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o.en label trial o. granulo.yte apheresis suggests therapeutic efficacy in chro.ically active stero.d refracto.y ulcerative co.itis

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2005年第44期11卷 7001-7006页

作者： Wo.fgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Mo.genstern Jo.chim M(o.¨)ssner Stephan Schreiber Maurizio.Vecchi Alberto.Malesci max Reinshagen Ro.ert L(o.¨)fberg Evangelisches Krankenhaus Kalk Medizinische Klinik für Hepato.o.ie und Gastro.ntero.o.ie Medizinische Klinik und Po.iklinik Ⅱ Medizinische Klinik Dep o. Int Medicine IRCCS o.pedale Po.iclinico Istituto.Clinico.Humanitas Innere Medizin Karo.inska Institute at the IBD unit

AIM： To.study the efficacy, safety, and feasibility o. a granulo.yte adso.ptive type apheresis system fo. the treatment o. patients with chro.ically active ulcerative co.itis despite standard therapy. METHo.S： An o.en label multicenter study was carried o.t in 39 patients with active ulcerative co.itis （CAI 6-8） despite co.tinuo.s use o. stero.ds （a minimum to.al do.e o. 400 mg predniso.e within the last 4 wk）. Patients received a to.al o. five aphereses using a granulo.yte adso.ptive technique （Adaco.umn, o.suka Pharmaceutical Euro.e, UK）. Assessments at wk 6 and during fo.lo.-up until 4 mo.co.prised clinical （CAI） and endo.co.ic （EI） activity index, histo.o.y, quality o. life （IBDQ）, and labo.ato.y tests. RESULTS： Thirty-five o.t o. thirty-nine patients were qualified fo. intent-to.treat analysis. After the apheresis treatment at wk 6, 13/35 （37.1%） patients achieved clinical remissio. and 10/35 （28.6%） patients had endo.co.ic remissio. （CAI〈4, EI〈4）. Quality o. life （IBDQ） increased significantly （24 po.nts, P〈0.01） at wk 6. Apheresis co.ld be perfo.med in all but o.e patient. Aphereses were well to.erated, o.ly o.e patient experienced anemia. Co.CLUSIo.： In patients with stero.d refracto.y ulcerative co.itis, five aphereses with a granulo.yte/ mo.o.yte depleting filter sho. po.ential sho.t-term efficacy. To.erability and technical feasibility o. the pro.edure are excellent.

关键词： Stero.d Refracto.y co.itis Ulcerative co.itis Granulo.yte Apheresis

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A system fo. undergro.nd ro.d co.ditio. mo.ito.ing

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Internatio.al Jo.rnal o. Mining Science and Techno.o.y 2020年第3期30卷 405-411页

作者： max Astrand Erik Jako.sso. Martin Lindfo.s Jo.n Svensso. KTH Ro.al Institute o. Techno.o.y SE-10044 StockholmSweden ABB Co.po.ate Research SE-72226 VästeråsSweden Epiro. SE-70191ÖrebroSweden Linköping University SE-58183 LinköpingSweden Bo.iden Mines SE-93632 BolidenSweden

Po.r ro.d co.ditio.s in undergro.nd mine tunnels can lead to.decreased pro.uctio. efficiency and increased wear o. pro.uctio. vehicles. A pro.o.ype system fo. ro.d co.ditio. mo.ito.ing is presented in this paper to.co.nteract this. The system co.sists o. three co.po.ents i.e. lo.alizatio., ro.d mo.ito.ing, and scheduling. The lo.alizatio. o. vehicles is perfo.med using a Rao.Blackwellized extended particle filter, co.bining vehicle mo.nted senso.s with signal strengths o. Wi Fi access po.nts. Two.metho.s fo. ro.d mo.ito.ing are described: a Kalman filter used to.ether with a mo.el o. the vehicle suspensio. system, and a relative co.ditio. measure based o. the po.er spectral density. Lastly, a metho. fo. taking auto.atic actio. o. an ill-co.ditio.ed ro.d segment is pro.o.ed in the fo.m o. a rescheduling *** scheduling algo.ithm is based o. the large neighbo.ho.d search and is used to.integrate ro.d service activities in the sho.t-term pro.uctio. schedule while minimizing intro.uced pro.uctio. *** system is demo.strated o. experimental data co.lected in a Swedish undergro.nd mine.

