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Endoscopic ultrasound-guided fine-needle aspiration for suspected malignancies adjacent to the gastrointestinal tract

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World Journal of Gastroenterology 2014年第26期20卷 8599-8605页

作者： Pietro Gambitta Antonio Armellino Edoardo Forti maurizio Vertemati Paola Enrica Colombo Paolo Aseni Unità di Chirurgia Endoscopica ed Ecoendoscopia Ospedale Niguarda Ca’ Granda Dipartimento di Scienze Biomediche e Cliniche "L. Sacco" Università degli Studi di Milano Servizio di Fisica Sanitaria Ospedale Niguarda Ca’ Granda HPB and Transplantation Surgery Ospedale Niguarda Ca’ Granda

AIM: To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in association with a multidisciplinary team evaluation for the detection of gastrointestinal malignancies.

关键词： Gastrointestinal neoplasm Endoscopic ultrasonography Clinical scoring system Fine needle aspiration Clinical decision support system

Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovineand porcine-derived bone:a comparative case report in humans

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Regenerative Biomaterials 2017年第2期4卷 125-128页

作者： Renzo Guarnieri Patricia DeVilliers maurizio Grande Luigi Vito Stefanelli Stefano Di Carlo Giorgio Pompa Adjunct Professor Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly Adjunct Assistant Professor of Pathology University of Alabama at BirminghamBirminghamALUSA Private Dental Implant Practice RomaItaly Assistant Professor Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly Professor Director Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly.

To evaluate and compare histomorphometrically the bone response to two xenografts,one bovine and the other porcine,grafted in adjacent extraction sockets in a *** this case report,two adjacent maxillary premolars were extracted,and the sockets were filled with two different xenogeneic bone substitutes(first premolar with bovine bone,and second premolar with porcine bone)to counteract post-extraction volume *** 6 months bone core specimens were harvested during the placement of implants at the regenerated ***,for the bovine xenograft the percentage of newly formed bone(osteoid)was 26.85%,the percentage of the residual graft material was 17.2%and the percentage of connective tissue 48.73%,while for the porcine xenograft,newly formed bone(osteoid)represented 32.19%,residual graft material was 6.57%and non-mineralized connective tissue was 52.99%.Histological results indicated that both biomaterials assessed in this study as grafts for socket preservation technique are biocompatible and *** bone derived demonstrated to be less resorbable than porcine bone *** xenogenic biomaterials did not interfere with the normal bone reparative processes.

关键词： socket preservation bovine bone-derived porcine bone-derived histology

Comment on:“A review on radiofrequency,microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis”

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 640-642页

作者： Michele Finotti maurizio Romano Marco Brizzolari Michele Scopelliti Giacomo Zanus 4th Surgery Unit Regional Hospital TrevisoUniversity of PaduaDipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche(DISCOG)PaduaItaly Baylor Scott&White Annette C.and Harold C.Simmons Transplant Institute Baylor University MedicalDallasTXUSA

We read with great interest the published article of Cheung et al.(1)on Hepatobiliary Surgery and *** authors provided a comprehensive review and critical evaluation of the three main locoregional ablation(LRA)techniques for liver cancer:radiofrequency(RFA),microwave(MWA),and high-intensity focused ultrasound ablations(HIFU).The focus of the paper is on their application to patients affected by hepatocellular carcinoma(HCC)in the context of end-stage liver disease.

关键词： hepatocellular Surgery al.

Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation

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World Journal of Gastroenterology 2017年第25期23卷 4491-4499页

作者： Francesca Romana Ponziani Maria Assunta Zocco Francesca D’Aversa maurizio Pompili Antonio Gasbarrini Internal Medicine Gastroenterology and Hepatology Division Agostino Gemelli Hospital

