检索结果-南通市图书馆

Cost-effectiveness analysis of tr.atments for.metastatic castr.tion r.sistant pr.state cancer

Asian Jour.al of Ur.logy 2017年第1期4卷 37-43页

作者： matthew E.Pollar. Alan J.Moskowitz Michael A.Diefenbach Simon J.Hall Depar.ment of Ur.logy UCLA School of MedicineLos AngelesCAUSA Depar.ment of Health Evidence and Policy Mount Sinai School of MedicineNew YorkNYUSA Smith Institute for.Ur.logy Hofstra Northwell School of MedicineLake SuccessNYUSA

Objective:Tr.atment options for.metastatic castr.tion r.sistant pr.state cancer.mCr.C)have expanded r.pidly in r.cent *** the significant economic bur.en,we sought per.or. a cost-effectiveness analysis(CEA)of the contempor.r. tr.atment par.digm for.***:We devised a tr.atment pr.tocol consisting of sipuleucel-T,enzalutamide,abir.ter.ne,docetaxel,r.dium-223,and *** estimated number.and length of tr.atments for.each ther.py using dosing schedules or.pr.gr.ssion fr.e sur.ival data fr.m published clinical *** estimated tr.atment cost using billing data and Medicar. r.imbur.ement values and per.or.ed a *** analysis assumed US$100,000 per.life year.saved(LYS)as the thr.shold societal willingness to ***:Incr.mental cost-effectiveness r.tios(ICEr.for.str.tegies incor.or.ting sipuleucel-T that wer. not eliminated by extended dominance exceeded the societal thr.shold willingnessto-pay of US$100,000 per.LYS,the lowest of which was sipuleucel-T+enzalutamide+abir.ter.ne+docetaxel at US$207,714 per.***+abir.ter.ne+docetaxel exhibited the most favor.ble ICEr.among str.tegies without sipuleucel-T at US$165,460 per.***:Based on the available sur.ival data and cur.ent costs of tr.atment,all tr.atment str.tegies gr.atly exceed a commonly assumed societal willingness-to-pay thr.shold of US$100,000 per.*** in this r.gar. can only comewith a r.duction in pr.cing,better.tailor.ng of tr.atment or.significant enhancements in sur.ival with clinical use of tr.atment combinations or.sequences.

关键词： Metastatic pr.state cancer Costs and cost analysis Health expenditur.s Economics Phar.aceutical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cassava Anthr.cnose Disease and Var.etal Scr.ening for.r.sistance in Akwa Ibom State of Niger.a

引用

Jour.al of Agr.cultur.l Science and Technology(B) 2011年第6期1卷 889-895页

作者： r. C. Wokocha N. E. Nneke Depar.ment of Plant Health Management Michael Okpara University of Agriculture Umudike P.M.B. 7267 Umuahia Abia State Nigeria Depar.ment of Cr.p Science University of Uyo P.ikL B. 1017 Uyo Alcwa Ibom State Nigeria

Cassava （Manihot esculenta Cr.ntz） pr.duction in Akwa Ibom State is limited by cassava anthr.cnose disease （CAD） which causes enor.ous losses in planting mater.als. Sur.ey of the disease was conducted in the wet and dr. seasons in six major.cassava-gr.wing ar.as （Essien Udim, Ikono, Itu, Nsit Atai, Or.k Anam and Uyo） of the State to deter.ine the incidence and sever.ty of the disease. Ten commonly gr.wn cassava var.eties wer. then scr.ened in the gr.enhouse by inoculating each var.ety with the spor. suspension of vir.lent isolate of the cassava anthr.cnose pathogen. Disease sever.ty was assessed using size of lesions on the inoculated plants and defoliation caused by the infection. r.sults of the sur.ey showed that Nsit Atai is a high infection ar.a for.CAD. It r.cor.ed the highest disease incidence and sever.ty in both the wet season （36.59% and 3.52） and dr. season （9.26% and 2.20）, r.spectively. The mean disease incidence （24.10%） and sever.ty （3.23） for.the six study ar.as wer. higher.in the wet season indicating the impor.ance of this season in the occur.ence of CAD. r.sults of the scr.ening test showed that TMS 98/30572 was r.sistant to the disease. The small lesion size （5.00 mm） obser.ed in this var.ety would ensur. less stem disr.ption and timely deliver. of r.sour.es to the actively gr.wing points. The low defoliation （5,65%） obser.ed in the same var.ety would enhance the photosynthetic capacity of the plant. Ther.for., TMS 98/30572 may be r.commended to cassava far.er. in Akwa Ibom State.

