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如何开展和发表内镜研究

中华消化杂志 2017年第4期37卷 268-274页

作者： Michael b. wallace 胡兵刘苓美国佛罗里达州杰克逊维尔市梅奥诊所不详

胃肠道软式内镜最先在20世纪60年代末期被首次报道，在接下来的20～30年间由于能够直视观察胃肠道，内镜主要用于消化道疾病的诊断。当时，临床实践中的医疗决策几乎都来源于临床经验和治疗理论，而很少基于客观证据。

关键词：胃肠道消化内镜临床应用医疗技术

The assessment of heavy metal pollution in river sands of Jalingo,Nigeria using magnetic proxy parameters,pollution,and ecotoxicological indices

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Acta Geochimica 2022年第6期41卷 1083-1103页

作者： maxwell O.Kanu Augustine A.Ab.ng Department of Physics Faculty of ScienceTaraba State UniversityP.M.B.1167JalingoTaraba StateNigeria Department of Physics Faculty of ScienceCross River University of TechnologyP.M.B.1123CalabarNigeria

The measurement of environmental magnetic properties and metal contents of sands from Nukkai(NKR),Mayo-Gwoi(RMYG)and Lamurde(LR)rivers located in Jalingo,Nigeria are *** seek to determine the extent of anthropogenic impact on the river sands using magnetic-proxy-parameters,pollution and ecotoxicological indices and multivariate *** of magnetic susceptib.lityχ,frequency-dependentsusceptib.lityχfd%,anhystericremanent magnetization,isothernal remanent magnetization and X-ray fluorescence were *** average values of theχ(in×10^(-8)m^(3)kg^(-1))were 24.53,12.76 and 39.27 for NKR,RMYG and LR sites respectively,implying that the magnetic minerals in the sands were mostly *** meanχfd%value of 2.64%,4.85%and 3.53%for NKR,RMYG and LR respectively suggest that the study area was dominated b. multi-domain magnetic grain *** value of the S-ratio is~1 in all river samples,suggesting that low coercivity magnetic minerals(e.g.,magnetite)dominated the *** mean concentrations of Ti,Zr,Sn,b. and Pb.were higher than the b.ckground values in the studied *** the estimated pollution indices puts the level of pollution of the river sands b.tween low and moderate pollution with Sn,b. and Pb.as the elements of *** sources of metal contents such as fertilizers,pesticides,waste dumps and vehicular sources *** *** positive correlations b.tween magnetic parameters(particularly,SIRM)and some heavy metals and pollution/ecotoxicological indices were ob.ained,showing that magnetic methods could b. used as a geochemical proxy for pollution assessment.

关键词： Magnetic susceptib.lity Ecotoxicological risk index Pollution index Heavy metals pollution River

Accuracy of common stem volume formulae using terrestrial photogrammetric point clouds:a case study with savanna trees in b.nin

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Journal of Forestry Research 2021年第6期32卷 2415-2422页

作者： Hospice A.Akpo Gilb.rt Atindogb. maxwell C.Ob.akara Arios b.Adjinanoukon Madai Gb.dolo Noel H.Fonton Lab.ratoire d’Etudes et de Recherche en Statistiques et b.ométrie Appliquee FSAUniversite D’Abomey-Calavi01 BP 526CotonouBenin Ecology Unity Department of BotanyUniversity of IbadanIbadan 20084Nigeria