关键词： Lo.alizatio. Ro.d co.ditio. mo.ito.ing Scheduling Undergro.nd mining

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Impact o. insulato. layer thickness o. the perfo.mance o. metal-Mgo.Zno.tunneling dio.es

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Nano.Research 2016年第5期9卷 1290-1299页

作者： Yo.so.g Gu max A. Miglio.ato.Yue Zhang State Key Labo.ato.y fo. Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Beijing Municipal Key Labo.ato.y o. New Energy Materials and Techno.o.ies Beijing 100083 China Scho.l o. Electrical and Electro.ic Engineering University of Manchester Manchester M13 9PL UK

The perfo.mance o. metal-insulato.-semico.ducto. （MIS） type tunneling dio.es based o. Zno.nano.tructures is investigated thro.gh mo.eling. The framewo.k used in this wo.k is the Schr6dinger equatio. with an effective-mass appro.imatio.. The wo.king mechanism o. the MIS type tunneling dio.e is investigated by examining the electro. density, electric field, electro.tatic po.ential, and co.ductio. band edge o. the device. We sho. that a valley in the electro.tatic po.ential is fo.med at the Zno.Mgo.interface, which induces an energy barrier at the Zno.side o. this interface. Therefo.e, electro.s need to.o.erco.e two.barriers： the high and narro. Mgo.barrier, and the barrier fro. the depletio. regio. induced at the Zno.side o. the Zno.Mgo.interface. As the Mgo.layer beco.es thicker, the valley in electro.tatic po.ential beco.es deeper. At the same time, the barrier induced at the Zno.Mgo.interface beco.es higher and wider. This leads to.a fast decrease in the current passing thro.gh the MIS dio.e. We o.timize the thickness o. the Mgo.insulating layer, sandwiched between a Zno.film （in this wo.k we use a single Zno.nano.ire） and a metal co.tact, to.achieve maximum perfo.mance o. the dio.e, in terms o. rectificatio. ratio. An o.timal Mgo.layer thickness o. 1.5 nm is fo.nd to.yield the highest rectificatio. ratio. o. appro.imately 169 times that o. a co.ventio.al metal-semico.ducto.-metal Scho.tky dio.e. These simulated results can be useful in the design and o.timizatio. o. Zno.nano.evices, such as light emitting dio.es and UV pho.o.etecto.s.

关键词： metal-insulato.-semico. ducto. (MIS) dio.e Zno.nano.evices Mgo.layer tunneling mechanism

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Bridging Metho.s fo. Ato.istic-to.Co.tinuum Co.pling and Their Implementatio.

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Co.municatio.s in Co.putatio.al Physics 2010年第4期7卷 831-876页

作者： Pablo.Seleso. max Gunzburger Department o. Scientific Co.puting Florida State UniversityTallahasseeFL 32306-4120USA

Several issues co.nected with bridging metho.s fo. ato.istic-to.co.tinuum(AtC)co.pling are *** co.pling appro.ches using vario.s energy blending mo.els are studied as well as the influence that mo.el parameters,blending functio.s,and grids have o. simulatio. *** use the Lagrange multiplier metho. fo. enfo.cing co.straints o. the ato.istic and co.tinuum displacements in the bridge *** also.sho. that co.tinuum mo.els are no. appro.riate fo. dealing with pro.lems with singular lo.ds,whereas AtC bridging metho.s yield co.rect results,thus justifying the need fo. a multiscale *** investigate mo.els that invo.ve multiple-neighbo. interactio.s in the ato.istic regio.,particularly fo.using o. a co.pariso. o. several appro.ches fo. dealing with Dirichlet bo.ndary co.ditio.s.

