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Three-dimensional models:from cell culture to Patient-Derived Organoid and its application to future liposarcoma research

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Oncology Research 2025年第1期33卷 1-13页

作者： SAYUMI TAHARA SYDNeY ReNTSCH FeRNANDA COSTAS CASAL De FARIA PATRICIA SARCHeT ROMA KARNA FeDeRICA CALORe RAPHAeL e.POLLOCK Department of Surgery Division of Surgical OncologyThe James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA Department of Cancer Biology and Genetics The James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other *** to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma *** cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under *** vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell ***,they do not fully recapitulate human dedifferentiated liposarcoma(DDLPS)***,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between *** the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and Patient-Derived tumor Organoids(PDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy *** this review,we first provide a general overview of 3D cell cultures compared to 2D cell *** then focus on one of the recent 3D cell culture applications,Patient-Derived Organoids(PDOs),summarizing and discussing several PDO ***,we discuss the current and future applications of PDOs to sarcoma,particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma Patient-Derived Organoid(PDO) Spheroid Three-dimensional(3D)cell culture

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong Li Andrey e.Miroshnichenko School of Physics and electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical engineering Rowan University School of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells

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Cellular & Molecular Immunology 2019年第11期16卷 846-847页

作者： matthew A.Huggins Sara e.Hamilton Department of Laboratory Medicine and Pathology Center for ImmunologyUniversity of Minnesota Medical SchoolMinneapolisMN 55414USA

Regulation of cells with cytotoxic functionality is crucial to provide an effective and proportional response to immune ***8 T cells and NK cells are responsible for differentiating infected or tumorigenic host cells from healthy self-cells and removing them from the ***-15 signaling promotes the survival,maturation,and proliferation of CD8 T cells and NK cells.1 In a recent work,Zhou et *** a novel regulatory checkpoint that inhibits activation through the IL-15 signaling pathway.2 This study dissects the mechanism through which the deubiquitinase Otub1 negatively regulates CD8 T cell and NK cell activation in response to *** findings identify an intriguing and previously undescribed checkpoint that can potentially be manipulated to modulate the immune ***,the authors demonstrate that by removing Otub1 inhibition,immune tolerance to self-cells and tumor antigens can be broken.

关键词： ubiquitin al. removing

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Role of cardiovascular intervention as a bridge to liver transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10651-10657页

作者： Zankhana Raval matthew e Harinstein James D Flaherty Bluhm Cardiovascular Institute Feinberg School of Medicine of Northwestern UniversityChicago IL 60611 United States University of Pittsburgh Medical Center Heart and Vascular Institute Pittsburgh PA 15219 United States

end stage liver disease(eSLD) is associated with many specific derangements in cardiovascular physiology, which influence perioperative outcomes and may pro-foundly influence diagnostic and management strate-gies in the preoperative period. This review focuses on evidence-based diagnosis and management of coro-nary, hemodynamic and pulmonary vascular disease in this population with an emphasis on specific strategies that may provide a bridge to transplantation. Specifi-cally, we address the underlying prevalence of cardio-vascular disease states in the eSLD population, and relevant diagnostic criteria thereof. We highlight tradi-tional and non-traditional predictors of cardiovascular outcomes following liver transplant, as well as data to guide risk-factor based diagnostic strategies. We go on to discuss the alterations in cardiovascular physiology which influence positive- and negative-predictive values of standard noninvasive testing modalities in the eSLD population, and review the data regarding the safetyand efficacy of invasive testing in the face of eSLD and its co-morbidities. Finally, based upon the totality of available data, we outline an evidence-based ap-proach for the management of ischemia, heart failure and pulmonary vascular disease in this population. It is our hope that such evidence-driven strategies can be employed to more safely bridge appropriate candidates to liver transplant, and to improve their cardiovascular health and outcomes in the peri-operative period.

关键词： Perioperative management Liver transplantation Coronary heart disease Cirrhotic cardiomyopathy Heart failure Pulmonary vascular disease

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Skeletal Blood Flow in Bone Repair and Maintenance

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Bone Research 2013年第4期1卷 311-322页

作者： Ryan e.Tomlinson matthew J.Silva Department of Orthopaedic Surgery Washington University in St.Louis Musculoskeletal Research Center Washington University in St.Louis

Bone is a highly vascularized tissue, although this aspect of bone is often overlooked. In this article, the importance of blood flow in bone repair and regeneration will be reviewed. First, the skeletal vascular anato- my, with an emphasis on long bones, the distinct mechanisms for vascularizing bone tissue, and methods for remodeling existing vasculature are discussed. Next, techniques for quantifying bone blood flow are briefly summarized. Finally, the body of experimental work that demonstrates the role of bone blood flow in fracture healing, distraction osteogenesis, osteoporosis, disuse osteopenia, and bone grafting is examined. These results illustrate that adequate bone blood flow is an important clinical consideration, particularly during bone regeneration and in at-risk patient groups.

关键词： blood flow angiogenesis vascular remodeling fracture bone repair

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Major Trends in Population Growth Around the World

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China CDC weekly 2021年第28期3卷 604-613页

作者： Danan Gu Kirill Andreev matthew e.Dupre United Nations Population Division New YorkUSA Department of Population Health Sciences&Department of Sociology Duke UniversityNorth CarolinaUSA

Summary The world’s population continues to grow,albeit at a slower *** decelerating growth is mainly attributable to fertility declines in a growing number of ***,there are substantial variations in the future trends of populations across regions and countries,with sub-Saharan African countries being projected to have most of the increase.

