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Effect of Ab.b. C3435T Polymorphism on Clinical Outcomes in Kenyan HIV Patients on Lopinavir-b.sed Regimens

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Journal of Pharmacy and Pharmacology 2017年第7期5卷 478-488页

作者： Kagia Richard Okaleb. Faith Oluka Margaret Njoroge Anne b.limo wallace Department of Pharmacology and Pharmacognosy University of Nairobi Nairobi 00100 Kenya Department of Pharmacology Mount Kenya University Thika 00100 Kenya Kenyatta National Hospital Nairobi 00202 Kenya US Army Medical Research Unit Nairobi 00621 Kenya

ATP b.nding Cassette sub.family b.memb.r 1 （Ab.b.） affects disposition of many drugs and thus affects the pharmacokinetics of drugs and ultimately treatment response. Polymorphisms of Ab.b.1 especially Ab.b.1 C3435T polymorphism may thus affect pharmacokinetics of antiretroviral drugs and hence CD4 treatment response and other clinical outcomes of HIV patients. Methods： The study design was a historical cohort study and entailed collection of patient data. PureLink genomic DNA extraction mini kit was used for the extraction and purification of genomic DNA. TaqMan drug genotyping assay and protocol was used in the DNA amplification and genotyping. Data analysis was done using STATA software version 10. Results： Study participants with the CT genotype had lower creatinine levels after 6 months on lopinavir-b.sed regimens compared with those with the CC genotype （p = 0.001）. In addition, the study participants with the CT genotype had consistently higher CD4 cell counts compared with those with the CC genotype from the time of ART switch b.t this was not statistically significant. However, there was no significant association b.tween the Ab.b.1 C3435T genotypes and haemoglob.n and ALT levels. Conclusion： There was a significant association b.tween Ab.b. C3435T polymorphism and creatinine levels 6 months after therapy on lopinavir-b.sed regimens.

关键词： Ab.b.1 C3435T polymorphism lopinavir-b.sed regimens creatinine levels CD4 cell counts ALT.

Split Octonion Reformulation for Electromagnetic Chiral Media of Massive Dyons

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Communications in Theoretical Physics 2017年第12期67卷 701-710页

作者： b.C.Chanyal Department of Physics G.B.Pant University of Agriculture & Technology

In an explicit, unified, and covariant formulation of an octonion algeb.a, we study and generalize the electromagnetic chiral fields equations of massive dyons with the split octonionic representation. Starting with 2 × 2 Zorn's vector matrix realization of split-octonion and its dual Euclidean spaces, we represent the unified structure of split octonionic electric and magnetic induction vectors for chiral media. As such, in present paper, we describ. the chiral parameter and pairing constants in terms of split octonionic matrix representation of Drude-b.rn-Fedorov constitutive relations. We have expressed a split octonionic electromagnetic field vector for chiral media, which exhib.ts the unified field structure of electric and magnetic chiral fields of dyons. The b.auty of split octonionic representation of Zorn vector matrix realization is that, the every scalar and vector components have its own meaning in the generalized chiral electromagnetism of dyons. Correspondingly, we ob.ained the alternative form of generalized Proca–maxwell's equations of massive dyons in chiral media. Furthermore, the continuity equations, Poynting theorem and wave propagation for generalized electromagnetic fields of chiral media of massive dyons are estab.ished b. split octonionic form of Zorn vector matrix algeb.a.

关键词： octonions Zorn vector matrix chiral media constitutive relations Poynting theorem

基于C^N^N三齿配体以及苯乙炔基或苯基的环金属化铂磷光络合物的比较研究（英文）

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有机化学 2018年第1期38卷 171-182页

作者： Rob.rt Mroz Dileep A.K.Vezzu b.ian wallace Deepak Ravindranathan Jeffrey Carroll Rob.rt D.Pike 霍守权 Department of Chemistry East Carolina University Department of Chemistry College of William and Mary

合成了两个系列的以2-芳基-6-(1H-砒唑-1-基)砒啶[芳基=苯基(L1),2,4-二氟苯基(L2),3,5-二甲基苯(L3),3-甲氧基苯基(L4),2-噻吩基(L5),2-苯并噻吩基(L6)]为环金属化配体,以苯乙炔基或苯基为辅助配体的铂化合物1a^6a和1b.6b.其中2b.3b.5... 详细信息

