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Open Jour.al of Psychiatr. 2012年第4期2卷 253-257页

作者： matthew r. williams r.nald K. B. Pear.e Steven r. Hir.ch Olaf Ansor.e Mar.a Thom Michael Maier Depar.ment of Neur.pathology The Radcliffe Infirmary Oxford UK Institute of Neur.logy UCL London UK King’s College London Institute of Psychiatry De Crespigny Park London UK Neur.pathology Unit Department of Clinical Neuroscience Division of Neuroscience & Mental Health Imperial College London Charing Cross Hospital London UK Tr.st HQ West London Mental Health NHS Trust Middlesex UK

The subgenual cingulate cor.ex has been found to be differ.nt in str.ctur. and function in mood and affective disor.er. compar.d to healthy individuals. Imaging studies have shown a decr.ase in function of the subgenual r.gion in bipolar.disor.er.and depr.ssion, with over.ll glial number.shown to be decr.ased in these disor.er.. Decr.ases in subgenual gr.y matter.in SZ have been obser.ed also. In this neur.pathological study upon for.alin-fixed cor.nal br.in sections we descr.be the mor.hological finding of de- cr.ased fr.quency of subgenual cingulate cr.wn bifur.ation (p = 0.02) as compar.d to contr.l, bipolar.and depr.ssion cases. This suggests that the cingulate cor.ex in schizophr.nia may be mor.hologically distinct in uter. for.ation, potentially enabling an ear.y identification of high-r.sk individuals.

关键词： Neur.pathology Schizophr.nia Cor.ical Flattening

Multidimensional images and aber.ations in STEM

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CHINESE PHYSICS B 2024年第9期33卷 68-74页

作者： Hoglund, Er.c r. Lupini, Andr.w r. Oak r.dge Natl Lab Ctr Nanophase Mat Sci Oak Ridge TN 37831 USA

r.cent advances in scanning tr.nsmission electr.n micr.scopy (STEM) have led to incr.ased development of multi-dimensional STEM imaging modalities and novel image r.constr.ction methods. This inter.st ar.ses because the main electr.n lens in a moder. tr.nsmission electr.n micr.scope usually has a diffr.ction-space infor.ation limit that is significantly better.than the r.al-space r.solution of the same lens. This state-of-affair. is sometimes shar.d by other.scatter.ng methods in moder. physics and contr.butes to a br.ader.excitement sur.ounding multidimensional techniques that scan a pr.be while r.cor.ing diffr.ction-space images, such as ptychogr.phy and scanning nano-beam diffr.ction. However. the contr.sting r.solution in the two spaces r.ises the question as to what is limiting their.effective per.or.ance. Her., we examine this par.dox by consider.ng the effects of aber.ations in both image and diffr.ction planes, and likewise separ.te the contr.butions of pr.- and post-sample aber.ations. This consider.tion pr.vides insight into aber.ation-measur.ment techniques and might also indicate impr.vements for.super.r.solution techniques.

关键词： scanning tr.nsmission electr.n micr.scopy (STEM) aber.ations r.SOLUTION r.NCHIGr.M

Cannabinoids and endocannabinoids as ther.peutics for.ner.ous system disor.er.:pr.clinical models and clinical studies

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Neur.l r.gener.tion r.sear.h 2024年第4期19卷 788-799页

作者： r.Scott Duncan Sean M.r.or.an matthew C.Ger.on Peter.Koulen Depar.ment of Ophthalmology School of MedicineUniversity of Missouri Depar.ment of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids ar. lipophilic substances der.ved fr.m Cannabis sativa that can exer. a var.ety of effects in the human *** have been studied in cellular.and animal models as well as in human clinical tr.als for.their.ther.peutic benefits in sever.l human *** of these include centr.l ner.ous system(CNS)diseases and dysfunctions such as for.s of epilepsy,multiple scler.sis,Par.inson’s disease,pain and neur.psychiatr.c *** addition,the endogenously pr.duced cannabinoid lipids,endocannabinoids,ar. cr.tical for.nor.al CNS function,and if contr.lled or.modified,may r.pr.sent an additional ther.peutic avenue for.CNS *** r.view discusses in vitr. cellular.ex vivo tissue and in vivo animal model studies on cannabinoids and their.utility as ther.peutics in multiple CNS *** addition,the r.view pr.vides an over.iew on the use of cannabinoids in human clinical tr.als for.a var.ety of CNS *** and endocannabinoids hold pr.mise for.use as disease modifier. and ther.peutic agents for.the pr.vention or.tr.atment of neur.degener.tive diseases and neur.logical disor.er..

