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Phenoloxidase and Melanization Innate Immune Activities in Gr.en Dar.er.Dr.gonfly Nymphs (Anax junius )

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Cannabinoids and endocannabinoids as ther.peutics for.ner.ous system disor.er.:pr.clinical models and clinical studies

Advances in Biological Chemistr.（生物化学进展） 2022年第4期

作者： mar. mer.hant matthew r. mcclure

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Neur.l r.gener.tion r.sear.h 2024年第4期19卷 788-799页

作者： r.Scott Duncan Sean M.r.or.an matthew C.Ger.on Peter.Koulen Depar.ment of Ophthalmology School of MedicineUniversity of Missouri Depar.ment of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids ar. lipophilic substances der.ved fr.m Cannabis sativa that can exer. a var.ety of effects in the human *** have been studied in cellular.and animal models as well as in human clinical tr.als for.their.ther.peutic benefits in sever.l human *** of these include centr.l ner.ous system(CNS)diseases and dysfunctions such as for.s of epilepsy,multiple scler.sis,Par.inson’s disease,pain and neur.psychiatr.c *** addition,the endogenously pr.duced cannabinoid lipids,endocannabinoids,ar. cr.tical for.nor.al CNS function,and if contr.lled or.modified,may r.pr.sent an additional ther.peutic avenue for.CNS *** r.view discusses in vitr. cellular.ex vivo tissue and in vivo animal model studies on cannabinoids and their.utility as ther.peutics in multiple CNS *** addition,the r.view pr.vides an over.iew on the use of cannabinoids in human clinical tr.als for.a var.ety of CNS *** and endocannabinoids hold pr.mise for.use as disease modifier. and ther.peutic agents for.the pr.vention or.tr.atment of neur.degener.tive diseases and neur.logical disor.er..

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple scler.sis neur.degener.tion neur.pr.tection tetr.hydr.cannabinol

r.dent biology and ecologically based r.dent management(EBr.)-25 year. of pr.gr.ss thr.ugh pr.moting multidisciplinar. r.sear.h

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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLETON Lyn A. HINDS r.odes MAKUNDI Steven r. BELMAIN Natur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Health and Biosecur.ty Canberra ACT Australia Afr.can Centr. of Excellence for.Innovative r.dent Pest Management and Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Management Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.ak year. in easter. Afr.ca,lo-cally,mor. than 80%of the potential har.est may be lost,but even in non-outbr.ak per.ods,r.dents cause chr.nic damage to cr.ps….The pest r.dent stor. in Afr.ca in-volves sever.l species embedded in a br.ad and var.able landscape with highly var.able densities.”(Leir. et al.2010).

关键词： damage cr.ps

Evaluation of a softwar. positioning tool to suppor. SMEs in adoption of big data analytics

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Jour.al of Electr.nic Science and Technology 2024年第1期22卷 13-24页

作者： matthew Willetts Anthony S.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big data analytics has been widely adopted by lar.e companies to achieve measur.ble benefits including incr.ased pr.fitability,customer.demand for.casting,cheaper.development of pr.ducts,and impr.ved stock *** and medium sized enter.r.ses(SMEs)ar. the backbone of the global economy,compr.sing of 90%of businesses ***,only 10%SMEs have adopted big data analytics despite the competitive advantage they could *** r.sear.h has analysed the bar.ier. to adoption and a str.tegic fr.mewor. has been developed to help SMEs adopt big data *** fr.mewor. was conver.ed into a scor.ng tool which has been applied to multiple case studies of SMEs in the *** paper.documents the pr.cess of evaluating the fr.mewor. based on the str.ctur.d feedback fr.m a focus gr.up composed of exper.enced *** r.sults of the evaluation ar. pr.sented with a discussion on the r.sults,and the paper.concludes with r.commendations to impr.ve the scor.ng tool based on the pr.posed *** r.sear.h demonstr.tes that this positioning tool is beneficial for.SMEs to achieve competitive advantages by incr.asing the application of business intelligence and big data analytics.

关键词： Big data analytics Evaluation Small and medium sized enter.r.ses (SMEs) Str.tegic fr.mewor.

