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Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

National Science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan Jiliang Yang Hao Guan Qi Zhang Xi Qin Changkui Duan Gabriele G.de Boo Brett C.Johnson Jeffrey C.Mc Callum matthew J.Sellars Sven Rogge Chunming Yin Jiangfeng Du CAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of New South Wales Centre of Excellence for Quantum Computation and Communication Technology School of Engineering RMIT University Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of Melbourne Centre of Excellence for Quantum Computation and Communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation *** this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation *** this technique,the optically excited state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and *** approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

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Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension

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Chronic Diseases and Translational Medicine 2024年第2期10卷 102-117页

作者： Nicholas R.Powell Tyler Shugg Jacob Leighty matthew Martin Rolf P.Kreutz Michael T.Eadon Dongbing Lai Tao Lu Todd C.Skaar Division of Clinical Pharmacology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Pharmacology and Toxicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Cardiology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephrology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Medical and Molecular Genetics School of MedicineIndiana UniversityIndianapolisIndianaUSA

Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive *** previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay *** AGT promoter variant rs5051 C>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT *** independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related *** We used in silico,in vitro,in vivo,and retrospective models to test this *** In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-eCLIP results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT ***,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression ***-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>***,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with *** We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White *** studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>*** like this will help clinicians move beyond the use of race as a surrogate for genotype.

关键词： angiotensinogen genetic and genomic medicine hypertension rs699

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A Cross-Sectional Study on the Impact of Operation Triple Zero (OTZ) Program on Viral Load Suppression amongst Members of the Adolescent Club in 68 Nigerian Army Reference Hospital Yaba Lagos, Nigeria

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World Journal of AIDS 2024年第2期14卷 35-44页

作者： Nkechinyere harrison Ismail Lawal Yakubu Adamu Kehinde Aribisala Adegbenga Olarinoye Uzoamaka Agbaim Funmilayo Owolabi Dooshima Okonkwo Laura Chittenden Nathan Okeji Centre for Infectious Disease Clinic 68 Nigerian Army Reference Hospital Lagos Nigeria United States Army Medical Research Directorate-Africa Abuja Nigeria Henry Jackson Foundation Medical Research International LTD/GTE Abuja Nigeria Nigerian Ministry of Defence Health Implementation Program Abuja Nigeria

Background: In Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HIV prevalence of 3.5%. The AYP living with HIV enrolled at the 68 NARHY, Lagos reflects the national challenges with poor viral suppression. The OTZ program aligns with the UNAIDS 95-95-95 goals. It seeks to empower AYPLHIV to be in charge of their treatment and commit to triple zero outcomeszero missed appointments, zero missed drugs, and zero viral loads. The purpose of the study was to assess the impact of the OTZ program on viral load suppression among members of the adolescent club in 68 NARHY, Lagos. Method: A cross-sectional retrospective study to evaluate the impact of the OTZ program on the viral load of 53 AYP enrolled in the OTZ program between March 2019 to December 2019 was analyzed. The Percentage of viral load suppression before enrollment compared with 6 and 12 months after enrollment into the OTZ program. The AYP is grouped into 10 - 14, 15 - 19, and 20 - 24 years. Activities conducted were peer driven monthly meetings with the AYP during which the adolescents interacted on issues relating to improving their treatment outcomes, healthcare workers reviewed their clinical status, viral load result, provider peer counseling, and caregivers engagement to support adherence to medication and ARV refills. Results: Before OTZ, 81% aged 10 - 14 years, 75% aged 15 - 19 years, and 25% aged 20 - 24 years were virally suppressed (VL less than 1000 copies/ml). Six months after enrollment, 94% were virally suppressed95% aged 10 - 14 years, 96% aged 15 - 19 years, and 66% aged 20-24 years. Twelve months after enrollment, 96% of AYP were virally suppressed100% aged 10-14 years, 93% aged 15 - 19 years, and 100% aged 20 - 24 years. Males viral load (VL) suppression improved from 79% to 96% and 92%, while females VL suppression improved from 69% to 93% and 100% at 6 and 12 months respectively. Conclusion: The OTZ activities contributed to improved viral l

关键词： Impact Operation Triple Zero Adolescent Viral Load Nigeria

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香港地区中学文凭考试英语口语实施网考的探索研究

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中国考试 2024年第2期 47-55页

作者： Cameron Smart Jennifer Shiu matthew Drysdale Andy Chan 吴泓霖(译) 香港考试及评核局中国香港999077 教育部教育考试院北京100084

香港地区中学文凭考试(Hong Kong Diploma of Secondary Education Examination,HKDSE)英语口语公开考试中的小组互动部分受疫情等多种因素的影响而无法正常开展,需要探索其他口试形式。本研究探讨使用基于网络的协作视频会议工具Zoom... 详细信息

