant correlations between Efp and ERα , ERβ immunoreactivity (Efp and ERα , P = 0.022; Efp and ERβ , P = 0.032). Efp expression was significantly higher in a subgroup with serous adenocarcinoma (P = 0.010) and with advanced disease (P = 0.026). No significant relationship was detected between Efp immunoreactivity and overall survival. Conclusion. The expression of Efp was detected in human epithelial ovarian cancer and high expression of Efp was correlated with advanced disease and serous adenocarcinoma, and ERs status.

关键词：上皮性卵巢癌 Efp 雌激素活性卵巢癌细胞株浆液性腺癌免疫组化研究指状病理学参数细胞增殖

西洛他唑抑制白细胞整合素Mac-1可能降低冠状动脉支架植入术后再狭窄的发生

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 55-56页

作者： Inoue T. Uchida T. sakuma M. 陶蕾

The aim of this study was to confirm clinically a hypothesis that cilostazol i nhibits leukocyte Mac-1, leading to prevention of post stent restenosis. The p latelet phosphodiesterase III inhibitor called cilostazol also inhibits alpha g ranule release of P selectin in platelets. The P selectin mediated plateletle ukocyte interaction promotes activation and upregulation of leukocyte Mac 1 aft er coronary stenting, which plays a key role on the mechanism of restenosis. Thu s, cilostazols potential inhibition of this process may lead to prevention of restenosis. Using flow cytometric analysis of whole blood obtained from the coro nary sinus, the expression of platelet membrane glycoproteins and neutrophil adh esion molecules was observed in 70 consecutive patients undergoing coronary sten ting. The patients were randomly assigned to either a cilostazol or ticlopidine group before stent placement. The restenosis rate was lower (15%vs. 31%, p< 0. 05) in the cilostazol group (n=34)than in the ticlopidine group (n=32). A stent induced increase in platelet P selectin(CD62P) expression and an increase in neutrophil Mac-1 (CD11b) expression were suppressed in the cilostazol group com pared with the ticlopidine group. Angiographic late lumen loss was correlated wi th the relative changes in platelet P selectin and neutrophil Mac-1 at 48 h af ter coronary stenting. Cilostazol may have effects on suppression of P selectin mediated platelet activation, platelet leukocyte interaction, and subsequent Mac 1 mediated leukocyte activation, which might lead to a reduced restenosis rate after coronary stent implantation.

关键词：再狭窄 Mac-1 白细胞整合素西洛他唑选择素冠状动脉支架噻氯匹啶支架植入术血小板膜糖蛋白黏附分子

全心冠状动脉磁共振血管造影检测冠状动脉狭窄

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 56-57页

作者： sakuma H. Ichikawa Y. Chino S. 刘少伟 Department of Radiology Mie University HospitalMieJapan Dr.

目的:本研究旨在确定全心冠状动脉磁共振(MR)血管造影在检测显著冠状动脉疾病中的诊断价值。背景:全心冠状动脉MR血管造影的准确性尚未在大量患者中得到检验。

关键词：磁共振血管造影自由呼吸造影图像阴性预测值窗口期移动度心动周期高特异性

β肾上腺素能受体激动剂对离体大鼠肺泡液体清除率的作用

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中华结核和呼吸杂志 2005年第6期28卷 390-393页

作者：谷秀李胜岐佐久间勉中国医科大学附属第二医院呼吸内科沈阳110004 日本金泽医科大学呼吸器外科

目的探讨β1肾上腺素能受体激动剂地诺帕明、β2肾上腺素能受体激动剂特布他林、β3肾上腺素能受体激动剂BRL37344对离体大鼠肺泡液体清除率(AFC)的作用及机制。方法5%白蛋白等渗生理盐水溶液和不同药物混合后灌注到离体大鼠的肺泡腔内... 详细信息

