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The Log-Concavity of Kazhdan-Lusztig Polynomials of Uniform Matroids

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Journal of Systems Science & Complexity 2023年第1期36卷 117-128页

作者： XIE matthew H Y ZHANG Philip B College of Science Tianjin University of TechnologyTianjin 300384China College of Mathematical Science Tianjin Normal UniversityTianjin 300387China

Elias,et al.(2016)conjectured that the Kazhdan-Lusztig polynomial of any matroid is *** by a computer proof of Moll’s log-concavity conjecture given by Kauers and Paule,the authors use a computer algebra system to pr... 详细信息

关键词： HolonomicFunctions Kazhdan-Lusztig polynomial log-concavity uniform matroid

Amyotrophic lateral sclerosis as a synaptopathy

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Neural Regeneration Research 2019年第2期14卷 189-192页

作者： matthew J.Fogarty Department of Physiology and Biomedical Engineering Mayo Clinic School of Biomedical Sciences The University of Queensland

The synapse is an incredibly specialized structure that allows for the coordinated communication of information from one neuron to another. When assembled into circuits, steady streams of excitatory and inhibitory synaptic activity shape neural outputs. At the organismal level, ensembles of neural networks underlie behavior, emotion and memory. Disorder or dysfunctions of synapses, a synaptopathy, may underlie a host of developmental and degenerative neurological conditions. There is a possibility that amyotrophic lateral sclerosis may be a result of a synaptopathy within the neuromotor system. To this end, particular attention has been trained on the excitatory glutamatergic synapses and their morphological proxy, the dendritic spine. The extensive detailing of these dysfunctions in vulnerable neuronal populations, including corticospinal neurons and motor neurons, has recently been the subject of original research in rodents and humans. If amyotrophic lateral sclerosis is indeed a synaptopathy, it is entirely consistent with other proposed pathogenic mechanisms – including glutamate excitotoxicity, accumulation of misfolded proteins and mitochondrial dysfunction at distal axon terminals(cortico-motor neuron and neuromuscular). Further, although the exact mechanism of disease spread from region to region is unknown, the synaptopathy hypothesis is consistent with emerging die-forward evidence and the prion-like propagation of misfolded protein aggregates to distant neuronal populations. Here in this mini-review, we focus on the timeline of synaptic observations in both cortical and spinal neurons from different rodent models, and provide a conceptual framework for assessing the synaptopathy hypothesis in amyotrophic lateral sclerosis.

关键词： motor neuron motor cortex corticospinal excitotoxicity synaptic transmission dendrites dendriticspines neuromuscular junction

Cross-Polarized GPR Imaging of Fracture Flow Channeling

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Journal of Earth Science 2015年第6期26卷 776-784页

作者： Georgios P.Tsoflias Christopher Perll matthew Baker matthew W.Becker Department of Geology the University of Kansas Chesapeake Energy Marathon Oil Corporation California State University Long Beach

Ground penetrating radar（GPR） can be used to image fractures and monitor fluid flow in the subsurface. Conventional GPR imaging uses single-polarization, co-polarized acquisition. We examine the use of cross-polarized GPR signals for imaging flow channeling in a discrete horizontal fracture. Numerical modeling（FDTD） demonstrates that when the fracture channel is oriented at an oblique angle to the survey line, depolarization of the GPR signal results in scattered energy along the cross-polarized components. When the channel is oriented parallel or orthogonal to the survey line, all scattered energy is captured by the co-polarized components and no signal is present in the cross-polarized orientation. Multipolarization, time-lapse 3D GPR field data were acquired at the Altona Flat Rock test site in New York State. The GPR surveys were conducted during background fresh fracture water conditions and during a natural gradient saline tracer test which was used to highlight flow channels along a sub-horizontal fracture. Amplitude analysis of the cross-polarized data reveals flow channeling that is in agreement with the co-polarized GPR images and with independent hydraulic tests. This investigation demonstrates that cross-polarized components of GPR signals can be used to enhance imaging of flow channels in fractured media.

关键词： GPR single-polarization cross-polarized data rapid flow saline tracer fractured rock.

Foot use and hand preference during feeding in captive black-and-white snub-nosed monkeys(Rhinopithecus bieti)

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Integrative Zoology 2013年第4期8卷 378-388页

作者： Jing PAN Wen XIAO matthew H.TALBERT matthew B.SCOTT Institute of Eastern-Himalaya Biodiversity Research Dali UniversityDaliYunnanChina Department of Psychology University of GeorgiaAthensGeorgiaUSA School of Life Sciences University of Science and Technology of ChinaHefeiAnhuiChina Kunming Institute of Zoology Chinese Academy of SciencesKunmingYunnanChina College of Engineering University of GeorgiaAthensGeorgiaUSA

Postural origin theory predicts that body postures are related to hand preference in nonhuman primates due to hemispheric *** preference,especially in manipulating objects,is also a good predictor of hemispheric specialization in *** studied limb(hand and foot)preferences in 11 captive adult black-and-white snub-nosed monkeys(Rhinopithecus bieti)to see how limb preference is influenced by postures and foot *** preference was significantly different for this group between quadrupedal standing and clinging postures,and sitting and clinging postures,but not between bipedal standing and clinging *** were significantly more likely to use the right hand in the clinging posture than in quadrupedal standing or sitting *** the sitting posture,individuals maintained their respective hand preference even when the food was on the other side of the *** was a gender difference in the sitting posture,where females preferred their right hand but males preferred their *** who did not routinely use their feet to manipulate objects,compared to those who did,shifted to greater right hand use from the clinging posture to the bipedal *** male individual and his offspring were more likely to use their feet to manipulate objects than the rest of the *** the present study,we reveal the first evidence of a postural effect on hand preference in *** as well as a foot preference in this *** results mostly agree with the postural origin theory and hemispheric specialization.