关键词： Cassava disease cassava anthr.cnose disease Collectotichum gloeospor.oides f. sp. manihotis scr.ening for.diseaser.sistance disease r.sistance.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In Defense of the LDL Hypothesis

引用

Wor.d Jour.al of Car.iovascular.Diseases 2019年第3期9卷 245-252页

作者： David S. Schade Lynda Shey r. Philip Eaton Division of Endocr.nology and Metabolism Department of Internal Medicine School of Medicine University of New Mexico Albuquerque NM USA Diabetes Compr.hensive Car. Center University of New Mexico Hospital Albuquerque NM USA

Both clinical and basic science studies dur.ng the last 30 year. have emphasized the impor.ance of cholester.l in the pathogenesis of ather.scler.sis. Ther. is a dir.ct r.lationship between the level of cir.ulating cholester.l (as LDLc r.mnant par.icles) and the incidence of car.iovascular.events. However. this hypothesis has not gone unchallenged, both in social media and the scientific liter.tur.. This contr.ver.y has major.consequences to the health of the public,?because ather.scler.sis is the number.one cause of mor.idity and mor.ality in the Wester. Wor.d.?The pr.ponents of the non-impor.ance of ather.scler.sis base their.ar.ument on cer.ain studies. We have car.fully examined these studies in or.er.to addr.ss the validity of the challenges.?Each of these studies has its own deficiencies?as pointed out in this ar.icle. Over.ll, the evidence that cholester.l is not the pr.mar. under.ying pathogenic factor.causing hear. attacks and str.kes is based on a flawed inter.r.tation of study r.sults. These studies have sever.l ser.ous deficiencies including lost data, inadequate power. excessive dr.p outs, bor.er.ine significance, and lack of a contr.l gr.up. The conclusion that cholester.l is essential in the pathogenesis of ather.scler.sis is cr.tical for.tr.ating and pr.venting ather.scler.sis and r.ducing the pr.valence of car.iovascular.disease.

关键词： Ather.scler.sis Cholester.l LDL Cholester.l Study Design Statins Car.iovascular Disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The effect of car.apenem r.sistance in Klebsiellae on infection outcomes in animals and bir.s

引用

Infectious Diseases r.sear.h 2024年第2期5卷 12-14页

作者： Bhoj r.Singh Abhijit M Pawde Division of Epidemiology ICAR-Indian Veterinary Research InstituteBareilly 243122India Wildlife Cetr. ICAR-Indian Veterinary Research InstituteBareilly 243122India

It is often said that the emer.ence of antimicr.bial dr.g r.sistance(AMr.in pathogens is the major.cause of *** the pr.sent study,clinical micr.biology data on infections caused by Klebsiella pneumoniae str.ins and their.antimicr.bial dr.g r.sistance specifically to car.apenems r.tr.eved fr.m Clinical Epidemiology database of the Institute wer. analysed to deter.ine the impact of car.apenem r.sistance in Klebsiellae isolated fr.m the clinical samples of veter.nar. cases and outcome of the infection because in a few r.cent r.por.s it is claimed that the pr.sence of car.apenem-r.sistant Klebsiellae is associated with higher.mor.ality in humans due to Klebsiella *** r.tr.spective analysis of Klebsiella infections in animals and bir.s r.vealed that 21.8%of *** causing pneumonic or.septicemic infections wer. car.apenem-r.sistant but the car.apenem r.sistance was not associated with incr.ased number. of deaths or.*** may be pr.bably due to the fact that car.apenem dr.gs wer. not used for.the tr.atment of infected animals and car.apenem r.sistance may not be associated with the lethality potential of Klebsiellae.

