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Low circulating levels of gastrin-17 in patients with Barrett's esophagus

World Journal of Gastroenterology 2005年第38期11卷 5988-5992页

作者： Pentti Sipponen matti Vauhkonen Timo Helske Ilpo Kriinen matti Hrknen Division of Pathology Department Internal Medicine Department of Clinical Chemistry

AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett ***: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI *** levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory ***: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels ＜0.5, ＜1, or ＜1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P＜0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P＜0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls.

关键词： Gastrin-17 Barrett's esophagus Chronic gastritis Atrophic gastritis Diagnostics

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Predicting stand age in managed forests using National Forest Inventory field data and airborne laser scanning

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Forest Ecosystems 2020年第3期7卷 579-589页

作者： matti Maltamo Hermanni Kinnunen Annika Kangas Lauri Korhonen University of Eastern Finland School of Forest SciencesP.O.Box 11180101JoensuuFinland Natural Resources Institute Finland Bioeconomy and EnvironmentP.O.Box 6880100JoensuuFinland

Background: The aim of this study was to construct a nationwide stand age model by using National Forest Inventory(NFI) data and nationwide airborne laser scanning(ALS) data. In plantation forestry, age is usually *** this is not the case in boreal managed forests, age is still seldom predicted in forest management *** age accurately in situ is also very laborious. On the other hand, tree age is one of the accurately measured sample tree attributes in NFI field data. Many countries also have a nationwide coverage of airborne laser scanning(ALS) data. In this study, we merged these data sources and constructed a nationwide, area-based model for stand ***: While constructing the model, we omitted old forests from the data, since the correlation between ALS height metrics and stand age diminished at stands with age > 100 years. Additionally, the effect of growth conditions was considerable, so we also utilized different geographical and NFI variables such as site fertility and soil type in the modeling. The resultant nationwide model for the stand age of managed forests yielded a root mean square error(RMSE) of about 14 years. The model could be improved further by additional forest structure variables, but such information may not be available in ***: The results showed that the prediction of stand age by ALS, geographical and NFI information was challenging, but stil possible with moderate success. This study is an example of the joint use of NFI and nationwide ALS data and re-use of NFI data in research.

关键词： Forest stock age LiDAR NFI Nationwide model Growth conditions

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The cost-effectiveness of hypertonic saline inhalations for infant bronchiolitis: a decision analysis

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World Journal of Pediatrics 2018年第1期14卷 26-34页

作者： Paula Heikkila Minna Mecklin matti Korppi Tampere Center for Child Health Research Universityof Tampere and Tampere University HospitalTampereFinland Department of Pediatrics Tampere University HospitalPOBOX200033521T ampereFinland

Background This study evaluated the cost-effectiveness of hypertonic saline (HS) inhalations for infant bronchiolitis, com-pared to normal saline inhalations or standard treatment without inhalations as controls. Methods The decision tree in the decision analysis was used to calculate the expected costs. Actual cost data were obtained from our retrospective case-control study on bronchiolitis treatment. The effectiveness of treatment, based on the hospitaliza-tion rate of those admitted to the emergency department and the length of stay (LOS) of those who were hospitalized, was collected from previous studies. For the effectiveness estimations, we made a meta-analysis summarizing the results of the meta-analysis of the Cochrane review in 2013 and the results of 10 studies published after it. Results The mean hospitalization rate was 24.7% in the HS inhalation group and 32.6% in the control group [risk ratio: 0.80, 95% confidence interval (CI) 0.67–0.96] and the mean LOS was 3.736 (HS group) and 4.292 (controls) days (mean difference: ? 0.55 days, 95% CI ? 0.96 to ? 0.15), respectively. The expected costs per patient, when both inpatients and outpatients were included, were €816 ($1111) in the HS inhalation group and €962 ($1310) in the control group. The expected costs per hospitalization, when only inpatients were included, were €2600 ($3540) in the HS inhalation group and €2890 ($3935) in the control group. Conclusions HS inhalations slightly reduced the expected hospitalization costs of infant bronchiolitis. However, the low effectiveness, rather than the cost, is the factor that will limit the use of HS inhalations in infant bronchiolitis.

关键词： Bronchiolitis Cost-effectiveness Decision analysis Hospitalization costs Hypertonic saline

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On the potential to predetermine dominant tree species based on sparse-density airborne laser scanning data for improving subsequent predictions of species-specific timber volumes

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Forest Ecosystems 2016年第2期3卷 95-111页

作者： Janne Raty Jari Vauhkonen matti Maltamo Timo Tokola University of Eastern Finland School of Forest Sciences Yliopistokatu 7 P.O.Box 111FI-80101 Joensuu Finland

