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Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?

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World Journal of Gastroenterology 2009年第10期15卷 1186-1193页

作者： Duygu Dee harrison-Findik Division of Gastroenterology and Hepatology Department of Internal Medicine University of Nebraska Medical Center Omaha NE 68198-5820 United States

Despite heavy consumption over a long period of time, only a small number of alcoholics develop alcoholic liver disease. This alludes to the possibility that other factors, besides alcohol, may be involved in the progression of the disease. Over the years, many such factors have indeed been identified, including iron. Despite being crucial for various important biological processes, iron can also be harmful due to its ability to catalyze Fenton chemistry. Alcohol and iron have been shown to interact synergistically to cause liver injury. Iron-mediated cell signaling has been reported to be involved in the pathogenesis of experimental alcoholic liver disease. Hepcidin is an iron-regulatory hormone synthesized by the liver, which plays a pivotal role in iron homeostasis. Both acute and chronic alcohol exposure suppress hepcidin expression in the liver. The sera of patients with alcoholic liver disease, particularly those exhibiting higher serum iron indices, have also been reported to display reduced prohepcidin levels. Alcohol-mediated oxidative stress is involved in the inhibition of hepcidin promoter activity and transcription in the liver. This in turn leads to an increase in intestinal iron transport and liver iron storage. Hepcidin is expressed primarily in hepatocytes. It is noteworthy that both hepatocytes and Kupffer cells are involved in the progression of alcoholic liver disease. However, the activation of Kupffer cells and TNF-α signaling has been reported not to be involved in the down-regulation of hepcidin expression by alcohol in the liver. Alcohol acts within the parenchymal cells of the liver to suppress the synthesis of hepcidin. Due to its crucial role in the regulation of body iron stores, hepcidin may act as a secondary risk factor in the progression of alcoholic liver disease. The clarification of the mechanisms by which alcohol disrupts iron homeostasis will allow for further understanding of the pathogenesis of alcoholic liver disease.

关键词： Alcohol Hepatocyte Kupffer cells Oxida-tive stress Second hit

Prostaglandin E1 administration post liver transplantation and renal outcomes:A retrospective single center experience

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World Journal of Transplantation 2024年第4期14卷 101-109页

作者： Vinay Jahagirdar Mohamed Ahmed Ifrah Fatima Hassam Ali Laura Alba John H Helzberg Lee S Cummings matthew Wilkinson Jameson Forster Alisa Likhitsup Department of Internal Medicine Saint Luke’s Health System of Kansas City and the University of Missouri-Kansas CityKansas CityMO 64111United States Department of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Internal Medicine Department of Gastroenterology and HepatologySaint Luke’s Health System of Kansas City and University of Missouri-Kansas CityKansas CityMO 64111United States Department of Surgery University of Missouri-Kansas City and Transplant SurgerySaint Luke’s Hospital of Kansas CityKansas CityMO 64111United States Department of Gastroenterology and Hepatology University of MichiganAnn ArborMI 48109United States

