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Severe acute kidney injury due to oxalate crystal induced severe interstitial nephritis:A case report

World Journal of Nephrology 2024年第2期13卷 24-30页

作者： maulik k lathiya Praveen Errabelli Sasmit Roy Neeharik Mareedu Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Centra Lynchburg General HospitalLynchburgVA 24551United States Department of Nephrology UPMC Western MarylandCumberlandMD 21502United States

BACkGROUND Acute kidney injury(AkI)due to interstitial nephritis is a known condition primarily attributed to various *** medication-induced interstitial nephritis is common,occurrences due to non-pharmacological factors are *** report presents a case of severe AkI triggered by intratubular oxalate crystal deposition,leading to interstitial *** aim is to outline the case and its management,emphasizing the significance of recognizing uncommon causes of interstitial *** SUMMARY A 71-year-old female presented with stroke-like symptoms,including weakness,speech difficulties,and cognitive *** hypertension had been managed with hydrochlorothiazide(HCTZ)for over two *** admis-sion,severe hypokalemia and AkI were noted,prompting discontinuation of HCTZ and initiation of prednisolone for acute interstitial *** investigations,including kidney biopsy,confirmed severe acute interstitial nephritis with oxalate crystal deposits as the underlying *** treatment,initial renal function showed minimal ***,with prednisolone therapy and supportive measures,her condition gradually improved,high-lighting the importance of comprehensive *** This case underscores the importance of a thorough diagnostic approach in identifying and addressing uncommon causes of interstitial *** occurrence of interstitial nephritis due to oxalate crystal deposition,especially without typical risk factors,emphasizes the need for vigilance in clinical practice.

关键词： Acute kidney injury Interstitial nephritis Oxalate crystal Hydrochlorothiazide Hypokalemia Case report

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World Journal of Nephrology 2023年第3期12卷 66-72页

作者： maulik k lathiya Praveen Errabelli Salvatore Mignano Susan M Cullinan Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Pathology Mayo ClinicRochesterMN 55905United States

BACkGROUND Anaplasmosis is a tick-borne disease with a range of clinical manifestations,from a flu-like illness with fever and myalgias to a severe systemic disease with multisystem organ *** renal involvement is not a common presentation,there have been few cases reporting acute kidney injury from *** SUMMARY We present a 55-year-old female with anaplasmosis who developed acute kidney injury due to membranoproliferative glomerulonephritis(MPGN).The patient originally presented with cough and shortness of *** was admitted to the hospital with a diagnosis of community acquired pneumonia and received *** the hospital course she developed severe acute renal *** serological work up didn’t provide any conclusive ***,she underwent kidney biopsy which showed MPGN pattern suggesting autoimmune,multiple myeloma or infectious *** work up was undertaken which was negative for autoimmune diseases,vasculitis panel,paraproteinemias but tested positive for IgG anaplasma with high titers indicating *** Our case shows a unique presentation of severe acute renal failure from MPGN from tick borne *** is usually seen with autoimmune diseases,hepatitis C virus infections,***,we suggest that tick borne illness should also be considered when evaluating acute renal failure cases in tick borne prevalent regions.

关键词： Acute kidney injury Membranoproliferative glomerulonephritis Tick-borne Anaplasmosis Case report

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Severe hypernatremia in hyperglycemic conditions;managing it effectively:A case report

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World Journal of Critical Care Medicine 2023年第1期12卷 29-34页

作者： maulik k lathiya Praveen Errabelli Susan M Cullinan Emeka J Amadi Department of Emergency Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Hospital Internal Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States