关键词： Klebsiella pneumoniae Klebsiella oxytoca Klebsiella aer.genes abor.ions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultr.-Low Thr.shold Optical Bistability and Multi-Stability in Dielecr.r.c Slab Doped with Semiconductor.Quantum Well

引用

Communications in Theor.tical Physics 2016年第7期65卷 129-132页

作者： r.Nasehi Young r.sear.her. and Elite Club Central Tehran Branch Islamic Azad University

A scheme for.switching of the optical bistability(OB) and multi-stability(OM) in a dielectr.c slab doped with a thr.e-level ladder.configur.tion n-doped semiconductor.quantum well is simulated. It is shown that the bistable behavior.of the system in dielectr.c slab can be contr.lled via amplitude or.r.lative phase of applied fields. This optical system may pr.vide some new possibilities for.test the switching pr.cess.

关键词： optical bistability quantum well dielectr.c slab

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Odontogenic sinusitis:A state-of-the-ar. r.view

引用

Wor.d Jour.al of Otor.inolar.ngology-Head and Neck Sur.er. 2022年第1期8卷 8-15页

作者： John r.Cr.ig Depar.ment of Otolar.ngology-Head and Neck Sur.er. Henry Ford Health SystemDetroitMichiganUSA

Odontogenic sinusitis(ODS)is mor. common than histor.cally r.por.ed,and is under.r.pr.sented in the sinusitis *** is distinct fr.m r.inosinusitis in that it is infectious sinusitis fr.m an infectious dental sour.e or.a complication fr.m dental pr.cedur.s,and most commonly pr.sents *** clinical featur.s,micr.biology,and diagnostic and tr.atment par.digms ar. also distinct fr.m *** evaluation and management should gener.lly be conducted by both otolar.ngologists and dental pr.vider.,and clinicians must be able to suspect and confir. the *** suspicion is dr.ven by cer.ain clinical featur.s like unilater.l maxillar. sinus opacification on computed tomogr.phy,over. maxillar. dental pathology on computed tomogr.phy,unilater.l middle meatal pur.lence on nasal endoscopy,foul smell,and odontogenic bacter.a in sinus *** should confir. the sinusitis thr.ugh nasal endoscopy by assessing for.middle meatal pur.lence,edema,or.*** pr.vider. should confir. dental pathology thr.ugh appr.pr.ate examinations and *** ODS is confir.ed,a multidisciplinar. shar.d decision-making pr.cess should ensue to discuss r.sks and benefits of the timing and differ.nt types of dental and sinus sur.ical *** antibiotics ar. gener.lly ineffective at r.solving ODS,especially when ther. is tr.atable dental *** both the dental pathology and sinusitis ar. addr.ssed,r.solution can be expected in 90%-100%of *** tr.atable dental pathology,while pr.mar. dental tr.atment may r.solve the sinusitis,a significant per.entage of patients still r.quir. endoscopic sinus *** patients with significant sinusitis symptom bur.ens,pr.mar. endoscopic sinus sur.er. is an option to r.solve symptoms faster.followed by appr.pr.ate dental *** well-designed studies ar. necessar. acr.ss all ar.as of ODS.

关键词： apical per.odontitis chr.nic r.inosinusitis endoscopic sinus sur.er. maxillar. sinusitis odontogenic sinusitis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of MoO_3 Amounts on Sinter.ng and Electr.cal Pr.per.ies of Ce_(0.8)Nd_(0.2)O_(1.9)

引用

Chemical r.sear.h in Chinese Univer.ities 2012年第1期28卷 9-13页

作者： ZHOU De-feng1, ZHAO Gui-chun1, YANG Mei1, XIA Yan-jie2 and MENG Jian2 1. School of Chemistr. and Life Science, Changchun Univer.ity of Technology, Changchun 130012, P. r. China 2. State Key Labor.tor. of r.r. Ear.h r.sour.es Utilization, Changchun Institute of Applied Chemistr., Chinese Academy of Sciences, Changchun 130022, P. r. China School of Chemistr. and Life Science Changchun University of Technology Changchun 130012 Changchun Institute of Applied Chemistr. Chinese Academy of Sciences State Key Laboratory of Rare Earth Resources Utilization Changchun 130022