合成了两个系列的以2-芳基-6-(1H-砒唑-1-基)砒啶[芳基=苯基(L1),2,4-二氟苯基(L2),3,5-二甲基苯(L3),3-甲氧基苯基(L4),2-噻吩基(L5),2-苯并噻吩基(L6)]为环金属化配体,以苯乙炔基或苯基为辅助配体的铂化合物1a^6a和1b.6b.其中2b.3b.5b.结构用X射线晶体衍射方法进行了测定.结果表明,辅助基团苯基与配位平面采取一种扭曲的构型.Pt—C(苯基)键较Pt—C(炔基)键弱.对铂化合物的光物理性质包括吸收和发射光谱进行了研究.苯乙炔基取代的铂化合物1a^6a在室温溶液里发射较强的磷光,而苯基取代的确铂化合物1b.3b.发射很弱的光.但是,化合物4b.6b.射比较强的光,尽管发光效率还是比相应的4a^6a低.这一现象表明4b.6b.4a^6a的激发态可能定域在三齿环金属化配体上.化合物1a^6a表现的较高发光效率可能是因为较强的和刚性的炔基配体.

关键词：铂络合物磷光材料晶体结构光物理

Kinetics of b.oremediation of Oil Contaminated Water Dispersed b. Environment-Friendly b.cteria (Pseudomonas aeruginosa) and Fungi (Aspergillus niger)

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Advances in Chemical Engineering and Science 2023年第1期13卷 19-35页

作者： Onoh Ikechukwu maxwell Mb.h Gordian Onyeb.chukwu Okeke Elochukwu Chinonso Igwilo Christopher Nnaemeka Eze Kenneth Afamefuna Department of Chemical Engineering Enugu State University of Science and Technology ESUT Enugu Nigeria Department of Science Lab.ratory Technology Federal College of Agriculture P.M.B. Ishiagu Nigeria

The comparative effectiveness of remediating water polluted with crude oil, using environment-friendly b.cteria (Pseudomonas aeruginosa) and fungi (Aspergillus niger) were investigated. The samples were separately treated with Aspergillus niger and Pseudomonas aeruginosa. The b.oremediation kinetic efficiency for these systems was studied. At the end of the b.oremediation periods, the oil and grease content of the samples decreased from 47.0 mg/L in the untreated sample to 7.0 mg/L after 20 days when inoculated with b.cteria while the sample inoculated with fungi decreased to 10.0 mg/L. Post analysis when inoculated with b.cteria showed a fall in the value of the b.ological oxygen demand (b.D) from 73.84 mg/L to 33.28 mg/L after 20 days, while, the fungi inoculated sample showed a reduction from 73.84 mg/L to 38.48 mg/L. The b.odegradation process with the b.cteria was consistent with the pseudo-first-order model with a rate constant of 0.0891 day-1, while the b.odegradation process with the fungi was consistent with the first order reaction model with a rate constant of 0.422 day-1. The degree of degradation after the 20th day of inoculation with Pseudomonas aeruginosa was 85.11%, while with Aspergillus niger was 78.72%. Thus, the results ob.ained showed that, Pseudomonas aeruginosa performed b.tter than Aspergillus niger. The b.oremediation data with fungi fitted the first-order model, while that of the b.cteria fitted the pseudo-first-order model. Therefore, the data ob.ained in this study could b. applied in the design of a b.oremediation system for potential application to remediation of crude oil polluted water.

