检索结果-南通市图书馆

The role of the robot-assisted procedure during total pancreatectomy: a viewpoint

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第3期10卷 405-406页

作者： matteo De Pastena Alessandro esposito Roberto Salvia General and Pancreatic Surgery Unit Pancreas InstituteUniversity of VeronaVeronaItaly

We read with great interest the article published in HepatoBiliary Surgery and Nutrition,“Robotic-assisted versus open total pancreatectomy:a propensity score-matched study”(1).Total pancreatectomy(TP)is a complex procedure,primarily performed for diseases involving the entire pancreas,which is increasing its diffusion due to a wide range of pancreatic diseases,including main duct intraductal papillary mucinous neoplasms.

关键词： neoplasms Surgery diseases

Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第9期8卷 1600-1607页

作者： Fiorenza Ferrari Elisa Scalzotto Pasquale esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco Department of Nephrology Dialysis&Transplantation International Renal Research Institute VicenzaSt.Bortolo HospitalVicenza 36100Italy Department of Internal Medicine NephrologyDialysis and Transplantation ClinicsGenoa University and IRCCS Policlinico San MartinoGenova 16132Italy Department of Cardiology Coronary Intensive Care UnitSt.Bortolo HospitalVicenza 36100Italy Department of Cardiology Coronary Intensive Care UnitChioggia HospitalVenezia 36100Italy Neonatal and Pediatric Intensive Care Unit G.Gaslini InstituteGenoa 16147Italy Department of Cardiovascular and Thoracic Sciences Catholic University of the Sacred Heart Agostino Gemelli FoundationRome 00168Italy Division of Nephrology and Dialysis Azienda Ospedaliera G.BrotzuPiazzale Ricchi n°1Cagliari 09134Italy

BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical *** To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of *** We performed a retrospective cohort,multi-centre *** January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary *** monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU *** Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required *** the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak ***,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly *** In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart ***,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage.

关键词： Cardiorenal syndrome type 1 Acute kidney injury Biomarker Neutrophil gelatinase-associated lipocalin

Pancreaticoduodenectomy in patients ≥ 75 years of age:Are there any differences with other age ranges in oncological and surgical outcomes? Results from a tertiary referral center

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第17期23卷 3077-3083页

作者： Salvatore Paiella matteo De Pastena Tommaso Pollini Giovanni Zancan Debora Ciprani Giulia De Marchi Luca Landoni Alessandro esposito Luca Casetti Giuseppe Malleo Giovanni Marchegiani Massimiliano Tuveri Enrico Marrano Laura Maggino Erica Secchettin Deborah Bonamini Claudio Bassi Roberto Salvia General and Pancreatic Surgery Department Pancreas InstituteUniversity and Hospital Trust of Verona Gastroenterology B Department Pancreas InstituteUniversity and Hospital Trust of Verona

AIM To compare surgical and oncological outcomes after pancreaticoduodenectomy(PD) in patients ≥ 75 years of age with two younger cohorts of patients. METHODS The prospectively maintained Institutional database of pancreatic resection was queried for patients aged ≥ 75 years(late elderly, LE) submitted to PD for any disease from January 2010 to June 2015. We compared clinical, demographic and pathological features and survival outcomes of LE patients with 2 exact matched cohorts of younger patients [≥ 40 to 64 years of age(adults, A) and ≥ 65 to 74 years of age(young elderly, YE)] submitted to PD, according to selected variables. RESULTS The final LE population, as well as the control groups, were made of 96 subjects. Up to 71% of patients was operated on for a periampullary malignancy and pancreatic cancer(PDAC) accounted for 79% of them. Intraoperative data(estimated blood loss and duration of surgery) did not differ among the groups. The overall complication rate was 65.6%, 61.5% and 58.3% for LE, YE and A patients, respectively, P = NS). Reoperation and cardiovascular complications were significantly more frequent in LE than in YE and A groups(P = 0.003 and P = 0.019, respectively). When considering either all malignancies and PDAC only, the three groups did not differ in survival. Considering all benign diseases, the estimated mean survival was 58 and 78 mo for ≥ and < 75 years of age(YE + A groups), respectively(P = 0.012). CONCLUSION Age is not a contraindication for PD. A careful selection of LE patients allows to obtain good surgical and oncological results.