Antibiotics are usually prescribed to cure infections but they also have significant modulatory effects on the gut microbiota. Several alterations of the intestinal bacterial community have been reported during antibiotic treatment, including the reduction of beneficial bacteria as well as of microbial alpha-diversity. Although after the discontinuation of antibiotic therapies it has been observed a trend towards the restoration of the original condition, the new steady state is different from the previous one, as if antibiotics induced some kind of irreversible perturbation of the gut microbial community. The poorly absorbed antibiotic rifaximin seem to be different from the other antibiotics, because it exerts non-traditional effects additional to the bactericidal/bacteriostatic activity on the gut microbiota. Rifaximin is able to reduce bacterial virulence and translocation, has anti-inflammatory properties and has been demonstrated to positively modulate the gut microbial composition. Animal models, culture studies and metagenomic analyses have demonstrated an increase in Bifidobacterium, Faecalibacterium prausnitzii and Lactobacillus abundance after rifaximin treatment, probably consequent to the induction of bacterial resistance, with no major change in the overall gut microbiota composition. Antibiotics are therefore modulators of the symbiotic relationship between the host and the gut microbiota. Specific antibiotics, such as rifaximin, can also induce eubiotic changes in the intestinal ecosystem; this additional property may represent a therapeutic advantage in specific clinical settings.

关键词： Intestinal bacteria Antibiotic Rifaximin Gut microbiota Eubiosis Dysbiosis Gut microbiota modulation

Lightweight SOA-Based Twin-Engine Architecture for Enterprise Systems in Fixed and Mobile Environments

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China Communications 2016年第9期13卷 183-194页

作者： Tongguang Zhang Shuai Zhao Budan Wu maurizio Farina Bo Cheng Junliang Chen State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China Adaptive Software Company Via Posillipo 255Naples 80123Italy

Mobile devices as a popular computing platform for enterprise systems have enabled certain tasks to be executed out of ***,the work may be interrupted due to the server shutdown or network disconnection when employees access traditional single-engine Business Process Management *** overcome this defect,we present a lightweight twin-engine architecture based on Service Oriented Architecture(SOA).In this paper,we discuss in detail the design and implementation of the architecture,and present a trigger mechanism to activate engines according to the states of hybrid environments since it is critical for the two types of engines to cooperate closely in hybrid environments with fixed and mobile computing *** experimental results validate the usability of the architecture.

关键词： twin-engine SOA enterprise system mobile environment

Time difference correlation between earthquake lights and seismic ground accelerations

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Applied Geophysics 2021年第1期18卷 9-16,128页

作者： Juan Antonio Lira maurizio Mulas Facultad de Ciencias Físicas Universidad Nacional Mayor de San MarcosLima 1Peru Sección Física Departamento Académico de CienciasPontificia Universidad Católica del PerúLima 32Peru Escuela Superior Politécnica del Litoral ESPOLFacultad de Ingeniería en Ciencias de la TierraCampus Gustavo Galindo Km 30.5 Vía PerimetralP.O.Box 09-01-5863

Although earthquake lights have been known since ancient times,it has not been easy to study *** was not until the 60s that the first photographs of them were *** the Peruvian earthquake in 2007,it was possible to obtain the fi rst fi lm recording on earthquake ***,during the earthquakes in Ecuador in 2016 and in Mexico in 2017,two fi lms of the earthquake lights were *** fi lm recordings have helped in the study of earthquake lights,both for their objectivity and for their informational *** causal mechanisms have been proposed to explain earthquake lights:piezoelectricity,radon emanation,fluid diffusion,friction-vaporization,positive holes and dipole currents,among *** this work a time difference correlation between earthquake lights and seismic ground accelerations was found and we use both seismic data and fi lm recordings of earthquake lights to explain its *** the discussion section it is suggested that fracturing of rocks manifest itself to some extent in the form of static electricity producing earthquake lights through induction The induction model proposed is new and it can explain the formation of EQL,even if the earth’s crust has layers of large electrical *** model also explains the formation of seismic lights without the need for special conditions on the earth’s surface or in the atmosphere.A better understanding of the earthquake lights generation process can improve our understanding of seismicity and help in the prediction of earthquakes.

关键词： time diff erence correlation earthquake lights seismic ground accelerations rock fracturing

Immunotherapy for nonalcoholic fatty liver disease-related hepatocellular carcinoma:Lights and shadows

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1622-1636页

作者： Federico Costante Carlo Airola Francesco Santopaolo Antonio Gasbarrini maurizio Pompili Francesca Romana Ponziani Internal Medicine and Gastroenterology-Hepatology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRoma 00168Italy Catholic University Largo Francesco Vito 100168 RomaItaly