目的探讨β1肾上腺素能受体激动剂地诺帕明、β2肾上腺素能受体激动剂特布他林、β3肾上腺素能受体激动剂BRL37344对离体大鼠肺泡液体清除率(AFC)的作用及机制。方法5%白蛋白等渗生理盐水溶液和不同药物混合后灌注到离体大鼠的肺泡腔内,根据灌注前及其孵育1h后白蛋白浓度的变化来计算大鼠AFC。结果基础AFC为6.9%±2.2%,地诺帕明、特布他林、BRL37344可显著提高AFC(分别为17.1%±2.4%、19.5%±1.2%、19.9%±2.5%)。β1肾上腺素能受体阻滞剂Atenolol可完全抑制地诺帕明提高AFC(6.1%±0.9%)的作用,但不能阻滞特布他林和BRL37344的作用。β2肾上腺素能受体阻滞剂ICI118551完全抑制了特布他林和BRL37344提高AFC(分别为5.7%±0.6%和7.8%±2.6%)的作用,部分抑制了地诺帕明的作用(AFC为12.7%±1.8%)。β3肾上腺素能受体阻滞剂SR59230A部分抑制了BRL37344和特布他林的作用(AFC分别为13.8%±3.1%和14.5%±3.4%),但不能阻滞地诺帕明的作用。结论地诺帕明、特布他林、BRL37344可以显著提高大鼠的AFC。但地诺帕明和特布他林是分别通过β1、β2肾上腺素能受体起作用;而BRL37344可能是通过β2肾上腺素能受体调节的。ICI118551和SR59230A可能分别具有抑制β1或β2肾上腺素能受体的作用。

关键词：肺泡液体清除率 β肾上腺素能受体激动剂离体大鼠 BRL-37344 β2肾上腺素能受体激动剂 β1肾上腺素能受体阻滞剂 Atenolol 地诺帕明特布他林 5%白蛋白白蛋白浓度 AFC 药物混合盐水溶液受体调节抑制 β3 灌注

Clinical Feature of Japanese Patients with Fulminant Myocarditis—Myocarditis in Japanese Patients

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International Journal of Clinical Medicine 2011年第3期2卷 260-263页

作者： Hiroaki Kawano Yasuhiro Nagayoshi Sunao Kojima Nahoko Kakihara Satoshi sakuma Masumi Uchino Aiko Komatsu Machiko Asaka Mitsuhiro Shimomura Hiroshige Yamabe Hisao Ogawa Koichi Node Department of Cardiovascular Medicine Saga University Saga Japan

Fulminant myocarditis is commonly recognized as an acute myocarditis with cardiogenic shock requiring mechanical support systems. Before the development of mechanical assist devices, previous study described that most of patients with fulminant myocarditis die at acute phase because of rapidly progressive cardiac decompensation. To investigate the feature of myocarditis, we checked consecutive 18 patients (10 men, 8 women, 12yr-80yr) from April in 2001 to September 2008 in University. Of these patients 3 needed intraaortic balloon pumping (IABP) (2 men, 1 woman), 6 did both IABP and percutaneous cardiopulmonary support (PCPS) (2 men, 4 women). Three patients who need both IABP and PCPS died (2 men, 49yr and 65yr, 1 woman, 54yr) because of uncontrolled bacterial infection. No patients whose age was under 40yr (5 men, 4 women) died although a man needed IABP and 3 women did both IABP and PCPS. Sixteen patients were able to resume a normal life although 1 male patient needed permanent pacemaker, 1 female did cardiac resynchronization therapy, and a male and a female had left ventricular systolic dysfunction. In conclusion, the young patients had better prognosis than older even if mechanical assist is needed. Although half of patients needed mechanical assist, the prevention of multi-organ complications including bacterial infection is one of the most important keys in the treatment of fulminant myocarditis.

关键词： Myocarditis Mechanical Support Immunosuppressive Therapy Immunomodulation Therapy

Dopamine cannot promote oligomerization of unoxidized <i>α</i>-synuclein

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Journal of Biophysical Chemistry 2013年第3期4卷 110-114页

作者： Sakurako Shimotakahara Mika Matsui Chiseko sakuma Teruaki Takahashi Takashi Fujimoto Kazuo Furihata Masaki Kojima Shohei Seino Tomoya Machinami Yoichi Shibusawa Kenji Uéda Mitsuru Tashiro Department of Chemistry School of Sciences and Engineering Meisei University Tokyo Japan Division of Agriculture and Agricultural Life Sciences The University of Tokyo Tokyo Japan School of Life Science Tokyo University of Pharmacy and Life Science Tokyo Japan School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan

α-Synuclein is the major component of the filamentous Lewy bodies and Lewy neurites that define neuropathological features of Parkinson’s disease and dementia with Lewy bodies. To investigate the oligomerization process of α-synuclein in association with dopamine (DA), the structural propensities to form oligomers were studied using NMR and other biophysical techniques. The1H-15N HSQC spectra indicated that both N- and C-termini interacted with DA. Although interactions with DA were also observed in the presence of glutathione by ESI-MS, the significant suppression of oligomerization was observed in the size exclusion chromatography, suggesting that oxidations of α-synuclein are required for its oligomerization.

关键词： α-Synuclein Dopamine Glutathione Oligomerization