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Multiscale Hemodynamics Using GPU Clusters

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Communications in Computational Physics 2012年第1期11卷 48-64页

作者： mauro bisson Massimo Bernaschi Simone Melchionna Sauro Succi Efthimios Kaxiras Department of Computer Science University of Rome“Sapienza”Italy Istituto Applicazioni Calcolo Consiglio Nazionale delle RicercheRomeItaly Istituto Processi Chimico-Fisici Consiglio Nazionale delle RicercheRomeItaly Institute of Material Sciences and Engineering ´Ecole Polytechnique F´ed´erale de LausanneSwitzerland Freiburg Institute for Advanced Studies School of Soft Matter ResearchAlbertstr.1979104 FreiburgGermany Department of Physics and School of Engineering and Applied Sciences Harvard UniversityCambridgeMAUSA

The parallel implementation of MUPHY,a concurrent multiscale code for large-scale hemodynamic simulations in anatomically realistic geometries,for multi-GPU platforms is *** tests show excellent results,with a nearly linear parallel speed-up on up to 32GPUs and a more than tenfold GPU/CPU acceleration,all across the range of *** basic MUPHY scheme combines a hydrokinetic(Lattice Boltzmann)representation of the blood plasma,with a Particle Dynamics treatment of suspended biological bodies,such as red blood *** the best of our knowledge,this represents the first effort in the direction of laying down general design principles for multiscale/physics parallel Particle Dynamics applications in non-ideal *** configures the present multi-GPU version of MUPHY as one of the first examples of a high-performance parallel code for multiscale/physics biofluidic applications in realistically complex geometries.

关键词： Multi-GPU computing hemodynamics molecular dynamics irregular domain

New Insight in Ethylene Signaling： Autokinase Activity of ETR1 Modulates the Interaction of Receptors and EIN2

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Molecular Plant 2010年第5期3卷 882-889页

作者： Melanie M.A. bisson Georg Groth Heinrich-Heine Universitat Dusseldorf Biochemie der Pflanzen Universitatsstr. 1 40225 Dosseldorf Germany

Ethylene insensitive 2 （EIN2）, an integral membrane protein of the ER network, has been identified as the central regulator of the ethylene signaling pathway. Still, the mechanism by which the ethylene signal is transferred from the receptors to EIN2 has not been solved yet. Here, we show that protein phosphorylation is a key mechanism to control the interaction of EIN2 and the receptors. In vivo and in vitro fluorescence studies reveal that the kinase domain of the receptors is essential for the interaction. Cyanide, an ethylene agonist, which is known to reduce auto-phosphorylation of the ethylene receptor ethylene resistant 1 （ETR1） or a mutation in the kinase domain of ETR1 that prevents autophosphorylation （H353A）, increases the affinity of the receptors for EIN2. On the other hand, mimicking permanent auto-phosphorylation of ETR1 as in the mutant H353E releases the EiN2-ETR1 interaction from the control by the plant hormone. Based on our data, we propose a novel model on the integration of EIN2 in the ethylene signaling cascade.

关键词： Membrane biochemistry protein phosphorylation/dephosphorylation receptors signal transduction membrane proteins ethylene protein-protein interaction.

Targeting Plant Ethylene Responses by Controlling Essential Protein-Protein Interactions in the Ethylene Pathway

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Molecular Plant 2015年第8期8卷 1165-1174页

作者： Melanie M.A. bisson Georg Groth Institute of Biochemical Plant Physiology Heinrich-Heine University Dusseldorf D-40204 Dusseldorf Germany

The gaseous plant hormone ethylene regulates many processes of high agronomic relevance throughout the life span of plants. A central element in ethylene signaling is the endoplasmic reticulum （ER）-Iocalized membrane protein ETHYLENE INSENSITIVE2 （EIN2）. Recent studies indicate that in response to ethylene, the extra-membranous C-terminal end of EIN2 is proteolytically processed and translocated from the ER to the nucleus. Here, we report that the conserved nuclear localization signal （NLS） mediating nuclear import of the EIN2 C-terminus provides an important domain for complex formation with ethylene receptor ETHYLENE RESPONSE1 （ETR1）. EIN2 lacking the NLS domain shows strongly reduced affinity for the receptor. Interaction of EIN2 and ETR1 is also blocked by a synthetic peptide of the NLS motif. The corre- sponding peptide substantially reduces ethylene responses in planta. Our results uncover a novel mecha- nism and type of inhibitor interfering with ethylene signal transduction and ethylene responses in plants. Disruption of essential protein-protein interactions in the ethylene signaling pathway as shown in our study for the EIN2-ETR1 complex has the potential to guide the development of innovative ethylene antagonists for modern agriculture and horticulture.

