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糖降肾康颗粒治疗糖尿病肾病随机双盲安慰剂对照多中心临床试验

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中国新药与临床杂志 2011年第1期30卷 16-19页

作者：马松涛刘冬恋牛锐刘睿斌吉勤詹继红史伟张磊成都医学院药学院四川成都610083 成都尚科药业有限责任公司四川成都610000 重庆科瑞制药有限责任公司重庆400060 云南中医学院第一附属医院云南昆明650051 贵阳中医学院第一附属医院贵州贵阳550001 广西中医学院第一附属医院广西南宁530023 四川省人民医院四川成都610072

目的评价糖降肾康颗粒治疗糖尿病肾病(dN)的临床疗效与安全性。方法采用随机、双盲、双模拟、安慰剂平行对照、多中心临床试验设计。低剂量组:糖降肾康颗粒1袋+糖降肾康颗粒模拟剂1袋,3次·d^(-1),口服。高剂量组:糖降肾康颗粒2袋,2次... 详细信息

目的评价糖降肾康颗粒治疗糖尿病肾病(dN)的临床疗效与安全性。方法采用随机、双盲、双模拟、安慰剂平行对照、多中心临床试验设计。低剂量组:糖降肾康颗粒1袋+糖降肾康颗粒模拟剂1袋,3次·d^(-1),口服。高剂量组:糖降肾康颗粒2袋,2次·d,模拟剂2袋,1次·d^(-1),口服。安慰剂组:模拟剂,2袋,3次·d^(-1),口服。8 wk为一个疗程。所有受试者在试验期间糖尿病基础治疗不变。观察临床疗效,治疗前、治疗4 wk和8 wk末检查尿微量白蛋白排泄率(UAER)、24 h尿蛋白定量和空腹血糖。结果共纳入194例Ⅲ或Ⅳ期dN患者,剔除8例,脱落2例,184例按方案完成试验。高剂量组临床控制率为47%,低剂量组为42%,安慰剂组为18%,高、低剂量组疗效优于安慰剂组(P0.05)。治疗后,高、低剂量组和安慰剂组UAER分别为(83±157)、(212±612)和(298±783)μg·min^(-1),24 h尿蛋白定量分别为(477±427)、(675±856)和(812±1318)mg,高、低剂量组均低于安慰剂组(PdN具有良好的疗效,且安全性良好。

关键词：糖尿病肾病随机对照试验多中心研究糖降肾康颗粒

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新型棒碱在VCM装置干燥器的应用

聚氯乙烯 2003年第5期31卷 19-21页

作者：兰一刘岭梅合肥工业经济学校安徽合肥230051 上海氯碱化工股份有限公司上海200241

介绍了利用固碱进行VCM脱水干燥的机理及干燥流程设计,采用上海氯碱创业公司生产的棒碱后,上海氯碱化工股份有限公司的VCM装置从未出现过设备堵塞现象,2000年棒碱的平均单耗为3.8t/(万t·VCM),VCM的质量明显提高。

关键词：棒碱 VCM装置聚氯乙烯氯乙烯干燥器应用脱水干燥干燥流程固碱

每周应用紫杉醇、卡铂及同期放射治疗原发性宫颈癌的I期临床试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 48-49页

作者： Rogers P drake R.d 李焱

Standard primary treatment for locally advanced cervix cancer is radiation (RT) with concomitant platinum-based chemotherapy (CT). I ncomplete local control and the appearance of distant disease herald poor surviv al and warrant evaluation of new primary strategies. Paclitaxel and carboplatin are active agents in recurrent cervical carcinoma, have potent, synergistic in v itro radiosensitization, and are cytotoxic in weekly schedules. This study was d one to determine the maximum tolerated dose (MTd) and dose-limiting toxicity (d LT) of weekly pacli-taxel/carboplatin chemoradiotherapy in locally advanced cer vix cancer. Women with primary, previously untreated, squamous cell or adenocarc inoma of the cervix, FIGO stage IB2 to IVA, negative para-aortic lymph nodes, a dequate organ function and performance status were eligible. Pelvic RT (45 Gy ov er 5 weeks-180 cGy/day, four-field) was followed by two brachytherapy applicat ions (Point A low dose rate (LdR): 90 Gy, high dose rate (HdR): 75 Gy). concurre nt weekly CT was paclitaxel 50 mg/m2 and carboplatin, starting at AUC 1.5 and es calating in three-patient cohorts by AUC 0.5 (max AUC 3.5). dose escalation fol lowed a 4-week observation period for toxicity. A grade III-IV toxicity prompt ed up to three additional patients per dose level. A second event defined dLT. C T was administered concurrently throughout brachytherapy. Fifteen patients were enrolled and treated over four dose levels until dLT was reached. Median age was 44 years (range, 23-70); stages: IB2: 1, IIB: 9, IIIA: 1, IIIB: 4. Median RT t reatment time was 61 days (range, 55-79). Fourteen patients received brachyther apy (LdR: 8, HdR: 6), and one received external RT only due to cervical stenosis . The median number of weekly CT cycles was seven (range, 6-7). One CT dose was dropped in one patient for a grade II thrombocytopenia. One grade III ANC was o bserved at dose level II (AUC 2.0) but not seen in three additional patients. At dose level IV (AUC