香港地区中学文凭考试(Hong Kong Diploma of Secondary Education Examination,HKDSE)英语口语公开考试中的小组互动部分受疫情等多种因素的影响而无法正常开展,需要探索其他口试形式。本研究探讨使用基于网络的协作视频会议工具Zoom进行网考口试(Internet-delivered Speaking Test)的可能性方案。选取40名中学生进行网考口试的试测,由经验丰富的口试考官对考生表现进行评分,并使用基于学习者语料库的方法研究口试考生在话轮转换和语法准确性方面的表现。通过对考生话语的语言分析,以及从考生处和考官处分别收集的反馈结果,证实网考口试是可靠且可行的。

关键词：香港地区中学文凭考试口语测试网考口试面对面口试

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Air Quality Assessment of Ubeji Community near Petroleum-Related Activities

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Open Journal of Air Pollution 2024年第2期13卷 57-71页

作者： Adedoyin Olubunmi Bankole Akinyemi Olufemi Ogunkeyede Oluwafunmilayo Mary Haruna harrison Agboro Prince Alex Ekhorutomwen Osasenaga Israel Otuomagie Christabel Ifuwe Efe Jeffery Isukuru Department of Environmental Management and Toxicology College of Science Federal University of Petroleum Resources Effurun Delta State Nigeria Department of Biology and Environmental Science College of Arts and Sciences University of New Haven West Haven USA Department of Surveying and Geoinformatics Faculty of Environmental Science Dennis Osadebay University Asaba Asaba Nigeria

The escalating global concern over air pollution requires rigorous investigations. This study assesses air quality near residential areas affected by petroleum-related activities in Ubeji Community, utilizing Aeroqual handheld mobile multi-gas monitors and air quality multi-meters. Air sampling occurred on three distinct days using multi-gas monitors and meters, covering parameters such as CO, NO2, CH4, NH3, VOCs, Particulate Matter, Temperature, Relative Humidity, and Air Quality Index. Soil and plant samples were collected and analyzed for physicochemical and organic components. Air pollutant concentrations showed significant fluctuations. Carbon monoxide (CO) ranged from 0.00 to 3.22 ppm, NO2 from 0.00 to 0.10 ppm, CH4 from 4.00 to 2083 ppm, NH3 from 371 to 5086 ppm, and VOCs from 414 to 6135 ppm. Soil analysis revealed low total nitrogen, and undetected BTEX levels. Plant samples displayed a pH range of 7.72 to 9.45. CO concentrations, although below WHO limits, indicated potential vehicular and industrial influences. Fluctuations in NO2 and CH4 were linked to traffic, industrial activities, and gas flaring. NH3 levels suggested diverse pollution sources. The result in this study highlights the dynamic nature of air pollution in Ubeji community, emphasizing the urgent need for effective pollution control measures. Although CO concentrations were within limits, continuous monitoring is essential. Elevated NO2 levels gave information on the impact of industrial activities, while high CH4 concentrations may be associated with gas flaring and illegal refining. The study recommends comprehensive measures and collaborative efforts to address these complex issues, safeguarding both the environment and public health. This study shows the potential synergy between air quality sensors and plants for holistic environmental health assessments, offering valuable insights for environmental assessments and remediation endeavours. The findings call for stringent regulations and

关键词： Air Quality Assessment Bioindicators Ubeji Community Pollution Assessment

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Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature

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World Journal of Orthopedics 2024年第9期15卷 870-881页

作者： Christian J Rajkovic matthew L Merckling Alyssa W Lee Galadu Subah Aryan Malhotra Zachary D Thomas Sabrina L Zeller John V Wainwright Merritt D Kinon Department of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

BACKGROUND Chronic inflammatory pain is associated with increased expression of interleukin(IL)-1,an inflammatory cytokine,and activity on its receptor(IL-1R).In response,the body produces IL-1R antagonist(IL-1Ra)to reduce this *** conditioned serum(ACS)is the only biologic therapy for spinal pathologies that enhances the action of endogenous IL-1Ra reserves to improve *** systematic review investigates the effectiveness of ACS in treating pain and dis-ability caused by spinal *** To evaluate the use of ACS as a conservative management option for spinal *** A systematic review of PubMed/Medline was performed to identify studies inve-stigating administration of ACS for treatment of any spinal *** Six articles were included,comprising 684 patients treated with epidural(n=133)or transforaminal(n=551)ACS *** had an average age of 54.0 years with slight female predominance(53.2%).The lumbar spine was most com-monly treated,with 567 patients(82.9%)receiving injections for lumbar radicu-lopathy(n=67),degenerative disc disease(DDD)(n=372),or spinal stenosis(n=128);cervical injections were performed in 109 patients(15.9%).Mean(SD)follow-up was 21.7(4.8)weeks from first ACS *** studies investigating mecha-nical lumbar and lumbar or cervical radicular pain reported significant pain re-duction at final follow-up compared to *** achieved comparable or su-perior results to lumbar epidural steroid *** events were reported in 21 patients(3.1%),with no serious adverse *** ACS injection is a safe and effective intervention for pain reduction in many spinal pathologies,including cervical and lumbar radiculopathies.

