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“Oligometastatic pancreatic cancer”definition:The first step

Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 645-647页

作者： maximos frountzas Dimitrios Schizas Stylianos Kykalos Konstantinos G Toutouzas First Propaedeutic Department of Surgery Hippocration General HospitalNational and Kapodistrian University of AthensSchool of MedicineAthensGreece First Department of Surgery Laikon General HospitalNational and Kapodistrian University of AthensSchool of MedicineAthensGreece Second Department of Propaedeutic Surgery Laikon General HospitalNational and Kapodistrian University of AthensSchool of MedicineAthensGreece

Pancreatic ductal adenocarcinoma(PDAC)is nowadays the fourth leading cause of cancer-related death worldwide,but according to recent estimations it will become the second leading cause of cancer-related deaths in the USA up to 2030,following lung *** implementation of neoadjuvant chemotherapy during recent years led to an increase of overall survival at 35 months in PDAC after R0 resection[1].However,pancreatic cancer has a particularity that makes it a real challenge for clinicians:only 20%of patients are diagnosed early enough to have a resectable pancreatic cancer,whereas 40%of patients present with locally advanced or non-resectable disease,while the rest present with distant metastases[2].Systemic chemotherapy plays the main role in metastatic PDAC treatment:polychemotherapy regimens such as FOLFIRINOX(folinic acid,5-fluorouracil,irinotecan and oxaliplatin)or combination of gemcitabine/nab-paclitaxel seemed to improve median overall survival from 6.8 to 11.1 months and 6.7 to 8.5 months,respectively[3].

关键词： chemotherapy metastatic cancer

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Presentation and surgical management of xanthogranulomatous cholecystitis

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 117-127页

作者： maximos frountzas Dimitrios Schizas Efstathia Liatsou Konstantinos P Economopoulos Christina Nikolaou Konstantinos G Apostolou Konstantinos G Toutouzas Evangelos Felekouras First Propaedeutic Department of Surgery Hippocration General HospitalNational and Kapodistrian University of AthensSchool of Medicine114 Vas.Sofias Ave.11527AthensGreece Laboratory of Experimental Surgery and Surgical Research National and Kapodistrian University of AthensSchool of Medicine15B Ag.Thoma Str.11527AthensGreece First Department of Surgery Laikon General HospitalNational and Kapodistrian University of AthensSchool of Medicine17 Ag.Thoma Str.11527AthensGreece Society of Junior Doctors Surgery Workgroup75 Mikras Asias Str.11527AthensGreece Department of Surgery Duke University Medical Center2301 Erwin RdDurhamNC 27707USA

Background:Xanthogranulomatous cholecystitis(XGC)is a rare benign chronic inflammatory disease of the gallbladder that often presents as cholecystitis and most of the times requires surgical *** addition,distinguishing XGC from gallbladder cancer preoperatively is still a *** aim of the present systematic review was to outline the clinical presentation and surgical approach of *** sources:The present systematic review was designed using the PRISMA and AMSTAR *** searched MEDLINE,Scopus,***,EMBASE,Cochrane Central Register of Controlled Trials(CENTRAL)and Google Scholar databases from inception until June ***:The laparoscopic cholecystectomy rate(34%)was almost equal to the open cholecystectomy rate(47%)for *** important conversion rate(35%)was observed as *** XGC cases treated by surgery were associated with low mortality(0.3%),limited intraoperative blood loss(58-270 m L),low complication rates(2%–6%),along with extended operative time(82.6–120 minutes for laparoscopic and 59.6–240 minutes for open cholecystectomy)and hospital stay(3–9 days after laparoscopic and 8.3–18 days after open cholecystectomy).Intraoperative findings during cholecystectomies for XGC included empyema or Mirizzi *** addition,complex surgical procedures,like wedge hepatic resections and bile duct excision were required during operations for ***:XGC seemed to be a rare,benign inflammatory disease that presents similar features as gallbladder *** mortality and complication rates of XGC were low,despite the complex surgical procedures that might be required in some cases.

关键词： Xanthogranulomatous cholecystitis Surgical management Pathology Postoperative complications

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