关键词： I期临床试验晚期宫颈癌放射治疗剂量限制性毒性淋巴结阴性放疗敏感性非血液系统毒性细胞毒性药物近距离放射疗法剂量水平

电子入射氮原子的近域值双电离中电子关联分析(英文)

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IMP & HIRFL Annual Report 2006年 105-106页

作者：曹士娉 A.dorn M.dürr max-Planck-Institute for Nuclear Physics Saupfercheckweg 1 HeidelbergGermany. max-Planck-lnstitute for Nuclear Physics Saupfercheckweg 1 HeidelbergGermany.

The experiment on near threshold double ionization of helium by 106 eV electron impact was per- formed with reaction microscope in MPI-K: e+He→3e+He2+(1) The momenta of those three particles after double ionization were obtained by measuring their flight time and two dimensional *** electron detector of the setup has a hole in its center,which re- sults in the special structure shown in Fig.1a).Fig 1a)shows the two dimensional momentum distribu-

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33UH高矫顽力烧结NdFeB材料的制备

金属功能材料 2002年第1期9卷 5-7页

作者：常志梁李胜利高斌太原重型机械学院太原030024 太原刚玉磁电实业有限公司太原030012

针对永磁电机对磁钢的特殊要求 ,通过采用重稀土取代轻稀土 ,减少氧含量且低温长时间细晶粒液相烧结技术制备 33UH高矫顽力烧结NdFeB材料 ,经测试其静态性能指标同时达到Br ≥ 1 15T(11 5kG) ,Hcj ≥2 0 0 0kA/m(2 5 0kOe) ,(BH) max ... 详细信息

针对永磁电机对磁钢的特殊要求 ,通过采用重稀土取代轻稀土 ,减少氧含量且低温长时间细晶粒液相烧结技术制备 33UH高矫顽力烧结NdFeB材料 ,经测试其静态性能指标同时达到Br ≥ 1 15T(11 5kG) ,Hcj ≥2 0 0 0kA/m(2 5 0kOe) ,(BH) max ≥ 2 5 6kJ/m3 (32MGOe)

关键词：烧结高矫顽力制备永磁材料钕铁硼永磁电机

Systematic characterization of cleanroom-free fabricated macrovalves,demonstrating pumps and mixers for automated fluid handling tuned for organ-on-chip applications

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Microsystems & Nanoengineering 2022年第3期8卷 163-176页

作者： Elsbeth G.B.M.Bossink Anke R.Vollertsen Joshua T.Loessberg-Zahl Andries d.van der Meer Loe l.Segerink Mathieu Odijk BIOs Lab on a Chip Group MESA+instituteTechnical Medical CenterMax Planck Institute for Complex Fluid DynamicsUniversity of TwenteEnschedeThe Netherlands Applied Stem Cell Technologies Group Technical Medical CenterUniversity of TwenteEnschedeThe Netherlands

Integrated valves enable automated control in microfuidic systems,as they can be applied for mixing,pumping and compartmentalization *** automation would be highly valuable for applications in organ-on-chip(OoC)***,OoC systems typically have channel dimensions in the range of hundreds of micrometers,which is an order of magnitude larger than those of typical microfluidic *** most-used fabrication process for integrated,normally open polydimethylsiloxane(PdMS)valves requires a reflow photoresist that limits the achievable channel *** addition,the low stroke volumes of these valves make it challenging to achieve flow rates of microliters per minute,which are typically required in OoC ***,we present a mechanical'macrovalve'fabricated by multilayer soft lithography using micromilled direct *** demonstrate that these valves can close off rounded channels of up to 700μm high and 1000μm ***,we used these macrovalves to create a peristaltic pump with a pumping rate of up to 48μL/min and a mixing and metering device that can achieve the complete mixing of a volume of 6.4μL within only 17 *** initial cell culture experiment demonstrated that a device with integrated macrovalves is biocompatible and allows the cell culture of endothelial cells over multiple days under continuous perfusion and automated medium refreshment.