关键词： Spine Autologous conditioned serum Orthokine Regenokine Epidural steroid injection Interleukin-1 Inter-leukin-1 receptor antagonist

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英国房地产市场需要改革

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商业周刊（中文版） 2024年第1期 22-23页

作者： matthew Brooker 不详

想象一下,当你去买一辆新车,却发现只有三四款车,且都是同一颜色的。或者当你参观当地的超市,发现货架上只摆着一种面包、肉和蔬菜。这就是21世纪英国的新建住房市场。购买新房的英国人大多是从少数大公司那里购买的,这些大公司开发了... 详细信息

想象一下,当你去买一辆新车,却发现只有三四款车,且都是同一颜色的。或者当你参观当地的超市,发现货架上只摆着一种面包、肉和蔬菜。这就是21世纪英国的新建住房市场。购买新房的英国人大多是从少数大公司那里购买的,这些大公司开发了数百栋外观相似的大房子。

关键词：超市英国房地产新建住房 21世纪市场购买英国人

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准备好迎接生产和消费的新时代——Essity公司的北美可持续发展战略

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生活用纸 2024年第5期24卷 21-23页

作者： matthew Urmanski Essity公司的商用生活用纸业务部门北美销售与市场

2023年,全球生活用纸巨头Essity公司在各个地区进行了重大重组。对此,Tissue World杂志对Essity公司的商用生活用纸业务部门北美销售与市场副总裁matthew Urmanski进行了采访,了解Essity公司在北美地区的全新运营计划。对于总部位于瑞典... 详细信息

2023年,全球生活用纸巨头Essity公司在各个地区进行了重大重组。对此,Tissue World杂志对Essity公司的商用生活用纸业务部门北美销售与市场副总裁matthew Urmanski进行了采访,了解Essity公司在北美地区的全新运营计划。对于总部位于瑞典的Essity公司而言,2023年是一个战略上非常重要的时期。重点包括:2023年上半年持续获得高销售额增长和更高的利润率;完全退出俄罗斯市场;从英国政府获得220万英镑资金支持,用于其位于英格兰西北部的造纸厂试验使用氢能源;对Essity公司在亚洲的企业维达(Vinda)和欧洲生活用纸零售商品牌部门的所有权进行持续战略审查,旨在减少零售生活用纸业务在Essity公司总销售额中的市场份额。

关键词：销售与市场副总裁生活用纸运营计划可持续发展战略氢能源北美地区利润率

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Heavy Metal Levels and Ecological Risk in Crude Oil-Contaminated Soils from Okpare-Olomu, Niger Delta, Nigeria

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Journal of Environmental Protection 2024年第4期15卷 415-438页

作者： Adedoyin Olubunmi Bankole Akinyemi Olufemi Ogunkeyede harrison Agboro Prince Alex Ekhorutomwen Osasenaga Israel Otuomagie Khadijah Ateda Isimekhai Ekaette Akpan Fadairo Efe Jeffery Isukuru Department of Environmental Management and Toxicology College of Science Federal University of Petroleum Resources Effurun Nigeria Department of Biology and Environmental Science College of Arts and Sciences University of New Haven West Haven USA Department of Chemistry University of Abuja Abuja Nigeria Department of Science Laboratory Technology Petroleum Training Institute Effurun Nigeria

Crude oil spills have inflicted extensive disruption upon the Niger Delta ecosystem, resulting in crop loss and severe environmental damage. Such spills exacerbate heavy metal concentration within soil due to the presence of metallic ions. The Okpare-Olomu community has borne the brunt of crude oil pollution from illicit bunkering, sabotage, and equipment malfunction. This study targets an evaluation of ecological hazards linked to heavy metals (HMs) in crude oil impacted agriculturally soils within Okpare-Olomu in Ughelli South LGA of Delta State. In this study, 24 topsoil samples were obtained from areas affected by crude oil pollution;the heavy metal content was evaluated through atomic absorption spectrometry. The concentration ranges for HMs (mg/kg) in soil were: 24.1 - 23,174 (Cu);0.54 - 37.1 (Cd);9.05 - 54 (Cr);12 - 174 (Ni);18.5 - 8611 (Pb);and 148 - 9078 (Zn) at a soil depth of 0 - 15 cm. Notably, metal concentrations were recorded to be above permissible World Health Organization limits. Predominantly, Zn and Pb recorded higher heavy metal concentration when compared to other heavy metals analysed, notably at sampling points PT7 through PT24. Zinc and Pb contamination exhibited highly significant contamination factors, and contamination severity was evidenced across all sample points, signifying a grave risk level. Pollution load indices indicated pervasive extreme pollution levels. Geoaccumulation indices signaled moderate to strong pollution, mainly by Pb and Zn. Ecological risk assessments revealed variable levels of heavy metal contamination, from low to very high, with potential ecological risk reflecting markedly elevated levels. This study underscores the imperative for soil remediation to rectify ecological imbalances in agriculturally affected soil constituents.

关键词： Heavy Metals Crude Oil Pollution Degree of Contamination Potential Risk Index

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Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 137-143页

作者： matthew D.Geiger Anne M.Lynch Alan G.Palestine Nathan C.Grove Karen L.Christopher Richard S.Davidson Michael J.Taravella Naresh Mandava Jennifer L.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of Colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BCVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).Conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

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