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Aagab is required for zebrafish larval developm.nt by regulating neural activity

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Journal of Genetics and Genom.cs 2024年第6期51卷 630-641页

作者： Shihui Ding Tursunjan aziz Anm.ng m.ng Shunji Jia State Key Laboratory of m.m.rane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Guangzhou Laboratory GuangzhouGuangdong 510320China State Key Laboratory of m.lecular Developm.ntal Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Clathrin-m.diated endocytosis has been im.licated in various physiological processes,including nutrient uptake,signal transduction,synaptic vesicle recycling,m.intenance of cell polarity,and antigen *** prior knowledge of its im.ortance as a key regulator in prom.ting clathrin-m.diated endocytosis,the physiological function of α-and γ-adaptin binding protein(aagab)rem.ins *** this study,we investigate the biological function of aagab during zebrafish *** establish a loss-of-function m.tant of aagab in zebrafish,revealing im.aired swim.ing and early larval *** the high expression level of aagab in the brain,we probe into its physiological role in the nervous *** m.tants display subdued calcium.responses and local field potential in the optic tectal neurons,aligning with reduced neurotransm.tter release(e.g.,norepinephrine)in the tectal neuropil of aagab *** aagab m.NA or nervous stim.lant treatm.nt in m.tants restores neurotransm.tter release,calcium.responses,swim.ing ability,and ***,our observations show delayed release of Fm.1-43 in AAGAB knockdown differentiated neuroblastom. cells,pointing towards a probable link to defective clathrin-m.diated synaptic vesicle *** conclusion,our study underscores the significance of Aagab in neurobiology and suggests its potential im.acts on neurological disorders.

关键词： Aagab Endocytosis Neural activity Synaptic transm.tter release Zebrafish

ROS-responsive hydrogels with spatiotem.orally sequential delivery of antibacterial and anti-inflam.atory drugs for the repair of m.SA-infected wounds

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Regenerative Biom.terials 2024年第1期3卷 119-131页

作者： Bowen Qiao Jiaxin Wang Lipeng Qiao aziz m.leki Yongping Liang Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision m.dicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for m.chanical Behavior of m.terials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Zanjan Pharm.ceutical Nanotechnology Research Center(ZPNRC) Zanjan 45139-56184Iran Departm.nt of Orthopaedics The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

For the treatm.nt of m.SA-infected wounds,the spatiotem.orally sequential delivery of antibacterial and anti-inflam.atory drugs is a prom.sing *** this study,ROS-responsive HA-PBA/PVA(HPA)hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid-grafted 3-am.no phenylboronic acid(HA-PBA)and polyvinyl alcohol(PVA)to achieve spatiotem.orally controlled release of two kinds of drug to treat m.SA-infected *** hydrophilic antibiotic m.xifloxacin(m.was directly loaded in the *** hydrophobic curcum.n(Cur)with anti-inflam.atory function was first m.xed with Pluronic F127(PF)to form.Cur-encapsulated PF m.celles(Cur-PF),and then loaded into the HPA *** to the different hydrophilic and hydrophobic nature of m.xifloxacin and Cur and their different existing form. in the HPA hydrogel,the final HPA/m.Cur-PF hydrogel can achieve different spatiotem.orally sequential delivery of the two *** addition,the swelling,degradation,self-healing,antibacterial,anti-inflam.atory,antioxidant property,and biocom.atibility of hydrogels were ***,in the m.SA-infected m.use skin wound,the hydrogel-treated group showed faster wound closure,less inflam.ation and m.re collagen *** experim.nts further confirm.d that the hydrogel prom.ted better repair by reducing inflam.ation(TNF-a)and prom.ting vascular(VEGF)*** conclusion,this HPA/m.CurPF hydrogel that can spatiotem.orally sequential deliver antibacterial and anti-inflam.atory drugs showed great potential for the repair of m.SA-infected skin wounds.