BACkGROUND Diabetic ketoacidosis(DkA)and hyperglycemic hyperosmolar state(HHS)are common acute complications of diabetes mellitus with a high risk of *** combined with hypernatremia,the complications can be even *** is a rarely associated with DkA and HHS as both are usually accompanied by normal sodium or *** a result,a structured and systematic treatment approach is *** discuss the therapeutic approach and implications of this uncommon *** SUMMARY A 62-year-old man with no known past medical history presented to emergency department with altered mental *** work up in emergency room showed severe hyperglycemia with a glucose level of 1093 mg/dL and severe hypernatremia with a serum sodium level of 169 mEq/*** was admitted to the intensive care unit(ICU)and was started on insulin drip as per DkA *** 12 h of ICU admission,blood sugar was 300 mg/*** his mental status didn’t show much *** was dehydrated and had a corrected serum sodium level of>190 mEq/*** a result,dextrose 5%in water and ringer's lactate were *** was also given free water via an nasogastric(NG)tube and IV Desmopressin to improve his free water deficit,which improved his serum sodium to 140 mEq/*** The combination of DkA,HHS and hypernatremia is rare and extremely challenging to manage,but the most challenging part of this condition is selecting the correct type of fluids to treat these *** case illustrates that desmopressin and free water administration via the NG route can be helpful in this situation.

关键词： Diabetic ketoacidosis Hyperglycemic hyperosmolar state Hypernatremia Hyperglycemia Desmopressin Case repot

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Adenovirus F40/41 Gastroenteritis-Associated Emphysematous Gastritis:A Case Report

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Infectious Diseases & Immunity 2024年第2期4卷 93-95页

作者： maulik k.lathiya Abigail T.La Nou Maria E.Linnaus Susan M.Cullinan Emergency Department Mayo Clinic Health SystemEau Claire 54703WIUSA Critical Care Medicine Mayo Clinic Health SystemEau Claire 54703WIUSA General Surgery Department Mayo Clinic Health SystemEau Claire 54703WIUSA

Emphysematous gastritis(EG)is a rare form of gastritis characterized by gastric wall *** is associated with a high mortality *** case report describes a patient with a history of atrial fibrillation treated with apixaban,prior stroke,and schizoaffective disorder who showed epigastric tenderness on ***,no peritonitis signs were recorded,and laboratory values revealed high lactate levels and the presence of adenovirus F40/*** computed tomography scan showed extensive portal venous gas in the left hepatic lobe of the liver,as well as pneumatosis involving the entire stomach,indicating *** diagnosis was histologically confirmed and initially managed medically,which proved inefficacious,necessitating surgical intervention in the form of a laparotomy and esophagojejunostomy with Roux-en-Y *** case report suggests a potential association between EG and adenovirus F40/41–induced gastroenteritis,thereby emphasizing the challenging nature of *** underscores the need for comprehensive research to enhance our understanding of its underlying causes and effective treatment strategies.

关键词： Emphysema Gastritis Human adenovirus F40/41 Immunocompromised

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Vasopressin-induced hyponatremia in an adult normotensive trauma patient:A case report

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World Journal of Critical Care Medicine 2023年第1期12卷 35-40页

作者： maulik k lathiya Emily Pepperl Daniel Schaefer Hussam Al-Sharif Adel Zurob Susan M Cullinan Antonios Charokopos Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Pulmonary and Critical Care Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States

BACkGROUND Arginine vasopressin is a neuropeptide produced in the hypothalamus and released by the posterior pituitary *** addition to maintaining plasma osmolarity,under hypovolemic or hypotensive conditions,it helps maintain plasma volume through renal water reabsorption and increases systemic vascular *** synthetic analogues are widely used in the intensive care unit as a continuous infusion,in addition to hospital floors as an intravenous or intranasal dose.A limited number of cases of hyponatremia in patients with septic or hemorrhagic shock have been reported previously with *** report for the first time a normotensive patient who developed vasopressin-induced *** SUMMARY A 39-year-old man fell off a forklift and sustained an axial load injury to his *** had no history of previous *** was normal except for motor and sensory *** Imagine test showed endplate fracture at C7 and acute traumatic disc at C7 with cortical *** underwent cervical discectomy and fusion,laminectomy,and posterior instrumented *** intensive care unit admission post-surgery,he developed hyponatremia of 121-124 mEq/L post phenylephrine and vasopressin infusion to maintain blood pressure *** was evaluated for syndrome of inappropriate secretion of antidiuretic hormone,hypothyroid,adrenal-induced,or diuretic-induced *** the end of extensive evaluation for the underlying cause of hyponatremia,vasopressin was *** was also put on fluid restriction,given exogenous desmopressin,and a dextrose 5%in water infusion to prevent osmotic demyelination syndrome caused by sodium overcorrection which improved his sodium level to 135 mmol/*** The presentation of vasopressin-induced hyponatremia is uncommon in normotensive patients,and the most difficult aspect of this condition is determining the underlying cause of *** case illustrates that,considering the vast diffe

