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Advances in aggregatable nanoparticles for tumor-targeted drug delivery

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Chinese Chemical Letters 2020年第6期31卷 1366-1374,F0002页

作者： Wenqi Yu maxim shevtsov Xianchun Chen Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China Institute of Cytology of the Russian Academy of Sciences(RAS) St.Petersburg 194064.Russia

Recent days,aggregatable nanoparticles,which can specifically respond to certain stimulus,have shown great potential in tumor-targeted drug delivery with prolonged retention and deeper *** this review,we summarize recent advances in design of aggregatable nanoparticles by different ***(pH and enzyme)and external(light,temperature and ROS)stimuli are introduced for a comprehensive ***,the aggregated nanoparticles usually exhibit photothermal,photoacoustic,PET and enhanced MRI contrast,which is also *** the end,we discuss about the potential applications and challenges for the future clinical translation.

关键词： Stimuli-responsive nanoparticles Size aggregation Tumor-targeted drug delivery Transformation Microenvironment modulation

Expression of Mitochondrial Gene Fragments within the Tapetum Induce Male Sterility by Limiting the Biogenesis of the Respiratory Machinery in Transgenic Tobacco

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Journal of Integrative Plant Biology 2012年第2期54卷 115-129页

作者： Felix Shaya Svetlana Gaiduk Ido Keren Sofia shevtsov Hanita Zemah Eduard Belausov Dalia Evenor Moshe Reuveni Oren Ostersetzer-Biran Institute of Plant Sciences Agricultural Research Organization (ARO) Volcani CenterBet Dagan 50250 Israel Department of Plant Sciences The Hebrew University of JerusalemRehovot 76100 Israel Australian Research Council (ARC) Centre of Excellence in Plant Energy Biology The University of Western AustraliaCrawley WA 6009 Australia

Plant mitochondrial genomes （mtDNAs） are large and undergo frequent recombination events. A common phenotype that emerges as a consequence of altered mtDNA structure is cytoplasmic-male sterility （CMS）. The molecular basis for CMS remains unclear, but it seems logical that altered respiration activities would result in reduced pollen production. Analysis of tobacco （Nicotiana tabacum） mtDNAs indicated that CMS-associated loci often contain fragments of known organellar genes. These may assemble with organellar complexes and thereby interfere with normal respiratory functions. Here, we analyzed whether the expression of truncated fragments of mitochondrial genes （i.e. atp4, cox1 and rps3） may induce male sterility by limiting the biogenesis of the respiratory machinery, cDNA fragments corresponding to atp4f, coxlfand rps3f were cloned in-frame to a mitochondrial localization signal and a C-termini HA-tag under a tapetum-specific promoter and introduced to tobacco plants by Agrobacterium-mediated transformation. The constructs were then analyzed for their effect on mitochondrial activity and pollen fertility. Atp4f, Coxlf and Rps3f plants demonstrated male sterility phenotypes, which were tightly correlated with the expression of the recombinant fragments in the floral meristem. Fractionation of native organellar extracts showed that the recombinant ATP4f-HA, COXlf-HA and RPS3f-HA proteins are found in large membrane-associated particles. Analysis of the respiratory activities and protein profiles indicated that organellar complex I was altered in Atp4f, Coxlfand Rps3f plants.

关键词： CMS ORF-fragments Complex-I mitochondria tobacco

Developing and introducing of the resourcesaving technologies into the water-supply systems of mining enterprises

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Journal of Harbin Institute of Technology(New Series) 2000年第S1期7卷 35-37页

作者： Michael N.shevtsov Khabarovsk State University of Technology

The article deals with modeling the tailing ponds influence on water resources. New technology using hydrocyclons of new design has been offered for additional purification of gold dressing mill wastewater. Laboratory and plant test have determined the optimal parameters of hydrocyclon. Introduction of new technology into system of water supply will prevent environment pollution and make it possible to process recoverable resources.

关键词： ecology surface and underground water pollution circulating water supply system wastewater mining plants gold dressing mill hydrocyclon

Molecular epidemiological study of animal rabies in Kazakhstan

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Journal of Integrative Agriculture 2023年第4期22卷 1266-1275页

作者： Gulzhan N.YESSEMBEKOVA XIAO Shuang Assem ABENOV Talgat KARIBAEV Alexandr shevtsov Amirgazin ASYLULAN Yersyn Y.MUKHANBETKALIYEV SHUAI Lei BU Zhi-gao Sarsenbay K.ABDRAKHMANOV S.Seifullin Kazakh Agro Technical University Nur-Sultan 010011Kazakhstan State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China National Reference Center for Veterinary Medicine Center for BiotechnologyNur-Sultan 010000Kazakhstan National Center for Biotechnology Nur-Sultan 010000Kazakhstan

Rabies is a serious public health issue in Kazakhstan, with high economic impact and social burden. As part of a routine surveillance, 31 rabies-positive brain specimens taken from livestock(cattle) and carnivores(dogs, foxes, and cats)during 2013–2021 were subject to viral sequencing. Phylogenetic and Bayesian analysis were performed using obtained rabies virus(RABV) sequences. All 31 strains of RABV candidate belonged to the Cosmopolitan clade, of which 30strains belonged to steppe-type subclade, and 1 dog strain belonged to Other subclade. The 31 strains did not diverge from RABV strains in Kazakhstan and neighboring countries, including Russia, Mongolia, and China, suggesting that animal rabies has close relationship and transmission between borders. Fox-originated strains and cattle strains shared similar sequence signature, and some animal rabies cases had space–time intersection, showing that infected foxes were a major transmission source of cattle rabies in different Kazakhstan regions. Besides, free-roaming dogs played a pivotal role in rabies epizootics of cattle in Kazakhstan. The recent spread of animal rabies presents an increasing threat to public health, and provides updated information for improving current control and prevention strategies at the source for Kazakhstan and neighboring countries.