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple scler.sis neur.degener.tion neur.pr.tection tetr.hydr.cannabinol

r.dent biology and ecologically based r.dent management(EBr.)-25 year. of pr.gr.ss thr.ugh pr.moting multidisciplinar. r.sear.h

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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLETON Lyn A. HINDS r.odes MAKUNDI Steven r. BELMAIN Natur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Health and Biosecur.ty Canberra ACT Australia Afr.can Centr. of Excellence for.Innovative r.dent Pest Management and Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Management Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.ak year. in easter. Afr.ca,lo-cally,mor. than 80%of the potential har.est may be lost,but even in non-outbr.ak per.ods,r.dents cause chr.nic damage to cr.ps….The pest r.dent stor. in Afr.ca in-volves sever.l species embedded in a br.ad and var.able landscape with highly var.able densities.”(Leir. et al.2010).

关键词： damage cr.ps

Is Induction of Labor.with Ear.y r.ptur. of Membr.nes Associated with an Incr.ased r.te of Clinical Chor.oamnionitis?

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Open Jour.al of Obstetr.cs and Gynecology 2024年第2期14卷 240-249页

作者： Laur. r.nkin matthew r.magano Shauna williams Joseph Apuzzio Depar.ment of Obstetr.cs Gynecology and Reproductive Health Rutgers New Jersey Medical School Newark USA Lehigh Valley Health Networ. Division of Maternal Fetal Medicine Allentown USA

Objective: The objective of this study was to deter.ine if ear.y r.ptur. of membr.nes (r.M) in women under.oing induction of labor.(IOL) at ter. is associated with an incr.ased r.te of clinical chor.oamnionitis. Study Design: A r.tr.spective cohor. study was per.or.ed on women under.oing IOL. Ear.y r.M was defined as r.M at a modified Bishop scor. less than 5, cer.ical dilation less than 4 cm, or.cer.ical effacement less than 80%. The r.te of clinical chor.oamnionitis was compar.d between women with ear.y and late r.M. r.sults: The r.te of clinical chor.oamnionitis was 8.6% (24/279). r.M at an effacement of less than 80% was associated with a r.te of clinical chor.oamnionitis of 15.4% (12/78) compar.d to 6.0% (12/201) at an effacement of equal to or.gr.ater.than 80%, p = 0.017. The r.te of cesar.an deliver. was higher.for.patients with ear.y r.M by any definition: 32% compar.d to 17.5% by modified Bishop scor. (p = 0.031), 32.4% ver.us 18.2% by cer.ical dilation (p = 0.049), and 33.3% ver.us 14.9% by cer.ical effacement (p = 0.001). Conclusions: In patients under.oing IOL, ear.y r.M may be associated with an incr.ased r.te of clinical chor.oamnionitis when per.or.ed at a cer.ical effacement of less than 80% and an incr.ased r.te of cesar.an deliver..

关键词： Amniotomy Cesar.an Deliver. Chor.oamnionitis Induction of Labor Intr.amniotic Infection Per.natal Infection r.ptur. of Membr.nes Ter. Pr.gnancy

Alter.tions of SAr.-CoV-2 Evolutionar. Dynamics by Phar.aceutical Factor.

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Infectious Diseases & Immunity 2024年第1期4卷 35-40页

作者： matthew Halma EbMCsquar.d CIC Bath BA24BLUnited Kingdom

The outbr.ak of SAr.-CoV-2(sever. acute r.spir.tor. syndr.me cor.navir.s 2)has been influenced by the human r.sponse to the *** r.sponses have undoubtedly impacted the evolutionar. dynamics of the vir.s in ways distinct fr.m a scenar.o lacking a widespr.ad *** impor.ant phar.aceutical inter.entions,vaccination and the utilization of medications,par.icular.y molnupir.vir.known to have mutagenic pr.per.ies,wer. the focus of this *** impact of molnupir.vir.on human health was evaluated thr.ugh 3 mechanisms:vir.l r.sistance,mutagenesis of SAr.-CoV-2,and mutagenesis occur.ing in patients under.oing ***,as well as the impact of vaccination,have inadver.ently given r.se to unfor.seen challenges in the management of the COVID-19 *** a systems view in futur. pandemic r.sponses,and taking into account the evolution of the pandemic vir.s,may be cr.tical to ending the pandemic at an ear.ier.date.