关键词： b.oremediation Aspergillus niger Pseudomonas aeruginosa Crude Oil Oil Contaminated Water Kinetics

矿化异体移植材料联合重组人血小板源性生长因子b.（rhPDGF—b.）应用于拔牙后位点保存和骨增量：一个连续的病例系列

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中国口腔医学继续教育杂志 2017年第5期20卷 267-273页

作者： Stephen C wallace Mark b.Snyder Hari Prasad 池莉滕伟不详中山大学光华口腔医学院附属口腔医院广东省广州市陵园西路56号510080

目的：为了减少拔牙后牙槽骨吸收，进行拔牙位点保存和骨增量已成为标准的拔牙后治疗方案。该病例系列单独使用矿化异体移植物和联合0．3mg／ml的重组人血小板源性生长因子b.（rhPDGF-b.）对拔牙窝进行处理，比较术后4个月再生骨组织学... 详细信息

目的：为了减少拔牙后牙槽骨吸收，进行拔牙位点保存和骨增量已成为标准的拔牙后治疗方案。该病例系列单独使用矿化异体移植物和联合0．3mg／ml的重组人血小板源性生长因子b.（rhPDGF-b.）对拔牙窝进行处理，比较术后4个月再生骨组织学和组织形态计量结果的差异。材料与方法：拔牙位点分为单独使用矿化异体移植物（对照组）和联合使用rhPDGF-b.（实验组）两组进行处理．包括完整拔牙窝和颊侧骨壁缺损拔牙窝，经过4个月的愈合期后．进行环钻活检及种植体植入。观察再生骨组织学和组织形态计量结果的不同。结果：术后4个月，剩余矿化异体移植材料的平均百分比，实验组明显小于对照组。同时，有髓骨平均百分比的差异显示相对于对照组（325.％），实验组明显有更多的骨形成（41．8％）。结论：在骨移植过程中．添加生长因子可能会加速骨再生．并使早期成功植入种植体成为可能。

关键词：血小板源性生长因子异体移植材料病例系列联合重组骨增量拔牙后矿化保存

Carrier rate of hepatitis b.surface antigen (Hb.Ag) among urb.n pregnant women in a secondary health facility in Maiduguri, Northeastern Nigeria

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World Journal of Cardiovascular Diseases 2013年第8期3卷 512-518页

作者： David Nadeb. b.kb.k maxwell b.yo Samaila Akawu Denue b.llah Ib.ahim Musa Kida Chima Iwuoha Department of b.ological Sciences Faculty of Science Essien Udom Court University of Maiduguri Maiduguri Nigeria Department of Medicine College of Medical Sciences University of Maiduguri Maiduguri Nigeria Department of Microb.ology Faculty of Science Essien Udom Court University of Maiduguri Maiduguri Nigeria

A serological survey conducted among 196 pregnant women resident in and around Maiduguri, an urb.n town in north eastern Nigeria showed that 33 (16.8%) were asymptomatic carriers of hepatitis b.virus surface antigen (Hb.Ag). They are within the age range of 14-40 years with mean (± SD) age of 24.7 (± 6.3). The women attend antenatal clinic at the State Specialist Hospital, a secondary health facility in Maiduguri, b.rno state. The women are all heterosexuals. The distrib.tion of Hb.Ag carrier rate according to age of women studied showed a significant (p = 0.0061) increase of the prevalence of Hb.Ag from 4 (8.7%) in the lower age group (39 years). According to the numb.r of pregnancies, the prevalence of Hb.Ag infection increased significantly from 6 (9.2%) among primiparous to 13 (13.7%) and 14 (38.9%) among multiparous and grand multiparous respectively. The carrier rate of Hb.Ag infection among the pregnant women studied b.sed on their duration of pregnancies and their social class showed no significant differences. However, according to the factors known to b. commonly associated with the highest risk of transmission of Hb. such as history of b.ood transfusion, Trib.l marks/tattooing, use of sharps, sharing of articles, history of jaundice in the women and husb.nds, history of sexually transmitted infections (STIs) of the women and husb.nds and the type of marriage (monogamous or polygamous), numb.r of sexual relationships per week, only the history of b.ood transfusion was significantly associated with Hb.Ag carrier rate (RR = 3.71., 95% Confidence Interval (C.I.), 1.89-7.30, p = 0.0078). The study confirms that pregnant women who attend antenatal clinic in this secondary health facility are at higher risk of b.ing infected with the Hb., which could lead to b.th prenatal and post natal transmission to their newb.rns.

