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Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing

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Biomedical and Environmental Sciences 2024年第8期37卷 876-886页

作者： Yutong Wang Jing Li Shirong Xu Shengli Lin Zhenchen Hou Linlin Wang Yali Huang Yue Sun Wei Guo Lailai Yan Ying Wang chan Tian State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Department of Medical Genetics Peking UniversityBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Central Laboratory of School of Public Health Peking UniversityBeijing 100191China School of Basic Medical Sciences Peking UniversityBeijing 100191China

Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from *** A total of 141 couples were *** and follicular fluid from the wives and semen plasma from the husbands,were analyzed for REEs using inductively coupled plasma mass spectrometry(ICP-MS).Spearman's correlation coefficients and the Mann–Whitney U test were used to assess correlations and compare REE concentrations among three types of samples,*** models were utilized to estimate the individual REE effect on IVF-ET outcomes,while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET *** Higher La concentration in semen(median 0.089 ng/mL,P=0.03)was associated with a lower fertilization ***,this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection(ICSI)(P=0.27).In semen,the REEs mixture did not exhibit any significant association with clinical *** Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate,but not clinical pregnancy *** is the first to report REEs concentrations in follicular fluid with La,Ce,Pr,and Nd found at significantly lower concentrations than in serum,suggesting that these four REEs may not accumulate in the female reproductive ***,at the current exposure levels,mixed REEs exposure did not exhibit reproductive toxicity.

关键词： Rare earth elements In vitro fertilization Pregnancy outcomes Mixture exposure analysis

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Colorful facial markings are associated with foraging rates and affiliative relationships in a wild group-living cichlid fish

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Current Zoology 2024年第1期70卷 70-78页

作者： Brett M.Culbert James B.Barnett Isaac Y.Ligocki matthew G.Salena Marian Y.L.Wong Ian M.Hamilton Sigal Balshine Department of Integrative Biology University of GuelphGuelphOntarioCanada Department of Psychology Neuroscience&BehaviourMcMaster UniversityHamiltonOntarioCanada Department of Evolution Ecologyand Organismal BiologyThe Ohio State UniversityColumbusOHUSA Department of Biology Millersville UniversityMillersvillePAUSA School of Earth Atmospheric and Life SciencesUniversity of WollongongWollongongNew South WalesAustralia Department of Mathematics The Ohio State UniversityColumbusOHUSA

Many animals use color to signal their quality and/or behavioral *** signals have been well studied in the contexts of competi-tion and mate choice;however,the role of these signals in nonsexual,affiliative relationships is not as well ***,we used wild social groups of the cichlid fish Neolamprologus pulcher to investigate whether the size of a brightly colored facial patch was related to 1)individual quality,2)social dominance,and/or 3)affiliative *** with larger patches spent more time foraging and tended to perform more aggressive acts against conspecific territory *** did not find any evidence that the size of these yellow patches was related to social rank or body size,but dominant males tended to have larger patches than dominant ***,patch size had a rank-specific relationship with the number of affiliative interactions that individuals engaged *** males with large patches received fewer affiliative acts from their groupmates compared to dominant males with small ***,subordinates with large patches tended to receive more affiliative acts from their groupmates while performing fewer affiliative acts *** together,our results suggest that patch size reflects interindividual variation in foraging effort in this cichlid fish and offer some of the first evidence that colorful signals may shape affiliative relationships withinwildsocialgroups.

关键词： affiliation foraging Lake Tanganyika Neolamprologus pulcher visual signals

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“Keyboard sign”and“coffee bean sign”in the prenatal diagnosis of ileal atresia:A case report

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World Journal of Clinical Cases 2024年第24期12卷 5622-5627页

作者： Zhi-Hui Fei Qi-Yi Zhou Ling Fan chan Yin Department of Ultrasound Changde Maternal and Child Health Care HospitalChangde 415000Hunan ProvinceChina

BACKGROUND Ileal atresia is a congenital abnormality where there is significant stenosis or complete absence of a portion of the *** overall diagnostic accuracy of prenatal ultrasound in detecting jejunal and ileal atresia is *** report a case of ileal atresia diagnosed prenatally by ultrasound examination with the“keyboard sign”and“coffee bean sign”.CASE SUMMARY We report a case of ileal atresia diagnosed in utero at 31 weeks'of *** ultrasound examination revealed two rows of intestines arranged in an‘S’shape in the middle *** inner diameters were 1.7 cm and 1.6 cm,respectively.A typical“keyboard sign”was *** intestine canal behind the“keyboard sign”showed an irregular strong *** was no normal intestinal wall structure,showing a typical“coffee bean sign”.Termination of the pregnancy and autopsy findings confirmed the *** The prenatal diagnosis of ileal atresia is *** sonographic features of the“keyboard sign”and“coffee bean sign”are helpful in diagnosing the location of congenital jejunal and ileal atresia.