关键词：胰腺的癌症 Periampullary 癌症 Pancreaticoduodenectomy 老胰腺的外科

Severe cyclophosphamide-related hyponatremia in a patient with acute glomerulonephritis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Nephrology 2017年第4期6卷 217-220页

作者： Pasquale esposito Maria Valentina Domenech Nicoletta Serpieri Marta Calatroni Ilaria Massa Alessandro Avella Edoardo La Porta Luca Estienne Elena Caramella Teresa Rampino Department of Nephrology Dialysis and TransplantationFondazione IRCCS Policlinico "San Matteo" and University of Pavia

Cyclophosphamide is frequently used to treat cancer,autoimmune and renal diseases,such as rapidly progressive *** side effects are well-known,including bone marrow depression,infections,alopecia,sterility,bladder malignancy and hemorrhagic ***,in some cases cyclophosphamide use has been related to the onset of hyponatremia,by development of a syndrome of inappropriate ***,severe hyponatremia has been previously reported in patients treated with high-dose or moderate-dose of intravenous cyclophosphamide,while only few cases have been reported in patients treated with low ***,we discuss a case of a syndrome of inappropriate antidiuresis followed to a single low-dose of intravenous cyclophosphamide in a patient with a histological diagnosis of acute glomerulonephritis,presenting as acute kidney *** cyclophosphamide administration(500 mg IV),while renal function gradually improved,the patient developed confusion and *** examinations showed serum sodium concentration dropped to 122 mmol per liter associated with an elevated urinary osmolality of 199 mO sm/kg,while common causes of acute hyponatremia were *** was successfully treated with water restriction and hypertonic saline solution infusion with the resolution of the electrolyte *** case,together with the previous ones already reported,highlights that electrolyte profile should be strictly monitored in patients undergoing cyclophosphamide therapy in order to early recognize the potentially lifethreatening complications of acute water retention.

关键词：环磷酰胺癌症治疗方法临床分析

Clinical audit,a valuable tool to improve quality of care:General methodology and applications in nephrology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Nephrology 2014年第4期3卷 249-255页

作者： Pasquale esposito Antonio Dal Canton Unit of Nephrology Dialysis and TransplantationFondazione IRCCS Policlinico San Matteo and University of Pavia

Evaluation and improvement of quality of care provided to the patients are of crucial importance in the daily clinical practice and in the health policy planning and *** tools have been developed,including incident analysis,health technology assessment and clinical *** clinical audit consist of measuring a clinical outcome or a process,against welldefined standards set on the principles of evidencebased medicine in order to identify the changes needed to improve the quality of *** particular,patients suffering from chronic renal diseases,present many problems that have been set as topics for clinical audit projects,such as hypertension,anaemia and mineral metabolism *** the results of these studies have been encouraging,demonstrating the effectiveness of audit,overall the present evidence is not clearly in favour of clinical *** findings call attention to the need to further studies to validate this methodology in different operating *** review examines the principle of clinical audit,focusing on experiences performed in nephrology settings.

关键词：患者医疗卫生行业发展现状临床分析

Costimulatory blockade:A novel approach to the treatment of glomerular disease?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2015年第2期5卷 20-25页

作者： Pasquale esposito Teresa Rampino Antonio Dal Canton Department of Nephrology Dialysis and TransplantationFondazione IRCCS Policlinico San Matteo and University of Pavia

Costimulatory pathways(Cluster of differentiation 28,tumor necrosis factor-related,adhesion and T Cell Ig-and mucin-domain molecules) regulating the interactions between receptors on the T cells andtheir ligands expressed on several cell types,have a key role in controlling many immunological and non immunological ***,accumulating evidence indicate that these molecules are involved in the pathogenesis of numerous conditions,such as allograft rejection,atherosclerosis,rheumatoid arthritis,psoriasis and renal diseases,including *** or secondary(i.e.,associated with infections,drugs or systemic diseases,such as systemic lupus erythematosus,diabetes,etc.) glomerulonephritis represent a group of heterogeneous diseases with different pathogenic *** costimulatory molecules,in particular CD80 and CD40,have been found to be expressed on podocytes in the course of different experimental and clinical glomerulonephritis,costimulation has been thought as a new therapeutic target for patients with glomerular ***,although experimental data suggested that the blockade of costimulatory pathways is effective and safe in the prevention and treatment of glomerular diseases,clinical trials reported contrasting ***,at this moment,there is not a strong evidence for the general use of costimulatory blockade as an alternative treatment strategy in patients with primary or secondary ***,we critically discuss the current data and the main issues regarding the development of this innovative therapeutic approach.

关键词： Costimulation Glomerulonephritis Cluster of differentiation 80 Cytotoxic T-lymphocyte-associated antigen-4 Lupus nephritis Abatacept Proteinuria Podocytes