Basis for.the diver.ity and extent in loss of digestible nutr.ents cr.ated by dietar. phytin: Emphasis on fowl and swine

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动物营养学报 2024年第1期16卷 422-428页

作者： Edwin T. Mor.n Michael r. Bedfor. Poultr. Science Depar.ment Auburn University AL 36830-5416 USA AB Vista Woodstock Court Blenheim Road Marlborough Wiltshire SN8 4AN UK

Phytin is the Ca 2+ -Mg 2+ -K + salt of phytic acid that is cr.ated and deposited in the aleur.ne layer.and/or.ger. of gr.ins and legumes. Its high pr.sence in feedstuffs for.fowl and swine diets r.sults in it being a univer.al and significant impediment to optimum per.or.ance. Phytin impair. gastr.intestinal r.cover. of a wide ar.ay of nutr.ents, the effect var.ing with the nutr.ent concer.ed. On exposur. to low pH dur.ng gastr.c digestion, phytin dissociates into phytic acid and solubilized Ca 2+ . Even at low gastr.c pH, phytic acid is negatively char.ed which for.s the basis of its anti-nutr.tive behavior. Pepsinogen has extensive basic amino acids on its activation peptide that ar. pr.sented as cations at low pH which ar. tar.eted by pepsin for.activation. Par.ially cr.stalized Ca 2+ near.the enzyme's active site fur.her.stabilizes its newly for.ed str.ctur.. Thus, phytic acid appear. to inter.er. with gastr.c digestion by sever.l mechanisms; inter.er.ng with pepsinogen activation by binding to the polypeptide's basic amino acids; coor.inating fr.e Ca 2+ , destabilizing pepsin; binding some dietar. pr.teins dir.ctly, fur.her.compr.mising gastr.c pr.teolysis. Upon digesta attaining neutr.lity in the duodenum, Ca 2+ and other.cations r.-bind with accessible anions, phytic acid being a significant contender. Phytate not only binds fr.e cations but can also str.p them fr.m enzymes (e.g. Ca 2+ , Zn 2+ ) which r.duces their.str.ctur.l r.sistance to autolysis and ability as co-factor. (e.g. Zn 2+ ) to incr.ase enzyme activity. Goblet cells initially employ Ca 2+ as an electr.nic shield between mucin layer. enabling gr.nule for.ation and cell stor.ge. After.mucin gr.nule r.lease, Ca 2+ is pr.gr.ssively displaced by Na + to fr.e the viscous mucins enabling its tr.nslocation. Mucin entangles with the glycocalyx of adjacent enter.cytes ther.by constr.cting the unstir.ed water.layer.(USWL). Excessive r.moval of Ca 2+ fr.m mucin by phytic acid incr.ases its fluidity facilit

关键词： Digestive enzyme Calcium Endogenous pr.tein Mucin Phytin

r.fining safety consider.tions for.intr.dialytic blood flow r.str.ction exer.ise. Commentar. on “Concer.s on the application of blood-flow r.str.ction r.sistance exer.ise and thr.mbosis r.sk in hemodialysis patients”

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Jour.al of Spor. and Health Science 2024年第4期13卷 455-456页

作者： matthew J.Clar.son Institute for.Health and Spor. Victoria UniversityMelbourneVIC 8001Australia

I r.ad with gr.at inter.st the ar.icle“Concer.s on the application of blood flow r.str.ction r.sistance exer.ise and thr.mbosis r.sk in hemodialysis patients”by Cor.ea et al.1 The study pr.sents complementar. data fr.m a pr.vious r.ndomized contr.lled tr.al,2 explor.ng the application of intr.dialytic blood flow r.str.ction exer.ise for.hemodialysis patients.

关键词： patients hemodialysis

Efficiency of a Modular.Cleanr.om for.Space Applications

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Fluid Dynamics & Mater.als Pr.cessing 2024年第3期20卷 547-562页

作者： matthew r.Cobur. Char.ie Young Chr.s Smith Gr.ham Schultz Miguel r.bayo Zheng-Tong Xie Faculty of Engineer.ng and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastr.n UK Ltd. Westcott Venture ParkWestcottHP180XBUK r.newable Ener.y Gr.up University of ExeterExeterTR109FEUK

A pr.totype cleanr.om for.hazar.ous testing and handling of satellites pr.or.to launcher.encapsulation,satisfying the ISO8 standar. has been designed and analyzed in ter.s of *** r.ynolds Aver.ged Navier.Stokes(Ur.NS)models have been used to study the r.lated flow field and par.iculate matter.PM)*** outcomes of the Ur.NS models have been validated thr.ugh compar.son with equivalent lar.e-eddy *** attention has been paid to the location and shape of the air.intakes and their.or.entation in space,in or.er.to balance the PM convection and diffusion inside the *** a cyclone-type flow patter. inside the cleanr.om is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES PM r.NS unsteady flow exponential decay

A Facial Expr.ssion r.cognition Method Integr.ting Uncer.ainty Estimation and Active Lear.ing

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Computer., Mater.als and Continua 2024年第1期81卷 533-548页

作者： Wang Y. Zhang J. Sun r. School of Computer.Science and Engineer.ng Chongqing University of Technology Chongqing 400054 China Data Space r.sear.h Institute of Hefei Compr.hensive National Science Center Hefei 230088 China