关键词： Hyponatremia Vasopressin Normotensive Therapy Case report

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Spherical quantum dot described by a scalar exponential potential under the influence of a linear electric field

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Communications in Theoretical Physics 2025年第2期77卷 172-175页

作者： k Bakke Departamento de Física Universidade Federal da Paraíba

We study the confinement of a spinless charged particle to a spherical quantum dot under the influence of a linear electric field. The spherical quantum dot is described by a short-range potential given by the power-exponential potential. Then, by analysing the region near the spherical quantum dot centre, we discuss two cases where the energy levels can be obtained for s-waves and how the linear electric field modifies the spectrum of energy of the spherical quantum dot.

关键词： spherical quantum dot power-exponential potential short-range potential linear electric field

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： convective boundary condition Darcy-Forchheimer medium hybrid nanofluid Joule heating magnetohydrodynamic (MHD) numerical solution O175.2 O361 regression analysis squeezing flow

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Photoluminescence upgradation of La_(2)MgTiO_(6):2%Dy^(3+) perovskite with monovalent(Li^(+)),divalent(Ba^(2+),Sr^(2+)) and trivalent(Bi^(3+),Sm^(3+))cation sensitization

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Journal of Rare Earths 2025年第1期43卷 47-56,I0002页

作者： V.P.Veena k.Arun C.k.Shilpa S.V.Jasira k.M.Nissamudeen School of Pure and Applied Physics Kannur UniversityPayyanur CampusEdatKannurKrala67 India Department of Nanoscience and Nanotechnology Kannur UniversityPayyanur CampusEdatkannurKerala670327India

Nano phosphors of 2%Dy^(3+)(wt%)doped La_(2)MgTiO_(6) and monovalent/divalent/trivalent co-doped La_(1.98)Dy_(0.02)MgTiO_(6):x%A^(y+)(A^(y+):Li+,Ba^(2+),Sr^(2+),Bi^(3+),and Sm^(3+);0≤x≤2 wt%)were synthesized by combustion *** the XRD data,it is deduced that an increase in the valency of co-dopant increases the crystallinity of the double perovskite orthorhombic nanocrystal *** an increase in co-dopant size,an elevation in optical bandgap is visible with the highest bandgap of 3.835 eV for Bi^(3+).The photo-absorption is monotonically broadened for Sr^(2+),Sm^(3+),and Li+around 200-450 ***351 nm,Dy^(3+)triggered lattice shows major characteristic emission peaks at 480 nm(^(4)F_(9/2)→^(6)H_(15/2)),574 nm(^(4)F_(9/2)→^(6)H_(13/2)),and 670 nm(^(4)F_(9/2)→^(6)H_(11/2)).leading to near white light emission with CIE coordinates(0.341,0.376).Upon co-doping,the PL intensity is significantly increased with maximum emission for trivalent Sm^(3+),followed by divalent Sr^(2+)and monovalent Li+*** increasing excitation wavelength,Sr^(2+)shows a dominated output and it is found that divalent Sr^(2+)is a potential codopant that could enhance luminescence intensity up to 6 times with a Sr^(2+)→Dy^(3+)energy transfer efficiency of 86%.It is specified that the CIE coordinates of Li+co-doped samples show ideal white emission with color coordinates(0.333,0.336).The concluding outcomes signify the noblest rare earth Sm^(3+)co-doping and thus Sm^(3+)→Dy^(3+)energy transfer mechanism is discussed in detail.