关键词： Population Growth fertility

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Surgery for oligometastasis of pancreatic cancer

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Chinese Journal of Cancer Research 2015年第4期27卷 358-367页

作者： Fengchun Lu Katherine e.Poruk matthew J.Weiss Department of General Surgery Union Hospital Fujian Medical University Department of Surgery The Sol Goldman Pancreatic Cancer Research Center The Johns Hopkins University School of Medicine

The incidence of pancreatic adenocarcinoma（PDAC） has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy（PM） has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.

关键词： Pancreatic cancer(PC) oligometastasis hepatic metastasis pulmonary metastasis surgical management

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Simultaneous vs staged treatment of urolithiasis in patients undergoing radical prostatectomy

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World Journal of Clinical Cases 2014年第11期2卷 698-704页

作者： Boyd R Viers matthew K Tollefson David e Patterson matthew T Gettman Amy e Krambeck Mayo Clinic Department of Urology Rochester MN 55902 United States

AIM: To assess the outcomes of men treated for urolithiasis at the time of radical ***: From 1991 to 2010, 22 patients were retrospectively identified who were treated simultaneously(n = 10) at radical prostatectomy, or(n = 12) within 120 d prior to prostatectomy, for urolithiasis. Clinical characteristics were reviewed including: type of prostatectomy and stone surgery, location and amount of stone burden, perioperative change in hemoglobin and creatinine, stent frequency, total hospital d, stone-free rates, additional stone procedures and complications. Long-term functional outcomes including stress urinary incontinence and bladder neck contracture were reported. Differences between cohorts(simultaneous vs staged treatment) were assessed. ReSULTS: Among men undergoing radical prostatectomy, primary stone procedures included 12 ureteroscopy, 6 shock wave lithotripsy, 2 open nephrolithotomyand 2 percutaneous nephrolithotomy. In staged shock wave lithotripsy there were 4 complications and 3 additional procedures vs 1(P = 0.5) and 0(P = 0.2) in the simultaneous cohort. Meanwhile in staged ureteroscopy there were 5 complications and 1 additional procedure vs 1(P = 0.2) and 1(P = 0.9) in the simultaneous cohort. Additional procedures for residual stones was greater among patients with asymptomatic upper tract calculi 3(60%) relative to patients with symptomatic stones 2(13%; P = 0.02). Likewise, patients with proximal or multiple calculi had a greater total hospital days 5.5 vs 4.1(P = 0.04), additional procedures 6 vs 0(P = 0.04) and lower stone-free rates 39% vs 89%(P = 0.02) relative to men with distal stones. Finally, there was no difference in the incidence of bladder neck contracture(P = 0.4) or stress urinary incontinence(P = 0.7) between ***: Ureteroscopic treatment of symptomatic distal urolithiasis at radical prostatectomy appears to be safe and efficacious with a low rate of adverse postoperative outcomes.

关键词： Urolithiasis Kidney stone Prostate cancer Radical prostatectomy

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effects of Glomus mosseae on the toxicity of heavy metals to Vicia faba

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Journal of environmental Sciences 2006年第4期18卷 721-726页

作者： ZHANG Xu-hong LIN Ai-jun CHeN Bao-dong WANG You-shan smith Sally e.smith F Andrew Research Center for eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China Department of environmental engineering Beijing University of Chemical Technology Beijing 100029 China Lab of Soil and Microbe Department of Plant Nutrition and Resource Agriculture and Forestry Academy of Beijing Beijing 100089 China Soil and Land Systems School of Earth and Environmental Sciences The University of Adelaide Adelaide South Australia 5005 Australia

A glasshouse pot experiment was conducted to investigate effects of the arbuscular mycorrhizal fungus Glomus mosseae on the growth of Vicia faba and toxicity induced by heavy metals （HMs）（Cu, Zn, Pb and Cd） in a field soil contaminated by a mixture of these metals. There was also uninoculation treatment （NM） simultaneously. Mycorrhizal （GM） plants have significantly increased growth and tolerance to toxicity induced by heavy metals compared with NM plants. P uptake was significantly increased in GM plants. Mycorrhizal symbiosis reduced the transportation of HMs fi＇om root to shoot by immobilizing HMs in the mycorrhizal, shown by increasing the ratios of HMs from root to shoot. Oxidative stress, which can induce DNA damage, is an important mechanism of heavy metal toxicity. GM treatment decreased oxidative stress by intricating antioxidative systems such as peroxidases and non-enzymic systems including soluble protein. The DNA damage induced by heavy metals was detected using comet assay, which showed DNA damage in the plants was decreased by the GM treatment.

关键词： arbuscular mycorrhizal fungi (AMF) metal contamination metal toxicity DNA damage

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油气投资抉择的分析方法

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国外油气勘探 1985年第1期 1-4页

作者： Dennes e.smith 王凤琛 eCO Inc

对石油和天然气投资机会的评价常常过份地强调了未来的利润(假定油气井能投产),而忽视了系统地评价与每项计划有关的地质的和财务的风险。由于存在钻干井的风险,石油和天然气公司都力求把未来的利润增加到最大,而把财务风险减少到最小。

关键词：现值收益地球物理勘探地质利润收入地质勘探财政管理投资本位币美元探边井成功概率野猫井初探井风险费用

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