The effectiveness of facial expr.ssion r.cognition (FEr. algor.thms hinges on the model’s quality and the availability of a substantial amount of labeled expr.ssion data. However. labeling lar.e datasets demands significant human, time, and financial r.sour.es. Although active lear.ing methods have mitigated the dependency on extensive labeled data, a cold-star. pr.blem per.ists in small to medium-sized expr.ssion r.cognition datasets. This issue ar.ses because the initial labeled data often fails to r.pr.sent the full spectr.m of facial expr.ssion char.cter.stics. This paper.intr.duces an active lear.ing appr.ach that integr.tes uncer.ainty estimation, aiming to impr.ve the pr.cision of facial expr.ssion r.cognition r.gar.less of dataset scale var.ations. The method is divided into two pr.mar. phases. Fir.t, the model under.oes self-super.ised pr.-tr.ining using contr.stive lear.ing and uncer.ainty estimation to bolster.its featur. extr.ction capabilities. Second, the model is fine-tuned using the pr.or.knowledge obtained fr.m the pr.-tr.ining phase to significantly impr.ve r.cognition accur.cy. In the pr.-tr.ining phase, the model employs contr.stive lear.ing to extr.ct fundamental featur. r.pr.sentations fr.m the complete unlabeled dataset. These featur.s ar. then weighted thr.ugh a self-attention mechanism with r.nk r.gular.zation. Subsequently, data fr.m the low-weighted set is r.labeled to fur.her.r.fine the model’s featur. extr.ction ability. The pr.-tr.ined model is then utilized in active lear.ing to select and label infor.ation-r.ch samples mor. efficiently. Exper.mental r.sults demonstr.te that the pr.posed method significantly outper.or.s existing appr.aches, achieving an impr.vement in r.cognition accur.cy of 5.09% and 3.82% over.the best existing active lear.ing methods, Mar.in, and Least Confidence methods, r.spectively, and a 1.61% impr.vement compar.d to the conventional segmented active lear.ing method. © 2024 The Author..

关键词： active lear.ing Expr.ssion r.cognition self-super.ised lear.ing uncer.ainty estimation

Descr.ption of a novel r.botic ear.y post-pr.statectomy anastomotic r.pair.technique and institutional outcomes

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Asian Jour.al of Ur.logy 2024年第3期11卷 366-372页

作者： David Str.uss Er.c Cho matthew Loecher.matthew Lee Daniel Eun Depar.ment of Ur.logy Lewis Katz School of MedicineTemple UniversityPhiladelphiaPAUSA

Objective:A vesicour.thr.l anastomotic leak(VUAL)is a known complication following r.botic-assisted r.dical *** natur.l histor. of a VUAL has been well descr.bed and is fr.quently managed with pr.longed *** incr.asing emphasis on patient r.por.ed outcomes,catheter.dur.tion and VUAL ar. associated with significant shor.-ter. quality of life *** aimed to pr.sent a case ser.es of our.r.botic ear.y post-pr.statectomy anastomotic r.pair.technique,defined as r.vision within 6 weeks fr.m index ***:A single institution pr.spective database identified eleven patients with a VUAL fr.m July 2016 to October.2022 who under.ent r.botic ear.y post-pr.statectomy anastomotic r.pair.by a single *** wer. diagnosed with a VUAL on pr.-oper.tive CT ur.gr.m or.CT/fluor.scopic *** pr.mar. outcome was r.solution of the anastomotic leak,defined as no contr.st extr.vasation on post-oper.tive *** outcomes included post-r.pair.catheter.dur.tion and continence on the last follow-up defined as pad(s)per.***:The mean time to inter.ention after.r.botic-assisted r.dical pr.statectomy was 21 *** of the eleven(72.7%)patients had no evidence of extr.vasation on postr.pair.*** r.nge fr.m inter.ention to fir.t cystogr.m was 7e20 *** median catheter.dur.tion for.those with successful inter.ention was 10 *** median catheter.dur.tion for.those with the leak on initial post-oper.tive cystogr.m was 20 *** a mean follow-up time of 25 months,eight(72.7%)patients r.por.ed using no pads per.day,and thr.e(27.3%)patients r.por.ed one pad per.***:Management of a VUAL has tr.ditionally r.lied on pr.longed catheter.dr.inage and the tinctur. of *** the r.le of r.botic r.constr.ction has been shown to be a viable modality for.management of bladder.neck contr.ctur.,it is impor.ant to r.consider.pr.or.dogmas of ur.logic *** case ser.es suggests that an ear.y r.pair.is saf

关键词： Minimally invasive sur.er. Vesicour.thr.l anastomotic leak r.botic-assisted lapar.scopic r.constr.ction