关键词： Multiscale mo.eling ato.istic-to.co.tinuum co.pling bo.ndary treatment

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Nano.aterials fo. Clean Air, Energy and Water

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Pro.ress in Natural Science:Materials Internatio.al 2018年第2期28卷 97-98页

作者： G.Q.(max) Lu University o. Surrey

In the last decade,enviro.mental pressures due to.air and water po.lutio. and the drive fo. clean energy supply are rising,which have led to.the tremendo.s interest and investment in sustainable materials *** has been at the fo.efro.t o. research and develo.ment o. clean techno.o.ies fo. air,water and energy no. surprisingly because o. the stro.g need fo. such techno.o.ies to.balance develo.ment and

关键词： Energy and Water Nano.aterials fo. Clean Air

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Numerical micro.texture o.timizatio. fo. lubricated co.tacts-A critical discussio.

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Frictio. 2022年第11期10卷 1772-1809页

作者： max MARIAN Andreas ALMQVIST Andreas Ro.ENKRANZ Michel FILLo. Department o. Mechanical and Metallurgical Engineering Pontificia Universidad Católica de ChileSantiago 690411Chile Divisio. o. Machine Elements LuleåUniversity of TechnologyLuleåSE-97187Sweden Department o. Chemical Engineering Biotechnology and MaterialsFCFMUniversity of ChileSantiago 8370456Chile Institut Pprime CNRSUniversity of PoitiersPoitiers Cedex TSA 4112386073France

Despite numero.s experimental and theo.etical studies repo.ted in the literature,surface micro.texturing to.co.tro. frictio. and wear in lubricated tribo.co.tacts is still in the trial-and-erro. *** tribo.o.ical behavio.r and advantageo.s micro.texture geo.etries and arrangements largely depend o. the co.tact type and the o.erating *** scale implementatio. is hampered by the co.plexity o. numerical *** substantiates the urgent need to.numerically design and o.timize micro.textures fo. specific *** these aspects have no. been co.ered by o.her review articles yet,we aim at summarizing the existing state-o.–the art regarding o.timizatio. strategies fo. micro.textures applied in hydro.ynamically and elasto.ydro.ynamically lubricated *** analysis demo.strates the great po.ential o. o.timizatio. strategies to.further tailo. micro.textures with the o.erall aim to.reduce frictio. and wear,thus co.tributing to.ard an impro.ed energy efficiency and sustainability.

关键词： micro.texturing hydro.ynamics elasto.ydro.ynamics tribo.simulatio. o.timizatio.

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Why did life develo. o. the surface o. the Earth in the Cambrian？

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Geo.cience Fro.tiers 2016年第6期7卷 865-873页

作者： Carlo.Do.lio.i Jo.annes Pignatti max Co.eman Department o. Earth Sciences Sapienza University 00185 Rome Italy NASA Jet Pro.ulsio. Labo.ato.y California Institute of Technology Pasadena CA 91109 USA NASA Astro.io.o.y Institute USA

Life was limited fo. mo.t o. Earth＇s histo.y, remaining at a primitive stage and mo.tly marine until abo.t 0.55 Ga. In the Paleo.o.c, life eventually explo.ed and co.o.ized the co.tinental realm. Why had there been such a lo.g perio. o. delayed evo.utio. o. life？ Early life was do.inated by Archaea and Bacteria, which can survive io.izing radiatio. better than o.her o.ganisms. The magnetic field preserves the atmo.phere, which is the main shield o. UV radiatio.. We explo.e the hypo.hesis that the Cambrian explo.io. o. life co.ld have been enabled by the increase o. the magnetic field dipo.e intensity due to.the so.idificatio. o. the inner co.e, caused by the co.ling o. the Earth, and the co.co.itant decrease with time o. the high-energy so.ar flux since the birth o. the so.ar system. Therefo.e, the two.pheno.ena co.ld be respo.sible fo. the gro.th and thickening o. the atmo.phere and the develo.ment o. land surface life.

关键词： o.igin o. lifeInner co.e so.idificatio.So.ar io.izing radiatio.s

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Partial and Spectral-Visco.ity Mo.els fo. Geo.hysical Flo.s

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Chinese Annals o. Mathematics,Series B 2010年第5期31卷 579-606页

作者： Qingshan CHEN max GUNZBURGER Xiao.ing WANG Department o. Scientific Co.puting Florida State University Tallahassee FL 32306 USA. Department o. Mathematics. Flo.idaState University Tallahassee FL 32306 USA.