Background： Tree species recognition is the main bottleneck in remote sensing based inventories aiming to produce an input for species-specific growth and yield models. We hypothesized that a stratification of the target data according to the dominant species could improve the subsequent predictions of species-specific attributes in particular in study areas strongly dominated by certain species. Methods： We tested this hypothesis and an operational potential to improve the predictions of timber volumes, stratified to Scots pine, Norway spruce and deciduous trees, in a conifer forest dominated by the pine species. We derived predictor features from airborne laser scanning （ALS） data and used Most Similar Neighbor （MSN） and Seemingly Unrelated Regression （SUR） as examples of non-parametric and parametric prediction methods, respectively Results： The relationships between the ALS features and the volumes of the aforementioned species were considerably different depending on the dominant species. Incorporating the observed dominant species inthe predictions improved the root mean squared errors by 13.3-16.4 % and 12.6-28.9 % based on MSN and SUR, respectively, depending on the species. Predicting the dominant species based on a linear discriminant analysis had an overall accuracy of only 76 % at best, which degraded the accuracies of the predicted volumes. Consequently, the predictions that did not consider the dominant species were more accurate than those refined with the predicted species. The MSN method gave slightly better results than models fitted with SUR. Conclusions： According to our results, incorporating information on the dominant species has a clear potential to improve the subsequent predictions of species-specific forest attributes. Determining the dominant species based solely on ALS data is deemed challenging, but important in particular in areas where the species composition is otherwise seemingly homogeneous except being dominated by certain species

关键词： Forest inventory Light Detection and Ranging (LiDAR) Area-based approach Nearest neighbor estimation,Crown base height Intensity Volume model

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Tonsillitis in children: unnecessary laboratory studies and antibiotic use

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世界儿科杂志:英文版 2016年第1期12卷 114-117页

作者： Antti Kunnamo matti Korppi Merja Helminen Pediatric Research Centre Tampere University and Univesity HospitalTampereFinland

Background:The Finnish Current Care Guidelines on diagnostics and treatment of sore throat recommend the treatment of only group A streptococcus(GAS)positive cases with *** aim of the study was to evaluate how these guidelines are followed in the pediatric emergency ***:We analyzed retrospectively the data on microbiological studies and blood tests done,and data on prescribing of antibiotics,of 200 children admitted for febrile exudative ***:After the clinical diagnosis of exudative tonsillitis,antigen test and/or culture for GAS identifi cation was done in>95%of *** the 32(16%)children with GAS infection,but also 52(38%)of the 137 children without any evidence of bacterial infection received *** laboratory studies were done in 96%of *** C-reactive concentrations or white blood cell counts were not able to separate streptococcal from non-streptococcal *** serious bacterial infection was ***:The Finnish Current Care Guidelines lead to over-treatment with *** of the 200 children returned after discharge,suggesting that undertreatment did not happen.

关键词： exudative tonsillitis streptococcal antigen test streptococcal culture

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Cadmium in insects after ash fertilization

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Insect Science 2009年第1期16卷 93-98页

作者： Martin Lodenius Jussi Josefsson Kari Heliovaara Esa Tulisalo matti Nummelin Department of Biological and Environmental Sciences Department of Forest Ecology University of Helsinki Finland

Ash fertilization of forests returns nutrients to forest ecosystems and has a positive effect on soil pH, but it also may elevate Cd concentrations of forest biota. Cadmium concentrations of some forest insects （Formica ants, carabids and Coleopteran larvae from decaying wood） were investigated in southern Finland, where two plots were fertilized with wood ash, while two other plots represented unfertilized control plots. In ants, mean Cd concentration was 3.6 ± 1.4 mg/kg, with nest workers having significantly higher concentrations than workers trapped in pitfall traps. Concentrations at fertilized and unfertilized plots were similar. In carabid beetles, the average Cd concentration of Carabus glabratus was 0.44 ±0.36 mg/kg, with no significant difference between control plots and fertilized plots. In another carabid beetle, Pterostichus niger, mean Cd concentration was higher at fertilized plots compared to control plots. We conclude that the variation of Cd concentrations in the insects studied is more efficiently controlled by species-specific differences than fertilization history of the forest floor.

关键词： bioaccumulation cadmium Carabidae Coleoptera fertilization Formica,wood ash

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Compression curve analysis and compressive strength measurement of brittle granule beds in lieu of individual granule measurements

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Particuology 2016年第6期14卷 60-68页

作者： matti Jairvelainen Aaretti Kaleva Annikka Kaitajairvi ,Jarmo Laakso Ulla Kanerva Erkki Levanen Department of Materials Science Tampere University of Technology PO Box 589 FIN-33101 Tampere Finland VTT Technical Research Centre of Finland Sinitaival 6 PO Box 1300 FI33101 Tampere Finland

Powders in granulated form are used in various processes to facilitate convenient usage. The durability of the formed granules is a crucial parameter, typically evaluated by the compressive strength of the gran- ules. However, especially for granules with a diameter in the order of tens of microns, statistically relevant testing of individual granules is not a feasible alternative, and in such cases uniaxial bed compression is required. There has not been consensus on whether uniaxial compression of a granule bed can be used to study the fracture of micron size or brittle granules. In our case study of a bed of sintered kaolinite granules with diameters under 100 μm, we show how the compressive strength of individual granules can be obtained from the compressive measurement of the entire bed by plotting the relative density versus the logarithmic pressure scale. We compressed the kaolinite powder with different loads; microscopy confirmed that below the ana- lyzed strength the granules are intact, though the granules start to fracture in the curved region on the compression curve. We found that angle-fitting can be used to locate the average compressive strength on the compression curve and to follow the evolution of strength with sintering temperature. The experi- ments in unison demonstrate that compression curve analysis is applicable for strength analysis of brittle granules.