关键词： pumping mixer pump

Normative Values of Cardio-Respiratory Endurance in Adults in Benin

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Open Journal of Therapy and Rehabilitation 2021年第4期9卷 143-153页

作者： H. Etienne Alagnide d. didier Niama Natta Emmanuel Sogbossi Wilfried dahoueto Eric dossa M. Antonin Agbogbo G. Toussaint Kpadonou University Clinic of Physical Medicine and Rehabilitation CNHU-HKM Cotonou Benin

Cardiorespiratory endurance is a determining factor in the assessment of the state of health of a person. Objective: To determine the reference values for cardiorespiratory endurance in Beninese adults. Methods: Prospective transversal study, with a descriptive and analytical aim. It was carried out on healthy adult subjects (18 to 50 years old), of Cotonou and Abomey cities, from October 2017 to May 2018, without clinically identifiable orthopedic, cardiorespiratory, osteoarticular or neuromotor impairment. These subjects performed three different cardio-respiratory endurance tests: The six-minute walk test (WT6), cycloergometer test (CT) and the step test (ST). Data processing and analysis were done using SPSS version 22 software. A linear regression model was used to establish the prediction equation of maximal oxygen uptake (VO2 max) with the WT6 data. The significance level chosen was 5%. Results: Subjects average age was 30.0 ± 9.8 years. It was especially men (54.20%), students (42.13%), with a normal corpulence (69.91%). At WT6, they walked 365 m to 798 m (557.1 ± 93.6 m) with extreme heart rates (EHR) of 67 to 189 (136.7 ± 19.0) beats per minute. At ST, the extreme powers developed were 2.7 watts/kg and 11.8 watts/kg (6.4 ± 1.8 watts/kg), with EHR of 99 to 204 (168.4 ± 15.4) beats per minute. The predictor equation of VO2 max by WT6 was function of the subject’s weight, age and sex (R = 0.73). Conclusion- dana;">discussion: These normative values of cardio-respir

关键词： Cardio-Respiratory Endurance 6-Minute Walk Test Step Test VO2 max Benin

Optimization of the Algae Production in Innovative Ponds-The MAMBO Project

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Optimization of the Algae Production in Innovative Ponds-The...

Lack of correlation between rejection of tumor cells co-expresssing interleukin-2 and B7.1 and vaccine efficiency

The 19th European Biomass conference and Exhibition

作者： Prussi,M. Chiaramonti,d. Casini,d. Rodolfi,L. Bassi,N. Bacci,F. Bondioli,P. della,Bella,L. Rivolta,G. Chini Zittelli,G. Tredici,M.R.

Production of microalgae biomass as an alternative feedstock for biodiesel is a promising *** reduction in energy consumption of traditional algae cultivation systems is today one of the most important issues towards sustainable biofuel *** the MAMBO project an innovative pond has been designed and realized to investigate the possibility of reducing energy consumption of the cultivation phase as well as the use of *** aim of this project is in fact to demonstrate the possibility of using algae as an alternative and cost-effective feedstock for the biodiesel *** innovation is based on the reduction of the mean fluid velocity in the pond and the reduction of the water head,while maintaining sufficient turbulence and recirculation of the *** typical energy demand for mixing in a traditional raceway pond,operated at 20 cm depth and 20 cm/s speed,is estimated in 0.034 W/*** reduction in fluid velocity has a large impact on the energy demand of the cultivation phase（essential in view of biofuel production）,nevertheless the major drawback is that it also reduces the effectiveness of mixing,which is a key factor to obtain high productivity per unit area.A reduced culture depth also offers the advantage of a lower amount of water needed per square meter of pond maintaining the same area for solar energy input and leads to higher algae concentration in the fluid *** and solubilisation of carbon dioxide in the fluid stream also deserve *** have been developed in the innovative pond to avoid or reduce uneconomical co2 *** real flow field in both the traditional and the innovative ponds was evaluated by velocimetry measurement under actual operation *** methodology adopted in this research work was based on a combination of numerical and experimental activities.A numerical tool was designed to estimate the effect of the reduction in fluid velocity and culture depth on energy consumption a

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中国实验血液学杂志 1997年第3期5卷 315-316页

作者： G.Richter S.Cayeux C.Becker C.Beck A.Aicher B.drken T.Blankenstein max-delbrck-Center for Molecular Medicine Robert-Rssle-Strasse 1013122 BerlinRobert-Rssle KlinikFreie Universitt BerlinLindenberger Weg 8013125 BerlinGernmanyMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 BerlinMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 BerlinMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 BerlinRobert-Rssle KlinikFreie Universitt BerlinLindenberger Weg 8013125 BerlinGernmanyMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 Berlin

Gene modification of tumor cells to express a varietyof cytokines such as IL-2 or the co-stimulatory moleculeB7. 1 led to increased immunogenicity and reducedtumorigenicity of tumors has several models and thisprocess involves T cells. We have previously reporteddecreased tumorigenicity of the murine plasmacytomaJ558L (MHC class Ⅰ^+ and class Ⅱ^-) expressing IL-2 orB7. l. When systemic immunity was analyzed,

关键词： rejection interleukin vaccine immunity expressing cytokines immunized comparable nude alone