关键词： Ileal atresia The prenatal diagnosis Keyboard sign Coffee bean sign

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T lymphocyte proportion in Alzheimer’s disease prognosis

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World Journal of Clinical Cases 2024年第26期12卷 6001-6003页

作者： matthew Willman Gopi Patel Brandon Lucke-Wold College of Medicine University of FloridaGainesvilleFL 32610United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Bai et al investigate the predictive value of T lymphocyte proportion in Alzheimer's disease(AD)*** a retrospective study involving 62 AD patients,they found that a decrease in T lymphocyte proportion correlated with a poorer prognosis,as indicated by higher modified Rankin scale *** the study highlights the potential of T lymphocyte proportion as a prognostic marker,it suggests the need for larger,multicenter studies to enhance generalizability and ***,future research could use cognitive exams when evaluating prognosis and delve into immune mechanisms underlying AD *** limitations inherent in retrospective designs,Bai et al's work contributes to understanding the immune system's role in AD prognosis,paving the way for further exploration in this under-researched area.

关键词： Alzheimer's disease T lymphocyte T lymphocyte proportion Alzheimer's disease prognosis Modified rankin scale Immune cell count Electroencephalogram Immune function

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Gas Exchange Rates of Texas Persimmon (Diospyros texana) in Central Texas Woodlands

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American Journal of Plant Sciences 2024年第5期15卷 329-348页

作者： matthew B. Grunstra Oscar W. Van Auken Department of Integrative Biology University of Texas at San Antonio San Antonio TX USA

Diospyros texana (Texas persimmon) is a secondary species in most Juniperus ashei/Quercus fusiformis woodlands in central Texas. It has high density, but plants are mostly in the community understory. Light response curves at ambient and elevated levels of CO2 and temperature were measured for D. texana. The Anet (photosynthetic rate) increased significantly as both light level and CO2 levels increased but not temperature. The Amax (maximum photosynthetic rate) of D. texana in full sun at elevated levels of CO2 was increased for all treatments. Stomatal conductance increased with levels of CO2 but only if the interaction was removed from the model. Intercellular levels of CO2 increased with both temperature and CO2 treatments as did water use efficiency (WUE). Furthermore, light saturation (Lsat) increased with CO2 treatments and light compensation (Lcp) increased with temperature. The dark respiration (Rd) increased with both temperature and CO2 treatments. Markov population models suggested D. texana populations would remain ecologically similar in the future. However, sub-canopy light levels and herbivory should be considered when examining population projections. For example, Juniperus ashei juveniles are not recruited into any canopy unless there are high light levels. Herbivory reduces the success of Quercus juveniles from reaching the canopy. These factors do not seem to be a problem for D. texana juveniles which would allow them to reach the canopy without need of a high light gap and are not prevented by herbivory. Thus, Juniperus/Quercus woodlands will change in the future to woodlands with D. texana a more common species.

关键词： Replacement Dynamics Ecological Succession CO2 Concentrations Temperature Levels Photosynthetic Rates Drought Tolerance Herbivory Species Replacement Encroachment Juniper

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First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang chan Zhu Dongsheng Chen Baorui Liu Juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

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Trust beyond Technology Algorithms: A Theoretical Exploration of Consumer Trust and Behavior in Technological Consumption and AI Projects

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Journal of Computer and Communications 2024年第6期12卷 72-102页

作者： David Oyekunle Ugochukwu Okwudili matthew David Preston David Boohene Salford Business School University of Salford Manchester UK Computer Science Department Federal University (UFLA) Lavras Brazil Department of Entrepreneurship and Business Science University of Energy and Natural Resources Sunyani Ghana