Two.mo.els based o. the hydro.tatic primitive equatio.s are *** first mo.el is the primitive equatio.s with partial visco.ity o.ly,and is o.iented to.ards large-scale wave structures in the o.ean and *** seco.d mo.el is the visco.s primitive equatio.s with spectral eddy visco.ity,and is o.iented to.ards turbulent geo.hysical *** bo.h mo.els,the existence and uniqueness o. glo.al stro.g so.utio.s are *** the seco.d mo.el,the co.vergence o. the so.utio.s to.the so.utio.s o. the classical primitive equatio.s as eddy visco.ity parameters tend to.zero.is also.established.

关键词： Primitive equatio.s Partial visco.ity Spectral-eddy visco.ity

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Effects o. light emitting dio.e lights o. plant gro.th,develo.ment and traits a meta-analysis

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Ho.ticultural Plant Jo.rnal 2021年第6期7卷 552-564页

作者： Yuanchun Ma An Xu Zo.g-Ming(max)Cheng Co.lege o. Ho.ticulture Nanjing Agricultural UniversityNanjingJiangsu 210095China Department o. Plant Sciences University of TennesseeKnoxvilleTN 37996United States

The vario.s mo.o.hro.atic Light Emitting Dio.e(LED)lights are widely used in gro.th facility fo. cultivating vario.s plants,particularly ho.ticultural cro.s because o. their higher lumino.s efficiency,lo.er radiatio. and po.er co.sumptio. than the traditio.al white fluo.escent lamp ***,co.siderable inco.sistent effects have been repo.ted in *** co.ducted a meta-analysis to.assess the effects o. different co.o.s o. LED light o. plant gro.th,develo.ment and vario.s *** to.the light fro. white fluo.escent lamps,the red LED light significantly changed 4 o.t 26 plant characteristics by at least 37%,and blue LED light significantly increased 5 o. 26 assessed characteristics by 37%o. *** co.binatio. o. red/blue LED lights o.ly significantly increased dry weight by 161%amo.g 25 plant characteristics *** to.the white LED light,red LED light significantly decreased 2 o. 9 plant characteristics by at least 36%,and blue LED light significantly decreased o.ly 1 o. 9 plant characteristics,to.al chlo.o.hyll co.tent,by 42%.In the mo.erato.s analyzed,plant taxo.o.ic families significantly influenced the effects o. LED lights o. sho.t dry weight,and plant life cycles and plant taxo.o.ic families significantly affected the effect o. sto.atal *** systematic meta-analysis,we fo.nd that the effect o. LED o. plant gro.th and quality traits was speciesspecific,and the effect was affected by the cultivatio. ***,we suggest that researchers be mo.e targeted to.experiment,and co.lect traits asso.iated with practical pro.uctio.,especially related to.the quality o. pro.uct data,such as caro.eno.ds,antho.yanin and o.her antio.idant *** article is to.pro.ide mo.e data with practical applicatio.,guide the applicatio. o. LED in ho.ticultural plant facto.y.

关键词： LED Plant develo.ment Meta-analysis

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Tempo.al and spatial anti-aliasing fo. rendering reflectio.s o. water waves

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Co.putatio.al Visual Media 2021年第2期7卷 201-215页

作者： Namo.Po.ee Nelso. max Kei Iwasaki Yo.hino.i Do.ashi Ho.kaido.University Sapporo060-0814Japan University o. Califo.nia Davis95616USA Wakayama University Wakayama640-8441Japan

The reflectio. o. a bright light so.rce o. a dynamic surface such as water with waves can be difficult to.render well in real time due to.reflectio. aliasing and *** this paper,we pro.o.e a so.utio. to.this pro.lem by appro.imating the reflectio. directio. distributio. fo. the water surface as an elliptical Gaussian *** we analytically integrate the reflectio. co.tributio. thro.gho.t the rendering interval *** metho. can render in real time an animatio. o. the time integrated reflectio. o. a spherical light so.rce o. highly dynamic waves with reduced aliasing and flickering.

关键词： real-time rendering anti-aliasing reflectio. water surface water waves elliptical Gaussian

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