BACKGROUND Prostaglandin E1(PGE1),or alprostadil,is a potent vasodilator that improves hepatic blood flow and reduces ischemia-reperfusion injury post-liver transplantation(LT).However,the benefits of PGE1 on renal function after LT have not yet been well *** To assess the impact of PGE1 administration on renal function in patients who underwent liver or liver-kidney *** This retrospective study included all patients who underwent liver or liverkidney transplant at our institution from January,2011 to December,*** were classified based on whether they received ***1 was administered post-LT to those with transaminases>1000 U/L in the immediate postoperative ***,post-LT treatments and/or complications,renal function,and survival were *** logistic regression analysis was performed,and a two-tailed P value<0.05 was considered statistically *** A total of 145 patients underwent LT,with 44(30%)receiving *** patient characteristics were comparable,except the PGE1 group had significantly higher aspartate aminotransferase(AST)(1961.9 U/L±1862.3 U/L vs 878 U/L±741.4 U/L,P=0.000),alanine aminotransferase(1070.6 U/L±895 U/L vs 547.7 U/L±410 U/L,P=0.000),international normalized ratio on post-LT day 1(2±0.74 vs 1.8±0.4,P=0.03),a longer intensive care unit stay(8.1 days±11.8 days vs 3.8 days±4.6 days,P=0.003),more vasopressor use(55.53 hours±111 hours vs 16.33 hours±26.3 hours,P=0.002),and higher immediate postoperative complications(18.6%vs 4.9%,P=0.04).The PGE1 group also had a significantly higher 90-day readmission rate(29.6%vs 13.1%,P=0.02)and lower 1-year liver graft survival(87.5%vs 98.9%,P=0.005).However,30-day readmission(31.6%vs 27.4%,P=0.64),LT complications(hepatic artery thrombosis,biliary complications,rejection of liver graft,cardiomyopathy),1-year patient survival(96.9%vs 97.8%,P=0.77),overall liver graft survival,and overall patient survival were similar between t

关键词： Liver transplantation Alprostadil Protective agents Transplant Prostaglandin E1

Engineering the Smart Factory

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1046-1051页

作者： harrison Robert VERA Daniel AHMAD Bilal Warwick Manufacturing Group University of Warwick

The fourth industrial revolution promises to create what has been called the smart factory. The vision is that within such modular structured smart factories, cyber-physical systems monitor physical processes, create a virtual copy of the physical world and make decentralised decisions. This paper provides a view of this initiative from an automation systems perspective. In this context it considers how future automation systems might be effectively configured and supported through their lifecycles and how integration, application modelling, visualisation and reuse of such systems might be best achieved. The paper briefly describes limitations in current engineering methods, and new emerging approaches including the cyber physical systems （CPS） engineering tools being developed by the automation systems group （ASG） at Warwick Manufacturing Group, University of Warwick, UK.

关键词： index terms--smart factory Industry 4.0 automation systems cyber-physical systems engineering lifecycle

Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 335-342页

作者： Kenneth W Chow matthew T Bell Nicholas Cumpian Maryanne Amour Ryan H Hsu Viktor E Eysselein Neetika Srivastava Michael W Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUND Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in November *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** We evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(P=0.77),40.0%established post-AI(P=0.44),and 39.5%late post-AI(P=0.77).There were no significant differences in polyp detection rate(PDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic PDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy Adenoma detection rate Screening Colorectal adenoma

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非洲猪瘟对亚洲野猪种群的影响

国外畜牧学（猪与禽） 2024年第2期44卷 12-14页

作者：唐芬兰(译) 范美红(校) 李红(审) 张涛(制图) matthew S Luskin 不详

为了了解非洲猪瘟对亚洲猪种群分布的影响,文章对亚洲野猪、马来西亚野猪的种群动态进行了研究。通过相机捕捉法对马来西亚帕索研究林的野猪进行了长期监测,发现非洲猪瘟暴发前和暴发后野猪的数量有明显差异,说明非洲猪瘟对亚洲猪的影... 详细信息

为了了解非洲猪瘟对亚洲猪种群分布的影响,文章对亚洲野猪、马来西亚野猪的种群动态进行了研究。通过相机捕捉法对马来西亚帕索研究林的野猪进行了长期监测,发现非洲猪瘟暴发前和暴发后野猪的数量有明显差异,说明非洲猪瘟对亚洲猪的影响与欧洲一样,都很严重,养殖场(户)需要提高生物安全水平。

关键词：非洲猪瘟亚洲野猪相机捕捉种群

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The Effect of Gelatin on the Preparation of Silica Coated Iron Particles

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Chemical Research in Chinese Universities 2000年第3期16卷 223-229页

作者： WANG Gui hua Andrew harrison Department of Chemistry Shanghai Normal UniversityShanghai 200234P.R.China Department of Chemistry The University of EdinburghEdinburghEH93JJUK