In an era dominated by artificial intelligence (AI), establishing customer confidence is crucial for the integration and acceptance of AI technologies. This interdisciplinary study examines factors influencing customer trust in AI systems through a mixed-methods approach, blending quantitative analysis with qualitative insights to create a comprehensive conceptual framework. Quantitatively, the study analyzes responses from 1248 participants using structural equation modeling (SEM), exploring interactions between technological factors like perceived usefulness and transparency, psychological factors including perceived risk and domain expertise, and organizational factors such as leadership support and ethical accountability. The results confirm the model, showing significant impacts of these factors on consumer trust and AI adoption attitudes. Qualitatively, the study includes 35 semi-structured interviews and five case studies, providing deeper insight into the dynamics shaping trust. Key themes identified include the necessity of explainability, domain competence, corporate culture, and stakeholder engagement in fostering trust. The qualitative findings complement the quantitative data, highlighting the complex interplay between technology capabilities, human perceptions, and organizational practices in establishing trust in AI. By integrating these findings, the study proposes a novel conceptual model that elucidates how various elements collectively influence consumer trust in AI. This model not only advances theoretical understanding but also offers practical implications for businesses and policymakers. The research contributes to the discourse on trust creation and decision-making in technology, emphasizing the need for interdisciplinary efforts to address societal challenges associated with technological advancements. It lays the groundwork for future research, including longitudinal, cross-cultural, and industry-specific studies, to further explore consume

关键词： Consumer Trust AI-Driven Projects Transparency Ethical Accountability Structural Equation Modeling (SEM) Technology Acceptance Model (TAM) Interdisciplinary Study Organizational Factors Psychological Factors Behavioral Intention

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场景可供性视角下书画展释展路径与实践研究--基于“客中月光照家山--北京画院藏齐白石精品展”的观众调查

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东南文化 2024年第2期 139-146页

作者：郭青孙婵中南大学人文学院湖南长沙410083 湖南美术馆湖南长沙410012

近年来,书画展实践经验在美术馆与博物馆之间的交流互鉴日益增多,如何适应技术变革及社会变迁下观众行为模式与情感偏好的变化,是博物馆与美术馆同样需要回应的问题。从场景可供性视角出发,博物馆或美术馆通过“感知—认知—情感—社交... 详细信息

近年来,书画展实践经验在美术馆与博物馆之间的交流互鉴日益增多,如何适应技术变革及社会变迁下观众行为模式与情感偏好的变化,是博物馆与美术馆同样需要回应的问题。从场景可供性视角出发,博物馆或美术馆通过“感知—认知—情感—社交”的释展路径,将观众对于书画展览模糊的期待转化为实践活动与舒适物空间,以灵活匹配不同观众的行为模式与情感诉求,使书画展与观众的主观能动性与潜在行动力之间形成强耦合关系,从而切实提升其文化获得感与幸福感。该释展路径能够有效促进书画展与不同公众的能动性之间形成协调互补的关系。

关键词：书画展释展博物馆美术馆场景可供性观众调查

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Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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Genes & Diseases 2024年第3期11卷 148-150页

作者： Chen Tan Lingwa Wang Yifan Yang Shizhi He George G.Chen Jason YK.chan Michael CF.Tong C.A.van Hasselt Wenbin Xu Ling Feng Ru Wang Jugao Fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China Department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China Department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(IC)as a larynxpreserving approach for LA-LHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

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构建数字时代产业变革的工程生态

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中国科学院院刊 2024年第6期39卷 1022-1031页

作者：许正中产健中共中央党校(国家行政学院)经济学教研部北京100091 中国科协创新战略研究院北京100038

数字文明时代,科技创新成为催生新质生产力、引领国际竞争力的必然选择,也是大国参与国际治理和重构国际秩序的重要政策工具,更是熨平经济周期波动、摆脱周期约束的重要法宝。以高水平科技创新和科技自立自强为重要成果体现的崛起模式,... 详细信息

数字文明时代,科技创新成为催生新质生产力、引领国际竞争力的必然选择,也是大国参与国际治理和重构国际秩序的重要政策工具,更是熨平经济周期波动、摆脱周期约束的重要法宝。以高水平科技创新和科技自立自强为重要成果体现的崛起模式,还能有力提升国际治理中国方案的可行性和认可度。与此同时,数字时代的科技创新越来越强调以工程化思维促进科学技术知识和产业的有机化合,工程生态范式提供了一个分析研究产业变革的演变过程及产业变革中的产业创新机制的全新框架,有助于我们理解产业变革的激励、创造新兴产业的机会、适应变革和转型,以及推动有关政策认识和政策制定的过程和机制,从而能加速数字时代的产业原创、产业衍生、产业升级。进入新时代,要进一步培育催生产业变革的工程生态新范式,不断孕育引领下一次科技革命和产业变革的新动能。

关键词：数字文明时代科技创新自立自强工程生态

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