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World Journal of Gastroenterology 2008年第24期14卷 3919-3921页

作者： Serhat Aymaz arno J Dormann Department of Medicine Cologne City HospitalHolweideNeufelder Strasse 32

The incidence of adenocarcinoma of the esophago-gastric junction is constantly increasing. Curative treatment is no longer possible at the time of diagnosis in more than 50% of patients with esophageal carcinoma,and palliative treatment focusing on eliminating dysphagia is required. Endoscopic therapy with stent implantation is an established method of achieving this. It can be carried out quickly,with a low rate of early complications,and leads to fast symptomatic improvement,assessed using the dysphagia score. The relatively high rate of late complications such as stent migration,hemorrhage,and gastroesophageal mucosal prolapse has led to recent debate on the role of metal stents in palliative therapy. We present here a new type of stent design for transcardial application,which is intended to prevent bleeding due to mechanical mucosal lesions caused by the distal end of the stent extending into the stomach. The further intention of this case report is to force the discussion on individually designed nitinol stents in special anatomic conditions.

关键词： Esophagus cancer Treatment Palliativetherapy Endoscopic therapy Stent Cardiac cancer

MLMT与MLST在新生隐球菌基因分型中的应用研究

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贵州医科大学学报 2024年第1期49卷 84-89页

作者：朱键曹佳非康颖倩三上襄 Wieland meyer 贵阳市第二人民医院&贵州医科大学附属金阳医院消化内科贵州贵阳550081 贵州医科大学附属医院消化内科贵州贵阳550004 贵州医科大学研究生院贵州贵阳550004 千葉大学医学真菌研究中心日本千葉县260-8673 悉尼大学Westmead医学研究所澳大利亚悉尼NSW2145

目的探讨多位点微卫星灶分型(MLMT)和多位点序列分型(MLST)在新生隐球菌(***)基因分型中的应用。方法提取22株来源于国内及日本已明确为新生隐球菌的菌株DNA,经MLMT及MLST相应位点的引物进行扩增、测序;计算各微卫星灶(CNG1、CNG2及CN... 详细信息

目的探讨多位点微卫星灶分型(MLMT)和多位点序列分型(MLST)在新生隐球菌(***)基因分型中的应用。方法提取22株来源于国内及日本已明确为新生隐球菌的菌株DNA,经MLMT及MLST相应位点的引物进行扩增、测序;计算各微卫星灶(CNG1、CNG2及CNG3)序列中简单重复序列的重复数,确定菌株MLMT的基因型;将本研究菌株的MLST中各位点序列和网上数据库相应序列进行对比,获取该菌株的MLST基因型;比较两种方法在分型中分辨能力。结果在22株菌中,有16株的基因型为MLMT17/MLST5(16/22,72.73%),MLMT将所有菌株分为7型,而MLST分为4型;根据MLST分型,MLMT17、16、34及39的菌株为MLST5;MLMT2、14、29相对应MLST66、32及31;两种方法的分型分辨能力比较,差异无统计学意义(P=0.488)。结论 MLMT-17/MLST 5是我国和日本的新生隐球菌常见基因型,包含CNG1、CNG2及CNG3位点的MLMT可作为MLST的替代或补充。

关键词：新生隐球菌多位点微卫星灶分型多位点序列分型

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

Modern radiological assessment after neoadjuvant therapy in pancreatic cancer: an overview

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Journal of Pancreatology 2024年第3期7卷 207-211页

作者： Marcus Steingrüber Yousef Moulla Timm Denecke Hans-Jonas meyer Department of Diagnostic and Interventional Radiology University of LeipzigLeipzigGermany Department of Visceral TransplantThoracic and Vascular SurgeryUniversity of LeipzigLeipzigGermany

This narrative review provides an overview of the current radiological assessment of pancreatic cancer after neoadjuvant *** current literature was searched for evidence of the different radiological quantitative imaging modalities to stage pancreatic *** overview is given in a narrative *** quantitative imaging modalities comprise computed tomography(CT)perfusion,dual-energy CT,magnetic resonance imaging,and fluorodeoxyglucose positron emission tomography(FDG-PET)/*** analysis can be used to further characterize the tumors and to reflect the complex tumor microstructure before and after neoadjuvant *** extension of the tumor and infiltration of the surrounding tissue is of utter importance to decide,whether the neoadjuvant treatment leads to a resectability or *** is increasing evidence of the importance of quantitative imaging modalities to assess treatment response in patients with pancreatic cancer after neoadjuvant *** studies employing these modalities are needed to further investigate the benefit for the patients.

关键词： CT FDG-PET/CT MRI Neoadjuvant treatment Pancreatic cancer

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm Edwin J.Yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Three Problems on Trigonometric Sums

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Acta Mathematica Sinica,English Series 2019年第6期35卷 721-727页

作者： Yves meyer CMLA ENS Paris-Saclay

Let Λ ? R^n be a uniformly discrete set and let C_Λ be the vector space consisting of all mean periodic functions whose spectrum is simple and contained in Λ. If Λ is a gentle set then for every f ∈ C_Λ we have f(x) = O(ω_Λ(x)) as |x| →∞ and ω_Λ(x) can be estimated(Theorem 4.1). This line of research was proposed by Jean-Pierre Kahane in 1957.