关键词： rabies livestock carnivores phylogenetic analysis

Subsolidus Conceptual Design of CaO-AI_2O_3-TiO_2-SiO_2 System and Its Significance for Manufacturing Advanced Ceramics

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China's Refractories 2016年第1期25卷 44-52页

作者： Michail I. RYSCHENKO Yaroslav N. PITAK Elena Yu. FEDORENKO Maria Yu. LISYUTKINA Alexey V. shevtsov National Technical University "Kharkiv Polytechnic Institute" Kharkov 61002 Ukraine

The article deals the structure of the CaO -Al2O3 - TiO2 -SiO2 system as a basis for obtaining advanced ce- ramics with a complex of high-operational characteris- tics. As a result o[＇investigations the phase charctcteristics are represented trod the graph of the relationship of the elementaory tetrahedra has been plotted. The most techno- logical system area ,for the production of heat resistant advanced ceramics has been determined. The batches for producing heat and chemical resistant dense advanced ceramics made of natural, technical and technogenic raw materials have been developed.

关键词： geometric - topological characteristics thermodynamic analysis resource conservation ceramic eomprising tialite sintering processes phase formation

Long-Term Results (Seven and More Years) of Sparing Treatment of Subjects with Descending Aortic Aneurysms

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Health 2019年第6期11卷 661-670页

作者： Vladimir Petrovich Krylov Dmitry Evgeniyevich shevtsov Gennadiy Adolfovich Popel Valentina Nikolaevna Gayduk Leonid Ivanovich Reut Aleksey Leonidovich Smaliakou Nadezhda Vladimirovna Mankevich Republican Research and Practical Centre of Cardiology Minsk Belarus Belarusian Association of Physicians Ministry of Health of Belarus Minsk Belarus

Descending aortic aneurysms (DAAs), including dissecting aneurysms (DA) have a multifactorial etiology and pathogenesis, therefore raising questions about the leading role of operative treatment to repair the lesion. Objective: To investigate remote (7 and more years) results of treatment in patients with DAAs in operative treatment only if there is a danger of aneurysm rupture. A total of 82 patients with atherosclerotic DAA identified between 2008 and 2011, and 22 patients with type 1 or 3 DeBakey dissecting aneurysms (DA) who had not been operated in the acute period due to a number of reasons were examined. The follow-up period of these groups was 7 or more years. When using a sparing treatment to treat DAA, we saw survival of 90.1 at 2 years, 76.8% at 4 years, 59.4% at 6 years, and 57.5% at 7 years with the uniform increase in mortality rate, mainly due to a comorbidity. Survival in DA group (77.3%) was better due to a younger age and was 68.4% in operated and 54% in non-operated patients at 7 years. It is symptomatic that the aneurysm rupture rate was not always affected by operative treatment. Therefore, it seems like medical treatment is more consistent with etiopathogenesis of the disease compared to surgery during the stabilization period.

关键词： Descending Aortic Aneurysms Medical and Surgical Treatment 7-Year Treatment Results Survival

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铁道车辆车轮外形的优化设计

国外铁道车辆 2007年第4期44卷 24-29,42页

作者： I．Y．shevtsov[荷] 蒋修治（译）刘新明（校）

介绍了基于轮轨接触几何特性,采用数值优化技术,设计车轮外形的方法。

关键词：车轮外形设计形状优化轮轨接触

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寻找阿拉斯加世界最大飞地的荒野传奇

环球人文地理 2023年第17期 16-25页

作者：曹愉钦陈曦Stanley 9s_马骁 Konstantin shevtsov shorex.koss mariemilyphotos Starover Sibiriak bennymarty ?摄图网

“如果你已年老，必须想尽办法去一次阿拉斯加。如果你还年轻，请远离阿拉斯加，因为阿拉斯加的美比世界上任何地方都宏大。过早经历最美的东西，将使今后的人生索然无味。”——《国家地理》创始人Henry Gannett

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Sparing Treatment of Thoracic and Abdominal Aortic Aneurysms

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Health 2018年第4期10卷 458-466页

作者： V. P. Krylov D. E. shevtsov G. A. Popel A. S. Zhigalkovich V. N. Gaiduk L. I. Reut A. L. Smolyakov L. G. Shestakova N. V. Mankevich Belarusian Association of Physicians Republican Research and Practical Centre “Cardiology” Minsk Belarus

A comparison of results of sparing treatment obtained at 2, 4 and 6 years of follow-up in subjects with descending aortic atherosclerotic aneurysms (DAAs), and during the period between 1.5 and 8.9 years in subjects with dissecting thoracoabdominal aortic aneurysms (DTAAs) has been made. All subjects received conservative treatment to maintain optimal levels of BP, cholesterol and LDL cholesterol, as well as to reduce oxidative and inflammatory processes in aorta, strengthen aortic walls and stabilize the course of the disease. Rapid negative changes (diameter increased by more than 5 mm within a 6-month period) and the absence of contraindications for surgery prompted us to perform open or endovascular aortic repair. Available data suggest that both DAAs and TAAs are comorbidities, which at any time can abruptly terminate patient’s life, and operative treatment guarantees no safety from ruptures. When using sparing treatment of DAA, survival rates were 90.1% at 2 years, 76.8% at 4 years, and 59.4% at 6 years, with uniform survival increment mainly due to comorbidity. Survival rate seen in TAA group (81.8%) was more acceptable due to a younger age of patients.

关键词： Atherosclerotic and Dissecting Aneurysms Inflammation Surgical and Medical Treatment Long-Term Results