关键词： bipedal standing foot preference gender difference limb preference postural origin theory

Experimental study of the restoring force mechanism in the self-centering beam （SCB）

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Frontiers of Structural and Civil Engineering 2016年第3期10卷 272-282页

作者： Abhilasha MAURYA matthew R. EATHERTON Department of Civil and Environmental Engineering Virginia Tech Blacksburg VA 2406 USA

In the past, several self-centering （SC） seismic systems have been developed. However, examples of selfcentering systems used in practice are limited due to unusual field construction practices, high initial cost premiums and deformation incompatibility with the gravity framing. A self centering beam moment frame （SCB-MF） has been developed that mitigates several of these issues while adding to the advantages of a typical SC system. The self-centering beam （SCB） is a shop-fabricated, self-contained structural component that when implemented in a moment resisting frame can bring a building back to plumb after an earthquake. This paper describes the SCB concepts and experimental program on five SCB specimens at two-third scale relative to a prototype building. Experimental results are presented including the global force-deformation behavior. The SCBs are shown to undergo 5%-6% story drift without any observable damage to the SCB body and columns. Strength equations developed for the SCB predict the moment capacity well, with a mean difference of 6% between experimental and predicted capacities. The behavior of the restoring force mechanism is described. The limit states that cause a loss in system＇s restoring force which lead to a decrease in the selfcentering capacity of the SCB-MF, are presented.

关键词： self-centering seismic system seismic design hysteretic behavior restoring force resilient structural system

Inverse elastographic method for analyzing the ocular lens compression test

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 89-100页

作者： matthew A.Reilly Andre Cleaver Department of Biomedical Engineering The Ohio State University ColumbusOH 43210USA†Department of Ophthalmology and Visual Science The Ohio State UniversityColumbusOH 43210USA Department of Mechanical Engineering Tufts University MedfordMA 02155USA

The ocular lens stiffens dramatically with age,resulting in a loss of ***,the mechanisn of stiffening remains unknown,at least in part due to dificulties in making reliable measurements of the intrinsic mechanical properties of the *** experiments have employed manual compression testing to evaluate the stiffness of murine lenses which have genotypes pertinent to human lens *** experiments compare the extrinsic stifness of lenses fom the genotype of interest to the wild-type lens in an effort to reach conclusions regarding the cellular or molcular basis of lens ***,these comparisons are con-founded by alterations in lens size and geometry which invariably accompany these genetic ***,we utilize manual lens comprsion to characterize the stifness of a porcine lens and a murine *** inverse elastographic technique was then developed to estimate the intrinsic shear modulus of each lens as well as the elastic modulus of the lens *** results were in good agreement with the previous literature values.

关键词： Presbyopia lens compression lens mechanical properties finite element analysis lens biomechanics

Effects of natural products on ischemic heart diseases and cardiovascular system

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Acta Pharmacologica Sinica 2002年第12期23卷 89-98页

作者： Benny KH TAN,matthew WHITEMAN Department of Pharmacology Department of Biochemistry Faculty of Medicine National University of Singapore Singapore

INTRODUCTION Ischemic heart diseases remain the leading causeof death in most developed countries as seen over thepast quarter-century. Reducing the mortality rate andprevention of myocardial infarction (MI) are of utmostimportance. The use of Western medicinal drugs forthe treatment of hypertension, congestive heart failureand post MI are widely accepted. Although some Tra-ditional Chinese Medicines have been used in mainland,Hong Kong, Taiwan of China in clinics and other Chi-nese communities worldwide for centuries, our under-

关键词： myocardial infarction herbal medicine antioxidants cardiovascular system Salvia miltiorrhiza

Extracellular DNA and autoimmune diseases

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Cellular & Molecular Immunology 2018年第8期15卷 746-755页

作者： Hantao Lou matthew C Pickering Molecular Immunology Imperial College LondonLondon W120NNUK Centre for Complement and Inflammation Research Imperial College LondonLondon W120NNUK

Extracellular DNA is secreted from various sources including apoptotic cells,NETotic neutrophils and bacterial *** DNA can stimulate innate immune responses to induce type-I IFN production after being *** process is central in antiviral responses but it also plays important role in the pathogenesis of a range of autoimmune diseases such as systemic lupus *** discuss the recent advances in the understanding of the role of extracellular DNA,released from apoptotic and NETotic cells,in autoimmunity.

关键词： DNA type I IFN autoimmunity

Evaluation of a software positioning tool to support SMEs in adoption of big data analytics

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Journal of Electronic Science and Technology 2024年第1期22卷 13-24页

作者： matthew Willetts Anthony S.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big data analytics has been widely adopted by large companies to achieve measurable benefits including increased profitability,customer demand forecasting,cheaper development of products,and improved stock *** and medium sized enterprises(SMEs)are the backbone of the global economy,comprising of 90%of businesses ***,only 10%SMEs have adopted big data analytics despite the competitive advantage they could *** research has analysed the barriers to adoption and a strategic framework has been developed to help SMEs adopt big data *** framework was converted into a scoring tool which has been applied to multiple case studies of SMEs in the *** paper documents the process of evaluating the framework based on the structured feedback from a focus group composed of experienced *** results of the evaluation are presented with a discussion on the results,and the paper concludes with recommendations to improve the scoring tool based on the proposed *** research demonstrates that this positioning tool is beneficial for SMEs to achieve competitive advantages by increasing the application of business intelligence and big data analytics.

关键词： Big data analytics Evaluation Small and medium sized enterprises (SMEs) Strategic framework