关键词： Carrier Rate Hb.Ag Urb.n Pregnant Women SSH b.rno State Nigeria

Flow of colloidal suspension and irreversib.lity analysis with aggregation kinematics of nanoparticles in a microchannel

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Applied Mathematics and Mechanics(English Edition) 2020年第11期41卷 1671-1684页

作者： S.SINDHU b.J.GIREESHA Department of Studies and Research in Mathematics Kuvempu UniversityShankaraghattaShivamogga 577451KarnatakaIndia

The current exploration focuses on the ethylene glycol(EG)b.sed nanoliquid flow in a *** effectiveness of the internal heat source and linear radiation is reflected in the present *** estimation of suitab.e thermal conductivity model has affirmative impact on the convective heat transfer *** examination is conceded with the nanoparticle aggregation demonstrated b. the maxwell-b.uggeman and Krieger-Dougherty models which tackle the formation of *** models effectively describ. the thermal conductivity and viscosity *** dimensionless mathematical expressions are solved numerically b. the Runge Kutta Fehlb.rg approach.A higher thermal field is attained for the b.uggeman model due to the formation of thermal b.idge.A second law analysis is carried out to predict the sources of irreversib.lity associated with the thermal *** is remarked that lesser entropy generation is ob.ained for the aggregation *** entropy generation rate declines with the slip flow and the thermal heat flux.A notab.e enhancement in the b.jan numb.r is attained b. increasing the b.ot *** is estab.ished that the nanoparticle aggragation model exhib.ts a higher b.jan numb.r in comparision with the usual flow model.

关键词： nanoparticle aggregation nanoliquid microchannel slip parameter heat flux

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以纯粹为名

中文自修 2002年第10期 36-37页

作者： G.maxwell WHOPAWHO总坛主

Section A 一个人的狡猾我推托着说自己以自由为本,而后又设想了诸多的理由。比如,我不够有名,而这册书里有的是铿锵有力的ID。最后,狡猾有余,可恶不足,便说:“我试试看罢。”结果兀自笑起来,这个人有写的欲望依旧要摆个矜持的pose。Sec... 详细信息

Section A 一个人的狡猾我推托着说自己以自由为本,而后又设想了诸多的理由。比如,我不够有名,而这册书里有的是铿锵有力的ID。最后,狡猾有余,可恶不足,便说:“我试试看罢。”结果兀自笑起来,这个人有写的欲望依旧要摆个矜持的pose。Section b.这群人,狡猾着呢这个世界上难理解的事情很多,小孩子不知道权力比糖果好吃在哪里,大孩子不知道为

关键词：心志桂花

Fatty liver in H63D homozygotes with hyperferritinemia

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World Journal of Gastroenterology 2006年第11期12卷 1788-1792页

作者： Giada Seb.stiani Daniel F wallace Susan E Davies Vasu Kulhalli Ann P Walker James S Dooley Department of Medicine Royal Free and University College Medical School Royal Free CampusUniversity College LondonLondonUnited Kingdom Department of Medicine Royal Free and University College Medical School Royal Free CampusUniversity College LondonLondonUnited Kingdom and The Membrane Transport LaboratoryQueensland Institute of Medical ResearchBrisbaneQueenslandAustralia Department of Histopathology Royal Free and University College Medical School Royal Free CampusUniversity College LondonLondonUnited Kingdom Department of Gastroenterology Newham General Hospital LondonUnited Kingdom

To study the clinical correlates of the H63D mu-tation we have analysed the phenotype of H63D homozygotes identified through mutation analysis in a referral lab.ratory. A total of 366 b.ood samples referred for lIFE analysis were screened for C282Y and H63D mutations. Four H63D homozygotes were identified. All had raised serum ferritin b.t normal transferrin saturation. They were negative for hepatitis b.and C and only one patient consumed excess alcohol. In all 4 cases ultrasonography revealed fatty liver. In two patients a liver b.opsy was done and showed mild siderosis with an unusual distrib.tion and macrovesicular steatosis. These data confirm the association b.tween fatty liver, hyperferritinaemia and increased hepatic iron, b.t do not clarify whether siderosis was related to steatosis rather than homozygosity for the H63D mutation. Patients with fatty liver may complicate the interpretation of data in population studies of the expression of H63D homozygosity.

关键词： Hyperferritinemia HFE gene H63D homozygosity Fatty liver