About one-fourth of adults globally suffer from nonalcoholic fatty liver disease(NAFLD), which is becoming a leading cause of chronic liver disease worldwide. Its prevalence has rapidly increased in recent years, and is projected to increase even more. NAFLD is a leading cause of hepatocellular carcinoma(HCC), the sixth-most prevalent cancer worldwide and the fourth most common cause of cancer-related death. Although the molecular basis of HCC onset in NAFLD is not completely known, inflammation is a key player. The tumor microenvironment(TME) is heterogeneous in patients with HCC, and is characterized by complex interactions between immune system cells, tumor cells and other stromal and resident liver cells. The etiology of liver disease plays a role in controlling the TME and modulating the immune response. Markers of immune suppression in the TME are associated with a poor prognosis in several solid tumors. Immunotherapy with immune checkpoint inhibitors(ICIs) has become the main option for treating cancers, including HCC. However, meta-analyses have shown that patients with NAFLD-related HCC are less likely to benefit from therapy based on ICIs alone. Conversely, the addition of an angiogenesis inhibitor showed better results regarding the objective response rate and progression-free survival. Adjunctive diagnostic and therapeutic strategies, such as the application of novel biomarkers and the modulation of gut microbiota, should be considered in the future to guide personalized medicine and improve the response to ICIs in patients with NAFLD-related HCC.

关键词： Hepatocellular carcinoma Immunotherapy Liver cancer Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Obesity

Advances in medical decision support systems for diagnosis of acute graft-versus-host disease: molecular and computational intelligence joint approaches

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Frontiers in Biology 2011年第4期6卷 263-273页

作者： maurizio FIASCHÉ Maria CUZZOLA Giuseppe IRRERA Pasquale IACOPINO Francesco Carlo MORABITO DIMET University“Mediterranea”of Reggio CalabriaItaly Transplant Regional Center of Stem Cells and Cellular Therapy “A.Neri”Reggio CalabriaItaly School of Hematology University of MessinaItaly

Acute graft-versus-host disease (aGVHD) is a serious systemic complication of allogeneic hematopoietic stemcell transplantation (HSCT) causing considerable morbidity and mortality. Acute GVHD occurs when alloreactivedonor-derived T cells recognize host-recipient antigens as foreign. These trigger a complex multiphase process thatultimately results in apoptotic injury in target organs. The early events leading to GVHD seem to occur very soon,presumably within hours from the graft infusion. Therefore, when the first signs of aGVHD clinically manifest, thedisease has been ongoing for several days at the cellular level, and the inflammatory cytokine cascade is fully ***, it comes as no surprise that progress in treatment based on clinical diagnosis of aGVHD has been limited in the past30 years. It is likely that a pre-emptive strategy using systemic high-dose corticosteroids as early as possible couldimprove the outcome of aGVHD. Due to the deleterious effects of such treatment particularly in terms of infection riskposed by systemic steroid administration in a population that is already immune-suppressed, it is critical to identifybiomarker signatures for approaching this very complex task. Some research groups have begun addressing this issuethrough molecular and proteomic analyses, combining these approaches with computational intelligence techniques,with the specific aim of facilitating the identification of diagnostic biomarkers in aGVHD. In this review, we focus on theaGVHD scenario and on the more recent *** also attempt to give an overview of the classical and noveltechniques proposed as medical decision support system for the diagnosis of GVHD.

关键词： computational intelligence gene selection GVHD machine learning personalized modelling wrapper

A non-ideal solution theory for the mechanics and electrochemistry of charged membranes

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npj Computational Materials 2022年第1期8卷 1365-1378页

作者： Alain Boldini maurizio Porfiri Center for Urban Science and Progress Department of Mechanical and Aerospace EngineeringNew York University Tandon School of Engineering370 Jay StreetBrooklyn11201NYUSA Center for Urban Science and Progress Department of Mechanical and Aerospace EngineeringDepartment of Biomedical EngineeringNew York University Tandon School of Engineering370 Jay StreetBrooklyn11201NYUSA

Understanding how ions and solvent molecules migrate within charged membranes is fundamental for advancing the analysis of biological membranes and the design of energy storage and production *** efforts highlighted a significant interplay between mechanics and electrochemistry in charged membranes,calling for the development of high-fidelity models to describe their ***,we propose a continuum theory of the chemoelectromechanics of charged membranes,accounting for potentially large deformations and non-idealities of the solution permeating the *** demonstrate the potential applications of our theory within the study of ionic polymer *** theory predicts sizeable effects of non-idealities and mechanical deformations,enabling insight into the role of mechanics on solute and solvent transport within charged membranes.

关键词： interaction. theory electrochemistry