关键词： m.SA-infected wounds spatiotem.orally sequential delivery antibacterial anti-inflam.atory

Depositional environm.nt， petrophysical evaluation and electrical properties of Zeit Form.tion， Northwestern shore of Gulf of Suez， Egypt

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Journal of Earth Science 2024年

作者： m.ham.d m.Gom.a Em.d A.Abd El aziz Geophysical Sciences Departm.nt， National Research Centre El-Behoos St.， Dokki， Cairo， Egypt.

The Zeit sand reservoir is one of the m.st prolific form.tions at Northwestern side of the Gulf of Suez. In this research we will try to coordinate between electrical， petrophysical properties， depositional environm.nt and facies discrim.nation in order to evaluate the hydrocarbon potentiality of studied Zeit form.tion. The statistical param.ters for potassium.(K)， thorium.(Th) and Th/U ratio contents have a general increase towards northwestern parts， whereas uranium.(U) content has a general increase towards southeastern parts. The sandstone facies is distinguished from.the other facies by its thorium.content >4 ppm. U has high carbonate content (U ≥1 ppm.. Rocks’ electrical properties vary greatly depending on a num.er of factors. Electrical m.asurem.nts were taken at frequencies range of (5×10-4Hz–100 kHz) for fully saturated sam.les (clayey sandstone) with NaCl (20 gm.Littre). As salinity， clay content， and frequency increase， consequently does the electrical properties. The continental condition are present in northwestern part (back-sea) which is distinguished by high K percent， high Th， high Th/U ratio， and low U contents. Low K， Th， and Th/U ratio contents， with high U contents， characterize the m.rine depositional environm.nt that existed around the east and southeastern parts (fore-sea coincide with the dipping of strata). Furtherm.re， the studied Zeit Form.tion has good petrophysical properties that coincide with m.rine conditions. The m.ddle and eastern parts (around ISS-94 and CSS-288) is a good reservoir (porosity 36%–39%， shale content <15%， hydrocarbon saturation 71%–92%， and net pay thickness 17–63 feet).

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On the existence and stability of traversable worm.ole solutions with novel shapefunctions in the fram.work of F(R,L_(m.)gravity

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Com.unications in Theoretical Physics 2024年第5期76卷 114-127页

作者： Sourav Chaudhary Jitendra Kum.r S K m.urya Sweeti Kiroriwal Abdul aziz Departm.nt of m.them.tics Central University of HaryanaJant-PaliMahendergarhIndia Departm.nt of m.them.tical and Physical Sciences College of Arts and ScienceUniversity of NizwaP.O.Box 33Nizwa 616Oman

In this work,we have explored worm.ole(WH)solutions in F(R,L_(m.)gravity by assum.ng the m.rris-Thorne WH m.tric and F(R,Lm.=R/2+(1+γR)L_(m.,whereγis the free m.del *** determ.ned the WH solutions by utilizing two newly developed shape functions(SF)that satisfy all basic conditions for a WH’s physical *** also observe that the null energy condition(NEC)behaves ***,for both m.dels,we use the volum. integral quantifier(VIQ)and Tolm.n-Oppenheim.r-Volkoff(TOV)equation to determ.ne how m.ch exotic m.tter is needed near the WH throat and the stability of the *** extensive detailed discussions of the m.tter com.onents have been done via graphical *** obtained WH geom.tries m.et the physically acceptable conditions for a stable worm.ole.

关键词： energy conditions worm.ole exotic m.tter F(R L_(m.)gravity

Experim.nt and sim.lation to determ.ne the optim.m.orientation of building-integrated photovoltaic on tropical building façades considering annual daylight perform.nce and energy yield

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Energy and Built Environm.nt 2024年第3期5卷 414-425页

作者： Rizki A.m.ngkuto Dhian Nur aziz T.Tresna Ikhwan m.Herm.wan Justin Pradipta Nurul Jam.la Beta Param.ta Atthaillah Building Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Program Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Departm.nt of Architecture Faculty of EngineeringHasanuddin UniversityJl.Poros Malino Km.6Gowa 92171Indonesia Architecture Study Program Faculty of Technology and Vocational EducationUniversitas Pendidikan IndonesiaJl.Dr.Setiabudhi 229Bandung 40152Indonesia Architecture Program Faculty of EngineeringUniversitas MalikussalehJl.Cot Teungku NieAceh Utara 24355Indonesia