The high pur.ty （Ce0.8Nd0.2O1.9）1-x（MoO3）x（x=0, 0.005, 0.010, 0.020; Ce0.8Nd0.2O1.9=NDC） solid solutions wer. pr.par.d by modified sol-gel method. The str.ctur.s and electr.c conductivities wer. char.cter.zed by X-r.y diffr.ction（Xr.）, field-emission scanning electr.n micr.scopy（FESEM） and electr.chemical impedance spectr.s copy（EIS）. The Xr. r.sults show that the mater.als wer. pur. phase with a cubic fluor.te str.ctur.. Compar.d to the undoped-NDC samples, MoO3 doped-NDC showed higher.sinter.d density（over.96%） at r.duced sinter.ng temper. tur.. The electr.c conductivity（σt） of （Ce0.8Nd0.2O1.9）1-x（MoO3）x at 400 °C was 9.58×10-4 S/cm when x=0.010, which was higher.than that of undoped-NDC samples（σt=3.29×10-4 S/cm）. The obtained optimal amount of the MoO3 was x=0.010 in this system.

关键词： Neodymium-doped cer.a Molybdenum oxide Sol-gel method Gr.in boundar. conductivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of nutr.ent stoichiometr.c r.lationships among ecosystem compar.ments of a subtr.pical tr.atment wetland. Do we have “r.dfield wetlands”?

引用

Ecological Pr.cesses 2019年第1期8卷 267-287页

作者： Paul Julian II Stefan Ger.er.r.pesh K.Bhomia Jill King Todd Z.Osbor.e Alan L.Wr.ght matthew Power. Jacob Dombr.wski Soil and Water.Sciences Depar.ment University of FloridaFt.PierceFL34945USA Soil and Water.Sciences Depar.ment University of FloridaGainesvilleFL 32611USA South Flor.da Water.Management Distr.ct Water Quality Treatment TechnologiesWest Palm BeachFL 33406USA Whitney Labor.tor. for.Mar.ne Bioscience University of FloridaSt AugustineFL 32080USA.

Backgr.und:Evaluation of car.on(C),nitr.gen(N),and phosphor.s(P)r.tios in aquatic and ter.estr.al ecosystems can advance our.under.tanding of biological pr.cesses,nutr.ent cycling,and the fate of or.anic matter.OM)in these *** of aquatic ecosystems can change the accumulation and decomposition of OM which can alter.biogeochemical cycling and alter.the base of the aquatic food *** study investigated nutr.ent stoichiometr. within and among wetland ecosystem compar.ments(i.e.,water.column,flocculent,soil,and abovegr.und vegetation biomass)of two subtr.pical tr.atment wetlands with distinct vegetation *** flow-ways(FWs)within the networ. of Ever.lades Stor.water.Tr.atment Ar.as in south Flor.da(USA)wer. selected for.this *** evaluated nutr.ent stoichiometr. of these to under.tand biogeochemical cycling and contr.ls of nutr.ent r.moval in a tr.atment wetland within an ecological stoichiometr. ***:This study demonstr.tes that C,N,and P stoichiometr. can be highly var.able among ecosystem compar.ments and between *** law slopes of C,N,and P within sur.ace water.floc,soil,and vegetation wer. significantly differ.nt between and along ***:Assessment of wetland nutr.ent stoichiometr. between and within ecosystem compar.ments suggests unconstr.ined stoichiometr. r.lated to P that confor.s with the notion of P limitation in the *** in N:P r.tios between floc and soil suggest differ.nt pathways of or.anic nutr.ent accumulation and r.tention between *** nutr.ent stoichiometr. was highly var.able and decoupled(or.close to decoupled as indicated byr.ation between par.meter.),in par.icular.with r.spect to *** hypothesize that decoupling may be the impr.nt of var.ability in inflow nutr.ent ***,despite active biogeochemical cycles that could act to r.stor. nutr.ent stoichiometr. along the FW,ther. was little evidence that such balancing occur.ed,as the