关键词： fruit ripening ethylene responses peptide protein-protein interactions inhibitor

*** volcano high-resolution topography:airborne LiDAR modelling validated by GPS data

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International Journal of Digital Earth 2016年第7期9卷 710-732页

作者： Marina bisson Claudia Spinetti Marco Neri Alessandro Bonforte Istituto Nazionale di Geofisica e Vulcanologia via della Faggiola 32PisaItaly Istituto Nazionale di Geofisica e Vulcanologia Centro Nazionale Terremotivia di Vigna MurataRomeItaly Istituto Nazionale di Geofisica e Vulcanologia Sezione di CataniaOsservatorio EtneoPiazza RomaCataniaItaly

High-resolution digital topography is essential for land management and planning in any type of territory as well as the reproduction of the Earth surface in a geocoded digital format that allows several Digital Earth *** a volcanic environment,Digital Elevation Models are a valid reference for multi-temporal analyses aimed to observe frequent changes of a volcano edifice and for the relative detailed morphological and structural *** the first time,a DTM(Digital Terrain Model)and a DSM(Digital Surface Model)covering the entire *** volcano(Italy)derived from the same airborne Light Detection and Ranging(LiDAR)are here *** than 250 million 3D LiDAR points have been processed to distinguish ground elements from natural and anthropic *** end product is the highly accurate representation of *** landscape(DSM)and ground topography(DTM)dated *** models have a high spatial resolution of 2 m and cover an area of 620 *** DTM has been validated by GPS ground control *** vertical accuracy has been evaluated,resulting in a root-mean-square-error of±0.24 *** DTM is available as electronic supplement and represents a valid support for various scientific studies.

关键词： Airborne LiDAR GPS DEM Mt.Etna

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激光脉冲对钢材热处理的计算

激光杂志 2008年第5期29卷 66-68页

作者：吴艳梅 Thomas bisson 伏云昌李俊昌昆明理工大学昆明650051 Ecole Nationale Superieure des Arts et metiers France

将激光作用对象视为热物性参数为常量的均匀介质,介绍材料在激光脉冲列作用下温度场的解析计算方法。基于研究结果及钢材马氏体相变模型,提出一种,激光脉冲列对钢材表面相变硬化处理时硬化带尺寸的计算方法,并通过激光热处理实验对计算... 详细信息

将激光作用对象视为热物性参数为常量的均匀介质,介绍材料在激光脉冲列作用下温度场的解析计算方法。基于研究结果及钢材马氏体相变模型,提出一种,激光脉冲列对钢材表面相变硬化处理时硬化带尺寸的计算方法,并通过激光热处理实验对计算方法的可行性作出证明。

关键词：脉冲激光温度场热处理解析计算

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他们是肉造的

喜剧世界(下半月) 2013年第1期 22-23页

作者： Terry bisson

如果有一天,外星人真的和地球人有了亲密接触,那情形也许并不像人们幻想了几十年的壮丽和辉煌,而是有点囧,有点雷……"他们是肉造的。""肉?""对,是肉,他们是肉造的。这点确凿无疑,我们从这个星球上的各个地方挑选了几个,把他们带到我们... 详细信息

如果有一天,外星人真的和地球人有了亲密接触,那情形也许并不像人们幻想了几十年的壮丽和辉煌,而是有点囧,有点雷……"他们是肉造的。""肉?""对,是肉,他们是肉造的。这点确凿无疑,我们从这个星球上的各个地方挑选了几个,把他们带到我们的侦查舰上,对他们

关键词：无线电时间跨度

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创伤后应激障碍

英国医学杂志中文版 2008年第1期11卷 33-38页

作者： Jonathan I bisson 孟晓梅(译) Cardiff University University Hospital of Wales Cardiff CFI4 4XW 不详

许多世纪以来，人们对于创伤事件后的反应一直有着各种生动的描述，但是随着时间的流逝，这些描述已经发生了本质的变化。最早将创伤后应激障碍纳入精神疾病诊断的是精神疾病诊断与统计手册第三版（DSM—Ⅲ）和国际疾病分类法第10版（In... 详细信息

许多世纪以来，人们对于创伤事件后的反应一直有着各种生动的描述，但是随着时间的流逝，这些描述已经发生了本质的变化。最早将创伤后应激障碍纳入精神疾病诊断的是精神疾病诊断与统计手册第三版（DSM—Ⅲ）和国际疾病分类法第10版（International Classification of Diseases，10thedition）^2。这一创伤后出现的可以理解的情感反应是否应该被诊断为疾病（创伤后应激障碍）仍然存在争议砣，目前大家更关注的是对于该病是否存在过度诊断的问题，其次是一些创伤后应激障碍的患者是否归属为严重精神卫生问题。本文对该病的现状与进展进行了回顾，介绍了该病的易感者以及适宜的防治措施。

关键词：创伤后应激障碍国际疾病分类法精神卫生问题 Diseases 疾病诊断情感反应统计手册过度诊断