关键词： Photoluminescence Perovskite WLED Co-doping Rareearths

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Honeycomb-spiderweb-inspired self-similar hybrid cellular structures for impact applications

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Defence Technology(防务技术) 2025年第1期43卷 182-200页

作者： k.Tewari M.k.Pandit M.M.Mahapatra P.R.Budarapu School of Mechanical Sciences Indian Institute of Technology BhubaneswarBhubaneswar752050India

Inspired by nature's self-similar designs,novel honeycomb-spiderweb based self-similar hybrid cellular structures are proposed here for efficient energy absorption in impact *** energy absorption is enhanced by optimizing the geometry and topology for a given *** proposed hybrid cellular structure is arrived after a thorough analysis of topologically enhanced self-similar *** optimized cell designs are rigorously tested considering dynamic loads involving crush and high-velocity bullet ***,the influence of thickness,radial connectivity,and order of patterning at the unit cell level are also *** maximum crushing efficiency attained is found to be more than 95%,which is significantly higher than most existing traditional *** on,the first and second-order hierarchical self-similar unit cell designs developed during crush analysis are used to prepare the cores for sandwich *** tests are performed on the developed sandwich structures using the standard 9-mm *** influence of multistaging on impact resistance is also investigated by maintaining a constant total thickness and mass of the sandwich ***,in order to avoid layer-wise weak zones and hence,attain a uniform out-of-plane impact strength,off-setting the designs in each stage is *** sandwich structures with first and second-order self-similar hybrid cores are observed to withstand impact velocities as high as 170 m/s and 270 m/s,respectively.

关键词： Sandwich structures Honeycomb-spider web inspired Self-similar hierarchy Crush analysis High-velocity impact Strong and weak zones Multistaging

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Characterization and source apportionment of volatile organic compounds in Hong kong:A 5-year study for three different archetypical sites

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Journal of Environmental Sciences 2025年第5期151卷 424-440页

作者： Yuchen Mai Vincent Cheung Peter k.k.Louie kenneth Leung Jimmy C.H.Fung Alexis k.H.Lau Donald R.B.lake Dasa Gu Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong Kong 999077China Environmental Protection Department Hong Kong 999077China Environment and Ecology Bureau Hong Kong 999077China Department of Chemistry University of CaliforniaIrvine 92617USA

Initial success has been achieved in Hong kong in controlling primary air pollutants,but ambient ozone levels kept increasing during the past three *** organic compounds(VOCs)are important for mitigating ozone pollution as its major *** study analyzed VOC characteristics of roadside,suburban,and rural sites in Hong kong to investigate their compositions,concentrations,and source *** showthat the TVOC concentrations were 23.05±13.24,12.68±15.36,and 5.16±5.48 ppbv for roadside,suburban,and rural sites between May 2015 to June 2019,*** using Positive Matrix Factorization(PMF)model,six sources were identified at the roadside site over five years:Liquefied petroleum gas(LPG)usage(33%–46%),gasoline evaporation(8%–31%),aged air mass(11%–28%),gasoline exhaust(5%–16%),diesel exhaust(2%–16%)and fuel filling(75–9%).Similarly,six sources were distinguished at the suburban site,including LPG usage(30%–33%),solvent usage(20%–26%),diesel exhaust(14%–26%),gasoline evaporation(8%–16%),aged air mass(4%–11%),and biogenic emissions(2%–5%).At the rural site,four sources were identified,including aged airmass(33%–51%),solvent usage(25%–30%),vehicular emissions(11%–28%),and biogenic emissions(6%–12%).The analysis further revealed that fuel filling and LPG usage were the primary contributors to OFP and OH reactivity at the roadside site,while solvent usage and biogenic emissions accounted for almost half of OFP and OH reactivity at the suburban and rural sites,*** findings highlight the importance of identifying and characterizing VOC sources at different sites to help policymakers develop targeted measures for pollution mitigation in specific areas.

关键词： Volatile organic compounds Positive matrix factorization Source apportionment Ozone formation

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