关键词： Decomposition Miner.lization Ever.lades Tr.atment wetlands

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and Validation of LC-MS/MS Method for.the Quantification of Chir.l Separ.ted r.Bicalutamide in Human Plasma

引用

Amer.can Jour.al of Analytical Chemistr. 2013年第2期4卷 63-76页

作者： N. T. r.mar.o S. Vidyadhar. r. L. C. Sasidhar.B. Deepti r. Sur.ndr. Yadav Alkem r.sear.h Center Navi Mumbai India Chebr.lu Hanumaiah Institute of Phar.aceutical Sciences Guntur India GVK Biosciences Hyderabad India Vignan Phar.acy College Guntur India

A simple, r.pid, specific and pr.cise liquid chr.matogr.phy—tandem mass spectr.photometr.c (LC-MS/MS) method was developed and validated for.the quantification of chir.l separ.ted r.bicalutamide fr.m S-bicalutamide, in human plasma. Topir.mate (TPM) was used as inter.al standar., added to plasma sample pr.or.to extr.ction using t-butyl methyl ether.(TBME). Chr.matogr.phic separ.tion was achieved on CHIr.LPAK AD-r. column (150 mm×4.6 mm, 5 μm) with acteonitr.le: 0.1% for.ic acid Buffer.(50:50 v/v) as an isocr.tic mobile phase with a flow r.te of 1.0 mL·min-1. Quantitation was per.or.ed by tr.nsition of 429.0 → 255.0 (m/z) for.r.bicalutamide and 338.1 → 77.8 (m/z) for.topir.mate. The lower.limit of quantitation was 20 ng·mL-1with a 100 μL plasma sample. The concentr.tions of eight wor.ing standar.s showed linear.ty between 20 to 3200 ng·mL-1(r.≥ 0.9990). Chr.matogr.phic separ.tion was achieved within 6 min, compar.d to the 15 min of pr.vious methods. The aver.ge extr.ction r.cover.es of 3 quality contr.l concentr.tions wer. 98.56% for.r.bicalutamide and 92.42% for.topir.mate. The coefficient of var.ation was ≤15% for.intr.- and inter.batch assays. Ther.for. a r.pid, specific and sensitive LC-MS/MS method for.the quantification of r.bicalutamide in human plasma was developed and validated can be used in the bioequivalence study of this dr.g.

关键词： LC-MS/MS r.Bicalutamide Topir.mate Validation Human Plasma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

后路聚乙烯系绳可减少成人脊柱畸形多节段固定后近端交界性后凸的发生

引用

中华医学杂志 2021年第33期101卷 2635-2635页

作者：程云忠(编译) 海涌(编译) r.binovich EP Snyder.MH mcclure JJ 首都医科大学附属北京朝阳医院骨科不详

成人脊柱畸形(ASD)治疗目的主要是缓解症状、改善脊柱功能状况、重建稳定性以及恢复脊柱平衡。随着脊柱后路矫形器械的发展,保留脊柱运动节段的需要,脊柱医师越来越多地采取选择性后路节段性融合的手术策略,虽然可取得良好的临床疗效,... 详细信息

成人脊柱畸形(ASD)治疗目的主要是缓解症状、改善脊柱功能状况、重建稳定性以及恢复脊柱平衡。随着脊柱后路矫形器械的发展,保留脊柱运动节段的需要,脊柱医师越来越多地采取选择性后路节段性融合的手术策略,虽然可取得良好的临床疗效,但是术后融合节段近端交界性后凸(PJK)的发生也逐渐成为该领域研究的热点之一。PJK是ASD术后常见的并发症,主要表现为神经功能的下降、脊柱畸形恶化和脊柱不稳定,需要再次手术,ASD术后PJK的发生率可高达69.4%。

关键词：脊柱畸形脊柱功能手术策略临床疗效脊柱后路融合节段再次手术节段性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：