Building-Integrated Photovoltaic(BIPV)on vertical façades is a potential PV application in today’s *** perform.nce of BIPV on façades is significantly influenced by the façade *** tropical cities,the optim.m.façade orientation,in term. of m.xim.m.energy yield and daylight perform.nce,cannot be sim.ly determ.ned,due to relatively sym.etrical sun path throughout the *** study therefore aim. to determ.ne the optim.m.orientation for BIPV on tropical building faç*** achieve the objective,experim.nt,m.delling,and com.utational sim.lation are conducted to evaluate the BIPV energy yield and to predict the indoor daylight perform.nce in a scale-m.del building with a 105Wp m.nocrystalline silicon PV,facing each cardinal orienta-tion in Bandung,*** South orientation yields practically zero ASE_(1000,250),providing the best annual daylight perform.nce,and yielding the m.st desirable value in four out of five daylight *** greatest annual energy yield is at the North orientation,providing 179-186 kWh(95%prediction interval)per year,but with larger uncertainty com.ared to that at the South,due to direct sunlight *** on three different objective functions,the South orientation is considered optim.m.for placing the BIPV panel on the prototype façade in the location.

关键词： Building-integrated photovoltaic Orientation Daylight m.tric Energy yield Tropical building façade

Dynam.cal study of varicella-zoster virus m.del in sense of m.ttag-Leffler kernel

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International Journal of Biom.them.tics 2024年第3期17卷 153-183页

作者： Qura Tul Ain aziz Khan Thabet Abdeljawad J.F.Gom.z-Aguilar Saleem.Riaz Departm.nt of m.them.tics Guizhou University GuiyangGuizhou 550025P.R.China Departm.nt of m.them.tics and Sciences Prince Sultan University P.O.Bor 66833 11586 RiyadhSaudi Arabia Departm.nt of m.dical Research China m.dical University Taichung 40402Taiwan CONACyT-Tecnologico Nacional de m.cico/CENIDET Interior Internado Palm.ra S/N Col.Palmira C.P.62490CuernavacaMorelosMécico IConsejo Academico Universidad Virtual CNCIMonterreyMécico School of Autom.tion Northwestern Polytechnical University 170072 Xian P.R.China

The prim.ry varicella-zoster virus(VzV)infection that causes chickenpox(also known as varicella),spreads quickly am.ng people and,in severe circum.tances,can cause to fever and *** this paper,the m.ttag-Leffler fractional operator is used to exam.ne the m.them.tical representation of the *** fractional-order differential equations are created in term. of the disease's dynam.cal analysis such as S:Susceptible,V:Vaccinated,E:Exposed,I:Infectious and R:*** derive the existence criterion,positive solution,Hyers-Ulam.stability,and boundedness of results in order to exam.ne the suggested fractional-order m.del's ***,som. num.rical exam.les for the VzV m.del of various fractional orders are shown with the aid of the generalized Adam.-Bashforth-m.ulton approach to show the viability of the obtained results.

关键词： Varicella-zoster virus m.del Hyers-Ulam.stability ABC fractional operator Schauder fix point theory num.rical analysis

Com.arison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Am.et Kum.r Jesrani Syed m.Faiq Rahm. Rashid Tariq Ali Kalwar Rehan m.hsin Tahir aziz Nida Am.n Khan m.ham.ed m.barak Departm.nt of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Departm.nt of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Departm.nt of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Departm.nt of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is im.ortant for tim.ly intervention and long-term.*** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To com.are the diagnostic perform.nce of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and com.arative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departm.nts of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from.August 2022 to February *** consecutive patients with increased serum.creatinine levels and reduced glom.rular filtration rate(GFR)after three m.nths of transplantation were enrolled in this *** and RI were perform.d and the findings of these were evaluated against the kidney allograft biopsy results to determ.ne their diagnostic *** The m.an age of all patients was 35.32±11.08 *** these,126(81.8%)were m.les and 28(18.2%)were *** m.an serum.creatinine in all patients was 2.86±1.68 m./dL and the m.an estim.ted GFR was 35.38±17.27 m./m.n/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft dam.ge were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from.this study show that SWE is m.re sensitive and specific as com.ared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

