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物理化学学报 2004年第3期20卷 244-250页

作者：许小平 Andreas Hüther gerd maurer 福州大学化学化工学院福州350002 Lehrstuhl für Technische Thermodynamik Universitt Kaiserslautern

基于maurer和Prausnitz的凝胶相平衡条件,建立了凝胶的溶胀模型.模型假设凝胶是以凝胶组分及凝胶吸收的溶液为核心,以弹性半渗透膜为壳的复合体.并采用UNIQUAC方程计算凝胶相及与之共存液相的Gibbs过剩自由能,采用“phantomnetwork”理... 详细信息

基于maurer和Prausnitz的凝胶相平衡条件,建立了凝胶的溶胀模型.模型假设凝胶是以凝胶组分及凝胶吸收的溶液为核心,以弹性半渗透膜为壳的复合体.并采用UNIQUAC方程计算凝胶相及与之共存液相的Gibbs过剩自由能,采用“phantomnetwork”理论计算凝胶的弹性自由能,采用“自由体积”计算分子的尺度效应.同时以N-异丙基丙烯酰胺(IPAAm)为单体合成了IPAAm凝胶.研究了25℃时IPAAm凝胶在丙酮水溶液中的溶胀行为,并测定了丙酮在胶体相和与之共存液相中的分配,以检验模型的关联与预报能力.结果表明,模型预报的单体总量和交联剂浓度对凝胶溶胀的影响与实验符合得很好.而且凝胶溶胀时,能很好地预测丙酮在两相中的分配,表明模型具有很好的关联和预报能力.

关键词：水凝胶溶胀模型 N-异丙基丙烯酰胺丙酮水溶液溶胀行为胶体相液相关联预报

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The Swelling Equilibria of N-isopropylacrylamide Based Hydrogel in Aqueous Solution of Ethanol

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Chinese Journal of Chemical Engineering 2003年第3期11卷 264-268页

作者：许小平 HüTHER Andreas maurer gerd Department of Chemical Engineering Fuzhou UniversityFuzhou 350002China Lehrstuhl für Technische Thermodynamik Universitt KaiserslauternPostfach 304967663 KaiserslauternGermany

N-isopropylacrylamide (NIPAAm) was used to synthesize NIPAAm homopolymer (nonionized) and NIPAAm-sodium methacrylate copolymer (ionized). The swelling equilibria for both gels were obtained in aqueous solution of ethanol with concentration ranging from 0 to 100%(by mass) at 25℃. The swollen gel in water shrank first with the addition of a small amount of ethanol and then reswelled with further addition of ethanol showing not only a discontinuous volume phase transition but also a typical reentrant phenomenon. A thermodynamic model based on the UNIQUAC with the 'free-volume' contribution was applied to correlate and predict the swelling behavior of the poly(NIPAAM)-gels in ethanol-water mixture.

关键词： hydrogel swelling poly(N-isopropylacrylamide) model

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Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro

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World Journal of Gastroenterology 2005年第26期11卷 4024-4031页

作者： Christian Hafner Stefanie Meyer Thomas Langmann gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt Department of Dermatology University Hospital of Regensburg D-93042 Regensburg Germany Department of Clinical Chemistry University Hospital of Regensburg D-93042 Regensburg Germany Institute of Pathology University Hospital of Regensburg D-93042 Regensburg Germany Department of Internal Medicine University Hospital of Regensburg D-93042 Regensburg Germany

AIM:Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD). METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model. RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinAl, we found abundantly co-expressed EphB2 and ephrin-B1/2. Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrin- B1/2 expressing rat IEC-6-cells with recombinant EphB1-Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge. CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD.

关键词： Ephrin-B2 Crohn's disease IBD IEC-6 Wound healing Epithelial restitution

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