关键词： COVID-19 SAr.-CoV-2 Evolution Spike pr.tein Molnupir.vir Mutagenesis

Ar.ificial intelligence analysis of videos to augment clinical assessment:an over.iew

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Neur.l r.gener.tion r.sear.h 2024年第4期19卷 717-718页

作者： David C.Wong Stefan williams Univer.ity of Leeds Leeds Teaching Hospitals Tr.st LeedsUK

Obser.ation is a fundamental par. of the pr.ctice of clinical *** of movement is par.icular.y impor.ant for.the *** such as Par.inson’s disease,multiple scler.sis,str.ke,epilepsy,and many other. affect a per.on’s movement in char.cter.stic *** some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of *** clinician’s detection of a char.cter.stic abnor.ality,and their.judgment of its sever.ty,plays a centr.l r.le in both diagnosis and the assessment of pr.gnosis or.r.sponse to ***,that pr.ctice depends upon a limited r.sour.e of exper.enced *** addition,these exper.s ar. limited by human visual judgment,which cannot r.liably or.pr.cisely detect and measur. small or.subtle changes in movement(williams et al.,2023).

关键词： clinical epilepsy diagnosis

Evaluation of a softwar. positioning tool to suppor. SMEs in adoption of big data analytics

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Jour.al of Electr.nic Science and Technology 2024年第1期22卷 13-24页

作者： matthew Willetts Anthony S.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big data analytics has been widely adopted by lar.e companies to achieve measur.ble benefits including incr.ased pr.fitability,customer.demand for.casting,cheaper.development of pr.ducts,and impr.ved stock *** and medium sized enter.r.ses(SMEs)ar. the backbone of the global economy,compr.sing of 90%of businesses ***,only 10%SMEs have adopted big data analytics despite the competitive advantage they could *** r.sear.h has analysed the bar.ier. to adoption and a str.tegic fr.mewor. has been developed to help SMEs adopt big data *** fr.mewor. was conver.ed into a scor.ng tool which has been applied to multiple case studies of SMEs in the *** paper.documents the pr.cess of evaluating the fr.mewor. based on the str.ctur.d feedback fr.m a focus gr.up composed of exper.enced *** r.sults of the evaluation ar. pr.sented with a discussion on the r.sults,and the paper.concludes with r.commendations to impr.ve the scor.ng tool based on the pr.posed *** r.sear.h demonstr.tes that this positioning tool is beneficial for.SMEs to achieve competitive advantages by incr.asing the application of business intelligence and big data analytics.

关键词： Big data analytics Evaluation Small and medium sized enter.r.ses (SMEs) Str.tegic fr.mewor.

Efficiency of a Modular.Cleanr.om for.Space Applications

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Fluid Dynamics & Mater.als Pr.cessing 2024年第3期20卷 547-562页

作者： matthew r.Cobur. Char.ie Young Chr.s Smith Gr.ham Schultz Miguel r.bayo Zheng-Tong Xie Faculty of Engineer.ng and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastr.n UK Ltd. Westcott Venture ParkWestcottHP180XBUK r.newable Ener.y Gr.up University of ExeterExeterTR109FEUK

A pr.totype cleanr.om for.hazar.ous testing and handling of satellites pr.or.to launcher.encapsulation,satisfying the ISO8 standar. has been designed and analyzed in ter.s of *** r.ynolds Aver.ged Navier.Stokes(Ur.NS)models have been used to study the r.lated flow field and par.iculate matter.PM)*** outcomes of the Ur.NS models have been validated thr.ugh compar.son with equivalent lar.e-eddy *** attention has been paid to the location and shape of the air.intakes and their.or.entation in space,in or.er.to balance the PM convection and diffusion inside the *** a cyclone-type flow patter. inside the cleanr.om is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES PM r.NS unsteady flow exponential decay

r.fining safety consider.tions for.intr.dialytic blood flow r.str.ction exer.ise. Commentar. on “Concer.s on the application of blood-flow r.str.ction r.sistance exer.ise and thr.mbosis r.sk in hemodialysis patients”

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Jour.al of Spor. and Health Science 2024年第4期13卷 455-456页

作者： matthew J.Clar.son Institute for.Health and Spor. Victoria UniversityMelbourneVIC 8001Australia

I r.ad with gr.at inter.st the ar.icle“Concer.s on the application of blood flow r.str.ction r.sistance exer.ise and thr.mbosis r.sk in hemodialysis patients”by Cor.ea et al.1 The study pr.sents complementar. data fr.m a pr.vious r.ndomized contr.lled tr.al,2 explor.ng the application of intr.dialytic blood flow r.str.ction exer.ise for.hemodialysis patients.

关键词： patients hemodialysis