Enhancing m.ld Cognitive Im.airm.nt Detection through Efficient m.gnetic Resonance Im.ge Analysis

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Com.uters, m.terials & Continua 2024年第8期80卷 2081-2098页

作者： Atif m.hm.od Zhonglong Zheng Rizwan Khan Ahm.d Al Sm.di Farah Shahid Shahid Iqbal m.tasem.K.Alsm.di Yazeed Yasin Ghadi Syed aziz Shah m.stafa m.Ibrahim Departm.nt of Com.uter Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Departm.nt of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chem.cal and Environm.ntal Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Departm.nt of m.nagem.nt Inform.tion System. College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Departm.nt of Com.uter Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Departm.nt of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Them. Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroim.ging has em.rged over the last few decades as a crucial tool in diagnosing Alzheim.r’s disease(AD).m.ld cognitive im.airm.nt(m.I)is a condition that falls between the spectrum.of norm.l cognitive function and ***,previous studies have m.inly used handcrafted features to classify m.I,AD,and norm.l control(NC)*** paper focuses on using gray m.tter(Gm.scans obtained through m.gnetic resonance im.ging(m.I)for the diagnosis of individuals with m.I,AD,and *** im.rove classification perform.nce,we developed two transfer learning strategies with data augm.ntation(i.e.,shear range,rotation,zoom.range,channel shift).The first approach is a deep Siam.se network(DSN),and the second approach involves using a cross-dom.in strategy with custom.zed *** perform.d experim.nts on the Alzheim.r’s Disease Neuroim.ging Initiative(ADNI)dataset to evaluate the perform.nce of our proposed *** experim.ntal results dem.nstrate superior perform.nce in classifying the three binary classification tasks:NC ***,NC ***,and m.I ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augm.ntation to accurately diagnose m.I,AD,and norm.l control individuals using Gm.*** findings provide prom.sing results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheim.r’s disease m.ld cognitive im.airm.nt norm.l control transfer learning classification augm.ntation

Biochem.cal Liver Functions and m.lecular Identification of Fasciola hepatica from.Experim.ntally Infected Rat m.del

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Open Journal of Anim.l Sciences 2024年第2期14卷 88-100页

作者： Om.ia m. Kandil Em.d B. Ata m.rgarita P. Gabrashanska Hatem.A. Shalaby Tam.r H. Abd El-aziz Noha m. F. Hassan Soad m. Nasr m.ham.d A. Helal Ebtesam.m. Al-Olayan Departm.nt of Parasitology & Anim.l Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experim.ntal m.rphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Departm.nt of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was perform.d to evaluate the liver function status as well as m.lecular characterization of the recovered worm. in rats experim.ntally infected with F. hepatica. Sixteen m.le Wister rats aged 30 days were random.y allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted m.tacercaria of F. hepatica per anim.l. The other group was kept non-infected (control group). At zero tim. (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum.sam.les were collected via puncture of retro-orbital plexus of veins from.each rat. Serum.enzym. level (AST and ALT) and total protein were m.asured, and the serum.protein profile was carried out using agarose gel electrophoresis. During the period of the experim.nt, serum.ALT and AST activities and serum.total globulins significantly increased while serum.total proteins and album.n m.rkedly decreased in the infected group. On the 14th WPI, the data of the electropherogram.showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was m.rkedly decreased in the infected group. The m.lecular analysis confirm.d the am.lification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from.the infected liver of rats with am.licon sizes of 630, 510 and 560 bp, respectively. Sequencing of the am.lified ITS gene resulted in the determ.nation of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession num.ers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat m.del is suitable for routine experim.ntal infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the developm.nt of adult stages in the bile ducts. Furtherm.re, m.lecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum.Enzym.s Serum.Protein Electrophoresis m.lecular Characterization