A method is described for coating fine iron particles(~1 μm) with a uniform silica layer, produced by the hydrolysis of tetraethyl orthosilicate. The presence of a small amount of gelatin on the surface of the iron particles facilitates this process. The X ray photoelectron measurements indicated that the gelatin interacted with the surface of the iron particles by means of both nitrogen(in —NH 2 groups) and oxygen(in —COOH groups) and then bound to the silica. The silica coating increases the resistance of the iron particles to oxidation on heating in air, which makes the temperature at which an observable oxidization occurs from 330 ℃ to 400 ℃ raised.

关键词： Fine iron particles Silica coating Gelatin

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Moth diversity in three biofuel crops and native prairie in Illinois

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Insect Science 2013年第3期20卷 407-419页

作者： Terry harrison May R. Berenbaum Department of Entomology University of Ilfinois at Urbana-Champaign Urbana Illinois USA

The expanding demand for biofuel feedstock may lead to large-scale con- scription of land for monoculture production ofbiofuel crops with concomitant substantial negative impacts on biodiversity. We compared moth diversity in light-trap samples from corn, miscanthus, switchgrass and native prairie, to determine whether there is an observ- able relationship between plant species diversity and moth abundance and diversity. Moth alpha diversity was highest in prairie and was higher in switchgrass than in the other two biofuel crops. Beta diversity generally was low among the biofuel crops, and prairie shared lower beta diversity with switchgrass than with corn or miscanthus. Analysis of variance showed no significant differences in moth abundance per species among treatments. The alpha and beta diversity index findings are consistent with those of other studies on arthro- pods in biofuel crops and provide evidence to suggest that large-scale conversion of acreage to biofuel crops may have substantial negative effects on arthropod biodiversity both within the cropping systems and in the surrounding landscape.

关键词： agricultural landscapes biodiversity bioenergy ecosystem services moths prairies

Reliability-based design in rock engineering: Application of Bayesian regression methods to rock strength data

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 612-627页

作者： Nezam Bozorgzadeh John P.harrison Department of Civil Engineering GeoEngineering Centre at Queen’s-RMC(Royal Military College of Canada)KingstonCanada Department of Civil and Mineral Engineering University of TorontoTorontoCanada

Reliability-based design (RBD) is being adopted by geotechnical design codes worldwide, and it is therefore necessary that rock engineering practice evolves to embrace RBD. This paper examines the Hoek-Brown (H-B) strength criterion within the RBD framework, and presents three distinct analyses using a Bayesian approach. Firstly, a compilation of intact compressive strength test data for six rock types is used to examine uncertainty and variability in the estimated H-B parameters m and σc, and corresponding predicted axial strength. The results suggest that within- and between-rock type variabilities are so large that these parameters need to be determined from rock testing campaigns, rather than reference values being used. The second analysis uses an extensive set of compressive and tensile (both direct and indirect) strength data for a granodiorite, together with a new Bayesian regression model, to develop joint probability distributions of m and σc suitable for use in RBD. This analysis also shows how compressive and indirect tensile strength data may be robustly used to fit an H-B criterion. The third analysis uses the granodiorite data to investigate the important matter of developing characteristic strength criteria. Using definitions from Eurocode 7, a formal Bayesian interpretation of characteristic strength is proposed and used to analyse strength data to generate a characteristic criterion. These criteria are presented in terms of characteristic parameters mk and σck, the values of which are shown to depend on the testing regime used to obtain the strength data. The paper confirms that careful use of appropriate Bayesian statistical analysis allows the H-B criterion to be brought within the framework of RBD. It also reveals that testing guidelines such as the International Society for Rock Mechanics and Rock Engineering (ISRM) suggested methods will require modification in order to support RBD. Importantly, the need to fully understand the implications of

关键词： Reliability-based design(RBD) Hoek-Brown(HeB)criterion Bayesian regression Indirect tensile strength Characteristic strength criterion