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Multimodal therapy in oligometastatic prostate cancer: A glimpse into the future?

Asian Journal of Urology 2021年第2期8卷 248-250页

作者： Sophie Knipper Gunhild von Amsberg Franziska Stolzenbach Thomas Steuber matthias heck matthias Eiber Christoph Berliner Tobias Maurer Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of OncologyUniversity Hospital Hamburg-EppendorfHamburgGermany Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of UrologyUniversity Hospital Hamburg-EppendorfHamburgGermany Department of Urology Technical University of MunichMunichGermany Department of Nuclear Medicine Technical University of MunichMunichGermany Department of Nuclear Medicine University Hospital Hamburg-EppendorfHamburgGermany

Dear editor,Since the introduction of radiotracer-labeled prostatespecific membrane antigen(PSMA)targeting positron emission tomography(PET),imaging of prostate cancer(PCa)improved drastically[1,2].Subsequently,metastases may be detected in earlier stages with possible implications on treatment planning[3].Here,we described the multimodal treatment approach on a young patient with newly diagnosed metastatic PCa conducted according to the results of repeated PSMAePET imaging.

关键词： metastatic cancer treatment

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Cytoreductive radical prostatectomy after chemohormonal therapy in patients with primary metastatic prostate cancer

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Asian Journal of Urology 2022年第1期9卷 69-74页

作者： Christa Babst Thomas Amiel Tobias Maurer Sophie Knipper Lukas Lunger Robert Tauber Margitta Retz Kathleen Herkommer matthias Eiber Gunhild von Amsbergb Markus Graefen Juergen Gschwend Thomas Steuber matthias heck Department of Urology Technical University of MunichRechts der Isar Medical CenterMunichGermany Martini-Klinik Prostate Cancer Center HamburgGermany

Objective:Cytoreductive radical prostatectomy(cRP)has been proposed as local treatment option in metastatic hormone-sensitive prostate cancer(mHSPC)to prevent local complications and potentially improve oncological *** this study,we examined the feasibility of a multimodal concept with primary chemohormonal therapy followed by cRP and analyzed prostate size reduction under systemic treatment,postoperative complication rates,as well as early postoperative ***:In this retrospective study,38 patients with mHSPC underwent cRP after primary chemohormonal therapy(3-monthly luteinising hormone-releasing hormone-analogue+six cycles 3-weekly docetaxel 75 mg/m2)at two centers between September 2015 and December ***:Overall,10(26%)patients had high volume and 28(74%)patients had low volume disease at diagnosis,according to CHAARTED *** prostate-specific antigen(PSA)decreased from 65 ng/mL(interquartile range[IQR]35.0-124.5 ng/mL)pre-chemotherapy to 1 ng/mL(IQR 0.3-1.7 ng/mL)*** gland volume was significantly reduced by a median of 50%(IQR 29%-56%)under chemohormonal therapy(p=0.003).Postoperative histopathology showed seminal vesicle invasion in 33(87%)patients and negative surgical margins in 17(45%)*** complications(Grade 3 according to Clavien-Dindo)were observed in 4(11%)patients within 30 *** was reached in 87%of patients after 1 month and in 92%of patients after 6 *** time to castration-resistance from begin of chemohormonal therapy was 41.1 months and from cRP was 35.9 *** PSA-nadir≤1 ng/mL versus>1 ng/mL was a significant predictor of time to castration-resistance after cRP(median not reached versus 5.3 months;p<0.0001).Conclusion:We observed a reduction of prostate volume under chemohormonal therapy going along with a low postoperative complication and high early continence ***,the oncologic benefit from cRP is still under evaluation.

关键词： Metastatic hormone-sensitive prostate cancer Chemohormonal therapy Cytoreductive radical prostatectomy Feasibility Prevent local complications Continence rate

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倾斜台实验诊断血管迷走神经性晕厥——心功能诊断的新方法

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德国医学 2000年第1期17卷 38-40页

作者： Martin H.Hust Karl F.heck matthias W.Keim 宋玉娥 Medizinische Klinik Kreiskrankenhaus Reutlingen Steinenbergstraβe 31 D-72764 Reutlingen Germany 同济医科大学附属同济医院

晕厥是指突发的、短暂的意识和肌张力障碍。多为收缩压降低(在70mmHg 以下)使脑血流量减少所致。患者晕厥前期常有恶心、面色苍白、眩晕、上腹部不适、视物模糊等症状。据统计,约20%～30%的人在其一生中至少发生过一次晕厥。其中以年青... 详细信息

晕厥是指突发的、短暂的意识和肌张力障碍。多为收缩压降低(在70mmHg 以下)使脑血流量减少所致。患者晕厥前期常有恶心、面色苍白、眩晕、上腹部不适、视物模糊等症状。据统计,约20%～30%的人在其一生中至少发生过一次晕厥。其中以年青人或运动员常见。而大多数晕厥患者常很难找到病因。血管神经性晕厥最常见。以往主要通过详细询问病史。

关键词：晕厥血管迷走神经性倾斜台实验

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