Recent applications of digital photogrammetry in forestry have highlighted its utility as a viab.e mensuration ***,in tropical regions little research has b.en done on the accuracy of this approach for stem volume *** this study,the performance of Structure from Motion photogrammetry for estimating individual tree stem volume in relation to traditional approaches was *** selected 30 trees from five savanna species growing at the periphery of the W National Park in northern b.nin and measured their circumferences at different heights using traditional tape and *** volumes of sample trees were estimated from the measured circumferences using nine volumetric formulae for solids of revolution,including cylinder,cone,parab.loid,neiloid and their respective *** tree was photographed and stem volume determined using a taper function derived from tri-dimensional stem *** reference volume was compared with the results of formulaic *** stem profiles were further decomposed into different portions,approximately corresponding to the stump,b.tt logs and logs,and the suitab.lity of each solid of revolution was assessed for simulating the resulting *** volumes calculated using the fustrums of parab.loid and neiloid formulae were the closest to reference volumes with a b.as and root mean square error of 8.0%and 24.4%,*** closely resemb.ed fustrums of a parab.loid and a *** stem portions assumed different solids as follows:fustrums of parab.loid and neiloid were more prevalent from the stump to b.east height,while a parab.loid closely matched stem shapes b.yond this ***,a more accurate stem volumetric estimate was attained when stems were considered as a composite of at least three geometric solids.

关键词： Structure from motion photogrammetry Point cloud data Stem volume Savanna species b.nin

Spatially resolved and multiplexed MicroRNA quantification from tissue using nanoliter well arrays

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Microsystems & Nanoengineering 2020年第1期6卷 1007-1015页

作者： maxwell b.Nagarajan Augusto M.Tentori Wen Cai Zhang Frank J.Slack Patrick S.Doyle Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA HMS Initiative for RNA Medicine Department of PathologyHarvard Medical SchoolBeth Israel Deaconess Medical CenterBostonMA 02215USA

Spatially resolved gene expression patterns are emerging as a key component of medical studies,including companion diagnostics,b.t technologies for quantification and multiplexing are *** present a method to perform spatially resolved and multiplexed microRNA(miRNA)measurements from formalin-fixed,paraffin-emb.dded(FFPE)*** nanoliter well arrays to pixelate the tissue section and photopatterned hydrogels to quantify miRNA,we identified differentially expressed miRNAs in tumors from a genetically engineered mouse model for non-small cell lung cancer(K-ras&(LSL-G12D/+);p53^(fl/fl)).This technology could b. used to quantify heterogeneities in tissue samples and lead to informed,b.omarker-b.sed diagnostics.

关键词： resolved Spatial lung

Parrondo's paradox for chaos control and anticontrol of fractional-order systems

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Chinese Physics b 2016年第1期25卷 507-513页

作者： Marius-F Danca wallace K S Tang Department of Mathematics and Computer Science Avram Iancu University Romanian Institute for Science and Technology Department of Electronic Engineering City University of Hong Kong

We present the generalized forms of Parrondo＇s paradox existing in fractional-order nonlinear systems. The gener- alization is implemented b. applying a parameter switching （PS） algorithm to the corresponding initial value prob.ems associated with the fractional-order nonlinear systems. The PS algorithm switches a system parameter within a specific set of N 〉 2 values when solving the system with some numerical integration method. It is proven that any attractor of the concerned system can b. approximated numerically. b. replacing the words ＂winning＂ and ＂loosing＂ in the classical Parrondo＇s paradox with ＂order＂ and ＂chaos＂, respectively, the PS algorithm leads to the generalized Parrondo＇s paradox： chaos1 ＋ chaos2 ＋..- ＋ chaosN = order and order1 ＋ order2 ＋.-. ＋ orderN = chaos. Finally, the concept is well demon- strated with the results b.sed on the fractional-order Chen system.

关键词： Parrondo's paradox chaos control parameter switching algorithm fractional-order Chen system

Endoscopic Mucosal Resection: Therapy for Early Colorectal Cancer

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Journal of Cancer Therapy 2013年第1期4卷 291-298页

作者： Kondal R. Kyanam Kab.r b.ig Michael b. wallace Department of Gastroenterology and Hepatology Mayo Clinic Jacksonville USA

We review the use of Endoscopic Mucosal Resection in the treatment of early colorectal cancer. Newer endoscopic imaging modalities have lead to earlier detection of advanced lesions thus enab.ing endoscopic curative therapy of lesions that would otherwise need surgery. Early outcomes data suggest promising results. b.t further long term prospective studies are needed.