关键词： GranuleMechanical characterization Pressing Compressive strength Sintering Compression curves

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The(Pictorial)Construction of Collective Identities in the Third Reich

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Language and Semiotic Studies 2016年第3期2卷 107-124页

作者： Michael ranta Lund University Sweden

Collective identities of the Self vs. the Other are not only conveyed in and between cultures through verbal discourse, but also through pictures. Cultural encounters are often comprehended by storytelling, the verbal expression of which has been abundantly studied. Pictorial manifestations of narration, however, have received comparatively less attention. Mostly, narration has been associated with verbal discourses, where, briefl y put, events or situations are temporally ordered. Even though the narrative capacity of pictures has been taken for granted by e.g. art historians, attempts to elucidate the semiotic and cognitive basis of visual narrativity, esp. in static pictures, have been relatively rare(cf. ranta, 2013).Within cognitive science, narratives are regarded as crucial and fundamental cognitive instruments or tools(e. g. Bruner, 1990; Schank, 1995). As Roger Schank suggests, the identity of(sub-) cultures is to a considerable extent based upon the sharing of narrative structures. According to Schank, culturally shared stories—or stories in general—occur frequently in highly abbreviated form, as "skeleton stories" or "gists", not least in pictorial form. Moreover, in ways that correspond to Schank's account of storytelling and cognition, these may also have implications for conceptions of one's home-culture in relation to an alien-culture. Many pictures and visual artworks have indeed been produced in order to consolidate, modify, and demarcate certain cultural *** this paper, I shall focus upon one(and even today highly relevant) example of creating cultural identity, namely the racist confrontation of the "Aryans" vs. the Other(esp. Jews, but also Slavs and Romani) as promoted by National Socialist thinking and politics during the Third Reich in German history. Some concrete pictorial examples indicating these attempts will be discussed and analysed from a narratological and cognitive semiotic perspective.

关键词： art pictures National Socialism narrativity cultural encounters cognitive semiotics cognitive psychology

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A systems biological approach to identify key transcription factors and their genomic neighborhoods in human sarcomas

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Chinese Journal of Cancer 2011年第1期30卷 27-40页

作者： Antti Ylipaa Olli Yli-Harja Wei Zhang matti Nykter Department of Signal Processing Tampere University of Technology Tampere 33101 Finland Department of Pathology the University of Texas MD Anderson Cancer Center Houston Texas 77030 USA.

Identification of genetic signatures is the main objective for many computational oncology studies. The signature usually consists of numerous genes that are differentially expressed between two clinically distinct groups of samples, such as tumor subtypes. Prospectively, many signatures have been found to generalize poorly to other datasets and, thus, have rarely been accepted into clinical use. Recognizing the limited success of traditionally generated signatures, we developed a systems biology-based framework for robust identification of key transcription factors and their genomic regulatory neighborhoods. Application of the framework to study the differences between gastrointestinal stromal tumor (GIST) and leiomyosarcoma (LMS) resulted in the identification of nine transcription factors (SRF, NKX2-5, CCDC6, LEF1, VDR, ZNF250, TRIM63, MAF, and MYC). Functional annotations of the obtained neighborhoods identified the biological processes which the key transcription factors regulate differently between the tumor types. Analyzing the differences in the expression patterns using our approach resulted in a more robust genetic signature and more biological insight into the diseases compared to a traditional genetic signature.

关键词：转录因子系统生物学生物方法肉瘤居民区基因组人类维生素D受体

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Finland is following the trend--sperm quality in Finnish men

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Asian Journal of Andrology 2013年第2期15卷 162-164,I0004页

作者： Helena E Virtanen Sergey Sadov matti Vierula Jorma Toppari Departments of Physiology and Paediatrics University of Turku Turku FI-20520 Finland

Finnish men have had a reputation for good semen quality. This was based on semen studies comparing Finnish men with other Europeans. However, those studies also showed that sperm concentrations of young men from the general population were only two-thirds of those of fertile men. Longitudinal follow-up of semen quality in young Finnish men showed a sig- nificant decline during 1998-2006, suggesting that Finland is following the global trend of impaired male reproductive health.

关键词： NORDIC-BALTIC AREA SEMEN QUALITY REGIONAL DIFFERENCES POPULATION FERTILITY COUNTS

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