关键词： Mean periodic functions almost periodic functions trigonometric sums

SolarGAN:Synthetic annual solar irradiance time series on urban building facades via Deep Generative

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能源与人工智能(英文) 2023年第2期12卷 1-21页

作者： Yufei Zhang arno Schlueter Christoph Waibel Chair of Architecture and Building Systems(A/S) ETH ZurichStefano-Franscini-Platz 18093 ZurichSwitzerland

Building Integrated Photovoltaics (BIPV) is a promising technology to decarbonize urban energy systems viaharnessing solar energy available on building envelopes. While methods to assess solar irradiation, especiallyon rooftops, are well established, the assessment on building facades usually involves a higher effort due tomore complex urban features and obstructions. The drawback of existing physics-based simulation programsare that they require significant manual modeling effort and computing time for generating time resolveddeterministic results. Yet, solar irradiation is highly intermittent and representing its inherent uncertainty maybe required for designing robust BIPV energy systems. Targeting on these drawbacks, this paper proposes adata-driven model based on Deep Generative Networks (DGN) to efficiently generate stochastic ensembles ofannual hourly solar irradiance time series on building facades with uncompromised spatiotemporal resolutionat the urban scale. The only input required are easily obtainable fisheye images as categorical shading maskscaptured from 3D models. In principle, even actual photographs of urban contexts can be utilized, given they are semantically segmented. The potential of our approach is that it may be applied as a surrogate for timeconsuming simulations, when facing lacking information (e.g., no 3D model exists), and to use the generatedstochastic time-series ensembles in robust energy systems planning. Our validations exemplify a good fidelityof the generated time series when compared to the physics-based simulator. Due to the nature of the usedDGNs, it remains an open challenge to precisely reconstruct the ground truth one-to-one for each hour of theyear. However, we consider the benefits of the approach to outweigh the shortcomings. To demonstrate themodel’s relevance for urban energy planning, we showcase its potential for generative design by parametricallyaltering characteristic features of the urban environment and produc

关键词： Urban solar potential Data-driven Deep Generative Networks(DGN) Building-integrated photovoltaic(BIPV) Generative Adversarial Network(GAN) Variational Autoencoder(VAE)

Genetics of complex diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第2期7卷 167-168页

作者： MOTULSKY arno G. University of Washington Seattle WA 98195 USA

Approaches to the study of the genetic basis of common complex diseases and their clinical applications are con-sidered. Monogenic Mendelian inheritance in such conditions is infrequent but its elucidation may help to detect pathogenic mechanisms in the more common variety of complex diseases. Involvement by multiple genes in complex diseases usually occurs but the isolation and identification of specific genes so far has been exceptional. The role of common polymorphisms as indicators of disease risk in various studies is discussed.

关键词： Complex disease Polymorphisms Multifactorial inheritance Monogenic inheritance

THERMOCHROMIC EFFECTS OF LEUCO DYES STUDIED IN POLYPROPYLENE

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Chinese Journal of Polymer Science 2006年第4期24卷 363-368页

作者： arno Seeboth Detlef L(o|¨)tzsch Elvira Potechius Renate Vetter Fraunhofer Institute for Applied Polymer Research

A series of thermochromic polypropylene foils were prepared by embedding various leuco dye-developer-solvent systems in the polymer matrix. Bisphenol A, laurylgallate, ethylgallate and p-hydroxybenzoic acid methyl ester were used as developers, crystal violet lactone and 3,3-bis-（1-n-butyl-2-methyl-3-indolyl）-phthalide as dyes and l-octanoic acid methyl ester as solvent. The molar ratio between the three components of the investigated leuco dye-developer-solvent systems was kept constant. All obtained polypropylene foils exhibit an excellent thermochromic behavior. The foils, prepared by extrusion technology, switch from color to colorless with increasing temperature. The influence of molecular structure of the developer on the intensity of the colored state and the influence of a developer-surfactant complex on the resulting thermochromic properties were investigated. The results are presented and discussed in detail according to a molecular model suggesting that the ring-opening process of the leuco dye is triggered by the formation of dye-developer complexes via H-bondings.

关键词： Thermochromism Dyes Extrusion UV-Vis spectroscopy.

Reliability-based congestion pricing model under endogenous equilibrated market penetration and compliance rate of ATIS

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Journal of Central South University 2015年第3期22卷 1155-1165页

作者：钟绍鹏邓卫 Bushell max School of Transportation and Logistics Dalian University of Technology School of Transportation Southeast University Pedestrian and Bicycle Information Center University of North Carolina at Chapel Hill

A reliability-based stochastic system optimum congestion pricing(SSOCP) model with endogenous market penetration and compliance rate in an advanced traveler information systems(ATIS) environment was proposed. All travelers were divided into two classes. The first guided travelers were referred to as the equipped travelers who follow ATIS advice, while the second unguided travelers were referred to as the unequipped travelers and the equipped travelers who do not follow the ATIS advice(also referred to as non-complied travelers). Travelers were assumed to take travel time, congestion pricing, and travel time reliability into account when making travel route choice decisions. In order to arrive at on time, travelers needed to allow for a safety margin to their *** market penetration of ATIS was determined by a continuous increasing function of the information benefit, and the ATIS compliance rate of equipped travelers was given as the probability of the actually experienced travel costs of guided travelers less than or equal to those of unguided travelers. The analysis results could enhance our understanding of the effect of travel demand level and travel time reliability confidence level on the ATIS market penetration and compliance rate; and the effect of travel time perception variation of guided and unguided travelers on the mean travel cost savings(MTCS) of the equipped travelers, the ATIS market penetration, compliance rate, and the total network effective travel time(TNETT).

关键词： reliability advanced traveler information systems market penetration compliance rate stochastic system optimum congestion pricing non-additive path cost