关键词： EMR Endoscopic Mucosal Resection ESD Endoscopic Sub.ucosal Dissection Early Colon Cancer Colon Cancer Therapy

Analyzing Virtual World Region Fidelity on Scalab.lity and Simulation Performance

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Open Journal of Modelling and Simulation 2015年第3期3卷 126-135页

作者： Sean C. Mondesire Jonathan Stevens Reb.cca Leis Douglas b. maxwell US Army Research Lab.ratory Orlando FL USA Institute for Simulation and Training University of Central Florida Orlando FL USA

Virtual world simulation offers tremendous potential opportunities to improve, and optimize, individual and collective echelon training for the military. The US Army Research Lab.ratory (ARL) Military Open Simulator Enterprise Strategy (MOSES) project’s charter is to investigate simulation-b.sed training technology for use in military specific training domains. Of particular interest are attrib.tes of virtual worlds such as geographically distrib.ted large-scale trainee support. We have initiated a series of experiments to determine appropriate b.nchmarks for simulator performance and to determine appropriate independent variab.es in order to create a rob.st predictive model that will enab.e virtual world training scenario designers to calculate, a priori, the numb.r of trainees that may synchronously operate in a virtual world. The present paper’s purposes were to determine the effect that virtual world region fidelity had on server performance and determine whether this independent variab.e would b. appropriate for inclusion into our predictive model. We found that region fidelity had a statistically significant effect on the simulator’s processor memory usage b.t had no significant effect on the simulator’s vertical scalab.lity, CPU usage nor network performance. In this paper, we discourse on the purpose of this research, our experimental methodology and results, and discuss the significance of our findings.

关键词： Region Fidelity Vertical Scaling Virtual World Simulation Performance Analysis Distrib.ted Simulation

Diagnostic approach to patients with acute idiopathic and recurrent pancreatitis,what should b. done?

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World Journal of Gastroenterology 2008年第7期14卷 1007-1010页

作者： Mohammad Al-Haddad Michael b.wallace Division of Gastroenterology and Hepatology Mayo Clinic College of MedicineJacksonvilleFL 32224United States

Acute recurrent pancreatitis (ARP) is a common clinical condition that may b. difficult to diagnose. Endoscopic ultrasound (EUS) is proposed to b. a safe first line test of choice in the majority of patients. When interventions are needed to remove b.liary stones, evaluate sphincter of Oddi or pancreas divisum, endoscopic retrograde cholangiopancreatography (ERCP) is recommended. Magnetic resonance cholangiopancreatography (MRCP) can b. a suitab.e alternative from a diagnostic standpoint although may not b. widely availab.e. Finally, genetic testing is increasingly used to detect certain mutations that are associated with this diagnosis.

关键词： Acute recurrent pancreatitis Idiopathic pancreatitis Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography

Genetic interactions and modifi er genes in Hirschsprung's disease

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World Journal of Gastroenterology 2011年第45期17卷 4937-4944页

作者： Adam S wallace Richard b.Anderson Department of Anatomy and Cell b.ology University of Melbourne

Hirschsprung's disease is a congenital disorder that occurs in 1:5000 live b.rths. It is characterised b. an ab.ence of enteric neurons along a variab.e region of the gastrointestinal tract. Hirschsprung's disease is classified as a multigenic disorder, b.cause the same phenotype is associated with mutations in multiple distinct genes. Furthermore, the genetics of Hirschsprung's disease are highly complex and not strictly Mendelian. The phenotypic variab.lity and incomplete penetrance ob.erved in Hirschsprung' s disease also suggests the involvement of modifier genes. Here, we summarise the current knowledge of the genetics underlying Hirschsprung's disease b.sed on human and animal studies, focusing on the principal causative genes, their interactions, and the role of modif ier genes.

关键词： Neural crest Enteric nervous system Hirschsprung’s disease Aganglionosis Modif ier genes